Result of FASTA (omim) for
pFN21AE1330
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1330, 132 aa
1>>>pF1KE1330 132 - 132 aa - 132 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0910+/-0.000321; mu= 12.4346+/- 0.020
mean_var=78.6874+/-17.075, 0's: 0 Z-trim(115.6): 219 B-trim: 1164 in 1/52
Lambda= 0.144584
statistics sampled from 25897 (26198) to 25897 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.716), E-opt: 0.2 (0.307), width: 16
Scan time: 4.940
The best scores are: opt bits E(85289)
NP_444512 (OMIM: 608510) SH2 domain-containing pro ( 132) 888 194.1 5.6e-50
NP_001108409 (OMIM: 300490,308240) SH2 domain-cont ( 125) 355 82.9 1.6e-16
NP_002342 (OMIM: 300490,308240) SH2 domain-contain ( 128) 350 81.8 3.3e-16
XP_011543302 (OMIM: 258480,600829) PREDICTED: phos (1206) 285 69.1 2.1e-11
NP_001558 (OMIM: 258480,600829) phosphatidylinosit (1258) 285 69.2 2.2e-11
XP_011543301 (OMIM: 258480,600829) PREDICTED: phos (1258) 285 69.2 2.2e-11
XP_005274036 (OMIM: 258480,600829) PREDICTED: phos (1280) 285 69.2 2.2e-11
XP_005274035 (OMIM: 258480,600829) PREDICTED: phos (1280) 285 69.2 2.2e-11
NP_005532 (OMIM: 601582) phosphatidylinositol 3,4, (1188) 260 63.9 7.7e-10
NP_001017915 (OMIM: 601582) phosphatidylinositol 3 (1189) 260 63.9 7.7e-10
NP_001036236 (OMIM: 153390,615758) tyrosine-protei ( 509) 180 46.9 4.3e-05
NP_005347 (OMIM: 153390,615758) tyrosine-protein k ( 509) 180 46.9 4.3e-05
XP_016863512 (OMIM: 605768) PREDICTED: dual adapte ( 258) 175 45.6 5.4e-05
XP_016863513 (OMIM: 605768) PREDICTED: dual adapte ( 258) 175 45.6 5.4e-05
XP_011530144 (OMIM: 605768) PREDICTED: dual adapte ( 258) 175 45.6 5.4e-05
NP_001293080 (OMIM: 605768) dual adapter for phosp ( 263) 175 45.6 5.5e-05
XP_011530142 (OMIM: 605768) PREDICTED: dual adapte ( 267) 175 45.6 5.6e-05
NP_055210 (OMIM: 605768) dual adapter for phosphot ( 280) 175 45.6 5.8e-05
XP_005266939 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 173 45.4 0.00012
XP_011533955 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 173 45.4 0.00012
XP_016866134 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 173 45.4 0.00012
XP_005266938 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 173 45.4 0.00012
XP_011533956 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 173 45.4 0.00012
XP_011533957 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 173 45.4 0.00012
NP_002022 (OMIM: 606573) tyrosine-protein kinase F ( 505) 173 45.4 0.00012
XP_005266937 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 173 45.4 0.00012
XP_016879518 (OMIM: 604330) PREDICTED: GRB2-relate ( 217) 168 44.1 0.00013
NP_006604 (OMIM: 604330) GRB2-related adapter prot ( 217) 168 44.1 0.00013
NP_002077 (OMIM: 108355) growth factor receptor-bo ( 217) 165 43.5 0.0002
NP_005148 (OMIM: 189980) tyrosine-protein kinase A (1130) 171 45.3 0.00029
NP_009297 (OMIM: 189980) tyrosine-protein kinase A (1149) 171 45.3 0.00029
XP_011533958 (OMIM: 606573) PREDICTED: tyrosine-pr ( 392) 163 43.3 0.00042
XP_005254222 (OMIM: 124095) PREDICTED: tyrosine-pr ( 450) 162 43.1 0.00054
XP_016877414 (OMIM: 124095) PREDICTED: tyrosine-pr ( 450) 162 43.1 0.00054
NP_004374 (OMIM: 124095) tyrosine-protein kinase C ( 450) 162 43.1 0.00054
NP_001120662 (OMIM: 124095) tyrosine-protein kinas ( 450) 162 43.1 0.00054
NP_647611 (OMIM: 600038) megakaryocyte-associated ( 466) 160 42.7 0.00073
NP_647612 (OMIM: 600038) megakaryocyte-associated ( 507) 160 42.7 0.00078
XP_011526320 (OMIM: 600038) PREDICTED: megakaryocy ( 507) 160 42.7 0.00078
NP_002369 (OMIM: 600038) megakaryocyte-associated ( 508) 160 42.7 0.00078
NP_001129473 (OMIM: 164690) Abelson tyrosine-prote ( 542) 160 42.8 0.00082
NP_001248339 (OMIM: 604704) breast cancer anti-est ( 734) 161 43.1 0.00089
NP_001165602 (OMIM: 142370) tyrosine-protein kinas ( 504) 159 42.5 0.0009
NP_001165600 (OMIM: 142370) tyrosine-protein kinas ( 505) 159 42.5 0.0009
NP_001165604 (OMIM: 142370) tyrosine-protein kinas ( 505) 159 42.5 0.0009
NP_001165603 (OMIM: 142370) tyrosine-protein kinas ( 506) 159 42.5 0.0009
NP_001165601 (OMIM: 142370) tyrosine-protein kinas ( 525) 159 42.5 0.00093
NP_002101 (OMIM: 142370) tyrosine-protein kinase H ( 526) 159 42.5 0.00093
NP_001248338 (OMIM: 604704) breast cancer anti-est ( 825) 161 43.1 0.00097
NP_003558 (OMIM: 604704) breast cancer anti-estrog ( 825) 161 43.1 0.00097
>>NP_444512 (OMIM: 608510) SH2 domain-containing protein (132 aa)
initn: 888 init1: 888 opt: 888 Z-score: 1018.2 bits: 194.1 E(85289): 5.6e-50
Smith-Waterman score: 888; 100.0% identity (100.0% similar) in 132 aa overlap (1-132:1-132)
10 20 30 40 50 60
pF1KE1 MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLKLELETF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 GYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLKLELETF
70 80 90 100 110 120
130
pF1KE1 VNSNSDYVDVLP
::::::::::::
NP_444 VNSNSDYVDVLP
130
>>NP_001108409 (OMIM: 300490,308240) SH2 domain-containi (125 aa)
initn: 376 init1: 346 opt: 355 Z-score: 417.7 bits: 82.9 E(85289): 1.6e-16
Smith-Waterman score: 355; 43.5% identity (73.0% similar) in 115 aa overlap (1-114:1-115)
10 20 30 40 50
pF1KE1 MD-LPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREK
:: . :::..... : ::: :.::..:::::::.::: :::: ... .::::. . .
NP_001 MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 HGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLKLELET
: . .:: : :. : ..:.::: :.::.::.:. : :... : . .:..
NP_001 TGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGIREDPDV
70 80 90 100 110 120
120 130
pF1KE1 FVNSNSDYVDVLP
NP_001 CLKAP
>>NP_002342 (OMIM: 300490,308240) SH2 domain-containing (128 aa)
initn: 376 init1: 346 opt: 350 Z-score: 411.9 bits: 81.8 E(85289): 3.3e-16
Smith-Waterman score: 350; 44.2% identity (72.6% similar) in 113 aa overlap (1-112:1-113)
10 20 30 40 50
pF1KE1 MD-LPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREK
:: . :::..... : ::: :.::..:::::::.::: :::: ... .::::. . .
NP_002 MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 HGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLKLELET
: . .:: : :. : ..:.::: :.::.::.:. : :... : . .:
NP_002 TGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIRED
70 80 90 100 110 120
120 130
pF1KE1 FVNSNSDYVDVLP
NP_002 PDVCLKAP
>>XP_011543302 (OMIM: 258480,600829) PREDICTED: phosphat (1206 aa)
initn: 283 init1: 283 opt: 285 Z-score: 325.8 bits: 69.1 E(85289): 2.1e-11
Smith-Waterman score: 285; 42.9% identity (71.4% similar) in 98 aa overlap (5-102:21-118)
10 20 30 40
pF1KE1 MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCV
.:: :.. : :: . : ::.::.:::::. :.. :::
XP_011 MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 SFKNIVYTYRIFREKHGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRT
... :.::::. . . . .::..: : . : .: :::. . .::::.: :: :..
XP_011 LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE
70 80 90 100 110 120
110 120 130
pF1KE1 SPSLRWRGLKLELETFVNSNSDYVDVLP
XP_011 REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAERDGAEVLG
130 140 150 160 170 180
>>NP_001558 (OMIM: 258480,600829) phosphatidylinositol 3 (1258 aa)
initn: 283 init1: 283 opt: 285 Z-score: 325.5 bits: 69.2 E(85289): 2.2e-11
Smith-Waterman score: 285; 42.9% identity (71.4% similar) in 98 aa overlap (5-102:21-118)
10 20 30 40
pF1KE1 MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCV
.:: :.. : :: . : ::.::.:::::. :.. :::
NP_001 MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 SFKNIVYTYRIFREKHGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRT
... :.::::. . . . .::..: : . : .: :::. . .::::.: :: :..
NP_001 LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE
70 80 90 100 110 120
110 120 130
pF1KE1 SPSLRWRGLKLELETFVNSNSDYVDVLP
NP_001 REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLST
130 140 150 160 170 180
>>XP_011543301 (OMIM: 258480,600829) PREDICTED: phosphat (1258 aa)
initn: 283 init1: 283 opt: 285 Z-score: 325.5 bits: 69.2 E(85289): 2.2e-11
Smith-Waterman score: 285; 42.9% identity (71.4% similar) in 98 aa overlap (5-102:21-118)
10 20 30 40
pF1KE1 MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCV
.:: :.. : :: . : ::.::.:::::. :.. :::
XP_011 MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 SFKNIVYTYRIFREKHGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRT
... :.::::. . . . .::..: : . : .: :::. . .::::.: :: :..
XP_011 LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE
70 80 90 100 110 120
110 120 130
pF1KE1 SPSLRWRGLKLELETFVNSNSDYVDVLP
XP_011 REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLST
130 140 150 160 170 180
>>XP_005274036 (OMIM: 258480,600829) PREDICTED: phosphat (1280 aa)
initn: 283 init1: 283 opt: 285 Z-score: 325.4 bits: 69.2 E(85289): 2.2e-11
Smith-Waterman score: 285; 42.9% identity (71.4% similar) in 98 aa overlap (5-102:21-118)
10 20 30 40
pF1KE1 MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCV
.:: :.. : :: . : ::.::.:::::. :.. :::
XP_005 MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 SFKNIVYTYRIFREKHGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRT
... :.::::. . . . .::..: : . : .: :::. . .::::.: :: :..
XP_005 LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE
70 80 90 100 110 120
110 120 130
pF1KE1 SPSLRWRGLKLELETFVNSNSDYVDVLP
XP_005 REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAERDGAEVLG
130 140 150 160 170 180
>>XP_005274035 (OMIM: 258480,600829) PREDICTED: phosphat (1280 aa)
initn: 283 init1: 283 opt: 285 Z-score: 325.4 bits: 69.2 E(85289): 2.2e-11
Smith-Waterman score: 285; 42.9% identity (71.4% similar) in 98 aa overlap (5-102:21-118)
10 20 30 40
pF1KE1 MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCV
.:: :.. : :: . : ::.::.:::::. :.. :::
XP_005 MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 SFKNIVYTYRIFREKHGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRT
... :.::::. . . . .::..: : . : .: :::. . .::::.: :: :..
XP_005 LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE
70 80 90 100 110 120
110 120 130
pF1KE1 SPSLRWRGLKLELETFVNSNSDYVDVLP
XP_005 REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAERDGAEVLG
130 140 150 160 170 180
>>NP_005532 (OMIM: 601582) phosphatidylinositol 3,4,5-tr (1188 aa)
initn: 260 init1: 260 opt: 260 Z-score: 297.7 bits: 63.9 E(85289): 7.7e-10
Smith-Waterman score: 260; 42.1% identity (68.4% similar) in 95 aa overlap (7-101:7-101)
10 20 30 40 50 60
pF1KE1 MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKH
:: .:.. : :: . : ::.::.: :::: . ::: ..: ::::::. ..
NP_005 MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLKLELETF
. .:..:: . : .: .:: ..: :.:.:.:: :.
NP_005 DKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTESVV
70 80 90 100 110 120
130
pF1KE1 VNSNSDYVDVLP
NP_005 SPPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEHL
130 140 150 160 170 180
>>NP_001017915 (OMIM: 601582) phosphatidylinositol 3,4,5 (1189 aa)
initn: 260 init1: 260 opt: 260 Z-score: 297.7 bits: 63.9 E(85289): 7.7e-10
Smith-Waterman score: 260; 42.1% identity (68.4% similar) in 95 aa overlap (7-101:7-101)
10 20 30 40 50 60
pF1KE1 MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKH
:: .:.. : :: . : ::.::.: :::: . ::: ..: ::::::. ..
NP_001 MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLKLELETF
. .:..:: . : .: .:: ..: :.:.:.:: :.
NP_001 DKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTVESV
70 80 90 100 110 120
130
pF1KE1 VNSNSDYVDVLP
NP_001 VSPPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEH
130 140 150 160 170 180
132 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 22:42:32 2016 done: Sun Nov 6 22:42:33 2016
Total Scan time: 4.940 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]