Result of FASTA (omim) for
pFN21AE1122
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1122, 433 aa
1>>>pF1KE1122 433 - 433 aa - 433 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.9169+/-0.000324; mu= 2.3854+/- 0.020
mean_var=222.6722+/-45.530, 0's: 0 Z-trim(122.9): 11 B-trim: 42 in 1/60
Lambda= 0.085949
statistics sampled from 41847 (41862) to 41847 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.794), E-opt: 0.2 (0.491), width: 16
Scan time: 11.840
The best scores are: opt bits E(85289)
NP_001317669 (OMIM: 611053) iporin isoform 2 [Homo ( 638) 655 93.7 1.4e-18
NP_055621 (OMIM: 611053) iporin isoform 1 [Homo sa (1516) 655 94.0 2.8e-18
NP_001129471 (OMIM: 611053) iporin isoform 1 [Homo (1516) 655 94.0 2.8e-18
>>NP_001317669 (OMIM: 611053) iporin isoform 2 [Homo sap (638 aa)
initn: 976 init1: 655 opt: 655 Z-score: 454.3 bits: 93.7 E(85289): 1.4e-18
Smith-Waterman score: 725; 39.8% identity (58.4% similar) in 399 aa overlap (14-371:114-501)
10 20 30 40
pF1KE1 MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKA
:::::. ::...:: :..:::..:. ::
NP_001 QDPFSLTEKPPAEFCLSPDGSSEAISIDLLQKKGLVKAVNIAVDLIVAHFGTSRDPGVKA
90 100 110 120 130 140
50 60 70 80 90 100
pF1KE1 QLGDSRLSPDVGHLVLTTLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSS
.::.: .::.:::::: ::::..:.. :::: : :.: :::.. ::::::::.. : :
NP_001 KLGNSSVSPNVGHLVLKYLCPAVRAVLEDGLKAFVLDVIIGQRKNMPWSVVEASTQLGPS
150 160 170 180 190 200
110 120 130 140 150 160
pF1KE1 TRSLGTLYSQVSRLAPLSSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGF
:. : ::..::.. :.: ::.:::::::: ..::.::. : . ... : : ::
NP_001 TKVLHGLYNKVSQFPELTSHTMRFNAFILGLLNIRSLEFWFNHLYNHEDIIQTHYQPWGF
210 220 230 240 250 260
170 180 190
pF1KE1 FSLARGGCPSLSTELLLLLQPLSVLTFHLDLLFEH-------------------------
.: :. ::.: :::::::::..: : :::::.:
NP_001 LSAAHTVCPGLFEELLLLLQPLALLPFSLDLLFQHRLLQSGQQQRQHKELLRVSQDLLLS
270 280 290 300 310 320
200 210 220 230 240 250
pF1KE1 -HHHLPLGPPQAPAPPGPPPALQQTMQAM---LHFGGRLAQSLRGTSKEA-ASDPSDSPN
: : :. .. :: : .. ::. . . : . : :. :
NP_001 AHSTLQLARARGQEGPGDVDRAAQGERVKGVGASEGGEEEEEEEETEEVAEAAGGSGRAR
330 340 350 360 370 380
260 270 280 290 300
pF1KE1 LPTPGS--WWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEE--GAQERPLPTDEMAP
:. :: :: :.:.:: .:. :: ::. : ....:. :: : . :
NP_001 WARGGQAGWWYQLMQSSQVYIDGSIEG---SRFPRGSSNSSSEKKKGAGGGGPP--QAPP
390 400 410 420 430
310 320 330 340 350 360
pF1KE1 GRGLWLGRLFGVPGGPAENENGALKSRRP-SSWL--PPTVSVLALVKRGAPPEMP--SPQ
: : . :. . :: .: :: .: :. :: :::: ..:. : : ::
NP_001 PR---EGVVEGAEACPASEE--ALGRERGWPFWMGSPPD-SVLAELRRSREREGPAASPA
440 450 460 470 480 490
370 380 390 400 410 420
pF1KE1 ELE--ASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEG
: : :: :
NP_001 ENEEGASEPSPGGIKWGHLFGSRKAQREARPTNRLPSDWLSLDKSMFQLVAQTVGSRREP
500 510 520 530 540 550
>>NP_055621 (OMIM: 611053) iporin isoform 1 [Homo sapien (1516 aa)
initn: 943 init1: 655 opt: 655 Z-score: 449.1 bits: 94.0 E(85289): 2.8e-18
Smith-Waterman score: 725; 39.8% identity (58.4% similar) in 399 aa overlap (14-371:992-1379)
10 20 30 40
pF1KE1 MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKA
:::::. ::...:: :..:::..:. ::
NP_055 QDPFSLTEKPPAEFCLSPDGSSEAISIDLLQKKGLVKAVNIAVDLIVAHFGTSRDPGVKA
970 980 990 1000 1010 1020
50 60 70 80 90 100
pF1KE1 QLGDSRLSPDVGHLVLTTLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSS
.::.: .::.:::::: ::::..:.. :::: : :.: :::.. ::::::::.. : :
NP_055 KLGNSSVSPNVGHLVLKYLCPAVRAVLEDGLKAFVLDVIIGQRKNMPWSVVEASTQLGPS
1030 1040 1050 1060 1070 1080
110 120 130 140 150 160
pF1KE1 TRSLGTLYSQVSRLAPLSSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGF
:. : ::..::.. :.: ::.:::::::: ..::.::. : . ... : : ::
NP_055 TKVLHGLYNKVSQFPELTSHTMRFNAFILGLLNIRSLEFWFNHLYNHEDIIQTHYQPWGF
1090 1100 1110 1120 1130 1140
170 180 190
pF1KE1 FSLARGGCPSLSTELLLLLQPLSVLTFHLDLLFEH-------------------------
.: :. ::.: :::::::::..: : :::::.:
NP_055 LSAAHTVCPGLFEELLLLLQPLALLPFSLDLLFQHRLLQSGQQQRQHKELLRVSQDLLLS
1150 1160 1170 1180 1190 1200
200 210 220 230 240 250
pF1KE1 -HHHLPLGPPQAPAPPGPPPALQQTMQAM---LHFGGRLAQSLRGTSKEA-ASDPSDSPN
: : :. .. :: : .. ::. . . : . : :. :
NP_055 AHSTLQLARARGQEGPGDVDRAAQGERVKGVGASEGGEEEEEEEETEEVAEAAGGSGRAR
1210 1220 1230 1240 1250 1260
260 270 280 290 300
pF1KE1 LPTPGS--WWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEE--GAQERPLPTDEMAP
:. :: :: :.:.:: .:. :: ::. : ....:. :: : . :
NP_055 WARGGQAGWWYQLMQSSQVYIDGSIEG---SRFPRGSSNSSSEKKKGAGGGGPP--QAPP
1270 1280 1290 1300 1310
310 320 330 340 350 360
pF1KE1 GRGLWLGRLFGVPGGPAENENGALKSRRP-SSWL--PPTVSVLALVKRGAPPEMP--SPQ
: : . :. . :: .: :: .: :. :: :::: ..:. : : ::
NP_055 PR---EGVVEGAEACPASEE--ALGRERGWPFWMGSPPD-SVLAELRRSREREGPAASPA
1320 1330 1340 1350 1360 1370
370 380 390 400 410 420
pF1KE1 ELE--ASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEG
: : :: :
NP_055 ENEEGASEPSPGGIKWGHLFGSRKAQREARPTNRLPSDWLSLDKSMFQLVAQTVGSRREP
1380 1390 1400 1410 1420 1430
>>NP_001129471 (OMIM: 611053) iporin isoform 1 [Homo sap (1516 aa)
initn: 943 init1: 655 opt: 655 Z-score: 449.1 bits: 94.0 E(85289): 2.8e-18
Smith-Waterman score: 725; 39.8% identity (58.4% similar) in 399 aa overlap (14-371:992-1379)
10 20 30 40
pF1KE1 MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKA
:::::. ::...:: :..:::..:. ::
NP_001 QDPFSLTEKPPAEFCLSPDGSSEAISIDLLQKKGLVKAVNIAVDLIVAHFGTSRDPGVKA
970 980 990 1000 1010 1020
50 60 70 80 90 100
pF1KE1 QLGDSRLSPDVGHLVLTTLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSS
.::.: .::.:::::: ::::..:.. :::: : :.: :::.. ::::::::.. : :
NP_001 KLGNSSVSPNVGHLVLKYLCPAVRAVLEDGLKAFVLDVIIGQRKNMPWSVVEASTQLGPS
1030 1040 1050 1060 1070 1080
110 120 130 140 150 160
pF1KE1 TRSLGTLYSQVSRLAPLSSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGF
:. : ::..::.. :.: ::.:::::::: ..::.::. : . ... : : ::
NP_001 TKVLHGLYNKVSQFPELTSHTMRFNAFILGLLNIRSLEFWFNHLYNHEDIIQTHYQPWGF
1090 1100 1110 1120 1130 1140
170 180 190
pF1KE1 FSLARGGCPSLSTELLLLLQPLSVLTFHLDLLFEH-------------------------
.: :. ::.: :::::::::..: : :::::.:
NP_001 LSAAHTVCPGLFEELLLLLQPLALLPFSLDLLFQHRLLQSGQQQRQHKELLRVSQDLLLS
1150 1160 1170 1180 1190 1200
200 210 220 230 240 250
pF1KE1 -HHHLPLGPPQAPAPPGPPPALQQTMQAM---LHFGGRLAQSLRGTSKEA-ASDPSDSPN
: : :. .. :: : .. ::. . . : . : :. :
NP_001 AHSTLQLARARGQEGPGDVDRAAQGERVKGVGASEGGEEEEEEEETEEVAEAAGGSGRAR
1210 1220 1230 1240 1250 1260
260 270 280 290 300
pF1KE1 LPTPGS--WWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEE--GAQERPLPTDEMAP
:. :: :: :.:.:: .:. :: ::. : ....:. :: : . :
NP_001 WARGGQAGWWYQLMQSSQVYIDGSIEG---SRFPRGSSNSSSEKKKGAGGGGPP--QAPP
1270 1280 1290 1300 1310
310 320 330 340 350 360
pF1KE1 GRGLWLGRLFGVPGGPAENENGALKSRRP-SSWL--PPTVSVLALVKRGAPPEMP--SPQ
: : . :. . :: .: :: .: :. :: :::: ..:. : : ::
NP_001 PR---EGVVEGAEACPASEE--ALGRERGWPFWMGSPPD-SVLAELRRSREREGPAASPA
1320 1330 1340 1350 1360 1370
370 380 390 400 410 420
pF1KE1 ELE--ASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEG
: : :: :
NP_001 ENEEGASEPSPGGIKWGHLFGSRKAQREARPTNRLPSDWLSLDKSMFQLVAQTVGSRREP
1380 1390 1400 1410 1420 1430
433 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 02:55:53 2016 done: Mon Nov 7 02:55:54 2016
Total Scan time: 11.840 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]