Result of FASTA (omim) for
pFN21AE0966
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0966, 512 aa
1>>>pF1KE0966 512 - 512 aa - 512 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.1853+/-0.000438; mu= 7.6765+/- 0.027
mean_var=614.8484+/-143.546, 0's: 0 Z-trim(120.3): 77 B-trim: 0 in 0/59
Lambda= 0.051724
statistics sampled from 35222 (35301) to 35222 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.745), E-opt: 0.2 (0.414), width: 16
Scan time: 10.730
The best scores are: opt bits E(85289)
NP_001097 (OMIM: 602730,613751) activin receptor t ( 512) 3588 283.5 1e-75
XP_016863003 (OMIM: 602730,613751) PREDICTED: acti ( 526) 3473 274.9 4e-73
XP_016863005 (OMIM: 602730,613751) PREDICTED: acti ( 511) 3465 274.3 6e-73
XP_005265640 (OMIM: 602730,613751) PREDICTED: acti ( 533) 3465 274.3 6.1e-73
XP_016863004 (OMIM: 602730,613751) PREDICTED: acti ( 518) 3461 274.0 7.5e-73
NP_001265508 (OMIM: 102581) activin receptor type- ( 513) 2533 204.7 5.2e-52
NP_001607 (OMIM: 102581) activin receptor type-2A ( 513) 2533 204.7 5.2e-52
NP_001265509 (OMIM: 102581) activin receptor type- ( 405) 2038 167.6 6.2e-41
XP_011532347 (OMIM: 133239,190182,610168,614331) P ( 532) 919 84.3 9.5e-16
XP_016862595 (OMIM: 133239,190182,610168,614331) P ( 532) 919 84.3 9.5e-16
NP_003233 (OMIM: 133239,190182,610168,614331) TGF- ( 567) 919 84.4 9.8e-16
XP_011532345 (OMIM: 133239,190182,610168,614331) P ( 576) 919 84.4 9.9e-16
NP_001020018 (OMIM: 133239,190182,610168,614331) T ( 592) 919 84.4 1e-15
XP_011509989 (OMIM: 178600,265450,600799) PREDICTE (1037) 819 77.4 2.2e-13
NP_001195 (OMIM: 178600,265450,600799) bone morpho (1038) 819 77.4 2.2e-13
NP_001104502 (OMIM: 608981) activin receptor type- ( 413) 764 72.6 2.6e-12
NP_001104501 (OMIM: 608981) activin receptor type- ( 443) 759 72.2 3.5e-12
NP_660302 (OMIM: 608981) activin receptor type-1C ( 493) 759 72.3 3.6e-12
XP_011517252 (OMIM: 132800,190181) PREDICTED: TGF- ( 357) 756 71.8 3.7e-12
NP_001124388 (OMIM: 132800,190181) TGF-beta recept ( 426) 756 72.0 4e-12
XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF- ( 434) 756 72.0 4e-12
XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 756 72.0 4e-12
XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 756 72.0 4e-12
NP_004603 (OMIM: 132800,190181) TGF-beta receptor ( 503) 756 72.1 4.3e-12
NP_001293139 (OMIM: 132800,190181) TGF-beta recept ( 507) 756 72.1 4.3e-12
XP_016864048 (OMIM: 112600,603248,609441,616849) P ( 502) 743 71.1 8.4e-12
XP_016864050 (OMIM: 112600,603248,609441,616849) P ( 502) 743 71.1 8.4e-12
XP_016864049 (OMIM: 112600,603248,609441,616849) P ( 502) 743 71.1 8.4e-12
NP_001243721 (OMIM: 112600,603248,609441,616849) b ( 502) 743 71.1 8.4e-12
XP_011530503 (OMIM: 112600,603248,609441,616849) P ( 502) 743 71.1 8.4e-12
NP_001243723 (OMIM: 112600,603248,609441,616849) b ( 502) 743 71.1 8.4e-12
XP_016864047 (OMIM: 112600,603248,609441,616849) P ( 502) 743 71.1 8.4e-12
NP_001194 (OMIM: 112600,603248,609441,616849) bone ( 502) 743 71.1 8.4e-12
NP_001243722 (OMIM: 112600,603248,609441,616849) b ( 532) 743 71.2 8.6e-12
NP_064732 (OMIM: 601300) activin receptor type-1B ( 453) 740 70.8 9.4e-12
NP_004293 (OMIM: 601300) activin receptor type-1B ( 505) 740 70.9 9.8e-12
XP_005246996 (OMIM: 102576,135100) PREDICTED: acti ( 509) 731 70.3 1.6e-11
NP_001104537 (OMIM: 102576,135100) activin recepto ( 509) 731 70.3 1.6e-11
NP_001096 (OMIM: 102576,135100) activin receptor t ( 509) 731 70.3 1.6e-11
XP_005246997 (OMIM: 102576,135100) PREDICTED: acti ( 509) 731 70.3 1.6e-11
XP_011510408 (OMIM: 102576,135100) PREDICTED: acti ( 509) 731 70.3 1.6e-11
XP_006712888 (OMIM: 102576,135100) PREDICTED: acti ( 509) 731 70.3 1.6e-11
XP_011510410 (OMIM: 102576,135100) PREDICTED: acti ( 509) 731 70.3 1.6e-11
XP_011510409 (OMIM: 102576,135100) PREDICTED: acti ( 509) 731 70.3 1.6e-11
NP_004320 (OMIM: 174900,601299,610069) bone morpho ( 532) 717 69.3 3.3e-11
XP_011538406 (OMIM: 174900,601299,610069) PREDICTE ( 532) 717 69.3 3.3e-11
XP_011538405 (OMIM: 174900,601299,610069) PREDICTE ( 532) 717 69.3 3.3e-11
NP_001070869 (OMIM: 600376,601284) serine/threonin ( 503) 678 66.3 2.4e-10
NP_000011 (OMIM: 600376,601284) serine/threonine-p ( 503) 678 66.3 2.4e-10
XP_005269292 (OMIM: 600376,601284) PREDICTED: seri ( 503) 678 66.3 2.4e-10
>>NP_001097 (OMIM: 602730,613751) activin receptor type- (512 aa)
initn: 3588 init1: 3588 opt: 3588 Z-score: 1480.2 bits: 283.5 E(85289): 1e-75
Smith-Waterman score: 3588; 100.0% identity (100.0% similar) in 512 aa overlap (1-512:1-512)
10 20 30 40 50 60
pF1KE0 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL
430 440 450 460 470 480
490 500 510
pF1KE0 IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
::::::::::::::::::::::::::::::::
NP_001 IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
490 500 510
>>XP_016863003 (OMIM: 602730,613751) PREDICTED: activin (526 aa)
initn: 3470 init1: 3470 opt: 3473 Z-score: 1433.7 bits: 274.9 E(85289): 4e-73
Smith-Waterman score: 3473; 99.4% identity (99.6% similar) in 500 aa overlap (13-512:27-526)
10 20 30 40
pF1KE0 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGL
:. ::::::::::::::::::::::::::::::
XP_016 MPLPLSGPAMWRSGEPQRLWAWSPQAGDTRAGSGRGEAETRECIYYNANWELERTNQSGL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 ERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 NFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPP
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE0 YGHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQS
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE0 WQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNE
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE0 LCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRF
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE0 EPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGP
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE0 VDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAE
430 440 450 460 470 480
470 480 490 500 510
pF1KE0 ARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
490 500 510 520
>>XP_016863005 (OMIM: 602730,613751) PREDICTED: activin (511 aa)
initn: 3465 init1: 3465 opt: 3465 Z-score: 1430.6 bits: 274.3 E(85289): 6e-73
Smith-Waterman score: 3465; 100.0% identity (100.0% similar) in 495 aa overlap (18-512:17-511)
10 20 30 40 50 60
pF1KE0 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY
:::::::::::::::::::::::::::::::::::::::::::
XP_016 MMALLRSTNINNLSPVGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE0 HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE0 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE0 TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE0 HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL
420 430 440 450 460 470
490 500 510
pF1KE0 IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
::::::::::::::::::::::::::::::::
XP_016 IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
480 490 500 510
>>XP_005265640 (OMIM: 602730,613751) PREDICTED: activin (533 aa)
initn: 3465 init1: 3465 opt: 3465 Z-score: 1430.5 bits: 274.3 E(85289): 6.1e-73
Smith-Waterman score: 3465; 100.0% identity (100.0% similar) in 495 aa overlap (18-512:39-533)
10 20 30 40
pF1KE0 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLE
::::::::::::::::::::::::::::::
XP_005 AMWRSGEPQRLWAWSPQAGDTRAGGQPLPKGSGRGEAETRECIYYNANWELERTNQSGLE
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 RCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGN
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 FCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPY
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE0 GHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSW
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE0 QSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNEL
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE0 CHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFE
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE0 PGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPV
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE0 DEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEA
430 440 450 460 470 480
470 480 490 500 510
pF1KE0 RLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
:::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
490 500 510 520 530
>>XP_016863004 (OMIM: 602730,613751) PREDICTED: activin (518 aa)
initn: 3457 init1: 3457 opt: 3461 Z-score: 1428.9 bits: 274.0 E(85289): 7.5e-73
Smith-Waterman score: 3461; 99.0% identity (99.4% similar) in 500 aa overlap (13-512:19-518)
10 20 30 40 50
pF1KE0 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQD
:. .::::::::::::::::::::::::::::::::::::
XP_016 MGAGTRSLRVGVRATRARGTQGKSSGRGEAETRECIYYNANWELERTNQSGLERCEGEQD
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 KRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 HLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 DPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIF
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE0 STPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETM
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE0 SRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE0 THGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 THGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPF
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE0 EEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCV
430 440 450 460 470 480
480 490 500 510
pF1KE0 EERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
::::::::::::::::::::::::::::::::::::::
XP_016 EERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
490 500 510
>>NP_001265508 (OMIM: 102581) activin receptor type-2A i (513 aa)
initn: 2337 init1: 1547 opt: 2533 Z-score: 1054.7 bits: 204.7 E(85289): 5.2e-52
Smith-Waterman score: 2533; 67.3% identity (87.9% similar) in 511 aa overlap (3-512:4-513)
10 20 30 40 50
pF1KE0 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHC
: .:.:.. : .:. :..::.::...::::: .::::.:.: : :..::: ::
NP_001 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 YASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEA
.:.:.: ::.::.::.::::::.::::: .:: ...:.:::::::::.:::.:...::
NP_001 FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 GGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIH-EDPGP
. : .: : ..: :::.:. .. ::. :::.:::.: : : . .::::
NP_001 EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 PPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPG
::::::.:::::::::.::::::::::::::.:..:::::::.:::::::.: :..: ::
NP_001 PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE0 MKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGL
:::::.::::.:::::....:.::::::::.::::.:.::.:...::::::.::::.:::
NP_001 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE0 SYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQ
.:::::.: . .::::.:.:::.::::::::..::: .::::::..:: :: ::::::
NP_001 AYLHEDIPGLK-DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQ
310 320 330 340 350
360 370 380 390 400 410
pF1KE0 VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEI
::::::::::::::::::::::::::::::::::::::.::: :::::::::::::::::
NP_001 VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEI
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE0 GQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERV
:::::::..:::::::: ::...:.: :: :.:.:: ::::::::::::::::::: ::.
NP_001 GQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERI
420 430 440 450 460 470
480 490 500 510
pF1KE0 SLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
. ..: .: :.. .:..:: :::::.::::::.
NP_001 TQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
480 490 500 510
>>NP_001607 (OMIM: 102581) activin receptor type-2A isof (513 aa)
initn: 2337 init1: 1547 opt: 2533 Z-score: 1054.7 bits: 204.7 E(85289): 5.2e-52
Smith-Waterman score: 2533; 67.3% identity (87.9% similar) in 511 aa overlap (3-512:4-513)
10 20 30 40 50
pF1KE0 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHC
: .:.:.. : .:. :..::.::...::::: .::::.:.: : :..::: ::
NP_001 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 YASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEA
.:.:.: ::.::.::.::::::.::::: .:: ...:.:::::::::.:::.:...::
NP_001 FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 GGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIH-EDPGP
. : .: : ..: :::.:. .. ::. :::.:::.: : : . .::::
NP_001 EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 PPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPG
::::::.:::::::::.::::::::::::::.:..:::::::.:::::::.: :..: ::
NP_001 PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE0 MKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGL
:::::.::::.:::::....:.::::::::.::::.:.::.:...::::::.::::.:::
NP_001 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE0 SYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQ
.:::::.: . .::::.:.:::.::::::::..::: .::::::..:: :: ::::::
NP_001 AYLHEDIPGLK-DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQ
310 320 330 340 350
360 370 380 390 400 410
pF1KE0 VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEI
::::::::::::::::::::::::::::::::::::::.::: :::::::::::::::::
NP_001 VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEI
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE0 GQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERV
:::::::..:::::::: ::...:.: :: :.:.:: ::::::::::::::::::: ::.
NP_001 GQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERI
420 430 440 450 460 470
480 490 500 510
pF1KE0 SLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
. ..: .: :.. .:..:: :::::.::::::.
NP_001 TQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
480 490 500 510
>>NP_001265509 (OMIM: 102581) activin receptor type-2A i (405 aa)
initn: 1885 init1: 1095 opt: 2038 Z-score: 855.9 bits: 167.6 E(85289): 6.2e-41
Smith-Waterman score: 2038; 70.1% identity (88.6% similar) in 405 aa overlap (109-512:2-405)
80 90 100 110 120 130
pF1KE0 LDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTV
:::.:...:: . : .: : ..
NP_001 MCNEKFSYFPEMEVTQPTSNPVTPKPPYYNI
10 20 30
140 150 160 170 180 190
pF1KE0 LAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIH-EDPGPPPPSPLVGLKPLQLLEIKA
: :::.:. .. ::. :::.:::.: : : . .::::::::::.:::::::::.::
NP_001 LLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKA
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE0 RGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNL
::::::::::::.:..:::::::.:::::::.: :..: :::::::.::::.:::::...
NP_001 RGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSV
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE0 EVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSI
.:.::::::::.::::.:.::.:...::::::.::::.:::.:::::.: . .::::.:
NP_001 DVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK-DGHKPAI
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE0 AHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQ
.:::.::::::::..::: .::::::..:: :: :::::::::::::::::::::::::
NP_001 SHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQ
220 230 240 250 260 270
380 390 400 410 420 430
pF1KE0 RDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMR
:::::::::::::::::::.::: ::::::::::::::::::::::::..:::::::: :
NP_001 RDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKR
280 290 300 310 320 330
440 450 460 470 480 490
pF1KE0 PTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLV
:...:.: :: :.:.:: ::::::::::::::::::: ::.. ..: .: :.. .:..:
NP_001 PVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVV
340 350 360 370 380 390
500 510
pF1KE0 TSVTNVDLPPKESSI
: :::::.::::::.
NP_001 TMVTNVDFPPKESSL
400
>>XP_011532347 (OMIM: 133239,190182,610168,614331) PREDI (532 aa)
initn: 837 init1: 584 opt: 919 Z-score: 403.7 bits: 84.3 E(85289): 9.5e-16
Smith-Waterman score: 973; 37.6% identity (62.7% similar) in 482 aa overlap (41-479:34-504)
20 30 40 50 60
pF1KE0 LWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSG--
.: : :: :. : : ::...
XP_011 TDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEV---CVAVWRKNDENI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 TIELVKKGCWLD--DFNCYD--RQECVATEEN-P-QVYF-CCCEGNFCNERFTHLPEAGG
:.: : . : :: : .:. :.. : ...: : : .. ::. . .
XP_011 TLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIF-----S
70 80 90 100 110
130 140 150 160
pF1KE0 PEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYR-HRKPPYG------------
: . : ... : . :::: :... :.. :. :: .:. .
XP_011 EEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLM
120 130 140 150 160 170
170 180 190 200 210
pF1KE0 ----HVDI-HEDPGPPPPSPLVG-------LKPLQLLEIKARGRFGCVWKAQLMNDF---
: : :: : .. : :..: . ..:::. :.::.: ..
XP_011 EFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQ
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE0 ---VAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDK
::::::: .. ::..:..::: ..::::.:::..::.: ..: . ::::::: :
XP_011 FETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAK
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE0 GSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLK
:.: .:: ..:.:..: ... ...::...:: : : :. . : :.:::.::.:.:.:
XP_011 GNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPC-GRPKMP-IVHRDLKSSNILVK
300 310 320 330 340 350
340 350 360 370 380
pF1KE0 SDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAPEVLEGAINFQR-DAFLRIDMY
.::: : ::::..:..: : . ::::: :::::::::. .:.. ..: . :.:
XP_011 NDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVY
360 370 380 390 400 410
390 400 410 420 430 440
pF1KE0 AMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKH
.:.:::::..:::.:. : : .: :: .. .:: .: ... :.. . :: : . ::.:
XP_011 SMALVLWEMTSRCNAV-GEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNH
420 430 440 450 460 470
450 460 470 480 490 500
pF1KE0 PGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPP
:. ..: :. :::::: ::::.: :: :: :
XP_011 QGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
480 490 500 510 520 530
510
pF1KE0 KESSI
>>XP_016862595 (OMIM: 133239,190182,610168,614331) PREDI (532 aa)
initn: 837 init1: 584 opt: 919 Z-score: 403.7 bits: 84.3 E(85289): 9.5e-16
Smith-Waterman score: 973; 37.6% identity (62.7% similar) in 482 aa overlap (41-479:34-504)
20 30 40 50 60
pF1KE0 LWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSG--
.: : :: :. : : ::...
XP_016 TDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEV---CVAVWRKNDENI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 TIELVKKGCWLD--DFNCYD--RQECVATEEN-P-QVYF-CCCEGNFCNERFTHLPEAGG
:.: : . : :: : .:. :.. : ...: : : .. ::. . .
XP_016 TLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIF-----S
70 80 90 100 110
130 140 150 160
pF1KE0 PEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYR-HRKPPYG------------
: . : ... : . :::: :... :.. :. :: .:. .
XP_016 EEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLM
120 130 140 150 160 170
170 180 190 200 210
pF1KE0 ----HVDI-HEDPGPPPPSPLVG-------LKPLQLLEIKARGRFGCVWKAQLMNDF---
: : :: : .. : :..: . ..:::. :.::.: ..
XP_016 EFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQ
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE0 ---VAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDK
::::::: .. ::..:..::: ..::::.:::..::.: ..: . ::::::: :
XP_016 FETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAK
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE0 GSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLK
:.: .:: ..:.:..: ... ...::...:: : : :. . : :.:::.::.:.:.:
XP_016 GNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPC-GRPKMP-IVHRDLKSSNILVK
300 310 320 330 340 350
340 350 360 370 380
pF1KE0 SDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAPEVLEGAINFQR-DAFLRIDMY
.::: : ::::..:..: : . ::::: :::::::::. .:.. ..: . :.:
XP_016 NDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVY
360 370 380 390 400 410
390 400 410 420 430 440
pF1KE0 AMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKH
.:.:::::..:::.:. : : .: :: .. .:: .: ... :.. . :: : . ::.:
XP_016 SMALVLWEMTSRCNAV-GEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNH
420 430 440 450 460 470
450 460 470 480 490 500
pF1KE0 PGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPP
:. ..: :. :::::: ::::.: :: :: :
XP_016 QGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
480 490 500 510 520 530
510
pF1KE0 KESSI
512 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 15:19:00 2016 done: Mon Nov 7 15:19:02 2016
Total Scan time: 10.730 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]