Result of FASTA (omim) for
pFN21AE0555
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0555, 377 aa
1>>>pF1KE0555 377 - 377 aa - 377 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3608+/-0.000362; mu= 16.0618+/- 0.022
mean_var=58.7403+/-11.929, 0's: 0 Z-trim(112.7): 12 B-trim: 1490 in 2/49
Lambda= 0.167342
statistics sampled from 21736 (21742) to 21736 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.625), E-opt: 0.2 (0.255), width: 16
Scan time: 8.160
The best scores are: opt bits E(85289)
NP_005014 (OMIM: 602031) geranylgeranyl transferas ( 377) 2586 632.7 4.2e-181
XP_005272077 (OMIM: 602031) PREDICTED: geranylgera ( 381) 2561 626.7 2.8e-179
XP_011541792 (OMIM: 602031) PREDICTED: geranylgera ( 408) 2556 625.5 6.9e-179
XP_011541794 (OMIM: 602031) PREDICTED: geranylgera ( 285) 1730 426.0 5.3e-119
NP_004573 (OMIM: 179080) geranylgeranyl transferas ( 331) 452 117.5 4.6e-26
NP_002019 (OMIM: 134636) protein farnesyltransfera ( 437) 337 89.7 1.4e-17
>>NP_005014 (OMIM: 602031) geranylgeranyl transferase ty (377 aa)
initn: 2586 init1: 2586 opt: 2586 Z-score: 3372.3 bits: 632.7 E(85289): 4.2e-181
Smith-Waterman score: 2586; 100.0% identity (100.0% similar) in 377 aa overlap (1-377:1-377)
10 20 30 40 50 60
pF1KE0 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS
310 320 330 340 350 360
370
pF1KE0 WKTKDSKQCSENVHIST
:::::::::::::::::
NP_005 WKTKDSKQCSENVHIST
370
>>XP_005272077 (OMIM: 602031) PREDICTED: geranylgeranyl (381 aa)
initn: 2561 init1: 2561 opt: 2561 Z-score: 3339.6 bits: 626.7 E(85289): 2.8e-179
Smith-Waterman score: 2561; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:1-373)
10 20 30 40 50 60
pF1KE0 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS
310 320 330 340 350 360
370
pF1KE0 WKTKDSKQCSENVHIST
:::::::::::::
XP_005 WKTKDSKQCSENVESYNQISC
370 380
>>XP_011541792 (OMIM: 602031) PREDICTED: geranylgeranyl (408 aa)
initn: 2556 init1: 2556 opt: 2556 Z-score: 3332.6 bits: 625.5 E(85289): 6.9e-179
Smith-Waterman score: 2556; 100.0% identity (100.0% similar) in 372 aa overlap (1-372:1-372)
10 20 30 40 50 60
pF1KE0 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS
310 320 330 340 350 360
370
pF1KE0 WKTKDSKQCSENVHIST
::::::::::::
XP_011 WKTKDSKQCSENKEFPGLKDLCFKNIGSYCQELPSRNSVAIHKLNNKV
370 380 390 400
>>XP_011541794 (OMIM: 602031) PREDICTED: geranylgeranyl (285 aa)
initn: 1730 init1: 1730 opt: 1730 Z-score: 2257.4 bits: 426.0 E(85289): 5.3e-119
Smith-Waterman score: 1730; 100.0% identity (100.0% similar) in 249 aa overlap (124-372:1-249)
100 110 120 130 140 150
pF1KE0 GFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRA
::::::::::::::::::::::::::::::
XP_011 MTYTGLSCLVILGDDLSRVNKEACLAGLRA
10 20 30
160 170 180 190 200 210
pF1KE0 LQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQG
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE0 AGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYS
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE0 FWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLME
160 170 180 190 200 210
340 350 360 370
pF1KE0 ESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST
:::::::::::::::::::::::::::::::::::::::
XP_011 ESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENKEFPGLKDLCFKNIGSYCQEL
220 230 240 250 260 270
XP_011 PSRNSVAIHKLNNKV
280
>>NP_004573 (OMIM: 179080) geranylgeranyl transferase ty (331 aa)
initn: 463 init1: 252 opt: 452 Z-score: 588.9 bits: 117.5 E(85289): 4.6e-26
Smith-Waterman score: 477; 30.3% identity (60.6% similar) in 317 aa overlap (40-354:39-323)
10 20 30 40 50 60
pF1KE0 AGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNK
: : :.. ...:. .:.. .: .:.
NP_004 IIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 DDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGL
..:. .: : : ..:: :: . .. : :. .: ...
NP_004 EEILAFIKSCQ----------HECG-------GISASIGHDP---------HLLYTLSAV
70 80 90 100
130 140 150 160 170 180
pF1KE0 SCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWS
. :. : :... .. . . ...:: ::::: . : : : :: .:: .:.. .
NP_004 QILT-LYDSINVIDVNKVVEYVKGLQKEDGSFAGDIWG-EIDTRFSFCAVATLALLGKLD
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE0 GMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIK
.....::: .. :..:.:.. : :::.:. .: . : . ..:..: : . .
NP_004 AINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNS----DLLG
170 180 190 200 210
250 260 270 280 290 300
pF1KE0 RWCIMRQ--QNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVG
: :: ..: .:::.: :.:::.:: :.::.. ... . :: ::.::. ::. .:
NP_004 WWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRNFILACQDEETG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE0 GFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSK
::: : . : .:. ::: ::::. : : :.:.. . .. .:.
NP_004 GFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVNPVFCMPEEVLQRVNVQPELVS
280 290 300 310 320 330
370
pF1KE0 QCSENVHIST
>>NP_002019 (OMIM: 134636) protein farnesyltransferase s (437 aa)
initn: 324 init1: 132 opt: 337 Z-score: 436.9 bits: 89.7 E(85289): 1.4e-17
Smith-Waterman score: 392; 28.4% identity (55.6% similar) in 338 aa overlap (17-336:70-377)
10 20 30 40
pF1KE0 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETS
:: . :..: ....: :. : . : :..:
NP_002 VETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDAS
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE0 RLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFN
: . .. : .:..:: . : : . .: . . . :: : .
NP_002 RPWLCYWILHSLELLD--------EPIPQIVATDVCQFLELCQSPEGGFGG--------G
100 110 120 130 140
110 120 130 140 150 160
pF1KE0 PSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSR--VNKEACLAGLRALQLEDGSFCAV
:.. : :.: ::.... : :.: . . .:.: : : .:. :::: .
NP_002 PGQYP---------HLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFL-M
150 160 170 180 190
170 180 190 200 210 220
pF1KE0 PEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTF
:.: :.: .:::. . . : . .. . .: : .....:.. :.:.::: ::
NP_002 HVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTF
200 210 220 230 240 250
230 240 250 260 270 280
pF1KE0 CGIASLCLMGKLEEVFSEKELNRIKRWCIMRQ---QNGYHGRPNKPVDTCYSFWVGATLK
::.:.: .. : :. .. : : .: :: ..:..:: :: :: ::::: .. :
NP_002 CGLAALVIL-KRERSLNLKSL---LQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLP
260 270 280 290 300
290 300 310 320
pF1KE0 LLK-----------IFQYTNFEKN--RNYILSTQDRLVGGFAKWPDSHPDALHAYFGICG
::. ... :... ..::: . .::. : . : :. . . :
NP_002 LLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSG
310 320 330 340 350 360
330 340 350 360 370
pF1KE0 LSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST
::. .. :
NP_002 LSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFEELKDE
370 380 390 400 410 420
377 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 03:41:32 2016 done: Mon Nov 7 03:41:33 2016
Total Scan time: 8.160 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]