Result of FASTA (omim) for
pFN21AE0462
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0462, 227 aa
1>>>pF1KE0462 227 - 227 aa - 227 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7460+/-0.000332; mu= 12.3163+/- 0.021
mean_var=73.2734+/-14.987, 0's: 0 Z-trim(115.9): 11 B-trim: 677 in 1/55
Lambda= 0.149831
statistics sampled from 26595 (26605) to 26595 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.697), E-opt: 0.2 (0.312), width: 16
Scan time: 6.340
The best scores are: opt bits E(85289)
NP_872353 (OMIM: 612038) transmembrane emp24 domai ( 227) 1519 337.1 1.5e-92
NP_001289987 (OMIM: 612038) transmembrane emp24 do ( 186) 1197 267.5 1.1e-71
NP_001289991 (OMIM: 612038) transmembrane emp24 do ( 168) 1126 252.1 4.2e-67
NP_001289990 (OMIM: 612038) transmembrane emp24 do ( 168) 1126 252.1 4.2e-67
NP_001289988 (OMIM: 612038) transmembrane emp24 do ( 178) 880 198.9 4.5e-51
NP_001289989 (OMIM: 612038) transmembrane emp24 do ( 127) 804 182.4 3e-46
NP_006818 (OMIM: 605406) transmembrane emp24 domai ( 219) 319 77.7 1.7e-14
NP_057124 (OMIM: 616876) transmembrane emp24 domai ( 229) 175 46.6 4.2e-05
NP_006849 (OMIM: 605395) transmembrane emp24 domai ( 227) 159 43.1 0.00045
XP_006722694 (OMIM: 605395) PREDICTED: transmembra ( 189) 157 42.7 0.00052
>>NP_872353 (OMIM: 612038) transmembrane emp24 domain-co (227 aa)
initn: 1519 init1: 1519 opt: 1519 Z-score: 1782.8 bits: 337.1 E(85289): 1.5e-92
Smith-Waterman score: 1519; 100.0% identity (100.0% similar) in 227 aa overlap (1-227:1-227)
10 20 30 40 50 60
pF1KE0 MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 WDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 WDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 MALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 MALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRYR
130 140 150 160 170 180
190 200 210 220
pF1KE0 EERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV
:::::::::::::::::::::::::::::::::::::::::::::::
NP_872 EERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV
190 200 210 220
>>NP_001289987 (OMIM: 612038) transmembrane emp24 domain (186 aa)
initn: 1197 init1: 1197 opt: 1197 Z-score: 1408.0 bits: 267.5 E(85289): 1.1e-71
Smith-Waterman score: 1197; 100.0% identity (100.0% similar) in 178 aa overlap (1-178:1-178)
10 20 30 40 50 60
pF1KE0 MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 WDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 MALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRAS
130 140 150 160 170 180
190 200 210 220
pF1KE0 EERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV
NP_001 AYLLVI
>>NP_001289991 (OMIM: 612038) transmembrane emp24 domain (168 aa)
initn: 1126 init1: 1126 opt: 1126 Z-score: 1325.7 bits: 252.1 E(85289): 4.2e-67
Smith-Waterman score: 1126; 100.0% identity (100.0% similar) in 168 aa overlap (60-227:1-168)
30 40 50 60 70 80
pF1KE0 LYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVV
::::::::::::::::::::::::::::::
NP_001 MWDKQKEVFLPSTPGLGMHVEVKDPDGKVV
10 20 30
90 100 110 120 130 140
pF1KE0 LSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAA
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE0 KDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILT
100 110 120 130 140 150
210 220
pF1KE0 GIWQMRHLKSFFEAKKLV
::::::::::::::::::
NP_001 GIWQMRHLKSFFEAKKLV
160
>>NP_001289990 (OMIM: 612038) transmembrane emp24 domain (168 aa)
initn: 1126 init1: 1126 opt: 1126 Z-score: 1325.7 bits: 252.1 E(85289): 4.2e-67
Smith-Waterman score: 1126; 100.0% identity (100.0% similar) in 168 aa overlap (60-227:1-168)
30 40 50 60 70 80
pF1KE0 LYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVV
::::::::::::::::::::::::::::::
NP_001 MWDKQKEVFLPSTPGLGMHVEVKDPDGKVV
10 20 30
90 100 110 120 130 140
pF1KE0 LSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAA
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE0 KDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILT
100 110 120 130 140 150
210 220
pF1KE0 GIWQMRHLKSFFEAKKLV
::::::::::::::::::
NP_001 GIWQMRHLKSFFEAKKLV
160
>>NP_001289988 (OMIM: 612038) transmembrane emp24 domain (178 aa)
initn: 1188 init1: 880 opt: 880 Z-score: 1038.0 bits: 198.9 E(85289): 4.5e-51
Smith-Waterman score: 1094; 78.4% identity (78.4% similar) in 227 aa overlap (1-227:1-178)
10 20 30 40 50 60
pF1KE0 MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 WDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 MALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRYR
::::::::: ::
NP_001 MALFAGGKL-------------------------------------------------YR
130
190 200 210 220
pF1KE0 EERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV
140 150 160 170
>>NP_001289989 (OMIM: 612038) transmembrane emp24 domain (127 aa)
initn: 804 init1: 804 opt: 804 Z-score: 951.4 bits: 182.4 E(85289): 3e-46
Smith-Waterman score: 804; 100.0% identity (100.0% similar) in 119 aa overlap (60-178:1-119)
30 40 50 60 70 80
pF1KE0 LYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVV
::::::::::::::::::::::::::::::
NP_001 MWDKQKEVFLPSTPGLGMHVEVKDPDGKVV
10 20 30
90 100 110 120 130 140
pF1KE0 LSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAA
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE0 KDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILT
:::::::::::::::::::::::::::::
NP_001 KDKLTELQLRARQLLDQVEQIQKEQDYQRASAYLLVI
100 110 120
>>NP_006818 (OMIM: 605406) transmembrane emp24 domain-co (219 aa)
initn: 319 init1: 242 opt: 319 Z-score: 381.2 bits: 77.7 E(85289): 1.7e-14
Smith-Waterman score: 376; 34.2% identity (64.1% similar) in 231 aa overlap (1-227:1-218)
10 20 30 40 50
pF1KE0 MAGVGAGPLRAMGRQALLLLALCATGAQ---GLYFHIGETEKRCFIEEIPDETMVIGNYR
:.:... : : : : :: : : . .. ::. . ..:. ::: . .: : :
NP_006 MSGLSGPPARR-GPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAY-
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 TQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSN
.. :.. .. :: :... : :... :.. ...:.:.::.. ..:..:.
NP_006 -EISDQSG-----GAGGLRSHLKITDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE0 ST-RMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDY
.: :. .: : ::.. : .:.:: ::: .:: :... :.: : :.: .. :
NP_006 GTGRIP----DQL-VILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAY
120 130 140 150 160
180 190 200 210 220
pF1KE0 QRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV
.. :::..: :.:::: :::..:: . :: . ::. .:. ::.::::.
NP_006 MKKREEEMRDTNESTNTRVLYFSIFSMFCLIGLATWQVFYLRRFFKAKKLIE
170 180 190 200 210
>>NP_057124 (OMIM: 616876) transmembrane emp24 domain-co (229 aa)
initn: 137 init1: 94 opt: 175 Z-score: 212.7 bits: 46.6 E(85289): 4.2e-05
Smith-Waterman score: 175; 23.9% identity (59.5% similar) in 205 aa overlap (32-225:38-225)
10 20 30 40 50 60
pF1KE0 AGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQMW
: . .:.:: . .: .. . .: :.
NP_057 PFPVLLLAALPPVLLPGAAGFTPSLDSDFTFTLPAGQKECFYQPMPLKASLEIEY--QVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 DKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTRM
: :: . .. .:.::... .: :.: : ... ::...:. .. . .
NP_057 DGA---------GLDIDFHLASPEGKTLVFEQRKSDGVHTVETEV-GDYMFCFDNTFSTI
70 80 90 100 110
130 140 150 160 170
pF1KE0 A---LFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTE-LQLRARQLLDQVEQIQKE----
. .: ... :: ..::.:.. . :. :... ...:.....:...
NP_057 SEKVIF----FELILD-NMGEQAQEQEDWKKYITGTDILDMKLEDILESINSIKSRLSKS
120 130 140 150 160 170
180 190 200 210 220
pF1KE0 ---QDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV
: : : : : .::. .:: .::... :...... :. :::.:: :.
NP_057 GHIQTLLRAFEARDRNIQESNFDRVNFWSMVNLVVMVVVSAIQVYMLKSLFEDKRKSRT
180 190 200 210 220
>>NP_006849 (OMIM: 605395) transmembrane emp24 domain-co (227 aa)
initn: 118 init1: 84 opt: 159 Z-score: 194.0 bits: 43.1 E(85289): 0.00045
Smith-Waterman score: 159; 21.4% identity (52.7% similar) in 201 aa overlap (32-227:36-225)
10 20 30 40 50 60
pF1KE0 AGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQMW
: . .:.:: . : .. . .:.
NP_006 AALALALWLLMPPVEVGGAGPPPIQDGEFTFLLPAGRKQCFYQSAPANASLETEYQ----
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 DKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSN----
. . :: . ...:.: ...:.. ..: : ::...:. ..
NP_006 -------VIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYKLCFDNSFSTI
70 80 90 100 110
120 130 140 150 160 170
pF1KE0 STRMALFAGGKLRVHLDIQV-GEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDY
: ....: .. : .: : :: :. ... . . ..:. .
NP_006 SEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTL
120 130 140 150 160 170
180 190 200 210 220
pF1KE0 QRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV
: : : : .:.. .:: .:: .....:.:... :. :: ::. :. :
NP_006 LRAFEARDRNLQEGNLERVNFWSAVNVAVLLLVAVLQVCTLKRFFQDKRPVPT
180 190 200 210 220
>>XP_006722694 (OMIM: 605395) PREDICTED: transmembrane e (189 aa)
initn: 99 init1: 84 opt: 157 Z-score: 192.9 bits: 42.7 E(85289): 0.00052
Smith-Waterman score: 157; 23.3% identity (56.0% similar) in 159 aa overlap (74-227:29-187)
50 60 70 80 90 100
pF1KE0 EEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFT
:: . ...:.: ...:.. ..: :
XP_006 MRVEARGAATGTGWGGCGCAAVQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVE
10 20 30 40 50
110 120 130 140 150
pF1KE0 SHTPGDHQICLHSN----STRMALFAGGKLRVHLDIQV-GEHANNYPEIAAKDKLTELQL
::...:. .. : ....: .. : .: : :: :. ...
XP_006 PTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKE
60 70 80 90 100 110
160 170 180 190 200 210
pF1KE0 RARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLK
. . ..:. . : : : : .:.. .:: .:: .....:.:... :. ::
XP_006 SIETMRTRLERSIQMLTLLRAFEARDRNLQEGNLERVNFWSAVNVAVLLLVAVLQVCTLK
120 130 140 150 160 170
220
pF1KE0 SFFEAKKLV
::. :. :
XP_006 RFFQDKRPVPT
180
227 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 04:06:39 2016 done: Mon Nov 7 04:06:40 2016
Total Scan time: 6.340 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]