Result of FASTA (omim) for
pFN21AE1129
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1129, 166 aa
1>>>pF1KE1129 166 - 166 aa - 166 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3463+/-0.000344; mu= 12.4421+/- 0.021
mean_var=89.7151+/-17.338, 0's: 0 Z-trim(117.3): 75 B-trim: 170 in 2/50
Lambda= 0.135407
statistics sampled from 29083 (29165) to 29083 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.724), E-opt: 0.2 (0.342), width: 16
Scan time: 5.520
The best scores are: opt bits E(85289)
NP_001295087 (OMIM: 190170) protransforming growth ( 166) 1147 233.4 1.3e-61
NP_001295088 (OMIM: 190170) protransforming growth ( 165) 1130 230.1 1.3e-60
NP_003227 (OMIM: 190170) protransforming growth fa ( 160) 1026 209.8 1.6e-54
NP_001093161 (OMIM: 190170) protransforming growth ( 159) 1009 206.5 1.6e-53
XP_011530513 (OMIM: 600345) PREDICTED: probetacell ( 178) 248 57.8 9.8e-09
NP_001720 (OMIM: 600345) probetacellulin isoform 1 ( 178) 248 57.8 9.8e-09
NP_003683 (OMIM: 603421) tomoregulin-1 precursor [ ( 380) 211 50.9 2.5e-06
XP_011509192 (OMIM: 605734) PREDICTED: tomoregulin ( 365) 208 50.3 3.7e-06
NP_057276 (OMIM: 605734) tomoregulin-2 isoform 1 p ( 374) 208 50.3 3.8e-06
XP_016859228 (OMIM: 605734) PREDICTED: tomoregulin ( 337) 203 49.3 6.9e-06
NP_001292063 (OMIM: 605734) tomoregulin-2 isoform ( 346) 203 49.3 7e-06
XP_016863341 (OMIM: 131530,611718) PREDICTED: pro- (1010) 188 46.8 0.00012
XP_016863340 (OMIM: 131530,611718) PREDICTED: pro- (1060) 188 46.8 0.00012
NP_001423 (OMIM: 602061) proepiregulin preproprote ( 169) 178 44.1 0.00012
XP_016863339 (OMIM: 131530,611718) PREDICTED: pro- (1141) 188 46.9 0.00013
XP_016863338 (OMIM: 131530,611718) PREDICTED: pro- (1142) 188 46.9 0.00013
NP_001171602 (OMIM: 131530,611718) pro-epidermal g (1165) 188 46.9 0.00013
XP_011530009 (OMIM: 131530,611718) PREDICTED: pro- (1178) 188 46.9 0.00013
XP_016863337 (OMIM: 131530,611718) PREDICTED: pro- (1181) 188 46.9 0.00013
NP_001954 (OMIM: 131530,611718) pro-epidermal grow (1207) 188 46.9 0.00013
XP_016863335 (OMIM: 131530,611718) PREDICTED: pro- (1215) 188 46.9 0.00013
XP_005262853 (OMIM: 131530,611718) PREDICTED: pro- (1215) 188 46.9 0.00013
XP_016863334 (OMIM: 131530,611718) PREDICTED: pro- (1223) 188 46.9 0.00013
NP_001171601 (OMIM: 131530,611718) pro-epidermal g (1166) 184 46.1 0.00022
XP_016863336 (OMIM: 131530,611718) PREDICTED: pro- (1182) 184 46.1 0.00022
NP_001936 (OMIM: 126150) proheparin-binding EGF-li ( 208) 171 42.9 0.00037
NP_001648 (OMIM: 104640) amphiregulin preproprotei ( 252) 148 38.4 0.0096
>>NP_001295087 (OMIM: 190170) protransforming growth fac (166 aa)
initn: 1147 init1: 1147 opt: 1147 Z-score: 1227.3 bits: 233.4 E(85289): 1.3e-61
Smith-Waterman score: 1147; 100.0% identity (100.0% similar) in 166 aa overlap (1-166:1-166)
10 20 30 40 50 60
pF1KE1 MFKIGRGALDLFSELLSFGGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFKIGRGALDLFSELLSFGGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 CFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVL
70 80 90 100 110 120
130 140 150 160
pF1KE1 IITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
130 140 150 160
>>NP_001295088 (OMIM: 190170) protransforming growth fac (165 aa)
initn: 910 init1: 910 opt: 1130 Z-score: 1209.4 bits: 230.1 E(85289): 1.3e-60
Smith-Waterman score: 1130; 99.4% identity (99.4% similar) in 166 aa overlap (1-166:1-165)
10 20 30 40 50 60
pF1KE1 MFKIGRGALDLFSELLSFGGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQF
::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::
NP_001 MFKIGRGALDLFSELLSFGGIVLAACQALENSTSPLS-DPPVAAAVVSHFNDCPDSHTQF
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 CFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVL
60 70 80 90 100 110
130 140 150 160
pF1KE1 IITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
120 130 140 150 160
>>NP_003227 (OMIM: 190170) protransforming growth factor (160 aa)
initn: 1025 init1: 1025 opt: 1026 Z-score: 1099.8 bits: 209.8 E(85289): 1.6e-54
Smith-Waterman score: 1026; 94.4% identity (95.0% similar) in 160 aa overlap (7-166:6-160)
10 20 30 40 50 60
pF1KE1 MFKIGRGALDLFSELLSFGGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQF
: : ::. :::::::::::::::::::::::::::::::::::::::::
NP_003 MVPSAGQLALFAL-----GIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQF
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 CFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 CFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVL
60 70 80 90 100 110
130 140 150 160
pF1KE1 IITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
::::::::::::::::::::::::::::::::::::::::::::::
NP_003 IITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
120 130 140 150 160
>>NP_001093161 (OMIM: 190170) protransforming growth fac (159 aa)
initn: 910 init1: 910 opt: 1009 Z-score: 1081.9 bits: 206.5 E(85289): 1.6e-53
Smith-Waterman score: 1009; 93.8% identity (94.4% similar) in 160 aa overlap (7-166:6-159)
10 20 30 40 50 60
pF1KE1 MFKIGRGALDLFSELLSFGGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQF
: : ::. :::::::::::::::::: ::::::::::::::::::::::
NP_001 MVPSAGQLALFAL-----GIVLAACQALENSTSPLS-DPPVAAAVVSHFNDCPDSHTQF
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 CFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVL
60 70 80 90 100 110
130 140 150 160
pF1KE1 IITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
120 130 140 150
>>XP_011530513 (OMIM: 600345) PREDICTED: probetacellulin (178 aa)
initn: 234 init1: 221 opt: 248 Z-score: 277.8 bits: 57.8 E(85289): 9.8e-09
Smith-Waterman score: 263; 34.0% identity (62.5% similar) in 144 aa overlap (5-134:9-147)
10 20 30 40
pF1KE1 MFKIGRGALDLFSELLSFGGIVLAACQALENST-SP-----LSADPPVAAAVVS--
: ..: :. : ..: ..: : ::: :: : .:: :...
XP_011 MDRAARCSGASSLPLLLAL-ALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQ
10 20 30 40 50
50 60 70 80 90 100
pF1KE1 -----HFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKK
::. :: .. ..:..: :::.: :. :.::: ::.:::::..::. . ... .
XP_011 SKRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLF-YLRGDRGQ
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 QAITALVVVSIVALAVLIITCVLIHCCQ-VRKHCEWCRALICRHEKPSALLKGRTACCHS
. :..: .: . ..: .:. ::. .::
XP_011 ILVICLIAVMVVFIILVIGVCT---CCHPLRKRRKRKKKEEEMETLGKDITPINEDIEET
120 130 140 150 160 170
pF1KE1 ETVV
XP_011 NIA
>>NP_001720 (OMIM: 600345) probetacellulin isoform 1 pre (178 aa)
initn: 234 init1: 221 opt: 248 Z-score: 277.8 bits: 57.8 E(85289): 9.8e-09
Smith-Waterman score: 263; 34.0% identity (62.5% similar) in 144 aa overlap (5-134:9-147)
10 20 30 40
pF1KE1 MFKIGRGALDLFSELLSFGGIVLAACQALENST-SP-----LSADPPVAAAVVS--
: ..: :. : ..: ..: : ::: :: : .:: :...
NP_001 MDRAARCSGASSLPLLLAL-ALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQ
10 20 30 40 50
50 60 70 80 90 100
pF1KE1 -----HFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKK
::. :: .. ..:..: :::.: :. :.::: ::.:::::..::. . ... .
NP_001 SKRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLF-YLRGDRGQ
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 QAITALVVVSIVALAVLIITCVLIHCCQ-VRKHCEWCRALICRHEKPSALLKGRTACCHS
. :..: .: . ..: .:. ::. .::
NP_001 ILVICLIAVMVVFIILVIGVCT---CCHPLRKRRKRKKKEEEMETLGKDITPINEDIEET
120 130 140 150 160 170
pF1KE1 ETVV
NP_001 NIA
>>NP_003683 (OMIM: 603421) tomoregulin-1 precursor [Homo (380 aa)
initn: 206 init1: 188 opt: 211 Z-score: 234.5 bits: 50.9 E(85289): 2.5e-06
Smith-Waterman score: 211; 31.0% identity (66.7% similar) in 87 aa overlap (47-129:269-355)
20 30 40 50 60 70
pF1KE1 SFGGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPA
... ::.. . .:.:: :.:. . .: .
NP_003 DDTSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKAS
240 250 260 270 280 290
80 90 100 110 120 130
pF1KE1 CVCHSGYVGARCEHAD--LLAVVAASQKKQAITALVVVSIVALAVL--IITCVLIHCCQV
: :.:::.: .::..: .: :: . :: . .... : .:.. :. :. .:
NP_003 CRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKN
300 310 320 330 340 350
140 150 160
pF1KE1 RKHCEWCRALICRHEKPSALLKGRTACCHSETVV
NP_003 NRGRRQKQNLGHFTSDTSSRMV
360 370 380
>>XP_011509192 (OMIM: 605734) PREDICTED: tomoregulin-2 i (365 aa)
initn: 193 init1: 157 opt: 208 Z-score: 231.5 bits: 50.3 E(85289): 3.7e-06
Smith-Waterman score: 208; 31.1% identity (63.3% similar) in 90 aa overlap (49-136:252-336)
20 30 40 50 60 70
pF1KE1 GGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACV
: ::. .. ::.:: :. .. ..:.:
XP_011 TTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCR
230 240 250 260 270 280
80 90 100 110 120 130
pF1KE1 CHSGYVGARCEHAD--LLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHC
: .::.: .::. : .: :: . . : . .:.. . .::. ::.. : . ..:
XP_011 CDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVI---CVVVLC--ITRKC
290 300 310 320 330
140 150 160
pF1KE1 EWCRALICRHEKPSALLKGRTACCHSETVV
XP_011 PRSNRIHRQKQNTGHYSSDNTTRASTRLI
340 350 360
>>NP_057276 (OMIM: 605734) tomoregulin-2 isoform 1 precu (374 aa)
initn: 193 init1: 157 opt: 208 Z-score: 231.4 bits: 50.3 E(85289): 3.8e-06
Smith-Waterman score: 208; 31.1% identity (63.3% similar) in 90 aa overlap (49-136:261-345)
20 30 40 50 60 70
pF1KE1 GGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACV
: ::. .. ::.:: :. .. ..:.:
NP_057 TTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCR
240 250 260 270 280 290
80 90 100 110 120 130
pF1KE1 CHSGYVGARCEHAD--LLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHC
: .::.: .::. : .: :: . . : . .:.. . .::. ::.. : . ..:
NP_057 CDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVI---CVVVLC--ITRKC
300 310 320 330 340
140 150 160
pF1KE1 EWCRALICRHEKPSALLKGRTACCHSETVV
NP_057 PRSNRIHRQKQNTGHYSSDNTTRASTRLI
350 360 370
>>XP_016859228 (OMIM: 605734) PREDICTED: tomoregulin-2 i (337 aa)
initn: 225 init1: 157 opt: 203 Z-score: 226.7 bits: 49.3 E(85289): 6.9e-06
Smith-Waterman score: 203; 32.5% identity (63.9% similar) in 83 aa overlap (49-129:252-331)
20 30 40 50 60 70
pF1KE1 GGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACV
: ::. .. ::.:: :. .. ..:.:
XP_016 TTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCR
230 240 250 260 270 280
80 90 100 110 120 130
pF1KE1 CHSGYVGARCEHAD--LLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHC
: .::.: .::. : .: :: . . : . .:.. . .::. ::.. :
XP_016 CDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVI---CVVVLCITRAKL
290 300 310 320 330
140 150 160
pF1KE1 EWCRALICRHEKPSALLKGRTACCHSETVV
166 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 21:59:53 2016 done: Sun Nov 6 21:59:54 2016
Total Scan time: 5.520 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]