Result of FASTA (omim) for
pFN21AE0359
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0359, 582 aa
1>>>pF1KE0359 582 - 582 aa - 582 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.4817+/-0.000333; mu= 10.3918+/- 0.021
mean_var=150.5999+/-31.025, 0's: 0 Z-trim(120.3): 107 B-trim: 1420 in 1/55
Lambda= 0.104511
statistics sampled from 35322 (35437) to 35322 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.745), E-opt: 0.2 (0.415), width: 16
Scan time: 9.230
The best scores are: opt bits E(85289)
NP_001518 (OMIM: 605164) histone deacetylase 2 [Ho ( 488) 3343 515.7 1.4e-145
XP_016866288 (OMIM: 605164) PREDICTED: histone dea ( 458) 3116 481.5 2.6e-135
XP_011534090 (OMIM: 605164) PREDICTED: histone dea ( 458) 3116 481.5 2.6e-135
NP_004955 (OMIM: 601241) histone deacetylase 1 [Ho ( 482) 2880 445.9 1.4e-124
NP_003874 (OMIM: 605166) histone deacetylase 3 [Ho ( 428) 1833 288.0 4.3e-77
XP_011539611 (OMIM: 601241) PREDICTED: histone dea ( 289) 1614 254.9 2.7e-67
NP_060956 (OMIM: 300269) histone deacetylase 8 iso ( 377) 1089 175.8 2.3e-43
XP_011529288 (OMIM: 300269) PREDICTED: histone dea ( 441) 1083 174.9 4.8e-43
XP_011529289 (OMIM: 300269) PREDICTED: histone dea ( 379) 992 161.2 5.8e-39
XP_011535999 (OMIM: 605166) PREDICTED: histone dea ( 241) 933 152.1 1.9e-36
XP_016885135 (OMIM: 300269) PREDICTED: histone dea ( 274) 882 144.5 4.4e-34
NP_001159890 (OMIM: 300269) histone deacetylase 8 ( 286) 821 135.3 2.7e-31
XP_016885131 (OMIM: 300269) PREDICTED: histone dea ( 350) 816 134.6 5.3e-31
NP_001159891 (OMIM: 300269) histone deacetylase 8 ( 256) 721 120.2 8.5e-27
XP_016885130 (OMIM: 300269) PREDICTED: histone dea ( 389) 536 92.4 2.9e-18
XP_016885133 (OMIM: 300269) PREDICTED: histone dea ( 324) 530 91.4 4.8e-18
XP_016885129 (OMIM: 300269) PREDICTED: histone dea ( 415) 530 91.5 5.8e-18
XP_016885136 (OMIM: 300269) PREDICTED: histone dea ( 268) 469 82.2 2.4e-15
NP_001308157 (OMIM: 300272,300863) histone deacety (1215) 389 70.6 3.4e-11
NP_006035 (OMIM: 300272,300863) histone deacetylas (1215) 389 70.6 3.4e-11
NP_001308156 (OMIM: 300272,300863) histone deacety (1215) 389 70.6 3.4e-11
NP_001308158 (OMIM: 300272,300863) histone deacety (1215) 389 70.6 3.4e-11
NP_001308155 (OMIM: 300272,300863) histone deacety (1215) 389 70.6 3.4e-11
NP_001308154 (OMIM: 300272,300863) histone deacety (1229) 389 70.6 3.4e-11
XP_016885134 (OMIM: 300269) PREDICTED: histone dea ( 315) 374 67.9 5.6e-11
XP_016885132 (OMIM: 300269) PREDICTED: histone dea ( 341) 368 67.0 1.1e-10
XP_016868317 (OMIM: 606543) PREDICTED: histone dea (1025) 368 67.4 2.6e-10
NP_001308806 (OMIM: 606543) histone deacetylase 9 (1025) 368 67.4 2.6e-10
NP_001308826 (OMIM: 606543) histone deacetylase 9 (1025) 368 67.4 2.6e-10
XP_011513948 (OMIM: 606543) PREDICTED: histone dea (1035) 368 67.4 2.7e-10
XP_011513947 (OMIM: 606543) PREDICTED: histone dea (1038) 368 67.4 2.7e-10
XP_011513946 (OMIM: 606543) PREDICTED: histone dea (1038) 368 67.4 2.7e-10
XP_016868316 (OMIM: 606543) PREDICTED: histone dea (1043) 368 67.4 2.7e-10
XP_011513944 (OMIM: 606543) PREDICTED: histone dea (1043) 368 67.4 2.7e-10
XP_011513943 (OMIM: 606543) PREDICTED: histone dea (1043) 368 67.4 2.7e-10
XP_011513936 (OMIM: 606543) PREDICTED: histone dea (1044) 368 67.4 2.7e-10
NP_001308797 (OMIM: 606543) histone deacetylase 9 (1044) 368 67.4 2.7e-10
NP_848510 (OMIM: 606543) histone deacetylase 9 iso (1066) 368 67.4 2.7e-10
XP_016868315 (OMIM: 606543) PREDICTED: histone dea (1066) 368 67.4 2.7e-10
XP_011513940 (OMIM: 606543) PREDICTED: histone dea (1069) 368 67.4 2.7e-10
XP_011513941 (OMIM: 606543) PREDICTED: histone dea (1069) 368 67.4 2.7e-10
NP_848512 (OMIM: 606543) histone deacetylase 9 iso (1069) 368 67.4 2.7e-10
XP_011513939 (OMIM: 606543) PREDICTED: histone dea (1071) 368 67.4 2.7e-10
XP_011513938 (OMIM: 606543) PREDICTED: histone dea (1071) 368 67.4 2.7e-10
XP_011513950 (OMIM: 606543) PREDICTED: histone dea (1074) 368 67.4 2.7e-10
XP_011513937 (OMIM: 606543) PREDICTED: histone dea (1074) 368 67.4 2.7e-10
XP_011513951 (OMIM: 606543) PREDICTED: histone dea (1074) 368 67.4 2.7e-10
XP_011513931 (OMIM: 606543) PREDICTED: histone dea (1088) 368 67.4 2.8e-10
XP_011513933 (OMIM: 606543) PREDICTED: histone dea (1096) 368 67.4 2.8e-10
NP_478056 (OMIM: 606543) histone deacetylase 9 iso (1011) 342 63.5 4e-09
>>NP_001518 (OMIM: 605164) histone deacetylase 2 [Homo s (488 aa)
initn: 3343 init1: 3343 opt: 3343 Z-score: 2734.7 bits: 515.7 E(85289): 1.4e-145
Smith-Waterman score: 3343; 100.0% identity (100.0% similar) in 488 aa overlap (95-582:1-488)
70 80 90 100 110 120
pF1KE0 PFLSRPSRGGSSSSSSSRRRSPVAAVAGEPMAYSQGGGKKKVCYYYDGDIGNYYYGQGHP
::::::::::::::::::::::::::::::
NP_001 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHP
10 20 30
130 140 150 160 170 180
pF1KE0 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSK
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE0 QMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASG
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE0 FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTG
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE0 DLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGD
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE0 RLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELP
280 290 300 310 320 330
430 440 450 460 470 480
pF1KE0 YNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAV
340 350 360 370 380 390
490 500 510 520 530 540
pF1KE0 HEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEED
400 410 420 430 440 450
550 560 570 580
pF1KE0 KKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
::::::::::::::::::::::::::::::::::::::
NP_001 KKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
460 470 480
>>XP_016866288 (OMIM: 605164) PREDICTED: histone deacety (458 aa)
initn: 3116 init1: 3116 opt: 3116 Z-score: 2550.2 bits: 481.5 E(85289): 2.6e-135
Smith-Waterman score: 3116; 100.0% identity (100.0% similar) in 458 aa overlap (125-582:1-458)
100 110 120 130 140 150
pF1KE0 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
::::::::::::::::::::::::::::::
XP_016 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
10 20 30
160 170 180 190 200 210
pF1KE0 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE0 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE0 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE0 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE0 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE0 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
340 350 360 370 380 390
520 530 540 550 560 570
pF1KE0 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
400 410 420 430 440 450
580
pF1KE0 KSEQLSNP
::::::::
XP_016 KSEQLSNP
>>XP_011534090 (OMIM: 605164) PREDICTED: histone deacety (458 aa)
initn: 3116 init1: 3116 opt: 3116 Z-score: 2550.2 bits: 481.5 E(85289): 2.6e-135
Smith-Waterman score: 3116; 100.0% identity (100.0% similar) in 458 aa overlap (125-582:1-458)
100 110 120 130 140 150
pF1KE0 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
::::::::::::::::::::::::::::::
XP_011 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
10 20 30
160 170 180 190 200 210
pF1KE0 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE0 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE0 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE0 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE0 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE0 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
340 350 360 370 380 390
520 530 540 550 560 570
pF1KE0 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
400 410 420 430 440 450
580
pF1KE0 KSEQLSNP
::::::::
XP_011 KSEQLSNP
>>NP_004955 (OMIM: 601241) histone deacetylase 1 [Homo s (482 aa)
initn: 2924 init1: 2811 opt: 2880 Z-score: 2357.5 bits: 445.9 E(85289): 1.4e-124
Smith-Waterman score: 2880; 85.9% identity (95.0% similar) in 483 aa overlap (95-577:1-478)
70 80 90 100 110 120
pF1KE0 PFLSRPSRGGSSSSSSSRRRSPVAAVAGEPMAYSQGGGKKKVCYYYDGDIGNYYYGQGHP
:: .:: ..:::::::::.::::::::::
NP_004 MAQTQGT-RRKVCYYYDGDVGNYYYGQGHP
10 20
130 140 150 160 170 180
pF1KE0 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSK
::::::::::::::::::::::::::::::.::::::::::.::::::::::::::::::
NP_004 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSK
30 40 50 60 70 80
190 200 210 220 230 240
pF1KE0 QMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASG
::::::::::::::::::::::::::::::.:::::.::::.::::::::::::::::::
NP_004 QMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASG
90 100 110 120 130 140
250 260 270 280 290 300
pF1KE0 FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTG
150 160 170 180 190 200
310 320 330 340 350 360
pF1KE0 DLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGD
::::::::::::::::.:.::::::::: ::::..::::::.::::::::::.::::::
NP_004 DLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGD
210 220 230 240 250 260
370 380 390 400 410 420
pF1KE0 RLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELP
::::::::.:::::::: ::.::::.:::::::::::::::::::::::::: :::::::
NP_004 RLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELP
270 280 290 300 310 320
430 440 450 460 470 480
pF1KE0 YNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAV
:::::::::::::::::::::::::: ::.:::::::::::::::::::::::::::::.
NP_004 YNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAI
330 340 350 360 370 380
490 500 510 520 530 540
pF1KE0 HEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEED
:.::::: .:::::::: .:::::::.:::::::.::::::.: .. :: ::... :..
NP_004 PEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKK-AKRVKTEDE
390 400 410 420 430 440
550 560 570 580
pF1KE0 KKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
:.. ..: .: ::.:.:. :: ..::.: :
NP_004 KEKDPEEKKEVTEEEKTKE---EKPEAKGVKEEVKLA
450 460 470 480
>>NP_003874 (OMIM: 605166) histone deacetylase 3 [Homo s (428 aa)
initn: 1131 init1: 978 opt: 1833 Z-score: 1505.1 bits: 288.0 E(85289): 4.3e-77
Smith-Waterman score: 1833; 58.8% identity (84.4% similar) in 422 aa overlap (104-523:3-421)
80 90 100 110 120 130
pF1KE0 GSSSSSSSRRRSPVAAVAGEPMAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMT
: : :.:: :.::..:: ::::::::. .:
NP_003 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALT
10 20 30
140 150 160 170 180 190
pF1KE0 HNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGE
:.:.:.::::.:: ...:..:. ..: ..::..:: ::. . : ::. ..:... ::::.
NP_003 HSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGD
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE0 DCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVL
::::: ::::::. ::.:. ::..:: . :.:.::::::::::: ::::::::::::.
NP_003 DCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVI
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE0 AILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAG
.:::::::: :::::::::::::::.:::: :::::::::::::.:: :::::. ..::
NP_003 GILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAE
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE0 KGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLT
.:.:: .: :.::::::.:: ..:.:.:..:...:::. .:::::::::. ::::::::.
NP_003 SGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLS
220 230 240 250 260 270
380 390 400 410 420 430
pF1KE0 VKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYF
..::..::: ::.::.:::.:::::::.:::::::::::.. .. : .::::..:::::
NP_003 IRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYF
280 290 300 310 320 330
440 450 460 470 480 490
pF1KE0 GPDFKLHISPSN-MTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDE
.::: :: . :. . :::. .:...:.: .::::.:: :::.::.. .: : . : ::
NP_003 APDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDE
340 350 360 370 380 390
500 510 520 530 540 550
pF1KE0 DGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDK
: ..: . . . .: .:: :.. ...
NP_003 --ADAEER-GPEENYSRPEAPNEFYDGDHDNDKESDVEI
400 410 420
560 570 580
pF1KE0 KTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
>>XP_011539611 (OMIM: 601241) PREDICTED: histone deacety (289 aa)
initn: 1677 init1: 1565 opt: 1614 Z-score: 1329.0 bits: 254.9 E(85289): 2.7e-67
Smith-Waterman score: 1614; 80.6% identity (92.7% similar) in 289 aa overlap (289-577:1-285)
260 270 280 290 300 310
pF1KE0 LKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYA
::::::::::::::::::::::::::::::
XP_011 MTVSFHKYGEYFPGTGDLRDIGAGKGKYYA
10 20 30
320 330 340 350 360 370
pF1KE0 VNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAK
::.:.::::::::: ::::..::::::.::::::::::.::::::::::::::.:::::
XP_011 VNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAK
40 50 60 70 80 90
380 390 400 410 420 430
pF1KE0 CVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKL
::: ::.::::.:::::::::::::::::::::::::: :::::::::::::::::::::
XP_011 CVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKL
100 110 120 130 140 150
440 450 460 470 480 490
pF1KE0 HISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDK
:::::::::::: ::.:::::::::::::::::::::::::::::. :.::::: .::::
XP_011 HISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDK
160 170 180 190 200 210
500 510 520 530 540 550
pF1KE0 RISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEE
:::: .:::::::.:::::::.::::::.: .. :: ::... :..:.. ..: .: ::
XP_011 RISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKK-AKRVKTEDEKEKDPEEKKEVTEE
220 230 240 250 260
560 570 580
pF1KE0 DKSKDNSGEKTDTKGTKSEQLSNP
.:.:. :: ..::.: :
XP_011 EKTKE---EKPEAKGVKEEVKLA
270 280
>>NP_060956 (OMIM: 300269) histone deacetylase 8 isoform (377 aa)
initn: 953 init1: 551 opt: 1089 Z-score: 899.6 bits: 175.8 E(85289): 2.3e-43
Smith-Waterman score: 1089; 43.4% identity (77.1% similar) in 341 aa overlap (127-466:35-374)
100 110 120 130 140 150
pF1KE0 YSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATA
:.: :.:.:. :.:...:.: .:. :.
NP_060 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM
10 20 30 40 50 60
160 170 180 190 200 210
pF1KE0 EEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGA
:::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....:
NP_060 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA
70 80 90 100 110 120
220 230 240 250 260 270
pF1KE0 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD
: . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.::::
NP_060 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD
130 140 150 160 170 180
280 290 300 310 320 330
pF1KE0 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQI
:::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: ::
NP_060 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI
190 200 210 220 230 240
340 350 360 370 380 390
pF1KE0 FKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG
. ....:.. ..:.::::: :::...:: . ::.: : .::.. . ..: :.:::
NP_060 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG
250 260 270 280 290 300
400 410 420 430 440 450
pF1KE0 GGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYME
:::.. :.:::::: :.: : . .:.: ...: .:::. :.:.:: ..: :. ..
NP_060 GGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQ
310 320 330 340 350 360
460 470 480 490 500 510
pF1KE0 KIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEF
.: . . ::.
NP_060 QILNYIKGNLKHVV
370
>>XP_011529288 (OMIM: 300269) PREDICTED: histone deacety (441 aa)
initn: 525 init1: 525 opt: 1083 Z-score: 893.8 bits: 174.9 E(85289): 4.8e-43
Smith-Waterman score: 1083; 44.0% identity (77.7% similar) in 332 aa overlap (127-457:73-403)
100 110 120 130 140 150
pF1KE0 YSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATA
:.: :.:.:. :.:...:.: .:. :.
XP_011 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM
50 60 70 80 90 100
160 170 180 190 200 210
pF1KE0 EEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGA
:::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....:
XP_011 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA
110 120 130 140 150 160
220 230 240 250 260 270
pF1KE0 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD
: . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.::::
XP_011 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD
170 180 190 200 210 220
280 290 300 310 320 330
pF1KE0 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQI
:::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: ::
XP_011 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI
230 240 250 260 270 280
340 350 360 370 380 390
pF1KE0 FKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG
. ....:.. ..:.::::: :::...:: . ::.: : .::.. . ..: :.:::
XP_011 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG
290 300 310 320 330 340
400 410 420 430 440 450
pF1KE0 GGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYME
:::.. :.:::::: :.: : . .:.: ...: .:::. :.:.:: ..: :. ..
XP_011 GGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQ
350 360 370 380 390 400
460 470 480 490 500 510
pF1KE0 KIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEF
.:
XP_011 QILNYIKEKWPVGFGAQCFYLGKCGKAKTTEGQRNLKHVV
410 420 430 440
>>XP_011529289 (OMIM: 300269) PREDICTED: histone deacety (379 aa)
initn: 841 init1: 439 opt: 992 Z-score: 820.5 bits: 161.2 E(85289): 5.8e-39
Smith-Waterman score: 992; 45.2% identity (78.3% similar) in 299 aa overlap (127-424:73-370)
100 110 120 130 140 150
pF1KE0 YSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATA
:.: :.:.:. :.:...:.: .:. :.
XP_011 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM
50 60 70 80 90 100
160 170 180 190 200 210
pF1KE0 EEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGA
:::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....:
XP_011 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA
110 120 130 140 150 160
220 230 240 250 260 270
pF1KE0 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD
: . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.::::
XP_011 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD
170 180 190 200 210 220
280 290 300 310 320 330
pF1KE0 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQI
:::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: ::
XP_011 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI
230 240 250 260 270 280
340 350 360 370 380 390
pF1KE0 FKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG
. ....:.. ..:.::::: :::...:: . ::.: : .::.. . ..: :.:::
XP_011 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG
290 300 310 320 330 340
400 410 420 430 440 450
pF1KE0 GGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYME
:::.. :.:::::: :.: : . .:.:
XP_011 GGYNLANTARCWTYLTGVILGKTLSSEIPDHENMPVNT
350 360 370
>>XP_011535999 (OMIM: 605166) PREDICTED: histone deacety (241 aa)
initn: 869 init1: 716 opt: 933 Z-score: 775.2 bits: 152.1 E(85289): 1.9e-36
Smith-Waterman score: 933; 54.4% identity (82.3% similar) in 237 aa overlap (289-523:1-234)
260 270 280 290 300 310
pF1KE0 LKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYY
:::::::::.:: :::::. ..:: .:.::
XP_011 MTVSFHKYGNYFFPGTGDMYEVGAESGRYY
10 20 30
320 330 340 350 360 370
pF1KE0 AVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHA
.: :.::::::.:: ..:.:.:..:...:::. .:::::::::. ::::::::...::.
XP_011 CLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHG
40 50 60 70 80 90
380 390 400 410 420 430
pF1KE0 KCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFK
.::: ::.::.:::.:::::::.:::::::::::.. .. : .::::..:::::.:::
XP_011 ECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFT
100 110 120 130 140 150
440 450 460 470 480 490
pF1KE0 LHISPSN-MTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDP
:: . :. . :::. .:...:.: .::::.:: :::.::.. .: : . : :: :
XP_011 LHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDE--ADA
160 170 180 190 200
500 510 520 530 540 550
pF1KE0 DKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVK
..: . . . .: .:: :.. ...
XP_011 EER-GPEENYSRPEAPNEFYDGDHDNDKESDVEI
210 220 230 240
582 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 04:00:10 2016 done: Mon Nov 7 04:00:11 2016
Total Scan time: 9.230 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]