Result of FASTA (omim) for
pFN21AE1341
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1341, 166 aa
1>>>pF1KE1341 166 - 166 aa - 166 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2577+/-0.000371; mu= 12.5020+/- 0.023
mean_var=75.2652+/-15.136, 0's: 0 Z-trim(113.9): 146 B-trim: 23 in 1/51
Lambda= 0.147835
statistics sampled from 23288 (23468) to 23288 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.66), E-opt: 0.2 (0.275), width: 16
Scan time: 5.270
The best scores are: opt bits E(85289)
NP_000423 (OMIM: 160781,608758) myosin regulatory ( 166) 1086 240.7 8.4e-64
XP_016863735 (OMIM: 160782) PREDICTED: myosin ligh ( 173) 743 167.5 9.1e-42
NP_002468 (OMIM: 160782) myosin light chain 5 [Hom ( 173) 743 167.5 9.1e-42
XP_016863734 (OMIM: 160782) PREDICTED: myosin ligh ( 173) 743 167.5 9.1e-42
XP_006713949 (OMIM: 160782) PREDICTED: myosin ligh ( 328) 736 166.2 4.2e-41
NP_067046 (OMIM: 613993) myosin regulatory light c ( 175) 692 156.7 1.7e-38
NP_291024 (OMIM: 609211) myosin regulatory light c ( 172) 626 142.6 2.9e-34
NP_001138416 (OMIM: 609211) myosin regulatory ligh ( 172) 626 142.6 2.9e-34
NP_001138417 (OMIM: 609211) myosin regulatory ligh ( 172) 626 142.6 2.9e-34
NP_006088 (OMIM: 609905) myosin regulatory light p ( 172) 621 141.5 6.2e-34
XP_016863737 (OMIM: 160782) PREDICTED: myosin ligh ( 132) 590 134.8 4.9e-32
XP_016863736 (OMIM: 160782) PREDICTED: myosin ligh ( 132) 590 134.8 4.9e-32
XP_011513766 (OMIM: 613993) PREDICTED: myosin regu ( 208) 556 127.7 1.1e-29
XP_016867967 (OMIM: 613993) PREDICTED: myosin regu ( 132) 503 116.3 1.9e-26
XP_011513767 (OMIM: 613993) PREDICTED: myosin regu ( 163) 503 116.3 2.2e-26
XP_011513765 (OMIM: 613993) PREDICTED: myosin regu ( 231) 443 103.6 2.1e-22
XP_016867968 (OMIM: 613993) PREDICTED: myosin regu ( 99) 433 101.2 4.7e-22
XP_005249874 (OMIM: 613993) PREDICTED: myosin regu ( 155) 390 92.2 3.8e-19
NP_008819 (OMIM: 114180,614916,616247) calmodulin ( 149) 318 76.8 1.6e-14
NP_001734 (OMIM: 114182,616249) calmodulin isoform ( 149) 318 76.8 1.6e-14
NP_001316851 (OMIM: 114183) calmodulin isoform 1 [ ( 149) 318 76.8 1.6e-14
NP_005175 (OMIM: 114183) calmodulin isoform 1 [Hom ( 149) 318 76.8 1.6e-14
XP_006720321 (OMIM: 114180,614916,616247) PREDICTE ( 150) 318 76.8 1.6e-14
NP_001292553 (OMIM: 114182,616249) calmodulin isof ( 197) 318 76.9 1.9e-14
NP_005176 (OMIM: 114184) calmodulin-like protein 3 ( 149) 306 74.3 9.2e-14
NP_852667 (OMIM: 609905) myosin regulatory light p ( 118) 251 62.5 2.6e-10
NP_001292554 (OMIM: 114182,616249) calmodulin isof ( 113) 236 59.3 2.3e-09
NP_001316853 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 236 59.3 2.3e-09
NP_001292555 (OMIM: 114182,616249) calmodulin isof ( 113) 236 59.3 2.3e-09
NP_001316855 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 236 59.3 2.3e-09
NP_001316850 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 236 59.3 2.3e-09
NP_001316854 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 236 59.3 2.3e-09
NP_001316852 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 236 59.3 2.3e-09
NP_001186558 (OMIM: 609930) myosin light chain 6B ( 208) 238 59.9 2.8e-09
NP_002466 (OMIM: 609930) myosin light chain 6B [Ho ( 208) 238 59.9 2.8e-09
NP_004356 (OMIM: 602907) centrin-3 isoform 2 [Homo ( 167) 234 59.0 4.2e-09
NP_004335 (OMIM: 300006) centrin-2 [Homo sapiens] ( 172) 234 59.0 4.3e-09
NP_524147 (OMIM: 609931) myosin light polypeptide ( 151) 226 57.2 1.3e-08
NP_004057 (OMIM: 603187) centrin-1 [Homo sapiens] ( 172) 220 56.0 3.4e-08
NP_001284694 (OMIM: 602907) centrin-3 isoform 1 [H ( 191) 220 56.0 3.7e-08
NP_066299 (OMIM: 609931) myosin light polypeptide ( 151) 214 54.7 7.5e-08
NP_524144 (OMIM: 160780) myosin light chain 1/3, s ( 194) 211 54.1 1.4e-07
NP_524146 (OMIM: 160780) myosin light chain 1/3, s ( 150) 206 52.9 2.4e-07
NP_001317242 (OMIM: 610171) calmodulin-like protei ( 164) 198 51.3 8.5e-07
NP_619650 (OMIM: 610171) calmodulin-like protein 6 ( 181) 198 51.3 9.2e-07
XP_005244786 (OMIM: 610171) PREDICTED: calmodulin- ( 203) 198 51.3 1e-06
NP_062829 (OMIM: 607315) calcium-binding protein 5 ( 173) 197 51.1 1e-06
XP_016882481 (OMIM: 607315) PREDICTED: calcium-bin ( 284) 197 51.2 1.5e-06
NP_003270 (OMIM: 191039) troponin C, skeletal musc ( 160) 193 50.2 1.8e-06
NP_057450 (OMIM: 607314,614899) calcium-binding pr ( 220) 190 49.7 3.5e-06
>>NP_000423 (OMIM: 160781,608758) myosin regulatory ligh (166 aa)
initn: 1086 init1: 1086 opt: 1086 Z-score: 1266.5 bits: 240.7 E(85289): 8.4e-64
Smith-Waterman score: 1086; 100.0% identity (100.0% similar) in 166 aa overlap (1-166:1-166)
10 20 30 40 50 60
pF1KE1 MAPKKAKKRAGGANSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAALGRVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAPKKAKKRAGGANSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAALGRVN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 VKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGVLKADYVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGVLKADYVR
70 80 90 100 110 120
130 140 150 160
pF1KE1 EMLTTQAERFSKEEVDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD
::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EMLTTQAERFSKEEVDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD
130 140 150 160
>>XP_016863735 (OMIM: 160782) PREDICTED: myosin light ch (173 aa)
initn: 779 init1: 722 opt: 743 Z-score: 870.8 bits: 167.5 E(85289): 9.1e-42
Smith-Waterman score: 743; 64.0% identity (86.6% similar) in 172 aa overlap (1-166:1-172)
10 20 30 40 50
pF1KE1 MAPKKAKKRAGGA------NSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFA
:: .:.::. ::: .::::: ::::::::::::::.:::::::::::.::.::.:
XP_016 MASRKTKKKEGGALRAQRASSNVFSNFEQTQIQEFKEAFTLMDQNRDGFIDKEDLKDTYA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 ALGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGVL
.::..:::..:.: :.::: ::::::.::..:::::.:.: :::::::::..::.::: .
XP_016 SLGKTNVKDDELDAMLKEASGPINFTMFLNLFGEKLSGTDAEETILNAFKMLDPDGKGKI
70 80 90 100 110 120
120 130 140 150 160
pF1KE1 KADYVREMLTTQAERFSKEEVDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD
. .:....: .::.... ::::::: ::.:::::: : ..:::::::.
XP_016 NKEYIKRLLMSQADKMTAEEVDQMFQFASIDVAGNLDYKALSYVITHGEEKEE
130 140 150 160 170
>>NP_002468 (OMIM: 160782) myosin light chain 5 [Homo sa (173 aa)
initn: 779 init1: 722 opt: 743 Z-score: 870.8 bits: 167.5 E(85289): 9.1e-42
Smith-Waterman score: 743; 64.0% identity (86.6% similar) in 172 aa overlap (1-166:1-172)
10 20 30 40 50
pF1KE1 MAPKKAKKRAGGA------NSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFA
:: .:.::. ::: .::::: ::::::::::::::.:::::::::::.::.::.:
NP_002 MASRKTKKKEGGALRAQRASSNVFSNFEQTQIQEFKEAFTLMDQNRDGFIDKEDLKDTYA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 ALGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGVL
.::..:::..:.: :.::: ::::::.::..:::::.:.: :::::::::..::.::: .
NP_002 SLGKTNVKDDELDAMLKEASGPINFTMFLNLFGEKLSGTDAEETILNAFKMLDPDGKGKI
70 80 90 100 110 120
120 130 140 150 160
pF1KE1 KADYVREMLTTQAERFSKEEVDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD
. .:....: .::.... ::::::: ::.:::::: : ..:::::::.
NP_002 NKEYIKRLLMSQADKMTAEEVDQMFQFASIDVAGNLDYKALSYVITHGEEKEE
130 140 150 160 170
>>XP_016863734 (OMIM: 160782) PREDICTED: myosin light ch (173 aa)
initn: 779 init1: 722 opt: 743 Z-score: 870.8 bits: 167.5 E(85289): 9.1e-42
Smith-Waterman score: 743; 64.0% identity (86.6% similar) in 172 aa overlap (1-166:1-172)
10 20 30 40 50
pF1KE1 MAPKKAKKRAGGA------NSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFA
:: .:.::. ::: .::::: ::::::::::::::.:::::::::::.::.::.:
XP_016 MASRKTKKKEGGALRAQRASSNVFSNFEQTQIQEFKEAFTLMDQNRDGFIDKEDLKDTYA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 ALGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGVL
.::..:::..:.: :.::: ::::::.::..:::::.:.: :::::::::..::.::: .
XP_016 SLGKTNVKDDELDAMLKEASGPINFTMFLNLFGEKLSGTDAEETILNAFKMLDPDGKGKI
70 80 90 100 110 120
120 130 140 150 160
pF1KE1 KADYVREMLTTQAERFSKEEVDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD
. .:....: .::.... ::::::: ::.:::::: : ..:::::::.
XP_016 NKEYIKRLLMSQADKMTAEEVDQMFQFASIDVAGNLDYKALSYVITHGEEKEE
130 140 150 160 170
>>XP_006713949 (OMIM: 160782) PREDICTED: myosin light ch (328 aa)
initn: 772 init1: 722 opt: 736 Z-score: 858.9 bits: 166.2 E(85289): 4.2e-41
Smith-Waterman score: 736; 63.7% identity (86.5% similar) in 171 aa overlap (2-166:157-327)
10 20
pF1KE1 MAPKKAKKRAGGA------NSNVFSMFEQTQ
: .:.::. ::: .::::: :::::
XP_006 PPSASWPCVHTPDCGPGRTLSSCAERRRPEASRKTKKKEGGALRAQRASSNVFSNFEQTQ
130 140 150 160 170 180
30 40 50 60 70 80
pF1KE1 IQEFKEAFTIMDQNRDGFIDKNDLRDTFAALGRVNVKNEEIDEMIKEAPGPINFTVFLTM
:::::::::.:::::::::::.::.::.:.::..:::..:.: :.::: ::::::.::..
XP_006 IQEFKEAFTLMDQNRDGFIDKEDLKDTYASLGKTNVKDDELDAMLKEASGPINFTMFLNL
190 200 210 220 230 240
90 100 110 120 130 140
pF1KE1 FGEKLKGADPEETILNAFKVFDPEGKGVLKADYVREMLTTQAERFSKEEVDQMFAAFPPD
:::::.:.: :::::::::..::.::: .. .:....: .::.... ::::::: :
XP_006 FGEKLSGTDAEETILNAFKMLDPDGKGKINKEYIKRLLMSQADKMTAEEVDQMFQFASID
250 260 270 280 290 300
150 160
pF1KE1 VTGNLDYKNLVHIITHGEEKD
:.:::::: : ..:::::::.
XP_006 VAGNLDYKALSYVITHGEEKEE
310 320
>>NP_067046 (OMIM: 613993) myosin regulatory light chain (175 aa)
initn: 716 init1: 680 opt: 692 Z-score: 812.0 bits: 156.7 E(85289): 1.7e-38
Smith-Waterman score: 692; 62.7% identity (87.0% similar) in 161 aa overlap (6-166:14-174)
10 20 30 40 50
pF1KE1 MAPKKAKKRAGGANSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDT
: :.: ..:::::::::.:::::::::. .::::::.: : :::.:
NP_067 MASRKAGTRGKVAATKQAQRGSSNVFSMFEQAQIQEFKEAFSCIDQNRDGIICKADLRET
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 FAALGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKG
.. ::.:.: .::.: :..:. ::::::::::.:::::.:.::::.::.::..::: :::
NP_067 YSQLGKVSVPEEELDAMLQEGKGPINFTVFLTLFGEKLNGTDPEEAILSAFRMFDPSGKG
70 80 90 100 110 120
120 130 140 150 160
pF1KE1 VLKADYVREMLTTQAERFSKEEVDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD
:.. : ...: :::..:: ::.:::: : :..::.:::.: .:::::.::.
NP_067 VVNKDEFKQLLLTQADKFSPAEVEQMFALTPMDLAGNIDYKSLCYIITHGDEKEE
130 140 150 160 170
>>NP_291024 (OMIM: 609211) myosin regulatory light chain (172 aa)
initn: 617 init1: 379 opt: 626 Z-score: 736.0 bits: 142.6 E(85289): 2.9e-34
Smith-Waterman score: 626; 56.7% identity (83.5% similar) in 164 aa overlap (4-166:9-171)
10 20 30 40 50
pF1KE1 MAPKKAKKRAGGANSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAA
: .::: :.::::.::.:.:::::::::...::::::::::.::.: .:.
NP_291 MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 LGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGVLK
::. : . .: :..:::::::::.:::::::::.:.:::..: ::: :: :. :...
NP_291 LGK-NPTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQ
70 80 90 100 110
120 130 140 150 160
pF1KE1 ADYVREMLTTQAERFSKEEVDQMFAAFPPDVTGNLDYKNLVHIITHG-EEKD
::.::.:::...::. ::::... : : ::..: ....:. :: ..::
NP_291 EDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD
120 130 140 150 160 170
>>NP_001138416 (OMIM: 609211) myosin regulatory light ch (172 aa)
initn: 617 init1: 379 opt: 626 Z-score: 736.0 bits: 142.6 E(85289): 2.9e-34
Smith-Waterman score: 626; 56.7% identity (83.5% similar) in 164 aa overlap (4-166:9-171)
10 20 30 40 50
pF1KE1 MAPKKAKKRAGGANSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAA
: .::: :.::::.::.:.:::::::::...::::::::::.::.: .:.
NP_001 MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 LGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGVLK
::. : . .: :..:::::::::.:::::::::.:.:::..: ::: :: :. :...
NP_001 LGK-NPTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQ
70 80 90 100 110
120 130 140 150 160
pF1KE1 ADYVREMLTTQAERFSKEEVDQMFAAFPPDVTGNLDYKNLVHIITHG-EEKD
::.::.:::...::. ::::... : : ::..: ....:. :: ..::
NP_001 EDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD
120 130 140 150 160 170
>>NP_001138417 (OMIM: 609211) myosin regulatory light ch (172 aa)
initn: 617 init1: 379 opt: 626 Z-score: 736.0 bits: 142.6 E(85289): 2.9e-34
Smith-Waterman score: 626; 56.7% identity (83.5% similar) in 164 aa overlap (4-166:9-171)
10 20 30 40 50
pF1KE1 MAPKKAKKRAGGANSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAA
: .::: :.::::.::.:.:::::::::...::::::::::.::.: .:.
NP_001 MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 LGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGVLK
::. : . .: :..:::::::::.:::::::::.:.:::..: ::: :: :. :...
NP_001 LGK-NPTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQ
70 80 90 100 110
120 130 140 150 160
pF1KE1 ADYVREMLTTQAERFSKEEVDQMFAAFPPDVTGNLDYKNLVHIITHG-EEKD
::.::.:::...::. ::::... : : ::..: ....:. :: ..::
NP_001 EDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD
120 130 140 150 160 170
>>NP_006088 (OMIM: 609905) myosin regulatory light polyp (172 aa)
initn: 614 init1: 376 opt: 621 Z-score: 730.3 bits: 141.5 E(85289): 6.2e-34
Smith-Waterman score: 621; 56.7% identity (84.1% similar) in 164 aa overlap (4-166:9-171)
10 20 30 40 50
pF1KE1 MAPKKAKKRAGGANSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAA
: .::: :.::::.::.:.:::::::::...::::::::::.::.: .:.
NP_006 MSSKRAKAKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 LGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGVLK
::. : .: .. :..:::::::::.:::::::::.:.:::..: ::: :: :..: ..
NP_006 LGK-NPTDEYLEGMMSEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEASGFIH
70 80 90 100 110
120 130 140 150 160
pF1KE1 ADYVREMLTTQAERFSKEEVDQMFAAFPPDVTGNLDYKNLVHIITHG-EEKD
:..::.:::...::. ::::.:. : : ::..: ....:. :: ..::
NP_006 EDHLRELLTTMGDRFTDEEVDEMYREAPIDKKGNFNYVEFTRILKHGAKDKDD
120 130 140 150 160 170
166 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 22:51:17 2016 done: Sun Nov 6 22:51:18 2016
Total Scan time: 5.270 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]