Result of FASTA (omim) for
pFN21AB9686
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9686, 199 aa
1>>>pF1KB9686 199 - 199 aa - 199 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3130+/-0.000278; mu= 10.3864+/- 0.018
mean_var=122.0704+/-24.561, 0's: 0 Z-trim(121.7): 69 B-trim: 0 in 0/52
Lambda= 0.116083
statistics sampled from 38551 (38623) to 38551 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.784), E-opt: 0.2 (0.453), width: 16
Scan time: 5.940
The best scores are: opt bits E(85289)
NP_004600 (OMIM: 601010) transcription factor 15 [ ( 199) 1343 234.8 6.9e-62
NP_001073983 (OMIM: 609067) basic helix-loop-helix ( 201) 520 97.0 2.1e-20
XP_006716679 (OMIM: 609067) PREDICTED: basic helix ( 201) 520 97.0 2.1e-20
NP_068808 (OMIM: 602407) heart- and neural crest d ( 217) 254 52.5 5.8e-07
NP_005089 (OMIM: 603628) musculin [Homo sapiens] ( 206) 251 52.0 8e-07
XP_011513798 (OMIM: 101400,123100,180750,601622) P ( 202) 250 51.8 8.8e-07
NP_000465 (OMIM: 101400,123100,180750,601622) twis ( 202) 250 51.8 8.8e-07
XP_005268588 (OMIM: 602406) PREDICTED: heart- and ( 214) 250 51.8 9.2e-07
NP_004812 (OMIM: 602406) heart- and neural crest d ( 215) 250 51.8 9.2e-07
NP_938206 (OMIM: 603306) transcription factor 21 [ ( 179) 237 49.6 3.7e-06
NP_003197 (OMIM: 603306) transcription factor 21 [ ( 179) 237 49.6 3.7e-06
NP_660161 (OMIM: 609875) protein atonal homolog 7 ( 152) 228 48.0 9.2e-06
NP_803238 (OMIM: 608606) class A basic helix-loop- ( 189) 223 47.2 1.9e-05
NP_001277335 (OMIM: 187040,613065) T-cell acute ly ( 172) 221 46.9 2.3e-05
XP_016857682 (OMIM: 187040,613065) PREDICTED: T-ce ( 172) 221 46.9 2.3e-05
NP_003180 (OMIM: 187040,613065) T-cell acute lymph ( 331) 221 47.1 3.7e-05
XP_016857678 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 221 47.1 3.7e-05
NP_001274276 (OMIM: 187040,613065) T-cell acute ly ( 331) 221 47.1 3.7e-05
NP_001277333 (OMIM: 187040,613065) T-cell acute ly ( 331) 221 47.1 3.7e-05
XP_016857677 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 221 47.1 3.7e-05
XP_005271217 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 221 47.1 3.7e-05
NP_001277332 (OMIM: 187040,613065) T-cell acute ly ( 331) 221 47.1 3.7e-05
XP_016857679 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 221 47.1 3.7e-05
XP_016857680 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 221 47.1 3.7e-05
NP_001277334 (OMIM: 187040,613065) T-cell acute ly ( 331) 221 47.1 3.7e-05
XP_016857676 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 221 47.1 3.7e-05
NP_476527 (OMIM: 200110,209885,227260,607556) twis ( 160) 213 45.5 5.5e-05
NP_001258822 (OMIM: 200110,209885,227260,607556) t ( 160) 213 45.5 5.5e-05
XP_016871769 (OMIM: 604882,610370) PREDICTED: neur ( 214) 213 45.6 6.8e-05
NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo ( 214) 213 45.6 6.8e-05
NP_835455 (OMIM: 607194,609069,615935) pancreas tr ( 328) 206 44.6 0.00021
NP_005412 (OMIM: 186855,613065) T-cell acute lymph ( 108) 196 42.5 0.00029
NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapien ( 272) 199 43.4 0.00041
XP_005259969 (OMIM: 151440) PREDICTED: protein lyl ( 206) 195 42.6 0.00053
NP_005574 (OMIM: 151440) protein lyl-1 [Homo sapie ( 280) 195 42.7 0.00066
XP_016882306 (OMIM: 151440) PREDICTED: protein lyl ( 302) 195 42.7 0.0007
XP_016882305 (OMIM: 151440) PREDICTED: protein lyl ( 351) 195 42.8 0.00078
NP_005163 (OMIM: 601461) protein atonal homolog 1 ( 354) 195 42.8 0.00079
NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapien ( 237) 191 42.0 0.00094
NP_001035047 (OMIM: 277300,605195,608681) mesoderm ( 397) 194 42.7 0.00096
NP_005589 (OMIM: 162360) helix-loop-helix protein ( 133) 187 41.1 0.00097
NP_005590 (OMIM: 162361) helix-loop-helix protein ( 135) 183 40.4 0.0016
NP_001104531 (OMIM: 162361) helix-loop-helix prote ( 135) 183 40.4 0.0016
NP_006151 (OMIM: 601725) neurogenic differentiatio ( 382) 187 41.5 0.0021
NP_073565 (OMIM: 611513) neurogenic differentiatio ( 337) 186 41.3 0.0022
NP_061140 (OMIM: 608689) mesoderm posterior protei ( 268) 181 40.3 0.0033
XP_005264216 (OMIM: 609635) PREDICTED: transcripti ( 210) 179 39.9 0.0034
NP_786951 (OMIM: 609635) transcription factor 23 [ ( 214) 179 39.9 0.0035
NP_002491 (OMIM: 125853,601724,606394) neurogenic ( 356) 181 40.4 0.004
NP_001004311 (OMIM: 608697,612310) factor in the g ( 219) 176 39.4 0.005
>>NP_004600 (OMIM: 601010) transcription factor 15 [Homo (199 aa)
initn: 1343 init1: 1343 opt: 1343 Z-score: 1232.1 bits: 234.8 E(85289): 6.9e-62
Smith-Waterman score: 1343; 100.0% identity (100.0% similar) in 199 aa overlap (1-199:1-199)
10 20 30 40 50 60
pF1KB9 MAFALLRPVGAHVLYPDVRLLSEDEENRSESDASDQSFGCCEGPEAARRGPGPGGGRRAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MAFALLRPVGAHVLYPDVRLLSEDEENRSESDASDQSFGCCEGPEAARRGPGPGGGRRAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 GGGGAGPVVVVRQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GGGGAGPVVVVRQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 IAHLANVLLLGDSADDGQPCFRAAGSAKGAVPAAADGGRQPRSICTFCLSNQRKGGGRRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IAHLANVLLLGDSADDGQPCFRAAGSAKGAVPAAADGGRQPRSICTFCLSNQRKGGGRRD
130 140 150 160 170 180
190
pF1KB9 LGGSCLKVRGVAPLRGPRR
:::::::::::::::::::
NP_004 LGGSCLKVRGVAPLRGPRR
190
>>NP_001073983 (OMIM: 609067) basic helix-loop-helix tra (201 aa)
initn: 513 init1: 413 opt: 520 Z-score: 487.1 bits: 97.0 E(85289): 2.1e-20
Smith-Waterman score: 616; 59.3% identity (73.4% similar) in 199 aa overlap (1-180:1-194)
10 20 30 40 50
pF1KB9 MAFALLRPVG-AHVLYPDVRLLSEDEENRSESDASDQSFGC------CEGPEAARRGPGP
:.:: :::. .. :::.: :::::. :.:..::.. : : : ..:::
NP_001 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEK-PCRVHAARC-GLQGARRR---
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 GGGRRAGGGGGAG-PVVVVRQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIE
.::::::::: .: : :::..:::::::::.:::::::::::::::::.::::::::
NP_001 AGGRRAGGGGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIE
60 70 80 90 100 110
120 130 140 150 160
pF1KB9 TLRLASSYIAHLANVLLLGDSADDGQPC------FRAA--GSAKGAVPA--AADG-GRQP
:::::::::.::.:::: :.. ::::: :.:: :: : : :: . ::
NP_001 TLRLASSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPPPPARDGENTQP
120 130 140 150 160 170
170 180 190
pF1KB9 RSICTFCLSNQRKGGGRRDLGGSCLKVRGVAPLRGPRR
..::::::::::: . ::
NP_001 KQICTFCLSNQRKLSKDRDRKTAIRS
180 190 200
>>XP_006716679 (OMIM: 609067) PREDICTED: basic helix-loo (201 aa)
initn: 513 init1: 413 opt: 520 Z-score: 487.1 bits: 97.0 E(85289): 2.1e-20
Smith-Waterman score: 616; 59.3% identity (73.4% similar) in 199 aa overlap (1-180:1-194)
10 20 30 40 50
pF1KB9 MAFALLRPVG-AHVLYPDVRLLSEDEENRSESDASDQSFGC------CEGPEAARRGPGP
:.:: :::. .. :::.: :::::. :.:..::.. : : : ..:::
XP_006 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEK-PCRVHAARC-GLQGARRR---
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 GGGRRAGGGGGAG-PVVVVRQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIE
.::::::::: .: : :::..:::::::::.:::::::::::::::::.::::::::
XP_006 AGGRRAGGGGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIE
60 70 80 90 100 110
120 130 140 150 160
pF1KB9 TLRLASSYIAHLANVLLLGDSADDGQPC------FRAA--GSAKGAVPA--AADG-GRQP
:::::::::.::.:::: :.. ::::: :.:: :: : : :: . ::
XP_006 TLRLASSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPPPPARDGENTQP
120 130 140 150 160 170
170 180 190
pF1KB9 RSICTFCLSNQRKGGGRRDLGGSCLKVRGVAPLRGPRR
..::::::::::: . ::
XP_006 KQICTFCLSNQRKLSKDRDRKTAIRS
180 190 200
>>NP_068808 (OMIM: 602407) heart- and neural crest deriv (217 aa)
initn: 252 init1: 236 opt: 254 Z-score: 245.9 bits: 52.5 E(85289): 5.8e-07
Smith-Waterman score: 254; 42.0% identity (65.5% similar) in 119 aa overlap (30-143:52-169)
10 20 30 40 50
pF1KB9 MAFALLRPVGAHVLYPDVRLLSEDEENRSESDASDQSFGCCEGPEAARRGPGPGGGRRA
: . : :.. .:: : . : .. .
NP_068 AAAAAAAAAAASRCSHEENPYFHGWLIGHPEMSPPDYSMALSYSPEYASGAAGLDHSHYG
30 40 50 60 70 80
60 70 80 90 100 110
pF1KB9 GGGGGAGPVVV-----VRQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETL
: :::: . :..: .:: .:: ::::.:.::. :: ::. :.: :::::.::
NP_068 GVPPGAGPPGLGGPRPVKRRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTL
90 100 110 120 130 140
120 130 140 150 160 170
pF1KB9 RLASSYIAHLANVLLLGDSADDGQPCFRAAGSAKGAVPAAADGGRQPRSICTFCLSNQRK
:::.::::.: ..: :. ... :.:
NP_068 RLATSYIAYLMDLLAKDDQNGEAEA-FKAEIKKTDVKEEKRKKELNEILKSTVSSNDKKT
150 160 170 180 190 200
>>NP_005089 (OMIM: 603628) musculin [Homo sapiens] (206 aa)
initn: 301 init1: 221 opt: 251 Z-score: 243.5 bits: 52.0 E(85289): 8e-07
Smith-Waterman score: 251; 42.6% identity (62.3% similar) in 122 aa overlap (23-137:53-171)
10 20 30 40 50
pF1KB9 MAFALLRPVGAHVLYPDVRLLSEDEENRSESDASDQSFGCCEGPEAARRGPG
. ::.: .. .. :: . . : . :
NP_005 VPASKRPPLRGVERSYASPSDNSSAEEEDPDGEEERCALGTAGSAEGCKR--KRPRVAGG
30 40 50 60 70 80
60 70 80 90 100
pF1KB9 PGGGRRAGGGG-------GAGPVVVVRQRQAANARERDRTQSVNTAFTALRTLIPTEPVD
:.: ::::: :.. ::.::::::: : . .. ::. :.: .: : :
NP_005 GGAGGSAGGGGKKPLPAKGSAAECKQSQRNAANARERARMRVLSKAFSRLKTSLPWVPPD
90 100 110 120 130 140
110 120 130 140 150 160
pF1KB9 RKLSKIETLRLASSYIAHLANVLLLGDSADDGQPCFRAAGSAKGAVPAAADGGRQPRSIC
::::..:::::::::::: . :: : ..:
NP_005 TKLSKLDTLRLASSYIAHLRQ-LLQEDRYENGYVHPVNLTWPFVVSGRPDSDTKEVSAAN
150 160 170 180 190
170 180 190
pF1KB9 TFCLSNQRKGGGRRDLGGSCLKVRGVAPLRGPRR
NP_005 RLCGTTA
200
>>XP_011513798 (OMIM: 101400,123100,180750,601622) PREDI (202 aa)
initn: 225 init1: 172 opt: 250 Z-score: 242.7 bits: 51.8 E(85289): 8.8e-07
Smith-Waterman score: 250; 51.6% identity (66.7% similar) in 93 aa overlap (36-128:77-163)
10 20 30 40 50 60
pF1KB9 LRPVGAHVLYPDVRLLSEDEENRSESDASDQSFGCCEGPEAARRGPGPGGGRRAGGGGGA
.: :: : : : ::: .:::.
XP_011 GGGAGPGGAAGGGVGGGDEPGSPAQGKRGKKSAGCGGGG-----GAGGGGGSSSGGGSPQ
50 60 70 80 90 100
70 80 90 100 110 120
pF1KB9 GPVVVVRQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSYIAHLA
. . :: ::.:::.::::.: ::.::: .::: : : :::::.::.::. :: :
XP_011 SYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLY
110 120 130 140 150 160
130 140 150 160 170 180
pF1KB9 NVLLLGDSADDGQPCFRAAGSAKGAVPAAADGGRQPRSICTFCLSNQRKGGGRRDLGGSC
.::
XP_011 QVLQSDELDSKMASCSYVAHERLSYAFSVWRMEGAWSMSASH
170 180 190 200
>>NP_000465 (OMIM: 101400,123100,180750,601622) twist-re (202 aa)
initn: 225 init1: 172 opt: 250 Z-score: 242.7 bits: 51.8 E(85289): 8.8e-07
Smith-Waterman score: 250; 51.6% identity (66.7% similar) in 93 aa overlap (36-128:77-163)
10 20 30 40 50 60
pF1KB9 LRPVGAHVLYPDVRLLSEDEENRSESDASDQSFGCCEGPEAARRGPGPGGGRRAGGGGGA
.: :: : : : ::: .:::.
NP_000 GGGAGPGGAAGGGVGGGDEPGSPAQGKRGKKSAGCGGGG-----GAGGGGGSSSGGGSPQ
50 60 70 80 90 100
70 80 90 100 110 120
pF1KB9 GPVVVVRQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSYIAHLA
. . :: ::.:::.::::.: ::.::: .::: : : :::::.::.::. :: :
NP_000 SYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLY
110 120 130 140 150 160
130 140 150 160 170 180
pF1KB9 NVLLLGDSADDGQPCFRAAGSAKGAVPAAADGGRQPRSICTFCLSNQRKGGGRRDLGGSC
.::
NP_000 QVLQSDELDSKMASCSYVAHERLSYAFSVWRMEGAWSMSASH
170 180 190 200
>>XP_005268588 (OMIM: 602406) PREDICTED: heart- and neur (214 aa)
initn: 258 init1: 201 opt: 250 Z-score: 242.4 bits: 51.8 E(85289): 9.2e-07
Smith-Waterman score: 250; 43.0% identity (65.3% similar) in 121 aa overlap (43-162:73-176)
20 30 40 50 60 70
pF1KB9 VLYPDVRLLSEDEENRSESDASDQSFGCCEGPEAARRGPGPGGGRRAGGGGGAGPVVVVR
::.: :: . :: . :: : :
XP_005 QSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDAR---PGQSPGRLEALGGRLG-----R
50 60 70 80 90
80 90 100 110 120 130
pF1KB9 QRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSYIAHLANVLLLGD
.. .. .:: ::.:.:.::. :: ::. :.: :::::.:::::.::::.: .:: .
XP_005 RKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVL--AK
100 110 120 130 140 150
140 150 160 170 180 190
pF1KB9 SADDGQP-CFRAAGSAKGAVPAAADGGRQPRSICTFCLSNQRKGGGRRDLGGSCLKVRGV
.:..:.: :.: . :::::. .
XP_005 DAQSGDPEAFKAELKK-------ADGGRESKRKRELQHEGFPPALGPVEKRIKGRTGWPQ
160 170 180 190 200
pF1KB9 APLRGPRR
XP_005 QVWALELNQ
210
>>NP_004812 (OMIM: 602406) heart- and neural crest deriv (215 aa)
initn: 252 init1: 201 opt: 250 Z-score: 242.4 bits: 51.8 E(85289): 9.2e-07
Smith-Waterman score: 250; 43.0% identity (65.3% similar) in 121 aa overlap (43-162:73-176)
20 30 40 50 60 70
pF1KB9 VLYPDVRLLSEDEENRSESDASDQSFGCCEGPEAARRGPGPGGGRRAGGGGGAGPVVVVR
::.: :: . :: . :: : :
NP_004 QSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDAR---PGQSPGRLEALGGRLG-----R
50 60 70 80 90
80 90 100 110 120 130
pF1KB9 QRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSYIAHLANVLLLGD
.. .. .:: ::.:.:.::. :: ::. :.: :::::.:::::.::::.: .:: .
NP_004 RKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVL--AK
100 110 120 130 140 150
140 150 160 170 180 190
pF1KB9 SADDGQP-CFRAAGSAKGAVPAAADGGRQPRSICTFCLSNQRKGGGRRDLGGSCLKVRGV
.:..:.: :.: . :::::. .
NP_004 DAQSGDPEAFKAELKK-------ADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWP
160 170 180 190 200
pF1KB9 APLRGPRR
NP_004 QQVWALELNQ
210
>>NP_938206 (OMIM: 603306) transcription factor 21 [Homo (179 aa)
initn: 208 init1: 208 opt: 237 Z-score: 231.6 bits: 49.6 E(85289): 3.7e-06
Smith-Waterman score: 237; 38.2% identity (64.2% similar) in 123 aa overlap (21-137:25-143)
10 20 30 40 50
pF1KB9 MAFALLRPVGAHVLYPDVRLLSEDEENRSESDASDQSFGCCEGPEAARRGPGPGGG
.. ..: . ......: .: .: :: : :
NP_938 MSTGSLSDVEDLQEVEMLECDGLKMDSNKEFVTSNESTEESSNCENGSPQKGRG---GLG
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 RRAGGGGGAGPVVVVRQ------RQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSK
.: . .:. : : :.::::::: : . .. ::. :.: .: : : ::::
NP_938 KRRKAPTKKSPLSGVSQEGKQVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDTKLSK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 IETLRLASSYIAHLANVLLLGDSADDGQPCFRAAGSAKGAVPAAADGGRQPRSICTFCLS
..:::::::::::: ..: .:. ..:
NP_938 LDTLRLASSYIAHLRQILA-NDKYENGYIHPVNLTWPFMVAGKPESDLKEVVTASRLCGT
120 130 140 150 160 170
199 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 04:48:13 2016 done: Tue Nov 8 04:48:14 2016
Total Scan time: 5.940 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]