Result of FASTA (omim) for
pFN21AE1346
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1346, 255 aa
1>>>pF1KE1346 255 - 255 aa - 255 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9739+/-0.00032; mu= 16.5566+/- 0.020
mean_var=65.3071+/-13.306, 0's: 0 Z-trim(116.4): 298 B-trim: 0 in 0/55
Lambda= 0.158706
statistics sampled from 27196 (27512) to 27196 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.698), E-opt: 0.2 (0.323), width: 16
Scan time: 7.080
The best scores are: opt bits E(85289)
NP_001902 (OMIM: 116830) cathepsin G preproprotein ( 255) 1737 406.1 3.2e-113
XP_011534801 (OMIM: 116830) PREDICTED: cathepsin G ( 269) 1626 380.7 1.5e-105
NP_004122 (OMIM: 123910) granzyme B isoform 1 prep ( 247) 999 237.1 2.3e-62
NP_219491 (OMIM: 116831) granzyme H isoform 1 prep ( 246) 982 233.2 3.4e-61
NP_001332940 (OMIM: 123910) granzyme B isoform 2 [ ( 235) 927 220.6 2e-57
NP_001827 (OMIM: 118938) chymase isoform 1 preprop ( 247) 855 204.1 1.9e-52
XP_011534985 (OMIM: 116831) PREDICTED: granzyme H ( 212) 817 195.4 7.2e-50
NP_001257709 (OMIM: 116831) granzyme H isoform 2 p ( 182) 555 135.3 7.3e-32
NP_002768 (OMIM: 177020) myeloblastin precursor [H ( 256) 550 134.3 2.1e-31
NP_001919 (OMIM: 134350,613912) complement factor ( 253) 518 127.0 3.3e-29
NP_002760 (OMIM: 167800,276000,614044) trypsin-1 p ( 247) 515 126.3 5.3e-29
NP_001304264 (OMIM: 134350,613912) complement fact ( 260) 513 125.8 7.5e-29
XP_011514713 (OMIM: 167800,276000,614044) PREDICTE ( 472) 515 126.5 8.8e-29
NP_071329 (OMIM: 606135) kallikrein-14 preproprote ( 267) 508 124.7 1.7e-28
NP_001298111 (OMIM: 606135) kallikrein-14 prepropr ( 267) 508 124.7 1.7e-28
NP_001257710 (OMIM: 116831) granzyme H isoform 3 p ( 160) 505 123.8 1.8e-28
NP_006135 (OMIM: 140050) granzyme A precursor [Hom ( 262) 499 122.6 7e-28
NP_056411 (OMIM: 605505) kallikrein-13 precursor [ ( 277) 497 122.2 1e-27
NP_005308 (OMIM: 600311) granzyme M isoform 1 prep ( 257) 496 121.9 1.1e-27
NP_002762 (OMIM: 613578) trypsin-3 isoform 2 prepr ( 247) 488 120.1 3.8e-27
NP_001184027 (OMIM: 613578) trypsin-3 isoform 4 pr ( 240) 479 118.0 1.6e-26
NP_001184026 (OMIM: 613578) trypsin-3 isoform 3 pr ( 261) 479 118.0 1.7e-26
XP_011526078 (OMIM: 130130,162800,202700) PREDICTE ( 267) 479 118.0 1.7e-26
XP_011526077 (OMIM: 130130,162800,202700) PREDICTE ( 267) 479 118.0 1.7e-26
NP_001963 (OMIM: 130130,162800,202700) neutrophil ( 267) 479 118.0 1.7e-26
NP_031369 (OMIM: 613578) trypsin-3 isoform 1 prepr ( 304) 479 118.1 1.9e-26
NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 pr ( 260) 478 117.8 2e-26
NP_002761 (OMIM: 167800,601564) trypsin-2 isoform ( 247) 476 117.3 2.6e-26
NP_004908 (OMIM: 204700,603767) kallikrein-4 isofo ( 254) 475 117.1 3.1e-26
NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 pr ( 305) 474 116.9 4.2e-26
XP_011516267 (OMIM: 613578) PREDICTED: trypsin-3 i ( 333) 474 117.0 4.5e-26
NP_001012982 (OMIM: 602652) kallikrein-6 isoform A ( 244) 472 116.4 4.8e-26
NP_002765 (OMIM: 602652) kallikrein-6 isoform A pr ( 244) 472 116.4 4.8e-26
NP_005037 (OMIM: 604438) kallikrein-7 isoform 1 pr ( 253) 467 115.3 1.1e-25
NP_644806 (OMIM: 604438) kallikrein-7 isoform 1 pr ( 253) 467 115.3 1.1e-25
NP_006844 (OMIM: 604434) kallikrein-11 isoform 1 p ( 250) 452 111.8 1.2e-24
NP_001129504 (OMIM: 604434) kallikrein-11 isoform ( 250) 452 111.8 1.2e-24
NP_659196 (OMIM: 604434) kallikrein-11 isoform 2 [ ( 282) 452 111.9 1.3e-24
NP_001691 (OMIM: 162815) azurocidin preproprotein ( 251) 441 109.3 6.7e-24
XP_011526438 (OMIM: 177020) PREDICTED: myeloblasti ( 206) 438 108.6 9.3e-24
NP_001295012 (OMIM: 118938) chymase isoform 2 [Hom ( 136) 430 106.6 2.4e-23
NP_002095 (OMIM: 600784) granzyme K precursor [Hom ( 264) 419 104.3 2.3e-22
NP_665901 (OMIM: 605539) kallikrein-12 isoform 2 p ( 248) 414 103.1 4.8e-22
NP_036447 (OMIM: 605504) kallikrein-9 precursor [H ( 250) 414 103.1 4.9e-22
NP_001898 (OMIM: 118888) chymotrypsin-like proteas ( 264) 413 102.9 6e-22
NP_001897 (OMIM: 118890) chymotrypsinogen B isofor ( 263) 410 102.2 9.6e-22
NP_001070959 (OMIM: 605643) kallikrein-5 prepropro ( 293) 405 101.1 2.3e-21
NP_036559 (OMIM: 605643) kallikrein-5 preproprotei ( 293) 405 101.1 2.3e-21
XP_011525005 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 405 101.1 2.3e-21
XP_011525004 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 405 101.1 2.3e-21
>>NP_001902 (OMIM: 116830) cathepsin G preproprotein [Ho (255 aa)
initn: 1737 init1: 1737 opt: 1737 Z-score: 2153.6 bits: 406.1 E(85289): 3.2e-113
Smith-Waterman score: 1737; 100.0% identity (100.0% similar) in 255 aa overlap (1-255:1-255)
10 20 30 40 50 60
pF1KE1 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRT
190 200 210 220 230 240
250
pF1KE1 TMRSFKLLDQMETPL
:::::::::::::::
NP_001 TMRSFKLLDQMETPL
250
>>XP_011534801 (OMIM: 116830) PREDICTED: cathepsin G iso (269 aa)
initn: 1626 init1: 1626 opt: 1626 Z-score: 2016.0 bits: 380.7 E(85289): 1.5e-105
Smith-Waterman score: 1699; 94.8% identity (94.8% similar) in 269 aa overlap (1-255:1-269)
10 20 30 40
pF1KE1 MQPLLLLLAFLLPTGAEAG--------------EIIGGRESRPHSRPYMAYLQIQSPAGQ
::::::::::::::::::: :::::::::::::::::::::::::::
XP_011 MQPLLLLLAFLLPTGAEAGSASIELSAKCFLPGEIIGGRESRPHSRPYMAYLQIQSPAGQ
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 SRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQ
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 NDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRV
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE1 QRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPE
190 200 210 220 230 240
230 240 250
pF1KE1 VFTRVSSFLPWIRTTMRSFKLLDQMETPL
:::::::::::::::::::::::::::::
XP_011 VFTRVSSFLPWIRTTMRSFKLLDQMETPL
250 260
>>NP_004122 (OMIM: 123910) granzyme B isoform 1 prepropr (247 aa)
initn: 1041 init1: 669 opt: 999 Z-score: 1240.6 bits: 237.1 E(85289): 2.3e-62
Smith-Waterman score: 999; 57.4% identity (82.7% similar) in 249 aa overlap (1-245:1-247)
10 20 30 40 50 60
pF1KE1 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL
:::.:::::::: :.:::::::.:..::::::::::.: . . .::::::.:.::::
NP_004 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR
::::::::.::::::::::...: ::: : ..: : :: :: ....:::::::: :...:
NP_004 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
70 80 90 100 110 120
130 140 150 160 170
pF1KE1 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREVQLRVQRDRQC---LRIF
.: :.:. :: . ..:: :.:::::... . . . ::.::.. ::.::.: :: .
NP_004 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 GSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLP
:: ..:::: . .:..:::::::::.::.::.::::::...:.::.. :.::::.
NP_004 --YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVH
190 200 210 220 230
240 250
pF1KE1 WIRTTMRSFKLLDQMETPL
::. ::. .
NP_004 WIKKTMKRY
240
>>NP_219491 (OMIM: 116831) granzyme H isoform 1 prepropr (246 aa)
initn: 967 init1: 707 opt: 982 Z-score: 1219.6 bits: 233.2 E(85289): 3.4e-61
Smith-Waterman score: 982; 57.8% identity (82.0% similar) in 244 aa overlap (1-243:1-244)
10 20 30 40 50 60
pF1KE1 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL
:::.:::::::: :: . :::::.:..::::::::..:. . ...::::.:::.::::
NP_219 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR
::::: ::.::::::::::...: ::: : ..: : :: :: ....:::::::: :...
NP_219 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW
70 80 90 100 110 120
130 140 150 160 170
pF1KE1 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIF-GSY
. : :. :: .. ..:: ::.::::: ::: . ::.:: : ::.: :: :.: :.:
NP_219 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNY
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 DPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIR
. .::::: .. ...:::::::::.:..::.::.:::...:.:: :. .:: :::::.
NP_219 SRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK
190 200 210 220 230 240
240 250
pF1KE1 TTMRSFKLLDQMETPL
::.
NP_219 RTMKRL
>>NP_001332940 (OMIM: 123910) granzyme B isoform 2 [Homo (235 aa)
initn: 926 init1: 596 opt: 927 Z-score: 1151.8 bits: 220.6 E(85289): 2e-57
Smith-Waterman score: 927; 56.0% identity (82.8% similar) in 232 aa overlap (18-245:6-235)
10 20 30 40 50 60
pF1KE1 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL
.::::::.:..::::::::::.: . . .::::::.:.::::
NP_001 MQTFPSGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL
10 20 30 40
70 80 90 100 110 120
pF1KE1 TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR
::::::::.::::::::::...: ::: : ..: : :: :: ....:::::::: :...:
NP_001 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
50 60 70 80 90 100
130 140 150 160 170
pF1KE1 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREVQLRVQRDRQC---LRIF
.: :.:. :: . ..:: :.:::::... . . . ::.::.. ::.::.: :: .
NP_001 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 GSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLP
:: ..:::: . .:..:::::::::.::.::.::::::...:.::.. :.::::.
NP_001 --YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVH
170 180 190 200 210 220
240 250
pF1KE1 WIRTTMRSFKLLDQMETPL
::. ::. .
NP_001 WIKKTMKRY
230
>>NP_001827 (OMIM: 118938) chymase isoform 1 preproprote (247 aa)
initn: 843 init1: 621 opt: 855 Z-score: 1062.4 bits: 204.1 E(85289): 1.9e-52
Smith-Waterman score: 855; 52.4% identity (77.6% similar) in 246 aa overlap (1-244:3-246)
10 20 30 40 50
pF1KE1 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSR-CGGFLVRED
. :: ::: ::: . ::::::::: : .::::::::::.: . : :. :::::.:..
NP_001 MLLLPLPLLL-FLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRN
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 FVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRR
:::::::: : .:.:::::::: ..:.: :.. . . .:::.:: :...:::::.:...
NP_001 FVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 VRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREVQLRVQRDRQCLRIF
. . :. . .: . . :: .: ::::::.. .. :.:::.::.::.. . : . :
NP_001 ASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSH-F
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 GSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLP
..: :.:::. :. :.:::::::::::: .::.::::::.:.. :: ::::.: . :
NP_001 RDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRP
180 190 200 210 220 230
240 250
pF1KE1 WIRTTMRSFKLLDQMETPL
:: ...
NP_001 WINQILQAN
240
>>XP_011534985 (OMIM: 116831) PREDICTED: granzyme H isof (212 aa)
initn: 802 init1: 542 opt: 817 Z-score: 1016.3 bits: 195.4 E(85289): 7.2e-50
Smith-Waterman score: 817; 55.2% identity (81.0% similar) in 210 aa overlap (35-243:1-210)
10 20 30 40 50 60
pF1KE1 LLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAH
::..:. . ...::::.:::.::::::::
XP_011 MAFVQFLQEKSRKRCGGILVRKDFVLTAAH
10 20 30
70 80 90 100 110 120
pF1KE1 CWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNV
: ::.::::::::::...: ::: : ..: : :: :: ....:::::::: :... . :
XP_011 CQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTAV
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 NPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIF-GSYDPRR
:. :: .. ..:: ::.::::: ::: . ::.:: : ::.: :: :.: :.:.
XP_011 RPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNYSRAT
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 QICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTMR
.::::: .. ...:::::::::.:..::.::.:::...:.:: :. .:: :::::. ::.
XP_011 EICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIKRTMK
160 170 180 190 200 210
250
pF1KE1 SFKLLDQMETPL
XP_011 RL
>>NP_001257709 (OMIM: 116831) granzyme H isoform 2 precu (182 aa)
initn: 747 init1: 542 opt: 555 Z-score: 693.1 bits: 135.3 E(85289): 7.3e-32
Smith-Waterman score: 626; 44.4% identity (63.0% similar) in 243 aa overlap (1-243:1-180)
10 20 30 40 50 60
pF1KE1 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL
:::.:::::::: :: . :::::.:..::::::::..:. . ...::::.:::.::::
NP_001 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR
::::: ::.::::::::::...: ::: : ..: : :: :: ....:::::::: :...
NP_001 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYD
. : :. :: ..
NP_001 TTAVRPLRLPSSKA----------------------------------------------
130
190 200 210 220 230 240
pF1KE1 PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRT
.:::::::.:..::.::.:::...:.:: :. .:: :::::.
NP_001 -----------------QGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIKR
140 150 160 170
250
pF1KE1 TMRSFKLLDQMETPL
::.
NP_001 TMKRL
180
>>NP_002768 (OMIM: 177020) myeloblastin precursor [Homo (256 aa)
initn: 586 init1: 240 opt: 550 Z-score: 684.8 bits: 134.3 E(85289): 2.1e-31
Smith-Waterman score: 550; 39.0% identity (69.9% similar) in 246 aa overlap (6-243:13-248)
10 20 30 40 50
pF1KE1 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFL
.:::.:: .:.:.::.::.:..:::::::: ::... :. ::: :
NP_002 MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTL
10 20 30 40 50 60
60 70 80 90 100
pF1KE1 VREDFVLTAAHCWGSN----INVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDI
.. .:::::::: . .::.:::::.. .: ::::... ... . .:. .. ::.
NP_002 IHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLN-NYDAENKLNDV
70 80 90 100 110
110 120 130 140 150 160
pF1KE1 MLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRG-TDTLREVQLRVQR
.:.::: . . .: : ::. .. . :: : . :::::. . ...:.:... :
NP_002 LLIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTV--
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE1 DRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSY---GKSSGVPP
. .: :. .::. :.. . :::::::.:... .:: :. : .. . :
NP_002 ----VTFFCR--PH-NICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFP
180 190 200 210 220 230
230 240 250
pF1KE1 EVFTRVSSFLPWIRTTMRSFKLLDQMETPL
. ::::. .. :::.:.:
NP_002 DFFTRVALYVDWIRSTLRRVEAKGRP
240 250
>>NP_001919 (OMIM: 134350,613912) complement factor D is (253 aa)
initn: 513 init1: 211 opt: 518 Z-score: 645.3 bits: 127.0 E(85289): 3.3e-29
Smith-Waterman score: 518; 38.1% identity (65.1% similar) in 252 aa overlap (8-242:7-252)
10 20 30 40 50
pF1KE1 MQPLLLLLAFLLPTGAEA------GEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLV
:: :. :: : :.:.::::.. :.::::: .:.. : ::: ::
NP_001 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLN---GAHLCGGVLV
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 REDFVLTAAHCW----GSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIM
:..::.:::: ....: ::::.... : ... . ::. ::. . ::..:..
NP_001 AEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLL
60 70 80 90 100 110
120 130 140 150 160
pF1KE1 LLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMR-RGTDTLREVQLRVQRD
:::::... . : :. :... . ::::: ::::: :. : :.:..: : :
NP_001 LLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDR
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE1 RQCLRIFGSYD---PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGK---SSGV
: : .: .: .:. . .:. . ::::::::.:..: .:.:. :. ..
NP_001 ATCNR-RTHHDGAITERLMCA--ESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRK
180 190 200 210 220 230
230 240 250
pF1KE1 PPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL
: ..:::.:. :: ...
NP_001 KPGIYTRVASYAAWIDSVLA
240 250
255 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 01:24:24 2016 done: Mon Nov 7 01:24:25 2016
Total Scan time: 7.080 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]