Result of FASTA (omim) for
pFN21AE1289
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1289, 929 aa
1>>>pF1KE1289 929 - 929 aa - 929 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 15.2055+/-0.000428; mu= -23.6518+/- 0.027
mean_var=551.5238+/-109.948, 0's: 0 Z-trim(125.2): 62 B-trim: 0 in 0/60
Lambda= 0.054613
statistics sampled from 48485 (48579) to 48485 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.816), E-opt: 0.2 (0.57), width: 16
Scan time: 17.560
The best scores are: opt bits E(85289)
NP_114129 (OMIM: 606576) transcription initiation ( 929) 6223 505.3 5.5e-142
XP_011518043 (OMIM: 606576) PREDICTED: transcripti (1005) 6205 503.9 1.6e-141
NP_066554 (OMIM: 105400,162230,616924) neurofilame (1020) 403 46.8 0.00065
>>NP_114129 (OMIM: 606576) transcription initiation fact (929 aa)
initn: 6223 init1: 6223 opt: 6223 Z-score: 2670.0 bits: 505.3 E(85289): 5.5e-142
Smith-Waterman score: 6223; 99.8% identity (99.9% similar) in 929 aa overlap (1-929:1-929)
10 20 30 40 50 60
pF1KE1 MCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 MCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 PILDDVGEAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 PILDDVGEAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 KEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVPLEEDDELEEEEIINDENFLGKRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 KEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVPLEEDDELEEEEIINDENFLGKRP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 LDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 PPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 SPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 SPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 QIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 QIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 TSPKRISGPECTTPKASTSANSFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLG
:::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::
NP_114 TSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 TPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 TPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 DREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 DREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 KVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 KVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 LALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKPKEKEKKKDKKEKKKKKEKEKEKKE
::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::
NP_114 LALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 KEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIVISKVVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 KEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIVISKVVPA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 PEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAPVPLPLLAQAAAGPALLPSPGPAASGASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 PEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAPVPLPLLAQAAAGPALLPSPGPAASGASA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 KAPVRSVVTETVSTYVIRDEWGNQIWICPGCNKPDDGSPMIGCDDCDDWYHWPCVGIMTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 KAPVRSVVTETVSTYVIRDEWGNQIWICPGCNKPDDGSPMIGCDDCDDWYHWPCVGIMTA
850 860 870 880 890 900
910 920
pF1KE1 PPEEMQWFCPKCANKKKDKKHKKRKHRAH
:::::::::::::::::::::::::::::
NP_114 PPEEMQWFCPKCANKKKDKKHKKRKHRAH
910 920
>>XP_011518043 (OMIM: 606576) PREDICTED: transcription i (1005 aa)
initn: 5305 init1: 5305 opt: 6205 Z-score: 2661.9 bits: 503.9 E(85289): 1.6e-141
Smith-Waterman score: 6205; 99.7% identity (99.8% similar) in 929 aa overlap (1-929:78-1005)
10 20 30
pF1KE1 MCESYSRSLLRVSVAQICQALGWDSVQLSA
::::::::::::::::::::::::::::::
XP_011 LEDESGTLLRSGGGAGEQWQQGLRWRPRSGMCESYSRSLLRVSVAQICQALGWDSVQLSA
50 60 70 80 90 100
40 50 60 70 80 90
pF1KE1 CHLLTDVLQRYLQQLGRGCHRYSELYGRTDPILDDVGEAFQLMGVSLHELEDYIHNIEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CHLLTDVLQRYLQQLGRGCHRYSELYGRTDPILDDVGEAFQLMGVSLHELEDYIHNIEPV
110 120 130 140 150 160
100 110 120 130 140 150
pF1KE1 TFPHQIPSFPVSKNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEEQVPTDGGTS
:::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::
XP_011 TFPHQIPSFPVSKNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEE-QVPTDGGTS
170 180 190 200 210 220
160 170 180 190 200 210
pF1KE1 AEAMQVPLEEDDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEAMQVPLEEDDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLL
230 240 250 260 270 280
220 230 240 250 260 270
pF1KE1 EAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPPMLAPVAKSQMPTAKPLETKSFTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPPMLAPVAKSQMPTAKPLETKSFTP
290 300 310 320 330 340
280 290 300 310 320 330
pF1KE1 KTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHI
350 360 370 380 390 400
340 350 360 370 380 390
pF1KE1 PQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEAS
410 420 430 440 450 460
400 410 420 430 440 450
pF1KE1 IDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANSFTKSGSTP
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
XP_011 IDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTKSGSTP
470 480 490 500 510 520
460 470 480 490 500 510
pF1KE1 LPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYE
530 540 550 560 570 580
520 530 540 550 560 570
pF1KE1 EKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGR
590 600 610 620 630 640
580 590 600 610 620 630
pF1KE1 ETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDK
650 660 670 680 690 700
640 650 660 670 680 690
pF1KE1 DKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLF
710 720 730 740 750 760
700 710 720 730 740 750
pF1KE1 EEKEKPKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPV
::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPV
770 780 790 800 810 820
760 770 780 790 800 810
pF1KE1 ALAPSPVIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSQNRPKTPPPAPAPAPGPMLVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALAPSPVIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSQNRPKTPPPAPAPAPGPMLVSP
830 840 850 860 870 880
820 830 840 850 860 870
pF1KE1 APVPLPLLAQAAAGPALLPSPGPAASGASAKAPVRSVVTETVSTYVIRDEWGNQIWICPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APVPLPLLAQAAAGPALLPSPGPAASGASAKAPVRSVVTETVSTYVIRDEWGNQIWICPG
890 900 910 920 930 940
880 890 900 910 920
pF1KE1 CNKPDDGSPMIGCDDCDDWYHWPCVGIMTAPPEEMQWFCPKCANKKKDKKHKKRKHRAH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CNKPDDGSPMIGCDDCDDWYHWPCVGIMTAPPEEMQWFCPKCANKKKDKKHKKRKHRAH
950 960 970 980 990 1000
>>NP_066554 (OMIM: 105400,162230,616924) neurofilament h (1020 aa)
initn: 421 init1: 143 opt: 403 Z-score: 191.2 bits: 46.8 E(85289): 0.00065
Smith-Waterman score: 460; 27.1% identity (50.0% similar) in 664 aa overlap (89-744:419-993)
60 70 80 90 100 110
pF1KE1 TDPILDDVGEAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAE
: ..:. .:..: .... . .:
NP_066 LNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHI-------KVKSE
390 400 410 420 430 440
120 130 140 150 160 170
pF1KE1 ERKEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVPLEEDDELEEEEIINDENFLGK
:. . . : .:. :: :: :. : : .. :: : : : ..: :.
NP_066 EKIKVVEKSEKETVIVEEQTEETQV-TEEVTEEEEKEAKEEEGKEEEGGE--EEEAEGGE
450 460 470 480 490
180 190 200 210 220 230
pF1KE1 RPLDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTD
. :: ::: : . .. . : ::. : . . .: ::..:..
NP_066 EETKSPPAEEAA--------SPEKEAKSPVKEEAKSPAEAKSPEK-EEAKSPAEVKSPEK
500 510 520 530 540
240 250 260 270 280 290
pF1KE1 LAPPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSP--KTAQSPAMVG
:. : : ::: : . .. .: ....:: .:.::: . :.::: .
NP_066 AKSPAKEEAKSPPEAKS------PEKEEAKSP---AEVKSP-EKAKSPAKEEAKSPAEAK
550 560 570 580 590
300 310 320 330 340 350
pF1KE1 SPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKET
:: .. . :..: :::...::: . .. ..:.. ..:... : : : : :
NP_066 SPEKAKSPVKEEAKSPAEAKSPVKEEA--------KSPAEVKSPEKAKSPTKEEAKSPEK
600 610 620 630 640 650
360 370 380 390 400 410
pF1KE1 IQVKQIQTPPDAGKLNSENQPKKAVVAD-KTIEASIDAVIARACAEREPDPFEFSSGSES
. :. . .: .. :. : :. :. : . . : :.: . :. . :.
NP_066 AK------SPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEA---KSPEKAKSPVKEEA
660 670 680 690 700
420 430 440 450 460 470
pF1KE1 EGDIFTSPKRISGPECTTPKASTSANSFTKS-GSTPLPLSGGTSSSDNSWTMDASIDEVV
. ::.. ..: :. .:.: .: ..:: .. .. .: :. : .
NP_066 K-----SPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKS-PEKAKSPEKA
710 720 730 740 750
480 490 500 510 520 530
pF1KE1 RKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMK
. . .: : ::. . : ::.: : ::...:. :.:
NP_066 KTLDVKSPEAKTPAKEEARSPADKFP----------EKAKSP----VKEEVKSPEKAKSP
760 770 780 790 800
540 550 560 570 580 590
pF1KE1 KKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKE
:: . :.: : : . :. :::.:: .:. ..: : :. ::: : : .:
NP_066 LKEDAKAPEKEIPK---KEEVKSPVKEEEKPQEV--KVKEPPKK--AEEEKAPATPKTEE
810 820 830 840 850
600 610 620 630 640 650
pF1KE1 FEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAP--
.: . : :: : : ..... .: :. : ..: . ::: :.:.:
NP_066 KKDSKKEEAPK-------KEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEK
860 870 880 890 900
660 670 680 690 700 710
pF1KE1 --PLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKPKEKEKKKDKKEKKK
: . :: : : . .:.. : . : : :.:: :: :: ::.:
NP_066 EAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPA---EKKEAAPEK---KDTKEEKA
910 920 930 940 950 960
720 730 740 750 760 770
pF1KE1 KKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQD
:: .:: : : : :.. . :: : : ::
NP_066 KKPEEKPKTE---AKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKG
970 980 990 1000 1010
780 790 800 810 820 830
pF1KE1 KIVISKVVPAPEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAPVPLPLLAQAAAGPALLPS
NP_066 K
1020
929 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:36:01 2016 done: Sun Nov 6 04:36:04 2016
Total Scan time: 17.560 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]