Result of FASTA (omim) for
pFN21AB9722
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9722, 410 aa
1>>>pF1KB9722 410 - 410 aa - 410 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.6673+/-0.00042; mu= 5.6202+/- 0.027
mean_var=360.8089+/-74.688, 0's: 0 Z-trim(122.0): 63 B-trim: 138 in 1/55
Lambda= 0.067520
statistics sampled from 39348 (39430) to 39348 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.766), E-opt: 0.2 (0.462), width: 16
Scan time: 7.420
The best scores are: opt bits E(85289)
NP_004566 (OMIM: 113725) POU domain, class 4, tran ( 409) 2750 281.6 2.5e-75
NP_002691 (OMIM: 602459,602460) POU domain, class ( 338) 1208 131.2 3.7e-30
NP_006228 (OMIM: 601632) POU domain, class 4, tran ( 419) 1028 113.8 7.9e-25
NP_005595 (OMIM: 600494) POU domain, class 3, tran ( 443) 657 77.7 6.2e-14
NP_001231611 (OMIM: 607394) POU domain, class 2, t ( 438) 544 66.7 1.3e-10
XP_016872976 (OMIM: 607394) PREDICTED: POU domain, ( 356) 542 66.4 1.3e-10
XP_011541041 (OMIM: 607394) PREDICTED: POU domain, ( 432) 542 66.5 1.4e-10
XP_011541042 (OMIM: 607394) PREDICTED: POU domain, ( 432) 542 66.5 1.4e-10
NP_055167 (OMIM: 607394) POU domain, class 2, tran ( 436) 542 66.5 1.4e-10
NP_002690 (OMIM: 602479) POU domain, class 3, tran ( 451) 526 65.0 4.4e-10
XP_011541045 (OMIM: 607394) PREDICTED: POU domain, ( 403) 524 64.7 4.7e-10
XP_011541044 (OMIM: 607394) PREDICTED: POU domain, ( 403) 524 64.7 4.7e-10
XP_011541043 (OMIM: 607394) PREDICTED: POU domain, ( 403) 524 64.7 4.7e-10
NP_006227 (OMIM: 602480) POU domain, class 3, tran ( 500) 521 64.5 6.5e-10
NP_000298 (OMIM: 300039,304400) POU domain, class ( 361) 518 64.1 6.6e-10
NP_001116229 (OMIM: 173110,613038) pituitary-speci ( 317) 460 58.3 3.1e-08
NP_000297 (OMIM: 173110,613038) pituitary-specific ( 291) 454 57.7 4.4e-08
XP_011507957 (OMIM: 164175) PREDICTED: POU domain, ( 671) 460 58.8 4.7e-08
NP_001185715 (OMIM: 164175) POU domain, class 2, t ( 703) 460 58.8 4.9e-08
XP_011507956 (OMIM: 164175) PREDICTED: POU domain, ( 743) 460 58.8 5e-08
NP_001185712 (OMIM: 164175) POU domain, class 2, t ( 755) 460 58.9 5.1e-08
NP_002688 (OMIM: 164175) POU domain, class 2, tran ( 766) 460 58.9 5.1e-08
XP_011507955 (OMIM: 164175) PREDICTED: POU domain, ( 769) 460 58.9 5.1e-08
NP_001272916 (OMIM: 164177) POU domain, class 5, t ( 265) 442 56.5 9.3e-08
NP_002692 (OMIM: 164177) POU domain, class 5, tran ( 360) 444 56.9 9.7e-08
NP_001153014 (OMIM: 615739) putative POU domain, c ( 359) 426 55.1 3.3e-07
NP_001159490 (OMIM: 601583,609062) POU domain, cla ( 655) 411 54.0 1.3e-06
NP_976034 (OMIM: 164177) POU domain, class 5, tran ( 190) 346 46.9 5e-05
NP_001167002 (OMIM: 164177) POU domain, class 5, t ( 190) 346 46.9 5e-05
XP_016882380 (OMIM: 164176) PREDICTED: POU domain, ( 707) 338 46.9 0.00018
XP_011525344 (OMIM: 164176) PREDICTED: POU domain, ( 485) 334 46.3 0.00019
XP_016882382 (OMIM: 164176) PREDICTED: POU domain, ( 608) 334 46.4 0.00022
XP_011525343 (OMIM: 164176) PREDICTED: POU domain, ( 501) 331 46.0 0.00024
XP_011525342 (OMIM: 164176) PREDICTED: POU domain, ( 624) 331 46.2 0.00028
NP_001234923 (OMIM: 164176) POU domain, class 2, t ( 400) 326 45.4 0.0003
NP_002689 (OMIM: 164176) POU domain, class 2, tran ( 463) 326 45.5 0.00032
XP_005259067 (OMIM: 164176) PREDICTED: POU domain, ( 586) 326 45.6 0.00037
XP_011525345 (OMIM: 164176) PREDICTED: POU domain, ( 537) 324 45.4 0.0004
XP_016882385 (OMIM: 164176) PREDICTED: POU domain, ( 600) 324 45.5 0.00043
NP_001193955 (OMIM: 164176) POU domain, class 2, t ( 467) 321 45.0 0.00046
NP_001193954 (OMIM: 164176) POU domain, class 2, t ( 479) 321 45.0 0.00046
XP_016882381 (OMIM: 164176) PREDICTED: POU domain, ( 701) 324 45.6 0.00047
XP_016882375 (OMIM: 164176) PREDICTED: POU domain, ( 711) 324 45.6 0.00048
XP_016882377 (OMIM: 164176) PREDICTED: POU domain, ( 711) 324 45.6 0.00048
XP_016882376 (OMIM: 164176) PREDICTED: POU domain, ( 711) 324 45.6 0.00048
XP_016882378 (OMIM: 164176) PREDICTED: POU domain, ( 711) 324 45.6 0.00048
XP_016882379 (OMIM: 164176) PREDICTED: POU domain, ( 711) 324 45.6 0.00048
XP_016882374 (OMIM: 164176) PREDICTED: POU domain, ( 723) 324 45.6 0.00048
XP_016882373 (OMIM: 164176) PREDICTED: POU domain, ( 723) 324 45.6 0.00048
XP_016882383 (OMIM: 164176) PREDICTED: POU domain, ( 602) 321 45.2 0.00053
>>NP_004566 (OMIM: 113725) POU domain, class 4, transcri (409 aa)
initn: 2438 init1: 2438 opt: 2750 Z-score: 1473.4 bits: 281.6 E(85289): 2.5e-75
Smith-Waterman score: 2750; 99.8% identity (99.8% similar) in 410 aa overlap (1-410:1-409)
10 20 30 40 50 60
pF1KB9 MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 GGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDI
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GGGGGGGG-RSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDI
70 80 90 100 110
130 140 150 160 170 180
pF1KB9 VSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHH
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB9 HHHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HHHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAH
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB9 GLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTI
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB9 CRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRS
300 310 320 330 340 350
370 380 390 400 410
pF1KB9 LEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI
360 370 380 390 400
>>NP_002691 (OMIM: 602459,602460) POU domain, class 4, t (338 aa)
initn: 1377 init1: 979 opt: 1208 Z-score: 662.4 bits: 131.2 E(85289): 3.7e-30
Smith-Waterman score: 1506; 70.7% identity (86.3% similar) in 335 aa overlap (79-408:22-336)
50 60 70 80 90 100
pF1KB9 SSSNAGGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPP--SNIFGGLDE
:: .:::::::.:::.: .::::..::
NP_002 MMAMNSKQPFGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDE
10 20 30 40 50
110 120 130 140 150 160
pF1KB9 SLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPS
::::::::::::::::..:.: :::::::::::...:::: .::.::::::.
NP_002 SLLARAEALAAVDIVSHGKNH--------PFKPDATYHTMSSVPCTS--TSSTVPISHPA
60 70 80 90 100
170 180 190 200 210 220
pF1KB9 ALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATM
::.. : :: ::.:::.::::.:: :.......:. .:. . : :...:
NP_002 ALTS---------HPHHAVHQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQIHPHHLGAM
110 120 130 140 150
230 240 250 260 270 280
pF1KB9 NPMHQAALSMAHAHGLPSHMG---CMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSA
. .::: ..:.: : . : . :.:::..:::.:::::::::::::::::::::::.:
NP_002 GHLHQA-MGMSHPHTVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAA
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB9 LANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNG
:::::::::::::::::::::::::::::::::::.::::::::: ..::: .:::::::
NP_002 LANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKNSKPELFNG
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB9 AEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKR
.:.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SERKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKR
280 290 300 310 320 330
410
pF1KB9 MKYSAGI
:::::
NP_002 MKYSAVH
>>NP_006228 (OMIM: 601632) POU domain, class 4, transcri (419 aa)
initn: 1176 init1: 964 opt: 1028 Z-score: 566.7 bits: 113.8 E(85289): 7.9e-25
Smith-Waterman score: 1304; 58.9% identity (67.9% similar) in 414 aa overlap (85-408:29-417)
60 70 80 90 100 110
pF1KB9 GGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPP--SNIFGGLDESLLARA
:::.::::::::: ::.:..:::.:::::
NP_006 MMSMNSKQPHFAMHPTLPEHKYPSLHSSSEAIRRACLPTPPLQSNLFASLDETLLARA
10 20 30 40 50
120 130 140 150 160 170
pF1KB9 EALAAVDI-VSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGT
:::::::: :::.::: ::::::::::::..:::: .:.::..:
NP_006 EALAAVDIAVSQGKSH--------PFKPDATYHTMNSVPCTS---TSTVPLAH-------
60 70 80 90 100
180 190 200
pF1KB9 HHHHHHHHHHHHQPHQALE-GELLEHLS-PGLAL-------GAMAG--------------
::::::: ::::: :.::.:.: :.::: :: ::
NP_006 -----HHHHHHH--HQALEPGDLLDHISSPSLALMAGAGGAGAAAGGGGAHDGPGGGGGP
110 120 130 140 150
210 220 230 240
pF1KB9 ------------------------PDGAVVSTPAHA-PHMATMNPMHQ--AALSMAHAHG
: :.... :: ::: ... . . :: .: :
NP_006 GGGGGPGGGPGGGGGGGPGGGGGGPGGGLLGGSAHPHPHMHSLGHLSHPAAAAAMNMPSG
160 170 180 190 200 210
250 260
pF1KB9 LP--------SHMGC-----------------------------MSDVDADPRDLEAFAE
:: .: : . : :.:::.::::::
NP_006 LPHPGLVAAAAHHGAAAAAAAAAAGQVAAASAAAAVVGAAGLASICDSDTDPRELEAFAE
220 230 240 250 260 270
270 280 290 300 310 320
pF1KB9 RFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWL
280 290 300 310 320 330
330 340 350 360 370 380
pF1KB9 EEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLD
:::: ..:::..:::::::.::::::::::::::::::::::.:::::::::::::::::
NP_006 EEAEGAQREKMNKPELFNGGEKKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLD
340 350 360 370 380 390
390 400 410
pF1KB9 LKKNVVRVWFCNQRQKQKRMKYSAGI
:::::::::::::::::::::.::
NP_006 LKKNVVRVWFCNQRQKQKRMKFSATY
400 410
>>NP_005595 (OMIM: 600494) POU domain, class 3, transcri (443 aa)
initn: 621 init1: 368 opt: 657 Z-score: 371.1 bits: 77.7 E(85289): 6.2e-14
Smith-Waterman score: 663; 35.2% identity (59.6% similar) in 406 aa overlap (22-409:41-417)
10 20 30 40 50
pF1KB9 MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSS
:. :.::.: .. :.. . . .. :
NP_005 LLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQS----NGHPLSHAHQWITALS
20 30 40 50 60
60 70 80 90 100
pF1KB9 NAGGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIF--GGLDESL-
..:::::::::::::::: .....: :.. :. .. :: . :: . :
NP_005 HGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIK-------PSVVVQQGGRGDELH
70 80 90 100 110
110 120 130 140 150 160
pF1KB9 ----LARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISH
: . . . .:....... .. : : ..:. : : .: :...
NP_005 GPGALQQQHQQQQQQQQQQQQQQQQQQQQQRP--PHLVHHAANHHPGPGAWRSAAAAAHL
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB9 PSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMA
: ...... . :: ...: : : : : :: . :: :
NP_005 PPSMGASNGGLLYS-----QPSFTVNGML------G-AGGQPAGLHHHGLRDAHDEPHHA
180 190 200 210 220
230 240 250 260 270
pF1KB9 TMNPM-----HQAALSMAHAHGLPSHMGCMSDVDAD---PR--DLEAFAERFKQRRIKLG
.: :: .: :.: : : .: : ::: ::..:::::::::
NP_005 DHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLG
230 240 250 260 270 280
280 290 300 310 320 330
pF1KB9 VTQADVGSALANLKIPGVGSL-SQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHRE
:::::: ::..: :.. ::.::::::.: :: .:: :::.:. :::::..:
NP_005 FTQADVGLALGTL----YGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGS
290 300 310 320 330 340
340 350 360 370 380 390
pF1KB9 KLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVW
. .. ..:..::::: . : .::..: :.::...:...:..:.:.:.:::::
NP_005 PTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVW
350 360 370 380 390 400
400 410
pF1KB9 FCNQRQKQKRMKYSAGI
:::.:::.::: .:
NP_005 FCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ
410 420 430 440
>>NP_001231611 (OMIM: 607394) POU domain, class 2, trans (438 aa)
initn: 493 init1: 216 opt: 544 Z-score: 311.7 bits: 66.7 E(85289): 1.3e-10
Smith-Waterman score: 544; 35.9% identity (64.1% similar) in 351 aa overlap (68-404:9-341)
40 50 60 70 80 90
pF1KB9 APIAPSASSPSSSSNAGGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPP
:::. . :.. .. : : . . :
NP_001 MESPRTAKGGRDIKMSGDVAD----STDARSTLSQVEP
10 20 30
100 110 120 130 140 150
pF1KB9 SNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHS--PFKPDATYHT-MNTIPCTSA
.: .::: . ..: :. : ..:. ::. : : : : ... . .:. :: .
NP_001 GNDRNGLDFNRQIKTEDLS--DSLQQTLSHR--PCHLSQGPAMMSGNQMSGLNASPCQDM
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB9 ASSSSVPISHPSALAGTHHHHHHHHHHHHQP-HQALEGELLE--HLSPGLALGAMAGPDG
:: :... . : . . . :: .:.:. .:: . . :: : ..:: :
NP_001 ASLH--PLQQLVLVPGHLQSVSQFLLSQTQPGQQGLQPNLLPFPQQQSGLLL-PQTGP-G
100 110 120 130 140
220 230 240 250 260
pF1KB9 AVVSTPAHAPHM--ATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQR
. .. .: : . ....: .:. . . ::: : .: .: ..:: ::. ::::
NP_001 LASQAFGH-PGLPGSSLEPHLEASQHLPVPKHLPSSGG--ADEPSDLEELEKFAKTFKQR
150 160 170 180 190 200
270 280 290 300 310 320
pF1KB9 RIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEK
::::: ::.::: :.. :. : ...::.:: :::.:.:: .:: :::.:. ::..::.
NP_001 RIKLGFTQGDVGLAMG--KLYG-NDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAES
210 220 230 240 250 260
330 340 350 360 370 380
pF1KB9 SHRE-KLTKPELFNG-----AEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKL
: . ... : . . ..:..::::: . . .:: : .:.::::.:. :::.:
NP_001 SPSDPSVSTPSSYPSLSEVFGRKRKKRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQL
270 280 290 300 310 320
390 400 410
pF1KB9 DLKKNVVRVWFCNQRQKQKRMKYSAGI
...:.::::::::.:::.::.
NP_001 SMEKEVVRVWFCNRRQKEKRINCPVATPIKPPVYNSRLVSPSGSLGPLSVPPVHSTMPGT
330 340 350 360 370 380
>>XP_016872976 (OMIM: 607394) PREDICTED: POU domain, cla (356 aa)
initn: 515 init1: 216 opt: 542 Z-score: 311.6 bits: 66.4 E(85289): 1.3e-10
Smith-Waterman score: 542; 37.3% identity (65.5% similar) in 322 aa overlap (97-404:32-339)
70 80 90 100 110 120
pF1KB9 GGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKS
:.: .::: . ..: :. : ..:. :
XP_016 VNLESMHTDIKMSGDVADSTDARSTLSQVEPGNDRNGLDFNRQIKTEDLS--DSLQQTLS
10 20 30 40 50
130 140 150 160 170 180
pF1KB9 HHHHPPHHS--PFKPDATYHT-MNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHH
: .: : : : ... . .:. :: . :: :... . : . . .
XP_016 H--RPCHLSQGPAMMSGNQMSGLNASPCQDMASLH--PLQQLVLVPGHLQSVSQFLLSQT
60 70 80 90 100 110
190 200 210 220 230
pF1KB9 QP-HQALEGELLE--HLSPGLALGAMAGPDGAVVSTPAHAPHM--ATMNPMHQAALSMAH
:: .:.:. .:: . . :: : ..:: : . .. .: : . ....: .:. .
XP_016 QPGQQGLQPNLLPFPQQQSGLLL-PQTGP-GLASQAFGH-PGLPGSSLEPHLEASQHLPV
120 130 140 150 160 170
240 250 260 270 280 290
pF1KB9 AHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQS
. ::: : .: .: ..:: ::. ::::::::: ::.::: :.. :. : ...::.
XP_016 PKHLPSSGG--ADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMG--KLYG-NDFSQT
180 190 200 210 220
300 310 320 330 340 350
pF1KB9 TICRFESLTLSHNNMIALKPILQAWLEEAEKSHRE-KLTKPELFNG-----AEKKRKRTS
:: :::.:.:: .:: :::.:. ::..::.: . ... : . . ..:..::::
XP_016 TISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRKKRTS
230 240 250 260 270 280
360 370 380 390 400 410
pF1KB9 IAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI
: . . .:: : .:.::::.:. :::.:...:.::::::::.:::.::.
XP_016 IETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPI
290 300 310 320 330 340
XP_016 KPPVYNSRL
350
>>XP_011541041 (OMIM: 607394) PREDICTED: POU domain, cla (432 aa)
initn: 493 init1: 216 opt: 542 Z-score: 310.7 bits: 66.5 E(85289): 1.4e-10
Smith-Waterman score: 542; 37.3% identity (65.5% similar) in 322 aa overlap (97-404:28-335)
70 80 90 100 110 120
pF1KB9 GGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKS
:.: .::: . ..: :. : ..:. :
XP_011 MNDAKDIKMSGDVADSTDARSTLSQVEPGNDRNGLDFNRQIKTEDLS--DSLQQTLS
10 20 30 40 50
130 140 150 160 170 180
pF1KB9 HHHHPPHHS--PFKPDATYHT-MNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHH
: .: : : : ... . .:. :: . :: :... . : . . .
XP_011 H--RPCHLSQGPAMMSGNQMSGLNASPCQDMASLH--PLQQLVLVPGHLQSVSQFLLSQT
60 70 80 90 100 110
190 200 210 220 230
pF1KB9 QP-HQALEGELLE--HLSPGLALGAMAGPDGAVVSTPAHAPHM--ATMNPMHQAALSMAH
:: .:.:. .:: . . :: : ..:: : . .. .: : . ....: .:. .
XP_011 QPGQQGLQPNLLPFPQQQSGLLL-PQTGP-GLASQAFGH-PGLPGSSLEPHLEASQHLPV
120 130 140 150 160
240 250 260 270 280 290
pF1KB9 AHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQS
. ::: : .: .: ..:: ::. ::::::::: ::.::: :.. :. : ...::.
XP_011 PKHLPSSGG--ADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMG--KLYG-NDFSQT
170 180 190 200 210 220
300 310 320 330 340 350
pF1KB9 TICRFESLTLSHNNMIALKPILQAWLEEAEKSHRE-KLTKPELFNG-----AEKKRKRTS
:: :::.:.:: .:: :::.:. ::..::.: . ... : . . ..:..::::
XP_011 TISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRKKRTS
230 240 250 260 270 280
360 370 380 390 400 410
pF1KB9 IAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI
: . . .:: : .:.::::.:. :::.:...:.::::::::.:::.::.
XP_011 IETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPI
290 300 310 320 330 340
XP_011 KPPVYNSRLVSPSGSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSPTASQ
350 360 370 380 390 400
>>XP_011541042 (OMIM: 607394) PREDICTED: POU domain, cla (432 aa)
initn: 493 init1: 216 opt: 542 Z-score: 310.7 bits: 66.5 E(85289): 1.4e-10
Smith-Waterman score: 542; 37.3% identity (65.5% similar) in 322 aa overlap (97-404:28-335)
70 80 90 100 110 120
pF1KB9 GGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKS
:.: .::: . ..: :. : ..:. :
XP_011 MNDAKDIKMSGDVADSTDARSTLSQVEPGNDRNGLDFNRQIKTEDLS--DSLQQTLS
10 20 30 40 50
130 140 150 160 170 180
pF1KB9 HHHHPPHHS--PFKPDATYHT-MNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHH
: .: : : : ... . .:. :: . :: :... . : . . .
XP_011 H--RPCHLSQGPAMMSGNQMSGLNASPCQDMASLH--PLQQLVLVPGHLQSVSQFLLSQT
60 70 80 90 100 110
190 200 210 220 230
pF1KB9 QP-HQALEGELLE--HLSPGLALGAMAGPDGAVVSTPAHAPHM--ATMNPMHQAALSMAH
:: .:.:. .:: . . :: : ..:: : . .. .: : . ....: .:. .
XP_011 QPGQQGLQPNLLPFPQQQSGLLL-PQTGP-GLASQAFGH-PGLPGSSLEPHLEASQHLPV
120 130 140 150 160
240 250 260 270 280 290
pF1KB9 AHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQS
. ::: : .: .: ..:: ::. ::::::::: ::.::: :.. :. : ...::.
XP_011 PKHLPSSGG--ADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMG--KLYG-NDFSQT
170 180 190 200 210 220
300 310 320 330 340 350
pF1KB9 TICRFESLTLSHNNMIALKPILQAWLEEAEKSHRE-KLTKPELFNG-----AEKKRKRTS
:: :::.:.:: .:: :::.:. ::..::.: . ... : . . ..:..::::
XP_011 TISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRKKRTS
230 240 250 260 270 280
360 370 380 390 400 410
pF1KB9 IAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI
: . . .:: : .:.::::.:. :::.:...:.::::::::.:::.::.
XP_011 IETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPI
290 300 310 320 330 340
XP_011 KPPVYNSRLVSPSGSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSPTASQ
350 360 370 380 390 400
>>NP_055167 (OMIM: 607394) POU domain, class 2, transcri (436 aa)
initn: 493 init1: 216 opt: 542 Z-score: 310.7 bits: 66.5 E(85289): 1.4e-10
Smith-Waterman score: 542; 37.3% identity (65.5% similar) in 322 aa overlap (97-404:32-339)
70 80 90 100 110 120
pF1KB9 GGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKS
:.: .::: . ..: :. : ..:. :
NP_055 VNLESMHTDIKMSGDVADSTDARSTLSQVEPGNDRNGLDFNRQIKTEDLS--DSLQQTLS
10 20 30 40 50
130 140 150 160 170 180
pF1KB9 HHHHPPHHS--PFKPDATYHT-MNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHH
: .: : : : ... . .:. :: . :: :... . : . . .
NP_055 H--RPCHLSQGPAMMSGNQMSGLNASPCQDMASLH--PLQQLVLVPGHLQSVSQFLLSQT
60 70 80 90 100 110
190 200 210 220 230
pF1KB9 QP-HQALEGELLE--HLSPGLALGAMAGPDGAVVSTPAHAPHM--ATMNPMHQAALSMAH
:: .:.:. .:: . . :: : ..:: : . .. .: : . ....: .:. .
NP_055 QPGQQGLQPNLLPFPQQQSGLLL-PQTGP-GLASQAFGH-PGLPGSSLEPHLEASQHLPV
120 130 140 150 160 170
240 250 260 270 280 290
pF1KB9 AHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQS
. ::: : .: .: ..:: ::. ::::::::: ::.::: :.. :. : ...::.
NP_055 PKHLPSSGG--ADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMG--KLYG-NDFSQT
180 190 200 210 220
300 310 320 330 340 350
pF1KB9 TICRFESLTLSHNNMIALKPILQAWLEEAEKSHRE-KLTKPELFNG-----AEKKRKRTS
:: :::.:.:: .:: :::.:. ::..::.: . ... : . . ..:..::::
NP_055 TISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRKKRTS
230 240 250 260 270 280
360 370 380 390 400 410
pF1KB9 IAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI
: . . .:: : .:.::::.:. :::.:...:.::::::::.:::.::.
NP_055 IETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPI
290 300 310 320 330 340
NP_055 KPPVYNSRLVSPSGSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSPTASQ
350 360 370 380 390 400
>>NP_002690 (OMIM: 602479) POU domain, class 3, transcri (451 aa)
initn: 566 init1: 367 opt: 526 Z-score: 302.1 bits: 65.0 E(85289): 4.4e-10
Smith-Waterman score: 604; 36.5% identity (57.4% similar) in 411 aa overlap (16-409:41-402)
10 20 30 40
pF1KB9 MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSAS
:.:. . : . . .: :..: . .
NP_002 GPGGGAGGTGPLMHPDAAAAAAAAAAAERLHAGAAYREVQ-KLMHHEWLGAGAGHPVGLA
20 30 40 50 60
50 60 70 80 90
pF1KB9 SPSSSSNAGGGGGGGGGG--------GGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPP
:. ..::::: .:: :::: ::... ::::
NP_002 HPQWLPTGGGGGGDWAGGPHLEHGKAGGGGTGRADD-------GGGG-------------
70 80 90 100
100 110 120 130 140 150
pF1KB9 SNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATY-HTMNTIPCTSAAS
::. :. .. : :.. .:... :: : :: .: :. : . . . :.
NP_002 ----GGFHARLVHQGAAHAGA-AWAQGSTAHHLGPAMSP-SPGASGGHQPQPLGLYAQAA
110 120 130 140 150 160
160 170 180 190 200 210
pF1KB9 ---SSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGAV
... .. : .: :: :.. :.: :: :: ::: . :
NP_002 YPGGGGGGLAGMLAAGGGGAGPGLHHALHEDGHEAQ----LEP-SPPPHLGAHGHAHGH-
170 180 190 200 210
220 230 240 250 260
pF1KB9 VSTPAHAPHMATMNPMHQAALSMAHAH----GLPSHMGCMSDVDADPRD-LEAFAERFKQ
::: . .: :: :: : : : .: :: :: : :: ::..:::
NP_002 ----AHA------GGLHAAA---AHLHPGAGGGGSSVGEHSDEDAPSSDDLEQFAKQFKQ
220 230 240 250 260
270 280 290 300 310 320
pF1KB9 RRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAE
:::::: :::::: ::..: : . .::.::::::.: :: .:: :::.:. ::::..
NP_002 RRIKLGFTQADVGLALGTLY--G-NVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEETD
270 280 290 300 310 320
330 340 350 360 370 380
pF1KB9 KSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKN
.: . .. ..:..::::: . : .::..: :.::...:...:..:.:.:.
NP_002 SSSGSPTNLDKIAAQGRKRKKRTSIEVGVKGALESHFLKCPKPSAHEITGLADSLQLEKE
330 340 350 360 370 380
390 400 410
pF1KB9 VVRVWFCNQRQKQKRMKYSAGI
::::::::.:::.::: .::
NP_002 VVRVWFCNRRQKEKRMTPAAGAGHPPMDDVYAPGELGPGGGGASPPSAPPPPPPAALHHH
390 400 410 420 430 440
410 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 04:27:39 2016 done: Tue Nov 8 04:27:40 2016
Total Scan time: 7.420 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]