Result of FASTA (omim) for
pFN21AE1349
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1349, 469 aa
1>>>pF1KE1349 469 - 469 aa - 469 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.3392+/-0.000348; mu= 10.8679+/- 0.022
mean_var=203.8123+/-40.747, 0's: 0 Z-trim(122.4): 241 B-trim: 0 in 0/51
Lambda= 0.089838
statistics sampled from 40158 (40436) to 40158 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.788), E-opt: 0.2 (0.474), width: 16
Scan time: 10.430
The best scores are: opt bits E(85289)
NP_002612 (OMIM: 300383,312060) properdin precurso ( 469) 3644 484.7 2.3e-136
NP_001138724 (OMIM: 300383,312060) properdin precu ( 469) 3644 484.7 2.3e-136
XP_016885064 (OMIM: 300383,312060) PREDICTED: prop ( 334) 2647 355.3 1.5e-97
XP_016857926 (OMIM: 603075,608548) PREDICTED: hemi (4976) 819 119.7 1.8e-25
XP_011508340 (OMIM: 603075,608548) PREDICTED: hemi (5518) 819 119.8 2e-25
NP_114141 (OMIM: 603075,608548) hemicentin-1 precu (5635) 819 119.8 2e-25
NP_003237 (OMIM: 188060) thrombospondin-1 precurso (1170) 543 83.2 4.1e-15
NP_003238 (OMIM: 188061,603932) thrombospondin-2 p (1172) 539 82.7 5.9e-15
XP_016869182 (OMIM: 602682) PREDICTED: brain-speci (1660) 439 69.9 6e-11
XP_011515504 (OMIM: 602682) PREDICTED: brain-speci (1161) 434 69.1 7.4e-11
XP_011515501 (OMIM: 602682) PREDICTED: brain-speci (1584) 434 69.2 9.1e-11
NP_001693 (OMIM: 602682) brain-specific angiogenes (1584) 434 69.2 9.1e-11
XP_016869185 (OMIM: 602682) PREDICTED: brain-speci (1618) 434 69.3 9.2e-11
XP_016869184 (OMIM: 602682) PREDICTED: brain-speci (1623) 434 69.3 9.2e-11
XP_016869183 (OMIM: 602682) PREDICTED: brain-speci (1630) 434 69.3 9.2e-11
XP_016869181 (OMIM: 602682) PREDICTED: brain-speci (1662) 434 69.3 9.3e-11
XP_016869180 (OMIM: 602682) PREDICTED: brain-speci (1663) 434 69.3 9.3e-11
XP_016862127 (OMIM: 609298) PREDICTED: semaphorin- (1117) 431 68.7 9.4e-11
NP_001026872 (OMIM: 609298) semaphorin-5B isoform (1151) 431 68.7 9.6e-11
NP_001243275 (OMIM: 609298) semaphorin-5B isoform (1151) 431 68.7 9.6e-11
NP_001243276 (OMIM: 609298) semaphorin-5B isoform (1205) 431 68.7 9.9e-11
XP_016857396 (OMIM: 602683) PREDICTED: adhesion G (1530) 403 65.2 1.4e-09
XP_011534312 (OMIM: 602684) PREDICTED: adhesion G (1189) 401 64.8 1.5e-09
XP_016862128 (OMIM: 609298) PREDICTED: semaphorin- ( 794) 394 63.7 2.1e-09
NP_001243277 (OMIM: 609298) semaphorin-5B isoform (1057) 394 63.9 2.5e-09
XP_016866633 (OMIM: 602684) PREDICTED: adhesion G ( 813) 390 63.2 3e-09
XP_016866632 (OMIM: 602684) PREDICTED: adhesion G ( 827) 390 63.2 3.1e-09
XP_016866631 (OMIM: 602684) PREDICTED: adhesion G ( 869) 390 63.2 3.2e-09
XP_011534314 (OMIM: 602684) PREDICTED: adhesion G ( 908) 390 63.3 3.3e-09
XP_011534311 (OMIM: 602684) PREDICTED: adhesion G (1267) 390 63.4 4.1e-09
XP_016857400 (OMIM: 602683) PREDICTED: adhesion G (1478) 390 63.5 4.5e-09
XP_016866629 (OMIM: 602684) PREDICTED: adhesion G (1489) 390 63.5 4.5e-09
XP_006715597 (OMIM: 602684) PREDICTED: adhesion G (1489) 390 63.5 4.5e-09
XP_016857399 (OMIM: 602683) PREDICTED: adhesion G (1497) 390 63.5 4.5e-09
XP_016857398 (OMIM: 602683) PREDICTED: adhesion G (1511) 390 63.5 4.6e-09
XP_005248809 (OMIM: 602684) PREDICTED: adhesion G (1522) 390 63.5 4.6e-09
XP_016857397 (OMIM: 602683) PREDICTED: adhesion G (1530) 390 63.5 4.6e-09
NP_001695 (OMIM: 602684) adhesion G protein-couple (1522) 388 63.3 5.5e-09
XP_006715725 (OMIM: 612249) PREDICTED: thrombospon (1516) 381 62.4 1e-08
XP_006715723 (OMIM: 612249) PREDICTED: thrombospon (1559) 381 62.4 1e-08
XP_016865505 (OMIM: 609297) PREDICTED: semaphorin- ( 917) 377 61.6 1.1e-08
XP_011513495 (OMIM: 612249) PREDICTED: thrombospon (1588) 381 62.4 1.1e-08
XP_011513496 (OMIM: 612249) PREDICTED: thrombospon (1588) 381 62.4 1.1e-08
XP_006715722 (OMIM: 612249) PREDICTED: thrombospon (1614) 381 62.4 1.1e-08
NP_056019 (OMIM: 612249) thrombospondin type-1 dom (1657) 381 62.4 1.1e-08
XP_011512461 (OMIM: 609297) PREDICTED: semaphorin- (1027) 377 61.6 1.1e-08
XP_006714569 (OMIM: 609297) PREDICTED: semaphorin- (1074) 377 61.7 1.2e-08
XP_006714570 (OMIM: 609297) PREDICTED: semaphorin- (1074) 377 61.7 1.2e-08
XP_011512458 (OMIM: 609297) PREDICTED: semaphorin- (1074) 377 61.7 1.2e-08
XP_011512459 (OMIM: 609297) PREDICTED: semaphorin- (1074) 377 61.7 1.2e-08
>>NP_002612 (OMIM: 300383,312060) properdin precursor [H (469 aa)
initn: 3644 init1: 3644 opt: 3644 Z-score: 2569.1 bits: 484.7 E(85289): 2.3e-136
Smith-Waterman score: 3644; 100.0% identity (100.0% similar) in 469 aa overlap (1-469:1-469)
10 20 30 40 50 60
pF1KE1 MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 AFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 SEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 TRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSM
370 380 390 400 410 420
430 440 450 460
pF1KE1 VEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL
430 440 450 460
>>NP_001138724 (OMIM: 300383,312060) properdin precursor (469 aa)
initn: 3644 init1: 3644 opt: 3644 Z-score: 2569.1 bits: 484.7 E(85289): 2.3e-136
Smith-Waterman score: 3644; 100.0% identity (100.0% similar) in 469 aa overlap (1-469:1-469)
10 20 30 40 50 60
pF1KE1 MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 AFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 SEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 TRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSM
370 380 390 400 410 420
430 440 450 460
pF1KE1 VEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL
430 440 450 460
>>XP_016885064 (OMIM: 300383,312060) PREDICTED: properdi (334 aa)
initn: 2647 init1: 2647 opt: 2647 Z-score: 1872.5 bits: 355.3 E(85289): 1.5e-97
Smith-Waterman score: 2647; 100.0% identity (100.0% similar) in 334 aa overlap (136-469:1-334)
110 120 130 140 150 160
pF1KE1 GWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNH
::::::::::::::::::::::::::::::
XP_016 MGGWSGWGPWEPCSVTCSKGTRTRRRACNH
10 20 30
170 180 190 200 210 220
pF1KE1 PAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCS
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE1 APEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCN
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE1 HPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQS
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE1 RGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQR
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE1 LCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPE
280 290 300 310 320 330
pF1KE1 EEEL
::::
XP_016 EEEL
>>XP_016857926 (OMIM: 603075,608548) PREDICTED: hemicent (4976 aa)
initn: 797 init1: 331 opt: 819 Z-score: 578.1 bits: 119.7 E(85289): 1.8e-25
Smith-Waterman score: 904; 37.5% identity (61.9% similar) in 336 aa overlap (80-412:3873-4187)
50 60 70 80 90 100
pF1KE1 GVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNG
.: ::.: :::::..: : : : :
XP_016 EDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLP
3850 3860 3870 3880 3890 3900
110 120 130 140 150 160
pF1KE1 QCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPK
.:: :. . ... :... : : :.:: :. :: :. .:..:..:: :.::.:. .
XP_016 ANGGKPCQGS-DLEMRNCQNKPC-PVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQ
3910 3920 3930 3940 3950 3960
170 180 190 200 210 220
pF1KE1 CGGH-CPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPE
::. : :.: : :. . ::.::::..: :: :: :: : .::.: :. :
XP_016 HGGRPCEGNAVEIIMCNIRP-CPVHGAWSAWQPWGTCSESCGKGT----QTRARLCNNPP
3970 3980 3990 4000 4010
230 240 250 260 270 280
pF1KE1 PSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPV
:. :. : : ... :. ::. : :. :. : : :.:: : .. : :. ::
XP_016 PAFG--GSYCDGAETQMQVCNERN-CPIHGKWATWASWSACSVSCGGGARQRTRGCSDPV
4020 4030 4040 4050 4060 4070
290 300 310 320 330 340
pF1KE1 PQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGR
::.:: : :. ... .::. :::. :.:. :. :. : : .:. ::. : :
XP_016 PQYGGRKCEGSDVQSDFCNSD-PCPTHGNWSPWSGWGTCSR------TCN--GGQMRRYR
4080 4090 4100 4110 4120
350 360 370 380 390 400
pF1KE1 TCRGRK-FDGHR-CAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRL
:: . .: : :.: ...:..: . . ::. :::. : .:. : :: . ..:.::
XP_016 TCDNPPPSNGGRACGGPDSQIQRCNT-DMCPVDGSWGSWHSWSQCSASCGGGE-KTRKRL
4130 4140 4150 4160 4170 4180
410 420 430 440 450 460
pF1KE1 CTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEE
: .:
XP_016 CDHPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDS
4190 4200 4210 4220 4230 4240
>>XP_011508340 (OMIM: 603075,608548) PREDICTED: hemicent (5518 aa)
initn: 797 init1: 331 opt: 819 Z-score: 577.6 bits: 119.8 E(85289): 2e-25
Smith-Waterman score: 904; 37.5% identity (61.9% similar) in 336 aa overlap (80-412:4532-4846)
50 60 70 80 90 100
pF1KE1 GVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNG
.: ::.: :::::..: : : : :
XP_011 EDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLP
4510 4520 4530 4540 4550 4560
110 120 130 140 150 160
pF1KE1 QCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPK
.:: :. . ... :... : : :.:: :. :: :. .:..:..:: :.::.:. .
XP_011 ANGGKPCQGS-DLEMRNCQNKPC-PVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQ
4570 4580 4590 4600 4610
170 180 190 200 210 220
pF1KE1 CGGH-CPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPE
::. : :.: : :. . ::.::::..: :: :: :: : .::.: :. :
XP_011 HGGRPCEGNAVEIIMCNIRP-CPVHGAWSAWQPWGTCSESCGKGT----QTRARLCNNPP
4620 4630 4640 4650 4660 4670
230 240 250 260 270 280
pF1KE1 PSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPV
:. :. : : ... :. ::. : :. :. : : :.:: : .. : :. ::
XP_011 PAFG--GSYCDGAETQMQVCNERN-CPIHGKWATWASWSACSVSCGGGARQRTRGCSDPV
4680 4690 4700 4710 4720 4730
290 300 310 320 330 340
pF1KE1 PQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGR
::.:: : :. ... .::. :::. :.:. :. :. : : .:. ::. : :
XP_011 PQYGGRKCEGSDVQSDFCNSD-PCPTHGNWSPWSGWGTCSR------TCN--GGQMRRYR
4740 4750 4760 4770 4780
350 360 370 380 390 400
pF1KE1 TCRGRK-FDGHR-CAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRL
:: . .: : :.: ...:..: . . ::. :::. : .:. : :: . ..:.::
XP_011 TCDNPPPSNGGRACGGPDSQIQRCNT-DMCPVDGSWGSWHSWSQCSASCGGGE-KTRKRL
4790 4800 4810 4820 4830 4840
410 420 430 440 450 460
pF1KE1 CTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEE
: .:
XP_011 CDHPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDS
4850 4860 4870 4880 4890 4900
>>NP_114141 (OMIM: 603075,608548) hemicentin-1 precursor (5635 aa)
initn: 797 init1: 331 opt: 819 Z-score: 577.5 bits: 119.8 E(85289): 2e-25
Smith-Waterman score: 904; 37.5% identity (61.9% similar) in 336 aa overlap (80-412:4532-4846)
50 60 70 80 90 100
pF1KE1 GVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNG
.: ::.: :::::..: : : : :
NP_114 EDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLP
4510 4520 4530 4540 4550 4560
110 120 130 140 150 160
pF1KE1 QCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPK
.:: :. . ... :... : : :.:: :. :: :. .:..:..:: :.::.:. .
NP_114 ANGGKPCQGS-DLEMRNCQNKPC-PVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQ
4570 4580 4590 4600 4610
170 180 190 200 210 220
pF1KE1 CGGH-CPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPE
::. : :.: : :. . ::.::::..: :: :: :: : .::.: :. :
NP_114 HGGRPCEGNAVEIIMCNIRP-CPVHGAWSAWQPWGTCSESCGKGT----QTRARLCNNPP
4620 4630 4640 4650 4660 4670
230 240 250 260 270 280
pF1KE1 PSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPV
:. :. : : ... :. ::. : :. :. : : :.:: : .. : :. ::
NP_114 PAFG--GSYCDGAETQMQVCNERN-CPIHGKWATWASWSACSVSCGGGARQRTRGCSDPV
4680 4690 4700 4710 4720 4730
290 300 310 320 330 340
pF1KE1 PQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGR
::.:: : :. ... .::. :::. :.:. :. :. : : .:. ::. : :
NP_114 PQYGGRKCEGSDVQSDFCNSD-PCPTHGNWSPWSGWGTCSR------TCN--GGQMRRYR
4740 4750 4760 4770 4780
350 360 370 380 390 400
pF1KE1 TCRGRK-FDGHR-CAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRL
:: . .: : :.: ...:..: . . ::. :::. : .:. : :: . ..:.::
NP_114 TCDNPPPSNGGRACGGPDSQIQRCNT-DMCPVDGSWGSWHSWSQCSASCGGGE-KTRKRL
4790 4800 4810 4820 4830 4840
410 420 430 440 450 460
pF1KE1 CTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEE
: .:
NP_114 CDHPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDS
4850 4860 4870 4880 4890 4900
>>NP_003237 (OMIM: 188060) thrombospondin-1 precursor [H (1170 aa)
initn: 375 init1: 283 opt: 543 Z-score: 392.2 bits: 83.2 E(85289): 4.1e-15
Smith-Waterman score: 620; 30.6% identity (53.1% similar) in 343 aa overlap (129-444:365-681)
100 110 120 130 140 150
pF1KE1 LRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEM-------GGWSGWGPWEPCSVT
: .:::. ::: :. : ::..
NP_003 SCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTS
340 350 360 370 380 390
160 170 180 190 200
pF1KE1 CSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTH----GAWATWGPWTPCSA
:..: . : :.:. . ...: :.. ....: :. : . :.:. :.::. ::.
NP_003 CGNGIQQRGRSCD----SLNNRCEGSSVQTRTCHIQE-CDKRFKQDGGWSHWSPWSSCSV
400 410 420 430 440
210 220 230 240 250 260
pF1KE1 SCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVS
.: : :: : :..: :... :::: : : : . : ::. ::::::.: .
NP_003 TCGDG----VITRIRLCNSPSPQMN--GKPCEGEARETKACKK-DACPINGGWGPWSPWD
450 460 470 480 490 500
270 280 290 300 310 320
pF1KE1 PCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPC
: :::: : ..: ::.:.:: :: :.::.:...::: ::.:: .. ::
NP_003 ICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQ-DCPIDGCLSN-----PC
510 520 530 540 550
330 340 350 360 370 380
pF1KE1 IRRNMKSISCQEIP-GQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWS---
. ...: : :. . : : . .: .:. :. .: . .. .
NP_003 F----AGVKCTSYPDGSWKCGACPPGYSGNGIQCT----DVDECKEVPDACFNHNGEHRC
560 570 580 590 600
390 400 410 420 430
pF1KE1 EWSTWGLCMPPCGPNPT------------RARQRLCTPLLPKYPPTVSMVEGQGEKNVTF
: . : :: : : : ...: : : : . .. . .
NP_003 ENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKNAKCNYLGH
610 620 630 640 650 660
440 450 460
pF1KE1 WGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL
.. :. ::: :
NP_003 YSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQED
670 680 690 700 710 720
>>NP_003238 (OMIM: 188061,603932) thrombospondin-2 precu (1172 aa)
initn: 435 init1: 286 opt: 539 Z-score: 389.4 bits: 82.7 E(85289): 5.9e-15
Smith-Waterman score: 583; 32.2% identity (54.1% similar) in 351 aa overlap (131-464:369-674)
110 120 130 140 150
pF1KE1 YRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEM-----G--GWSGWGPWEPCSVTCS
.::: : ::: :. : :::::.
NP_003 TTCTCKKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCG
340 350 360 370 380 390
160 170 180 190 200
pF1KE1 KGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTH----GAWATWGPWTPCSASC
.::. : :.:. . . : : . ...::. .. : :. :.:. :.::. ::..:
NP_003 SGTQQRGRSCDVTS----NTCLGPSIQTRACSLSK-CDTRIRQDGGWSHWSPWSSCSVTC
400 410 420 430 440 450
210 220 230 240 250 260
pF1KE1 HGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPC
: . :: : :..: :.. :: : : . : . : : :::. : :.::.: : :
NP_003 GVG----NITRIRLCNSPVPQMG--GKNCKGSGRETKACQG-APCPIDGRWSPWSPWSAC
460 470 480 490 500
270 280 290 300 310 320
pF1KE1 PVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIR
:::. : . :.:: : ::.:: :.::. . ..:: ::::: .. ::.
NP_003 TVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKR-SCPVDGCLSN-----PCF-
510 520 530 540 550
330 340 350 360 370 380
pF1KE1 RNMKSISCQEIP-GQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTW
. .:. .: :. : : : : :. : :: ....: : . .::
NP_003 ---PGAQCSSFPDGSWSCGSCPVG--FLGN---GT-----HCEDLDECALVPDIC-FSTS
560 570 580 590 600
390 400 410 420 430 440
pF1KE1 GLCMPPC-GPNPTRARQRLCTPLLPKY----PPTVSMVEGQGEKNVTFWGRPLPRCEELQ
. : : . .: : : :.: : :.. .. ::.: .: :..
NP_003 KV--PRCVNTQPGFH----CLPCPPRYRGNQPVGVGLEAAKTEKQVC---EPENPCKD--
610 620 630 640 650
450 460
pF1KE1 GQKLVVEEKRPCLHVPACKDPEEEEL
. ... :... .::
NP_003 -KTHNCHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATY
660 670 680 690 700 710
>>XP_016869182 (OMIM: 602682) PREDICTED: brain-specific (1660 aa)
initn: 389 init1: 156 opt: 439 Z-score: 317.6 bits: 69.9 E(85289): 6e-11
Smith-Waterman score: 692; 30.7% identity (51.5% similar) in 398 aa overlap (80-439:264-631)
50 60 70 80 90 100
pF1KE1 GVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNG
:.::: :. :. :. : : : : :. :
XP_016 VCLRDAVAGGPENCLTSLTQDRGGHGATGGWKLWSLWGECTRDCGGGLQTRTRTCLPAPG
240 250 260 270 280 290
110 120 130
pF1KE1 QCSGKVAPGTLEWQLQACEDQQCCP--------------------EMG------GW----
: :.:: : :. . : : :.: :.
XP_016 -VEGGGCEGVLEEGRQ-CNREACGPAGRTSSRSQSLRSTDARRREELGDELQQFGFPAPQ
300 310 320 330 340 350
140 150 160 170 180 190
pF1KE1 SG------WGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTH
.: :.:: :: ::..: .:: : : . . . .: : .:.. :... :::.:
XP_016 TGDPAAEEWSPWSVCSSTCGEGWQTRTRFCV--SSSYSTQCSGPLREQRLCNNSAVCPVH
360 370 380 390 400
200 210 220 230 240 250
pF1KE1 GAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPP
::: :.::. ::..: : .. :.: : :. . :.:: : . . :. .
XP_016 GAWDEWSPWSLCSSTCGRGFRD----RTRTCRPPQFG----GNPCEGPEKQTKFCN-IAL
410 420 430 440 450 460
260 270 280 290 300 310
pF1KE1 CPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCP
::: :.:. :. : : ..:. :. .. : :: : ..:: : : ..:. : ::
XP_016 CPVDGNWNEWSSWSACSASCSQGRQQRTRECNGP--SYGGAECQGHWVETRDCFLQ-QCP
470 480 490 500 510
320 330 340 350 360 370
pF1KE1 VDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSI
:::.:..:. :. : :..: :.: : :.: : : : : : :.. :.: .
XP_016 VDGKWQAWASWGSC------SVTCG--AGSQRRERVCSGPFFGGAACQGPQDEYRQC-GT
520 530 540 550 560
380 390 400 410 420 430
pF1KE1 QHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQ-GEKNVTFW
:.:: . ...: . : : : : :. . . . . :.....:
XP_016 QRCPEPHEICDEDNFGAVIWKETPAGEVAAVR-C----PRNATGLILRRCELDEEGIAYW
570 580 590 600 610 620
440 450 460
pF1KE1 GRPLP-RCEELQGQKLVVEEKRPCLHVPACKDPEEEEL
: ::
XP_016 EPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGEGVSEVIQTLVEISQDGTSYSGDLLST
630 640 650 660 670 680
>>XP_011515504 (OMIM: 602682) PREDICTED: brain-specific (1161 aa)
initn: 290 init1: 195 opt: 434 Z-score: 315.9 bits: 69.1 E(85289): 7.4e-11
Smith-Waterman score: 676; 30.4% identity (51.1% similar) in 401 aa overlap (80-439:264-634)
50 60 70 80 90 100
pF1KE1 GVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNG
:.::: :. :. :. : : : : :. :
XP_011 VCLRDAVAGGPENCLTSLTQDRGGHGATGGWKLWSLWGECTRDCGGGLQTRTRTCLPAPG
240 250 260 270 280 290
110 120 130
pF1KE1 QCSGKVAPGTLEWQLQACEDQQCCP--------------------EMG------GW----
: :.:: : :. . : : :.: :.
XP_011 -VEGGGCEGVLEEGRQ-CNREACGPAGRTSSRSQSLRSTDARRREELGDELQQFGFPAPQ
300 310 320 330 340 350
140 150 160 170 180 190
pF1KE1 SG------WGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTH
.: :.:: :: ::..: .:: : : . . . .: : .:.. :... :::.:
XP_011 TGDPAAEEWSPWSVCSSTCGEGWQTRTRFCV--SSSYSTQCSGPLREQRLCNNSAVCPVH
360 370 380 390 400
200 210 220 230 240 250
pF1KE1 GAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPP
::: :.::. ::..: : .. :.: : :. . :.:: : . . :. .
XP_011 GAWDEWSPWSLCSSTCGRGFRD----RTRTCRPPQFG----GNPCEGPEKQTKFCN-IAL
410 420 430 440 450 460
260 270 280 290 300 310
pF1KE1 CP---VAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAV
:: : :.:. :. : : ..:. :. .. : :: : ..:: : : ..:. :
XP_011 CPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNGP--SYGGAECQGHWVETRDCFLQ-
470 480 490 500 510
320 330 340 350 360 370
pF1KE1 PCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHC
:::::.:..:. :. : :..: :.: : :.: : : : : : :.. :.:
XP_011 QCPVDGKWQAWASWGSC------SVTCG--AGSQRRERVCSGPFFGGAACQGPQDEYRQC
520 530 540 550 560
380 390 400 410 420
pF1KE1 YSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQ-GEKNV
. :.:: . ...: . : : : : :. . . . . :...
XP_011 -GTQRCPEPHEICDEDNFGAVIWKETPAGEVAAVR-C----PRNATGLILRRCELDEEGI
570 580 590 600 610 620
430 440 450 460
pF1KE1 TFWGRPLP-RCEELQGQKLVVEEKRPCLHVPACKDPEEEEL
..: : ::
XP_011 AYWEPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGEGVSEVIQTLVEISQDGTSYSGDL
630 640 650 660 670 680
469 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 01:18:15 2016 done: Mon Nov 7 01:18:17 2016
Total Scan time: 10.430 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]