Result of FASTA (omim) for
pFN21AE1294
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1294, 475 aa
1>>>pF1KE1294 475 - 475 aa - 475 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.3272+/-0.000512; mu= 4.8349+/- 0.031
mean_var=242.2277+/-49.214, 0's: 0 Z-trim(116.1): 257 B-trim: 1220 in 1/53
Lambda= 0.082407
statistics sampled from 26719 (26999) to 26719 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.665), E-opt: 0.2 (0.317), width: 16
Scan time: 9.990
The best scores are: opt bits E(85289)
NP_060677 (OMIM: 616755) E3 ubiquitin-protein liga ( 475) 3213 395.6 1.6e-109
XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 555) 3183 392.1 2.1e-108
NP_001317412 (OMIM: 616755) E3 ubiquitin-protein l ( 354) 2256 281.7 2.3e-75
XP_016857119 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 544) 2049 257.3 7.9e-68
XP_016857120 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 291) 1160 151.3 3.4e-36
NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 862 116.1 2.2e-25
NP_892030 (OMIM: 616017) E3 ubiquitin-protein liga ( 500) 835 112.9 2.1e-24
XP_011514091 (OMIM: 612548) PREDICTED: E3 ubiquiti ( 486) 781 106.5 1.8e-22
NP_001268379 (OMIM: 612548) E3 ubiquitin-protein l ( 486) 781 106.5 1.8e-22
NP_001268380 (OMIM: 612548) E3 ubiquitin-protein l ( 487) 779 106.2 2.1e-22
NP_835226 (OMIM: 612548) E3 ubiquitin-protein liga ( 487) 779 106.2 2.1e-22
NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485) 743 101.9 4e-21
NP_741983 (OMIM: 617007) tripartite motif-containi ( 493) 663 92.4 3e-18
NP_542783 (OMIM: 616017) E3 ubiquitin-protein liga ( 341) 635 88.9 2.3e-17
XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 613 86.5 1.8e-16
XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 613 86.5 1.8e-16
NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 613 86.5 1.8e-16
NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 613 86.5 1.8e-16
XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 613 86.5 1.8e-16
NP_001288073 (OMIM: 616017) E3 ubiquitin-protein l ( 296) 603 85.1 2.9e-16
NP_001008275 (OMIM: 613288) tripartite motif-conta ( 477) 573 81.7 4.8e-15
NP_001288075 (OMIM: 616017) E3 ubiquitin-protein l ( 263) 544 78.0 3.5e-14
NP_001288074 (OMIM: 616017) E3 ubiquitin-protein l ( 279) 544 78.0 3.7e-14
NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 538 77.6 9.2e-14
NP_006769 (OMIM: 605701) tripartite motif-containi ( 481) 536 77.3 1e-13
NP_976038 (OMIM: 609315) tripartite motif-containi ( 511) 534 77.1 1.3e-13
NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 529 76.5 1.8e-13
NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 529 76.5 1.9e-13
XP_011538873 (OMIM: 111620,111750,609017) PREDICTE ( 468) 527 76.2 2.1e-13
XP_011538872 (OMIM: 111620,111750,609017) PREDICTE ( 475) 527 76.3 2.1e-13
XP_006710376 (OMIM: 111620,111750,609017) PREDICTE ( 475) 527 76.3 2.1e-13
NP_061008 (OMIM: 111620,111750,609017) erythroid m ( 475) 527 76.3 2.1e-13
NP_001017922 (OMIM: 111620,111750,609017) erythroi ( 475) 527 76.3 2.1e-13
XP_011514090 (OMIM: 612548) PREDICTED: E3 ubiquiti ( 278) 494 72.1 2.2e-12
XP_011512523 (OMIM: 605701) PREDICTED: tripartite ( 499) 490 71.9 4.7e-12
XP_011512524 (OMIM: 605701) PREDICTED: tripartite ( 499) 490 71.9 4.7e-12
XP_011512525 (OMIM: 605701) PREDICTED: tripartite ( 499) 490 71.9 4.7e-12
XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450) 479 70.5 1.1e-11
XP_005253240 (OMIM: 608487) PREDICTED: tripartite ( 493) 478 70.4 1.2e-11
NP_149023 (OMIM: 608487) tripartite motif-containi ( 493) 478 70.4 1.2e-11
NP_439893 (OMIM: 605701) tripartite motif-containi ( 395) 476 70.1 1.3e-11
NP_000234 (OMIM: 134610,249100,608107) pyrin isofo ( 781) 479 70.8 1.6e-11
NP_001186502 (OMIM: 606559) E3 ubiquitin-protein l ( 494) 473 69.9 1.9e-11
NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498) 473 69.9 1.9e-11
NP_003132 (OMIM: 109092) E3 ubiquitin-protein liga ( 475) 472 69.7 2e-11
XP_016878725 (OMIM: 134610,249100,608107) PREDICTE ( 780) 472 69.9 2.8e-11
NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 468 69.3 2.9e-11
NP_067629 (OMIM: 605684) tripartite motif-containi ( 488) 466 69.0 3.3e-11
NP_001003827 (OMIM: 605684) tripartite motif-conta ( 488) 466 69.0 3.3e-11
XP_016878743 (OMIM: 613288) PREDICTED: tripartite ( 333) 461 68.2 3.9e-11
>>NP_060677 (OMIM: 616755) E3 ubiquitin-protein ligase T (475 aa)
initn: 3213 init1: 3213 opt: 3213 Z-score: 2087.3 bits: 395.6 E(85289): 1.6e-109
Smith-Waterman score: 3213; 100.0% identity (100.0% similar) in 475 aa overlap (1-475:1-475)
10 20 30 40 50 60
pF1KE1 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 ALAPSLKLANIVERYSSFPLDAILNARRAARPCQAHDKVKLFCLTDRALLCFFCDEPALH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ALAPSLKLANIVERYSSFPLDAILNARRAARPCQAHDKVKLFCLTDRALLCFFCDEPALH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 EQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 AFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 AFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 RHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 PGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 TQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 TQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFL
370 380 390 400 410 420
430 440 450 460 470
pF1KE1 DYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI
430 440 450 460 470
>>XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr (555 aa)
initn: 3183 init1: 3183 opt: 3183 Z-score: 2067.2 bits: 392.1 E(85289): 2.1e-108
Smith-Waterman score: 3183; 100.0% identity (100.0% similar) in 471 aa overlap (5-475:85-555)
10 20 30
pF1KE1 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRC
::::::::::::::::::::::::::::::
XP_016 AAAATGSSDSAGSGLRGCAGPKRWLLSSRGLKDELLCSICLSIYQDPVSLGCEHYFCRRC
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE1 ITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQ
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE1 AHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHT
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE1 EALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQK
240 250 260 270 280 290
220 230 240 250 260 270
pF1KE1 VQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKY
300 310 320 330 340 350
280 290 300 310 320 330
pF1KE1 TGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRF
360 370 380 390 400 410
340 350 360 370 380 390
pF1KE1 DVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDG
420 430 440 450 460 470
400 410 420 430 440 450
pF1KE1 NQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFS
480 490 500 510 520 530
460 470
pF1KE1 PGQSHANGKNVQPLRINTVRI
:::::::::::::::::::::
XP_016 PGQSHANGKNVQPLRINTVRI
540 550
>>NP_001317412 (OMIM: 616755) E3 ubiquitin-protein ligas (354 aa)
initn: 2256 init1: 2256 opt: 2256 Z-score: 1474.0 bits: 281.7 E(85289): 2.3e-75
Smith-Waterman score: 2256; 97.4% identity (98.9% similar) in 350 aa overlap (126-475:5-354)
100 110 120 130 140 150
pF1KE1 HDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTE
:..:. . . :::::::::::::::::::
NP_001 MPEKTAVDQPWTQALRELKDQLQALQDSEREHTE
10 20 30
160 170 180 190 200 210
pF1KE1 ALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKV
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE1 QRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYT
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE1 GPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFD
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE1 VEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGN
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE1 QYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSP
280 290 300 310 320 330
460 470
pF1KE1 GQSHANGKNVQPLRINTVRI
::::::::::::::::::::
NP_001 GQSHANGKNVQPLRINTVRI
340 350
>>XP_016857119 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr (544 aa)
initn: 2049 init1: 2049 opt: 2049 Z-score: 1338.7 bits: 257.3 E(85289): 7.9e-68
Smith-Waterman score: 2049; 99.7% identity (100.0% similar) in 308 aa overlap (168-475:237-544)
140 150 160 170 180 190
pF1KE1 ELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAML
.:::::::::::::::::::::::::::::
XP_016 RQRAGTHRSAAAAQATTGGDQAITPDDCPPQSSTKSLRTTIGEAFERLHRLLRERQKAML
210 220 230 240 250 260
200 210 220 230 240 250
pF1KE1 EELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKG
270 280 290 300 310 320
260 270 280 290 300 310
pF1KE1 KIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIV
330 340 350 360 370 380
320 330 340 350 360 370
pF1KE1 AYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGS
390 400 410 420 430 440
380 390 400 410 420 430
pF1KE1 IQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSW
450 460 470 480 490 500
440 450 460 470
pF1KE1 LYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI
::::::::::::::::::::::::::::::::::::::
XP_016 LYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI
510 520 530 540
>>XP_016857120 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr (291 aa)
initn: 1184 init1: 1160 opt: 1160 Z-score: 770.8 bits: 151.3 E(85289): 3.4e-36
Smith-Waterman score: 1160; 96.0% identity (98.3% similar) in 175 aa overlap (5-179:85-259)
10 20 30
pF1KE1 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRC
::::::::::::::::::::::::::::::
XP_016 AAAATGSSDSAGSGLRGCAGPKRWLLSSRGLKDELLCSICLSIYQDPVSLGCEHYFCRRC
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE1 ITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQ
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE1 AHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHT
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE1 EALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQK
:::::::::::::: .:::...:
XP_016 EALQLLKRQLAETKELRQSLRNALGLWRSSWGLKTPLETQIYAPAWPPTHCGVSGRS
240 250 260 270 280 290
>>NP_742013 (OMIM: 605700) E3 ubiquitin-protein ligase T (488 aa)
initn: 819 init1: 467 opt: 862 Z-score: 576.6 bits: 116.1 E(85289): 2.2e-25
Smith-Waterman score: 862; 33.5% identity (61.7% similar) in 472 aa overlap (4-470:22-481)
10 20 30 40
pF1KE1 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQ
.:. : ::.:: ..:: . : : ::. :::. :
NP_742 MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL
10 20 30 40 50 60
50 60 70 80 90
pF1KE1 EAQGARD--CPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPC-QAHDKV
: :: :: ::.: .: :. .:...:: .. :.:. : : : :. .
NP_742 E----RDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQ--LQAVKRKIRDESLCPQHHEAL
70 80 90 100 110
100 110 120 130 140 150
pF1KE1 KLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQL
.::: :. .:..: :. : :. .::: .: ...:. :. :... .: :. .
NP_742 SLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSS
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE1 LKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYS
... .: : ..: : : . ::.::: : :.:...: .:: . : ..... . .
NP_742 EEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLG
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE1 QQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTG--P
.. : . . : .. . .. .: : : :. . :.. ..: .. : . :
NP_742 DKRRDLAHLAAEVEGKCLQSG-FEMLKDVKSTLEKCE-KVKTMEVTSVSIELEKNFSNFP
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE1 LQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVE
:: ....... : .:::: ::: :.::.: : . . . . : :.:.::
NP_742 RQYFALRKILKQL---IADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFY
300 310 320 330 340
340 350 360 370 380 390
pF1KE1 VSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQY
::..:.:.:: ::::: :..::.:..:. ....:::: . : :.. . . .:..:
NP_742 PCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKY
350 360 370 380 390 400
400 410 420 430 440 450
pF1KE1 SACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQ
.: : :.: :... : .::.::::. : : :::. : : .::: . : :: : ::
NP_742 AATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGI
410 420 430 440 450 460
460 470
pF1KE1 SHANGKNVQPLRINTVRI
.:. ::. :: :
NP_742 -RAGRKNAAPLTIRPPTDWE
470 480
>>NP_892030 (OMIM: 616017) E3 ubiquitin-protein ligase T (500 aa)
initn: 751 init1: 368 opt: 835 Z-score: 559.1 bits: 112.9 E(85289): 2.1e-24
Smith-Waterman score: 835; 32.2% identity (60.8% similar) in 469 aa overlap (8-470:38-496)
10 20 30
pF1KE1 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITE
:: : .: . ..::. :.: : ::. :: .
NP_892 SSNIDPGDYVEMNDSITHLPSKVVIQDITMELHCPLCNDWFRDPLMLSCGHNFCEACIQD
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE1 HWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQAH-
: : .:. . ::::. . . : ..::. ...:: .. : :
NP_892 FW-RLQAKETF-CPECKMLCQYNNCTFNPVLDKLVEKIKKLPL------LKGHPQCPEHG
70 80 90 100 110
100 110 120 130 140 150
pF1KE1 DKVKLFCLTDRALLCFFCDEPALH--EQHQVTGIDDAFDELQRELKDQLQALQDSEREHT
...::: : :.:: : . : .... :.:: . .:: : :. . .:
NP_892 ENLKLFSKPDGKLICFQCKDARLSVGQSKEFLQISDAVHFFTEELAIQQGQLETTLKELQ
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE1 EALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQK
.. :. .: : . :. .. : .::..:. ..: .: ::. . ..: .
NP_892 TLRNMQKEAIAAHKENKLHLQQHVSMEFLKLHQFLHSKEKDILTELREEGKALNEEMELN
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE1 VQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERL-KG-KIHET-NLTYEDFPT
... ..: ... .: . . . :: ...: . : .: :. : .: . .
NP_892 LSQLQEQCLLAKDMLVSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVLATRELISRKLNL
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE1 SKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSP
..: ::.:: .:. . . . : . ::::: ::: :.:: . : : .:... . . :.:
NP_892 GQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVWHGDIK-KIMPDDP
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE1 KRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVM
.::: :.::::..:.:: :::: ::.::.:..:...:. :::: . : .::. . .
NP_892 ERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVRESIIRKGSCPLTPEQGFWLLRL
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE1 HDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCS
.. .. .: : :.. ..:::::..:::. : : :::: :. .::: . : ::
NP_892 RNQTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNAKTMTHIYTFSNTFMEKLYP
420 430 440 450 460 470
460 470
pF1KE1 YFSPGQSHANGKNVQPLRINTVRI
:: : . . :.: .::.:
NP_892 YFCPCLNDG-GENKEPLHILHPQ
480 490 500
>>XP_011514091 (OMIM: 612548) PREDICTED: E3 ubiquitin-pr (486 aa)
initn: 653 init1: 286 opt: 781 Z-score: 524.6 bits: 106.5 E(85289): 1.8e-22
Smith-Waterman score: 781; 30.0% identity (60.9% similar) in 470 aa overlap (5-468:10-467)
10 20 30 40 50
pF1KE1 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRR
:.:.: : ::: ....:. : : : .:. :.. . .:. :: ::.
XP_011 MAWQVSLPELEDRLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAE--LRCPVCRQ
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 TFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQAH-DKVKLFCLTDRALLCFFC
. . :...:: ..: .: : . : : . ..::: :. :.: .:
XP_011 AVDGSSSLPNVSLARVIEALR-LPGDP------EPKVCVHHRNPLSLFCEKDQELICGLC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 DEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSL
. :..: :: .. .......:: .. :.. ... : . : . .. . . .
XP_011 GLLGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 RTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQE
.: . :..::.:. :.. :: . . : .......... .: :. :. . :
XP_011 SWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQ-AQGTRERLAQAECVLE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 RLAETDRHTFLA--GVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHP
.... :.: :. ..:: .: ... : .. .: . . . .. :.:: ::. . :
XP_011 QFGNEDHHKFIRFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLP
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE1 VPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHY
.: : :::.::: : :: :.: : : : ..:.::: . ::.:..:: : ::
XP_011 APEPLKLDPATAHPLLELSKGNTVVQCG-LLAQRRASQPERFDYSTCVLASRGFSCGRHY
300 310 320 330 340
360 370 380 390 400 410
pF1KE1 WEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDK
:::::. :..: .:. . .:::::... .: .: . : ...: : : . : . : : .
XP_011 WEVVVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGH
350 360 370 380 390 400
420 430 440 450 460
pF1KE1 LDKVGVFLDYDQGLLIFYNAD---DMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLR
..:..: :.:: : :..:: :. ::::. : ::: .. : :.: :.
XP_011 PHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCW-HERGSNSLPMV
410 420 430 440 450 460
470
pF1KE1 INTVRI
XP_011 LPPPSGPGPLSPEQPTKL
470 480
>>NP_001268379 (OMIM: 612548) E3 ubiquitin-protein ligas (486 aa)
initn: 653 init1: 286 opt: 781 Z-score: 524.6 bits: 106.5 E(85289): 1.8e-22
Smith-Waterman score: 781; 30.0% identity (60.9% similar) in 470 aa overlap (5-468:10-467)
10 20 30 40 50
pF1KE1 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRR
:.:.: : ::: ....:. : : : .:. :.. . .:. :: ::.
NP_001 MAWQVSLPELEDRLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAE--LRCPVCRQ
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 TFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQAH-DKVKLFCLTDRALLCFFC
. . :...:: ..: .: : . : : . ..::: :. :.: .:
NP_001 AVDGSSSLPNVSLARVIEALR-LPGDP------EPKVCVHHRNPLSLFCEKDQELICGLC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 DEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSL
. :..: :: .. .......:: .. :.. ... : . : . .. . . .
NP_001 GLLGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 RTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQE
.: . :..::.:. :.. :: . . : .......... .: :. :. . :
NP_001 SWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQ-AQGTRERLAQAECVLE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 RLAETDRHTFLA--GVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHP
.... :.: :. ..:: .: ... : .. .: . . . .. :.:: ::. . :
NP_001 QFGNEDHHKFIRFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLP
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE1 VPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHY
.: : :::.::: : :: :.: : : : ..:.::: . ::.:..:: : ::
NP_001 APEPLKLDPATAHPLLELSKGNTVVQCG-LLAQRRASQPERFDYSTCVLASRGFSCGRHY
300 310 320 330 340
360 370 380 390 400 410
pF1KE1 WEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDK
:::::. :..: .:. . .:::::... .: .: . : ...: : : . : . : : .
NP_001 WEVVVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGH
350 360 370 380 390 400
420 430 440 450 460
pF1KE1 LDKVGVFLDYDQGLLIFYNAD---DMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLR
..:..: :.:: : :..:: :. ::::. : ::: .. : :.: :.
NP_001 PHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCW-HERGSNSLPMV
410 420 430 440 450 460
470
pF1KE1 INTVRI
NP_001 LPPPSGPGPLSPEQPTKL
470 480
>>NP_001268380 (OMIM: 612548) E3 ubiquitin-protein ligas (487 aa)
initn: 653 init1: 286 opt: 779 Z-score: 523.3 bits: 106.2 E(85289): 2.1e-22
Smith-Waterman score: 779; 29.9% identity (60.7% similar) in 471 aa overlap (5-468:10-468)
10 20 30 40 50
pF1KE1 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRR
:.:.: : ::: ....:. : : : .:. :.. . .:. :: ::.
NP_001 MAWQVSLPELEDRLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAE--LRCPVCRQ
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 TFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQAH-DKVKLFCLTDRALLCFFC
. . :...:: ..: .: : . : : . ..::: :. :.: .:
NP_001 AVDGSSSLPNVSLARVIEALR-LPGDP------EPKVCVHHRNPLSLFCEKDQELICGLC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 DEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSL
. :..: :: .. .......:: .. :.. ... : . : . .. . . .
NP_001 GLLGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 RTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQE
.: . :..::.:. :.. :: . . : .......... .: :. :. . :
NP_001 SWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQ-AQGTRERLAQAECVLE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 RLAETDRHTFLA---GVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIH
.... :.: :. ..:: .: ... : .. .: . . . .. :.:: ::. .
NP_001 QFGNEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE1 PVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVH
:.: : :::.::: : :: :.: : : : ..:.::: . ::.:..:: : :
NP_001 PAPEPLKLDPATAHPLLELSKGNTVVQCG-LLAQRRASQPERFDYSTCVLASRGFSCGRH
300 310 320 330 340
360 370 380 390 400 410
pF1KE1 YWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRD
::::::. :..: .:. . .:::::... .: .: . : ...: : : . : . : :
NP_001 YWEVVVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAG
350 360 370 380 390 400
420 430 440 450 460
pF1KE1 KLDKVGVFLDYDQGLLIFYNAD---DMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPL
. ..:..: :.:: : :..:: :. ::::. : ::: .. : :.: :.
NP_001 HPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCW-HERGSNSLPM
410 420 430 440 450 460
470
pF1KE1 RINTVRI
NP_001 VLPPPSGPGPLSPEQPTKL
470 480
475 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 19:23:29 2016 done: Sun Nov 6 19:23:30 2016
Total Scan time: 9.990 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]