Result of FASTA (omim) for
pFN21AE1326
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1326, 574 aa
1>>>pF1KE1326 574 - 574 aa - 574 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6771+/-0.000422; mu= 16.3048+/- 0.026
mean_var=65.8786+/-12.890, 0's: 0 Z-trim(110.7): 25 B-trim: 5 in 1/51
Lambda= 0.158016
statistics sampled from 19045 (19068) to 19045 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.586), E-opt: 0.2 (0.224), width: 16
Scan time: 9.080
The best scores are: opt bits E(85289)
NP_000289 (OMIM: 102900,266200,609712) pyruvate ki ( 574) 3703 853.6 0
NP_870986 (OMIM: 102900,266200,609712) pyruvate ki ( 543) 3497 806.6 0
XP_011507942 (OMIM: 102900,266200,609712) PREDICTE ( 510) 3297 761.0 0
XP_006711449 (OMIM: 102900,266200,609712) PREDICTE ( 510) 3297 761.0 0
XP_005254500 (OMIM: 179050) PREDICTED: pyruvate ki ( 591) 2559 592.8 1.1e-168
XP_006720633 (OMIM: 179050) PREDICTED: pyruvate ki ( 605) 2559 592.8 1.1e-168
XP_011519972 (OMIM: 179050) PREDICTED: pyruvate ki ( 566) 2551 590.9 3.6e-168
XP_005254502 (OMIM: 179050) PREDICTED: pyruvate ki ( 531) 2547 590.0 6.4e-168
NP_002645 (OMIM: 179050) pyruvate kinase PKM isofo ( 531) 2547 590.0 6.4e-168
NP_001193725 (OMIM: 179050) pyruvate kinase PKM is ( 605) 2492 577.5 4.3e-164
NP_001193728 (OMIM: 179050) pyruvate kinase PKM is ( 536) 2485 575.9 1.2e-163
NP_001303247 (OMIM: 179050) pyruvate kinase PKM is ( 566) 2484 575.7 1.4e-163
NP_872270 (OMIM: 179050) pyruvate kinase PKM isofo ( 531) 2480 574.7 2.5e-163
NP_872271 (OMIM: 179050) pyruvate kinase PKM isofo ( 531) 2480 574.7 2.5e-163
XP_016877802 (OMIM: 179050) PREDICTED: pyruvate ki ( 531) 2480 574.7 2.5e-163
XP_016856982 (OMIM: 102900,266200,609712) PREDICTE ( 383) 2396 555.5 1.1e-157
NP_001193727 (OMIM: 179050) pyruvate kinase PKM is ( 516) 2151 499.7 9.3e-141
NP_001193726 (OMIM: 179050) pyruvate kinase PKM is ( 457) 1946 453.0 9.8e-127
>>NP_000289 (OMIM: 102900,266200,609712) pyruvate kinase (574 aa)
initn: 3703 init1: 3703 opt: 3703 Z-score: 4559.4 bits: 853.6 E(85289): 0
Smith-Waterman score: 3703; 100.0% identity (100.0% similar) in 574 aa overlap (1-574:1-574)
10 20 30 40 50 60
pF1KE1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 HGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 SQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 ENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 LGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 NLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 QHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 AQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESG
490 500 510 520 530 540
550 560 570
pF1KE1 KLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
::::::::::::::::::::::::::::::::::
NP_000 KLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
550 560 570
>>NP_870986 (OMIM: 102900,266200,609712) pyruvate kinase (543 aa)
initn: 3497 init1: 3497 opt: 3497 Z-score: 4306.0 bits: 806.6 E(85289): 0
Smith-Waterman score: 3497; 100.0% identity (100.0% similar) in 541 aa overlap (34-574:3-543)
10 20 30 40 50 60
pF1KE1 QENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPA
::::::::::::::::::::::::::::::
NP_870 MEGPAGYLRRASVAQLTQELGTAFFQQQQLPA
10 20 30
70 80 90 100 110 120
pF1KE1 AMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_870 AMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGS
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 HEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_870 HEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQV
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 LVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_870 LVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENG
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 GVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_870 GVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE1 EGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_870 EGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLA
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE1 GKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_870 GKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHA
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE1 IAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_870 IAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQL
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE1 LSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_870 LSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLR
460 470 480 490 500 510
550 560 570
pF1KE1 GFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
:::::::::::::::::::::::::::::::
NP_870 GFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
520 530 540
>>XP_011507942 (OMIM: 102900,266200,609712) PREDICTED: p (510 aa)
initn: 3297 init1: 3297 opt: 3297 Z-score: 4060.0 bits: 761.0 E(85289): 0
Smith-Waterman score: 3297; 100.0% identity (100.0% similar) in 510 aa overlap (65-574:1-510)
40 50 60 70 80 90
pF1KE1 PAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATI
::::::::::::::::::::::::::::::
XP_011 MADTFLEHLCLLDIDSEPVAARSTSIIATI
10 20 30
100 110 120 130 140 150
pF1KE1 GPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIA
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE1 LDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVG
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE1 GRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRF
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE1 GVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIM
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE1 VARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANA
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE1 VLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEV
340 350 360 370 380 390
460 470 480 490 500 510
pF1KE1 TAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFP
400 410 420 430 440 450
520 530 540 550 560 570
pF1KE1 LLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
460 470 480 490 500 510
>>XP_006711449 (OMIM: 102900,266200,609712) PREDICTED: p (510 aa)
initn: 3297 init1: 3297 opt: 3297 Z-score: 4060.0 bits: 761.0 E(85289): 0
Smith-Waterman score: 3297; 100.0% identity (100.0% similar) in 510 aa overlap (65-574:1-510)
40 50 60 70 80 90
pF1KE1 PAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATI
::::::::::::::::::::::::::::::
XP_006 MADTFLEHLCLLDIDSEPVAARSTSIIATI
10 20 30
100 110 120 130 140 150
pF1KE1 GPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIA
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE1 LDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVG
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE1 GRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRF
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE1 GVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIM
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE1 VARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANA
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE1 VLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEV
340 350 360 370 380 390
460 470 480 490 500 510
pF1KE1 TAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFP
400 410 420 430 440 450
520 530 540 550 560 570
pF1KE1 LLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
460 470 480 490 500 510
>>XP_005254500 (OMIM: 179050) PREDICTED: pyruvate kinase (591 aa)
initn: 2575 init1: 2543 opt: 2559 Z-score: 3149.8 bits: 592.8 E(85289): 1.1e-168
Smith-Waterman score: 2559; 69.9% identity (87.9% similar) in 544 aa overlap (30-573:48-590)
10 20 30 40 50
pF1KE1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQ
:.: : . :.... .: ::::.: :
XP_005 SPGHTVFSSERSLLVRPRSHPEPKGEHYVTGSPT-PENQRTSAAMSKPHSEAGTAFIQTQ
20 30 40 50 60 70
60 70 80 90 100 110
pF1KE1 QLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNF
:: ::::::::::.: ::::: :..::.:.:: :::::::::: ::::::.:::.:::::
XP_005 QLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNF
80 90 100 110 120 130
120 130 140 150 160 170
pF1KE1 SHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVK
:::.::::::.: ::: :.::::..:. :::::.::::::::::::...:. .:::: :
XP_005 SHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKK
140 150 160 170 180 190
180 190 200 210 220 230
pF1KE1 GSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQ
:. . .:.: :. . . : .:.:: :: .:: ::..::.::::::: :.. : . :::.
XP_005 GATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTE
200 210 220 230 240 250
240 250 260 270 280 290
pF1KE1 VENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRA
::::: :::.:::::::: ::::..::.:..::.::::. ::.:::::.:::::: ::
XP_005 VENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRK
260 270 280 290 300 310
300 310 320 330 340 350
pF1KE1 ALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGR
.:: .:..:::::::::::::.:::::::.::::::::::::::::::::::::::::::
XP_005 VLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGR
320 330 340 350 360 370
360 370 380 390 400 410
pF1KE1 CNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVK
:: :::::.:::::::::: :::::::: :::::::::::::::::::::::..:.:::.
XP_005 CNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVR
380 390 400 410 420 430
420 430 440 450 460 470
pF1KE1 MQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGR
::: ::::::::.:: :::::::: ::.. ::::.::.:::::.::::..:::::: .::
XP_005 MQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGR
440 450 460 470 480 490
480 490 500 510 520 530
pF1KE1 SAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIES
::. ..:::::: .:::::. :.:::.:: ::.::.: ..: . ::.::: ::.:...
XP_005 SAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNV
500 510 520 530 540 550
540 550 560 570
pF1KE1 GKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
:: :::.. ::.:::.::::::::.:: :::. .
XP_005 GKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
560 570 580 590
>>XP_006720633 (OMIM: 179050) PREDICTED: pyruvate kinase (605 aa)
initn: 2575 init1: 2543 opt: 2559 Z-score: 3149.6 bits: 592.8 E(85289): 1.1e-168
Smith-Waterman score: 2559; 69.9% identity (87.9% similar) in 544 aa overlap (30-573:62-604)
10 20 30 40 50
pF1KE1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQ
:.: : . :.... .: ::::.: :
XP_006 SPGHTVFSSERSLLVRPRSHPEPKGEHYVTGSPT-PENQRTSAAMSKPHSEAGTAFIQTQ
40 50 60 70 80 90
60 70 80 90 100 110
pF1KE1 QLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNF
:: ::::::::::.: ::::: :..::.:.:: :::::::::: ::::::.:::.:::::
XP_006 QLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNF
100 110 120 130 140 150
120 130 140 150 160 170
pF1KE1 SHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVK
:::.::::::.: ::: :.::::..:. :::::.::::::::::::...:. .:::: :
XP_006 SHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKK
160 170 180 190 200 210
180 190 200 210 220 230
pF1KE1 GSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQ
:. . .:.: :. . . : .:.:: :: .:: ::..::.::::::: :.. : . :::.
XP_006 GATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTE
220 230 240 250 260 270
240 250 260 270 280 290
pF1KE1 VENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRA
::::: :::.:::::::: ::::..::.:..::.::::. ::.:::::.:::::: ::
XP_006 VENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRK
280 290 300 310 320 330
300 310 320 330 340 350
pF1KE1 ALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGR
.:: .:..:::::::::::::.:::::::.::::::::::::::::::::::::::::::
XP_006 VLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGR
340 350 360 370 380 390
360 370 380 390 400 410
pF1KE1 CNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVK
:: :::::.:::::::::: :::::::: :::::::::::::::::::::::..:.:::.
XP_006 CNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVR
400 410 420 430 440 450
420 430 440 450 460 470
pF1KE1 MQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGR
::: ::::::::.:: :::::::: ::.. ::::.::.:::::.::::..:::::: .::
XP_006 MQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGR
460 470 480 490 500 510
480 490 500 510 520 530
pF1KE1 SAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIES
::. ..:::::: .:::::. :.:::.:: ::.::.: ..: . ::.::: ::.:...
XP_006 SAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNV
520 530 540 550 560 570
540 550 560 570
pF1KE1 GKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
:: :::.. ::.:::.::::::::.:: :::. .
XP_006 GKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
580 590 600
>>XP_011519972 (OMIM: 179050) PREDICTED: pyruvate kinase (566 aa)
initn: 2575 init1: 2543 opt: 2551 Z-score: 3140.2 bits: 590.9 E(85289): 3.6e-168
Smith-Waterman score: 2551; 70.9% identity (88.9% similar) in 532 aa overlap (42-573:34-565)
20 30 40 50 60 70
pF1KE1 LRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLE
:.... .: ::::.: ::: :::::::::
XP_011 SSERGERLLTPGACSSEVPSAVPSRSGGTSAAMSKPHSEAGTAFIQTQQLHAAMADTFLE
10 20 30 40 50 60
80 90 100 110 120 130
pF1KE1 HLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESI
:.: ::::: :..::.:.:: :::::::::: ::::::.:::.::::::::.::::::.:
XP_011 HMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETI
70 80 90 100 110 120
140 150 160 170 180 190
pF1KE1 ANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAF
::: :.::::..:. :::::.::::::::::::...:. .:::: ::. . .:.: :.
XP_011 KNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAY
130 140 150 160 170 180
200 210 220 230 240 250
pF1KE1 RTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKG
. . : .:.:: :: .:: ::..::.::::::: :.. : . :::.::::: :::.::
XP_011 MEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKG
190 200 210 220 230 240
260 270 280 290 300 310
pF1KE1 VNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKII
:::::: ::::..::.:..::.::::. ::.:::::.:::::: :: .:: .:..::::
XP_011 VNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKII
250 260 270 280 290 300
320 330 340 350 360 370
pF1KE1 SKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCAT
:::::::::.:::::::.:::::::::::::::::::::::::::::::: :::::.:::
XP_011 SKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICAT
310 320 330 340 350 360
380 390 400 410 420 430
pF1KE1 QMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAA
::::::: :::::::: :::::::::::::::::::::::..:.:::.::: ::::::::
XP_011 QMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAA
370 380 390 400 410 420
440 450 460 470 480 490
pF1KE1 VYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRA
.:: :::::::: ::.. ::::.::.:::::.::::..:::::: .::::. ..::::::
XP_011 IYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRA
430 440 450 460 470 480
500 510 520 530 540 550
pF1KE1 AVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDL
.:::::. :.:::.:: ::.::.: ..: . ::.::: ::.:... :: :::.. ::.
XP_011 PIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDV
490 500 510 520 530 540
560 570
pF1KE1 VIVVTGWRPGSGYTNIMRVLSIS
:::.::::::::.:: :::. .
XP_011 VIVLTGWRPGSGFTNTMRVVPVP
550 560
>>XP_005254502 (OMIM: 179050) PREDICTED: pyruvate kinase (531 aa)
initn: 2575 init1: 2543 opt: 2547 Z-score: 3135.7 bits: 590.0 E(85289): 6.4e-168
Smith-Waterman score: 2547; 71.8% identity (89.1% similar) in 524 aa overlap (50-573:7-530)
20 30 40 50 60 70
pF1KE1 QRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDID
: ::::.: ::: ::::::::::.: ::::
XP_005 MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDID
10 20 30
80 90 100 110 120 130
pF1KE1 SEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVE
: :..::.:.:: :::::::::: ::::::.:::.::::::::.::::::.: ::: :.:
XP_005 SPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATE
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE1 SFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANT
:::..:. :::::.::::::::::::...:. .:::: ::. . .:.: :. . . :
XP_005 SFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENI
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE1 VWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQV
.:.:: :: .:: ::..::.::::::: :.. : . :::.::::: :::.:::::::: :
XP_005 LWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAV
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE1 DLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEG
:::..::.:..::.::::. ::.:::::.:::::: :: .:: .:..::::::::::::
XP_005 DLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEG
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE1 VKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMIT
:.:::::::.:::::::::::::::::::::::::::::::: :::::.::::::::::
XP_005 VRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIK
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE1 KPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFE
:::::::: :::::::::::::::::::::::..:.:::.::: ::::::::.:: ::::
XP_005 KPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFE
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE1 ELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRS
:::: ::.. ::::.::.:::::.::::..:::::: .::::. ..:::::: .:::::.
XP_005 ELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRN
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE1 AQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWR
:.:::.:: ::.::.: ..: . ::.::: ::.:... :: :::.. ::.:::.::::
XP_005 PQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWR
460 470 480 490 500 510
560 570
pF1KE1 PGSGYTNIMRVLSIS
::::.:: :::. .
XP_005 PGSGFTNTMRVVPVP
520 530
>>NP_002645 (OMIM: 179050) pyruvate kinase PKM isoform a (531 aa)
initn: 2575 init1: 2543 opt: 2547 Z-score: 3135.7 bits: 590.0 E(85289): 6.4e-168
Smith-Waterman score: 2547; 71.8% identity (89.1% similar) in 524 aa overlap (50-573:7-530)
20 30 40 50 60 70
pF1KE1 QRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDID
: ::::.: ::: ::::::::::.: ::::
NP_002 MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDID
10 20 30
80 90 100 110 120 130
pF1KE1 SEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVE
: :..::.:.:: :::::::::: ::::::.:::.::::::::.::::::.: ::: :.:
NP_002 SPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATE
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE1 SFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANT
:::..:. :::::.::::::::::::...:. .:::: ::. . .:.: :. . . :
NP_002 SFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENI
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE1 VWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQV
.:.:: :: .:: ::..::.::::::: :.. : . :::.::::: :::.:::::::: :
NP_002 LWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAV
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE1 DLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEG
:::..::.:..::.::::. ::.:::::.:::::: :: .:: .:..::::::::::::
NP_002 DLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEG
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE1 VKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMIT
:.:::::::.:::::::::::::::::::::::::::::::: :::::.::::::::::
NP_002 VRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIK
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE1 KPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFE
:::::::: :::::::::::::::::::::::..:.:::.::: ::::::::.:: ::::
NP_002 KPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFE
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE1 ELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRS
:::: ::.. ::::.::.:::::.::::..:::::: .::::. ..:::::: .:::::.
NP_002 ELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRN
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE1 AQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWR
:.:::.:: ::.::.: ..: . ::.::: ::.:... :: :::.. ::.:::.::::
NP_002 PQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWR
460 470 480 490 500 510
560 570
pF1KE1 PGSGYTNIMRVLSIS
::::.:: :::. .
NP_002 PGSGFTNTMRVVPVP
520 530
>>NP_001193725 (OMIM: 179050) pyruvate kinase PKM isofor (605 aa)
initn: 2508 init1: 2476 opt: 2492 Z-score: 3067.1 bits: 577.5 E(85289): 4.3e-164
Smith-Waterman score: 2492; 68.6% identity (86.9% similar) in 544 aa overlap (30-573:62-604)
10 20 30 40 50
pF1KE1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQ
:.: : . :.... .: ::::.: :
NP_001 SPGHTVFSSERSLLVRPRSHPEPKGEHYVTGSPT-PENQRTSAAMSKPHSEAGTAFIQTQ
40 50 60 70 80 90
60 70 80 90 100 110
pF1KE1 QLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNF
:: ::::::::::.: ::::: :..::.:.:: :::::::::: ::::::.:::.:::::
NP_001 QLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNF
100 110 120 130 140 150
120 130 140 150 160 170
pF1KE1 SHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVK
:::.::::::.: ::: :.::::..:. :::::.::::::::::::...:. .:::: :
NP_001 SHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKK
160 170 180 190 200 210
180 190 200 210 220 230
pF1KE1 GSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQ
:. . .:.: :. . . : .:.:: :: .:: ::..::.::::::: :.. : . :::.
NP_001 GATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTE
220 230 240 250 260 270
240 250 260 270 280 290
pF1KE1 VENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRA
::::: :::.:::::::: ::::..::.:..::.::::. ::.:::::.:::::: ::
NP_001 VENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRK
280 290 300 310 320 330
300 310 320 330 340 350
pF1KE1 ALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGR
.:: .:..:::::::::::::.:::::::.::::::::::::::::::::::::::::::
NP_001 VLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGR
340 350 360 370 380 390
360 370 380 390 400 410
pF1KE1 CNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVK
:: :::::.:::::::::: :::::::: :::::::::::::::::::::::..:.:::.
NP_001 CNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVR
400 410 420 430 440 450
420 430 440 450 460 470
pF1KE1 MQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGR
::: ::::::::..::.::::: ::. : : :. :.:.:::..:: :::.:::: .::
NP_001 MQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGR
460 470 480 490 500 510
480 490 500 510 520 530
pF1KE1 SAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIES
::. ..:::::: .:::::. :.:::.:: ::.::.: ..: . ::.::: ::.:...
NP_001 SAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNV
520 530 540 550 560 570
540 550 560 570
pF1KE1 GKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
:: :::.. ::.:::.::::::::.:: :::. .
NP_001 GKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
580 590 600
574 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 22:36:38 2016 done: Sun Nov 6 22:36:40 2016
Total Scan time: 9.080 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]