Result of FASTA (omim) for
pFN21AE1191
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1191, 824 aa
1>>>pF1KE1191 824 - 824 aa - 824 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.3471+/-0.000442; mu= -11.9244+/- 0.027
mean_var=380.3071+/-79.209, 0's: 0 Z-trim(121.6): 191 B-trim: 1618 in 1/57
Lambda= 0.065767
statistics sampled from 38244 (38451) to 38244 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.763), E-opt: 0.2 (0.451), width: 16
Scan time: 14.820
The best scores are: opt bits E(85289)
NP_002509 (OMIM: 603347) neuronal PAS domain-conta ( 824) 5537 540.0 1.6e-152
XP_005264010 (OMIM: 603347) PREDICTED: neuronal PA ( 889) 5537 540.0 1.7e-152
XP_005264016 (OMIM: 603347) PREDICTED: neuronal PA ( 835) 5130 501.4 7e-141
XP_016859704 (OMIM: 603347) PREDICTED: neuronal PA ( 838) 5128 501.2 8e-141
XP_011509544 (OMIM: 603347) PREDICTED: neuronal PA ( 794) 4762 466.4 2.2e-130
XP_005264018 (OMIM: 603347) PREDICTED: neuronal PA ( 700) 4740 464.3 8.3e-130
XP_016859703 (OMIM: 603347) PREDICTED: neuronal PA ( 843) 4127 406.2 3.1e-112
XP_016859705 (OMIM: 603347) PREDICTED: neuronal PA ( 789) 4085 402.2 4.7e-111
XP_011509545 (OMIM: 603347) PREDICTED: neuronal PA ( 637) 3656 361.4 7e-99
XP_005264017 (OMIM: 603347) PREDICTED: neuronal PA ( 786) 3502 346.9 2.1e-94
XP_016859706 (OMIM: 603347) PREDICTED: neuronal PA ( 732) 3095 308.2 8.3e-83
XP_011532713 (OMIM: 601851) PREDICTED: circadian l ( 846) 2567 258.2 1.1e-67
XP_011532712 (OMIM: 601851) PREDICTED: circadian l ( 846) 2567 258.2 1.1e-67
XP_011532711 (OMIM: 601851) PREDICTED: circadian l ( 846) 2567 258.2 1.1e-67
NP_004889 (OMIM: 601851) circadian locomoter outpu ( 846) 2567 258.2 1.1e-67
XP_005265844 (OMIM: 601851) PREDICTED: circadian l ( 846) 2567 258.2 1.1e-67
NP_001254772 (OMIM: 601851) circadian locomoter ou ( 846) 2567 258.2 1.1e-67
XP_016864343 (OMIM: 601851) PREDICTED: circadian l ( 846) 2567 258.2 1.1e-67
XP_016864344 (OMIM: 601851) PREDICTED: circadian l ( 787) 2384 240.8 1.8e-62
NP_001272965 (OMIM: 126110) aryl hydrocarbon recep ( 787) 342 47.1 0.00038
XP_011507848 (OMIM: 126110) PREDICTED: aryl hydroc ( 757) 330 45.9 0.00081
XP_016856779 (OMIM: 126110) PREDICTED: aryl hydroc ( 765) 330 45.9 0.00081
XP_011507847 (OMIM: 126110) PREDICTED: aryl hydroc ( 773) 330 45.9 0.00082
NP_848514 (OMIM: 126110) aryl hydrocarbon receptor ( 774) 330 45.9 0.00082
XP_005245211 (OMIM: 126110) PREDICTED: aryl hydroc ( 780) 330 45.9 0.00083
XP_011507846 (OMIM: 126110) PREDICTED: aryl hydroc ( 787) 330 45.9 0.00083
XP_011507844 (OMIM: 126110) PREDICTED: aryl hydroc ( 788) 330 45.9 0.00083
XP_011507845 (OMIM: 126110) PREDICTED: aryl hydroc ( 788) 330 45.9 0.00083
NP_001659 (OMIM: 126110) aryl hydrocarbon receptor ( 789) 330 45.9 0.00083
NP_001272964 (OMIM: 126110) aryl hydrocarbon recep ( 775) 329 45.8 0.00088
XP_016856778 (OMIM: 126110) PREDICTED: aryl hydroc ( 775) 329 45.8 0.00088
XP_005245210 (OMIM: 126110) PREDICTED: aryl hydroc ( 784) 329 45.8 0.00089
XP_016856780 (OMIM: 126110) PREDICTED: aryl hydroc ( 764) 328 45.7 0.00093
XP_011507849 (OMIM: 126110) PREDICTED: aryl hydroc ( 772) 328 45.7 0.00093
NP_001184254 (OMIM: 126110) aryl hydrocarbon recep ( 773) 328 45.7 0.00093
XP_016856777 (OMIM: 126110) PREDICTED: aryl hydroc ( 779) 328 45.7 0.00094
XP_005245208 (OMIM: 126110) PREDICTED: aryl hydroc ( 788) 328 45.7 0.00095
XP_016856785 (OMIM: 126110) PREDICTED: aryl hydroc ( 737) 324 45.3 0.0012
XP_016856781 (OMIM: 126110) PREDICTED: aryl hydroc ( 743) 324 45.3 0.0012
XP_005245214 (OMIM: 126110) PREDICTED: aryl hydroc ( 752) 324 45.3 0.0012
XP_016856784 (OMIM: 126110) PREDICTED: aryl hydroc ( 747) 323 45.2 0.0013
NP_851397 (OMIM: 603348) hypoxia-inducible factor ( 735) 322 45.1 0.0013
NP_001521 (OMIM: 603348) hypoxia-inducible factor ( 826) 322 45.2 0.0015
NP_001230013 (OMIM: 603348) hypoxia-inducible fact ( 850) 322 45.2 0.0015
XP_016856782 (OMIM: 126110) PREDICTED: aryl hydroc ( 727) 320 44.9 0.0015
XP_016856783 (OMIM: 126110) PREDICTED: aryl hydroc ( 751) 320 45.0 0.0015
NP_001025444 (OMIM: 602550) aryl hydrocarbon recep ( 582) 300 43.0 0.0047
XP_016873237 (OMIM: 602550) PREDICTED: aryl hydroc ( 582) 300 43.0 0.0047
XP_011518415 (OMIM: 602550) PREDICTED: aryl hydroc ( 582) 300 43.0 0.0047
XP_016873234 (OMIM: 602550) PREDICTED: aryl hydroc ( 587) 300 43.0 0.0047
>>NP_002509 (OMIM: 603347) neuronal PAS domain-containin (824 aa)
initn: 5537 init1: 5537 opt: 5537 Z-score: 2859.1 bits: 540.0 E(85289): 1.6e-152
Smith-Waterman score: 5537; 99.9% identity (100.0% similar) in 824 aa overlap (1-824:1-824)
10 20 30 40 50 60
pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 EVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 PSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 EFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 MCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 QHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVER
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 RQELALEDPPSEALHSSALKDKGSSLEPRQHFNALDVGASGLNTSHSPSASSRSSHKSSH
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
NP_002 RQELALEDPPSEALHSSALKDKGSSLEPRQHFNTLDVGASGLNTSHSPSASSRSSHKSSH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 TAMSEPTSTPTKLMAEASTPALPRSATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TAMSEPTSTPTKLMAEASTPALPRSATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 PQTVLQSTPAPMAQFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PQTVLQSTPAPMAQFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 NVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAVTQPQLGAGPQLPGQISSAQVTSQHLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAVTQPQLGAGPQLPGQISSAQVTSQHLL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 RESSVISTQGPKPMRSSQLMQSSGRSGSSLVSPFSSATAALPPSLNLTTPASTSQDASQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RESSVISTQGPKPMRSSQLMQSSGRSGSSLVSPFSSATAALPPSLNLTTPASTSQDASQC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 QPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPSEVSRTGRQVKYAQSQTVFQNPDAHPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPSEVSRTGRQVKYAQSQTVFQNPDAHPA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 NSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQARQQPPQHYLQVQAPTSLHSEQQDSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQARQQPPQHYLQVQAPTSLHSEQQDSLL
730 740 750 760 770 780
790 800 810 820
pF1KE1 LSTYSQQPGTLGYPQPPPAQPQPLRPPRRVSSLSESSGLQQPPR
::::::::::::::::::::::::::::::::::::::::::::
NP_002 LSTYSQQPGTLGYPQPPPAQPQPLRPPRRVSSLSESSGLQQPPR
790 800 810 820
>>XP_005264010 (OMIM: 603347) PREDICTED: neuronal PAS do (889 aa)
initn: 5537 init1: 5537 opt: 5537 Z-score: 2858.6 bits: 540.0 E(85289): 1.7e-152
Smith-Waterman score: 5537; 99.9% identity (100.0% similar) in 824 aa overlap (1-824:66-889)
10 20 30
pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIK
::::::::::::::::::::::::::::::
XP_005 TGTTRLNSEPVPLLCLPLLNCSRKNCIENLMDEDEKDRAKRASRNKSEKKRRDQFNVLIK
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE1 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE1 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE1 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE1 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE1 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE1 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE1 HFNALDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HFNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE1 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE
520 530 540 550 560 570
520 530 540 550 560 570
pF1KE1 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR
580 590 600 610 620 630
580 590 600 610 620 630
pF1KE1 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL
640 650 660 670 680 690
640 650 660 670 680 690
pF1KE1 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA
700 710 720 730 740 750
700 710 720 730 740 750
pF1KE1 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ
760 770 780 790 800 810
760 770 780 790 800 810
pF1KE1 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV
820 830 840 850 860 870
820
pF1KE1 SSLSESSGLQQPPR
::::::::::::::
XP_005 SSLSESSGLQQPPR
880
>>XP_005264016 (OMIM: 603347) PREDICTED: neuronal PAS do (835 aa)
initn: 5210 init1: 5130 opt: 5130 Z-score: 2650.3 bits: 501.4 E(85289): 7e-141
Smith-Waterman score: 5130; 99.5% identity (99.7% similar) in 769 aa overlap (1-769:66-834)
10 20 30
pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIK
::::::::::::::::::::::::::::::
XP_005 TGTTRLNSEPVPLLCLPLLNCSRKNCIENLMDEDEKDRAKRASRNKSEKKRRDQFNVLIK
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE1 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE1 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE1 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE1 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE1 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE1 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE1 HFNALDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HFNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE1 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE
520 530 540 550 560 570
520 530 540 550 560 570
pF1KE1 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR
580 590 600 610 620 630
580 590 600 610 620 630
pF1KE1 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL
640 650 660 670 680 690
640 650 660 670 680 690
pF1KE1 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA
700 710 720 730 740 750
700 710 720 730 740 750
pF1KE1 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ
760 770 780 790 800 810
760 770 780 790 800 810
pF1KE1 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV
::::::::::::::: . :
XP_005 PAQARQQPPQHYLQVLGHTL
820 830
>>XP_016859704 (OMIM: 603347) PREDICTED: neuronal PAS do (838 aa)
initn: 5208 init1: 5128 opt: 5128 Z-score: 2649.3 bits: 501.2 E(85289): 8e-141
Smith-Waterman score: 5128; 99.7% identity (100.0% similar) in 765 aa overlap (1-765:66-830)
10 20 30
pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIK
::::::::::::::::::::::::::::::
XP_016 TGTTRLNSEPVPLLCLPLLNCSRKNCIENLMDEDEKDRAKRASRNKSEKKRRDQFNVLIK
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE1 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE1 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE1 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE1 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE1 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE1 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE1 HFNALDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE1 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE
520 530 540 550 560 570
520 530 540 550 560 570
pF1KE1 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR
580 590 600 610 620 630
580 590 600 610 620 630
pF1KE1 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL
640 650 660 670 680 690
640 650 660 670 680 690
pF1KE1 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA
700 710 720 730 740 750
700 710 720 730 740 750
pF1KE1 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ
760 770 780 790 800 810
760 770 780 790 800 810
pF1KE1 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV
::::::::::::::.
XP_016 PAQARQQPPQHYLQILSVLETQK
820 830
>>XP_011509544 (OMIM: 603347) PREDICTED: neuronal PAS do (794 aa)
initn: 4762 init1: 4762 opt: 4762 Z-score: 2461.9 bits: 466.4 E(85289): 2.2e-130
Smith-Waterman score: 5278; 96.2% identity (96.4% similar) in 824 aa overlap (1-824:1-794)
10 20 30 40 50 60
pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 EVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHL
:::::::::::::::::::::::::::::::
XP_011 EVSAQTEICDIQQDWKPSFLSNEEFTQLMLE-----------------------------
70 80 90
130 140 150 160 170 180
pF1KE1 PSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 -SDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPK
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 EFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKE
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 MCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCH
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE1 QHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVER
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE1 RQELALEDPPSEALHSSALKDKGSSLEPRQHFNALDVGASGLNTSHSPSASSRSSHKSSH
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_011 RQELALEDPPSEALHSSALKDKGSSLEPRQHFNTLDVGASGLNTSHSPSASSRSSHKSSH
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE1 TAMSEPTSTPTKLMAEASTPALPRSATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAMSEPTSTPTKLMAEASTPALPRSATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLL
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE1 PQTVLQSTPAPMAQFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQTVLQSTPAPMAQFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDS
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE1 NVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAVTQPQLGAGPQLPGQISSAQVTSQHLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAVTQPQLGAGPQLPGQISSAQVTSQHLL
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE1 RESSVISTQGPKPMRSSQLMQSSGRSGSSLVSPFSSATAALPPSLNLTTPASTSQDASQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RESSVISTQGPKPMRSSQLMQSSGRSGSSLVSPFSSATAALPPSLNLTTPASTSQDASQC
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE1 QPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPSEVSRTGRQVKYAQSQTVFQNPDAHPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPSEVSRTGRQVKYAQSQTVFQNPDAHPA
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE1 NSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQARQQPPQHYLQVQAPTSLHSEQQDSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQARQQPPQHYLQVQAPTSLHSEQQDSLL
700 710 720 730 740 750
790 800 810 820
pF1KE1 LSTYSQQPGTLGYPQPPPAQPQPLRPPRRVSSLSESSGLQQPPR
::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSTYSQQPGTLGYPQPPPAQPQPLRPPRRVSSLSESSGLQQPPR
760 770 780 790
>>XP_005264018 (OMIM: 603347) PREDICTED: neuronal PAS do (700 aa)
initn: 4740 init1: 4740 opt: 4740 Z-score: 2451.4 bits: 464.3 E(85289): 8.3e-130
Smith-Waterman score: 4740; 99.9% identity (100.0% similar) in 700 aa overlap (125-824:1-700)
100 110 120 130 140 150
pF1KE1 GFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDS
::::::::::::::::::::::::::::::
XP_005 MDQNLLNFLPEQEHSEVYKILSSHMLVTDS
10 20 30
160 170 180 190 200 210
pF1KE1 PSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSR
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE1 PCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGY
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE1 LPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITY
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE1 HQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQHFNA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_005 HQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQHFNT
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE1 LDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQELPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQELPV
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE1 PGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLEQRTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLEQRTR
340 350 360 370 380 390
520 530 540 550 560 570
pF1KE1 ILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAV
400 410 420 430 440 450
580 590 600 610 620 630
pF1KE1 TQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSLVSPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSLVSPF
460 470 480 490 500 510
640 650 660 670 680 690
pF1KE1 SSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPS
520 530 540 550 560 570
700 710 720 730 740 750
pF1KE1 EVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQA
580 590 600 610 620 630
760 770 780 790 800 810
pF1KE1 RQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRVSSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRVSSLS
640 650 660 670 680 690
820
pF1KE1 ESSGLQQPPR
::::::::::
XP_005 ESSGLQQPPR
700
>>XP_016859703 (OMIM: 603347) PREDICTED: neuronal PAS do (843 aa)
initn: 4068 init1: 4068 opt: 4127 Z-score: 2135.9 bits: 406.2 E(85289): 3.1e-112
Smith-Waterman score: 5146; 94.3% identity (94.4% similar) in 824 aa overlap (1-824:66-843)
10 20 30
pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIK
::::::::::::::::::::::::::::::
XP_016 TGTTRLNSEPVPLLCLPLLNCSRKNCIENLMDEDEKDRAKRASRNKSEKKRRDQFNVLIK
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE1 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE1 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE1 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE1 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE1 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE1 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE1 HFNALDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE1 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE
520 530 540 550 560 570
520 530 540 550 560 570
pF1KE1 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR
580 590 600 610 620 630
580 590 600 610 620 630
pF1KE1 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL
:::::::::::::::::::::::::::::::::::::::
XP_016 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQ---------------------
640 650 660 670
640 650 660 670 680 690
pF1KE1 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA
:::::::::::::::::::::::::::::::::::
XP_016 -------------------------DASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA
680 690 700
700 710 720 730 740 750
pF1KE1 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ
710 720 730 740 750 760
760 770 780 790 800 810
pF1KE1 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV
770 780 790 800 810 820
820
pF1KE1 SSLSESSGLQQPPR
::::::::::::::
XP_016 SSLSESSGLQQPPR
830 840
>>XP_016859705 (OMIM: 603347) PREDICTED: neuronal PAS do (789 aa)
initn: 4834 init1: 4068 opt: 4085 Z-score: 2114.8 bits: 402.2 E(85289): 4.7e-111
Smith-Waterman score: 4739; 93.5% identity (93.8% similar) in 769 aa overlap (1-769:66-788)
10 20 30
pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIK
::::::::::::::::::::::::::::::
XP_016 TGTTRLNSEPVPLLCLPLLNCSRKNCIENLMDEDEKDRAKRASRNKSEKKRRDQFNVLIK
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE1 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE1 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE1 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE1 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE1 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE1 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE1 HFNALDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE1 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE
520 530 540 550 560 570
520 530 540 550 560 570
pF1KE1 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR
580 590 600 610 620 630
580 590 600 610 620 630
pF1KE1 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL
:::::::::::::::::::::::::::::::::::::::
XP_016 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQ---------------------
640 650 660 670
640 650 660 670 680 690
pF1KE1 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA
:::::::::::::::::::::::::::::::::::
XP_016 -------------------------DASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA
680 690 700
700 710 720 730 740 750
pF1KE1 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ
710 720 730 740 750 760
760 770 780 790 800 810
pF1KE1 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV
::::::::::::::: . :
XP_016 PAQARQQPPQHYLQVLGHTL
770 780
>>XP_011509545 (OMIM: 603347) PREDICTED: neuronal PAS do (637 aa)
initn: 3713 init1: 3656 opt: 3656 Z-score: 1896.2 bits: 361.4 E(85289): 7e-99
Smith-Waterman score: 3656; 99.5% identity (99.6% similar) in 546 aa overlap (1-546:66-611)
10 20 30
pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIK
::::::::::::::::::::::::::::::
XP_011 TGTTRLNSEPVPLLCLPLLNCSRKNCIENLMDEDEKDRAKRASRNKSEKKRRDQFNVLIK
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE1 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE1 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE1 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE1 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE1 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE1 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE1 HFNALDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HFNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE1 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE
520 530 540 550 560 570
520 530 540 550 560 570
pF1KE1 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR
::::::::::::::::::::::::::::::::: :
XP_011 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQAHLLTASTYVCTCALGVGLPCMDACLG
580 590 600 610 620 630
580 590 600 610 620 630
pF1KE1 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL
XP_011 PG
>>XP_005264017 (OMIM: 603347) PREDICTED: neuronal PAS do (786 aa)
initn: 3502 init1: 3502 opt: 3502 Z-score: 1815.9 bits: 346.9 E(85289): 2.1e-94
Smith-Waterman score: 4587; 87.4% identity (87.5% similar) in 824 aa overlap (1-824:66-786)
10 20 30
pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIK
::::::::::::::::::::::::::::::
XP_005 TGTTRLNSEPVPLLCLPLLNCSRKNCIENLMDEDEKDRAKRASRNKSEKKRRDQFNVLIK
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE1 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE1 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE1 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNV----------
220 230 240 250 260
220 230 240 250 260 270
pF1KE1 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP
XP_005 ------------------------------------------------------------
280 290 300 310 320 330
pF1KE1 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY
:::::::::::::::::::::::::::
XP_005 ---------------------------------MQFGKGKSCCYRFLTKGQQWIWLQTHY
270 280 290
340 350 360 370 380 390
pF1KE1 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ
300 310 320 330 340 350
400 410 420 430 440 450
pF1KE1 HFNALDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HFNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ
360 370 380 390 400 410
460 470 480 490 500 510
pF1KE1 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE
420 430 440 450 460 470
520 530 540 550 560 570
pF1KE1 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR
480 490 500 510 520 530
580 590 600 610 620 630
pF1KE1 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL
540 550 560 570 580 590
640 650 660 670 680 690
pF1KE1 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA
600 610 620 630 640 650
700 710 720 730 740 750
pF1KE1 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ
660 670 680 690 700 710
760 770 780 790 800 810
pF1KE1 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV
720 730 740 750 760 770
820
pF1KE1 SSLSESSGLQQPPR
::::::::::::::
XP_005 SSLSESSGLQQPPR
780
824 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 15:58:49 2016 done: Mon Nov 7 15:58:51 2016
Total Scan time: 14.820 Total Display time: 0.270
Function used was FASTA [36.3.4 Apr, 2011]