Result of FASTA (omim) for
pFN21AB9428
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9428, 518 aa
1>>>pF1KB9428 518 - 518 aa - 518 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.4588+/-0.000462; mu= -13.9519+/- 0.028
mean_var=758.0753+/-172.312, 0's: 0 Z-trim(121.7): 402 B-trim: 2324 in 1/60
Lambda= 0.046582
statistics sampled from 38029 (38698) to 38029 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.771), E-opt: 0.2 (0.454), width: 16
Scan time: 11.930
The best scores are: opt bits E(85289)
NP_006862 (OMIM: 605817) receptor-interacting seri ( 518) 3572 255.8 2.3e-67
NP_065690 (OMIM: 263650,605706) receptor-interacti ( 784) 526 51.3 1.2e-05
NP_003812 (OMIM: 603455) receptor-interacting seri ( 540) 516 50.4 1.6e-05
NP_848605 (OMIM: 608774) ankyrin repeat and protei ( 765) 479 48.1 0.00011
XP_011541039 (OMIM: 608774) PREDICTED: ankyrin rep ( 766) 479 48.1 0.00011
XP_016872964 (OMIM: 608774) PREDICTED: ankyrin rep ( 775) 399 42.8 0.0046
XP_011541038 (OMIM: 608774) PREDICTED: ankyrin rep ( 776) 399 42.8 0.0046
>>NP_006862 (OMIM: 605817) receptor-interacting serine/t (518 aa)
initn: 3572 init1: 3572 opt: 3572 Z-score: 1330.3 bits: 255.8 E(85289): 2.3e-67
Smith-Waterman score: 3572; 100.0% identity (100.0% similar) in 518 aa overlap (1-518:1-518)
10 20 30 40 50 60
pF1KB9 MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA
430 440 450 460 470 480
490 500 510
pF1KB9 PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
::::::::::::::::::::::::::::::::::::::
NP_006 PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
490 500 510
>>NP_065690 (OMIM: 263650,605706) receptor-interacting s (784 aa)
initn: 441 init1: 251 opt: 526 Z-score: 222.1 bits: 51.3 E(85289): 1.2e-05
Smith-Waterman score: 531; 30.8% identity (59.1% similar) in 413 aa overlap (20-416:21-402)
10 20 30 40 50
pF1KB9 MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAIS-
:. . : ::.:::: :....: .: .:.: : ..
NP_065 MEGDGGTPWALALLRTFDAGEFTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDD
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 -------REVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCP
.:.: : ...: . :. ..: .:: ..::.::: :: :. :
NP_065 RERMELLEEAKKMEMAKFRYILPVYGIC------REPV-GLVMEYMETGSLEKLLASE-P
70 80 90 100 110
120 130 140 150 160 170
pF1KB9 RPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQ
:: : :...:...:: .:: . : ::: ::::.:.::: . :::..::::. .: :.
NP_065 LPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSH
120 130 140 150 160 170
180 190 200 210 220
pF1KB9 SGTGSGEPG--GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLV
: : . : ::..:: :: . . .: .: :::::.:..:.::. .. . : ...
NP_065 SHDLSMD-GLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKK-PFADEKNIL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB9 YEAV-CNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQ
. : . .:: : . .: :. . : .::: ::...:. ::.::: .:... .
NP_065 HIMVKVVKGHRPELPPVCRARPR--ACSHLIRLMQRCWQGDPRVRPTFQEITSETEDLCE
240 250 260 270 280
290 300 310 320 330 340
pF1KB9 MVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEW
..... :..:. . : .: ..:. . :: .::
NP_065 KPDDEVKE---TAHDLDVKSPPEPRSEVVPAR---------LKRASAPTFD-NDYSLSEL
290 300 310 320 330
350 360 370 380 390 400
pF1KB9 LNKLNLEEPPSSVPKKCPSLTKRSRAQEE-QVPQAWT----AGTSSDSMAQPPQTPETST
:..:. :.: . . . ::.. : ..:.. . .:.:: . : . . .
NP_065 LSQLD-----SGVSQAVEGPEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLS
340 350 360 370 380 390
410 420 430 440 450 460
pF1KB9 FRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDN
:. . :: .. ::
NP_065 FERE-PSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAG
400 410 420 430 440
>>NP_003812 (OMIM: 603455) receptor-interacting serine/t (540 aa)
initn: 477 init1: 226 opt: 516 Z-score: 220.2 bits: 50.4 E(85289): 1.6e-05
Smith-Waterman score: 516; 32.8% identity (63.4% similar) in 320 aa overlap (14-311:11-320)
10 20 30 40 50
pF1KB9 MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVK-------IVN
: . ..: . . ...:. ::: :.: : .:::: ...
NP_003 MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLD
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 S--KAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKP-ALVTKFMENGSLSGLLQSQC
: : . ::.. . . ..: . :. . .:. ..::..: ::::. ::. .
NP_003 SERKDVLREAEILHKARFSYILPILGICN------EPEFLGIVTEYMPNGSLNELLHRKT
60 70 80 90 100 110
120 130 140 150 160
pF1KB9 PRP---WPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQ
: ::: :.:.:..::. :::...: :::.::: .:.::: :.:::.:::::: ..
NP_003 EYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWR
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB9 --GGSQSGTGSGEP-GGTLGYLAPELFVNVNR-KASTASDVYSFGILMWAVLAGRE-VEL
. ::: .... : :::. :. :: . .. .:: :.::.... : ::. .. :
NP_003 MMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFED
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB9 PTEPSLVYEAVCNRQNRPSLAE--LPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECL
:.: .. .: .. .:: . : :: . : . :.. :...: .:::: .::
NP_003 VTNPLQIMYSV-SQGHRPVINEESLPY---DIPHRARMISLIESGWAQNPDERPSFLKCL
240 250 260 270 280
290 300 310 320 330
pF1KB9 PKTDEVFQMVENN--MNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQH
. . :.. :. ..:... : :... :.
NP_003 IELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCG
290 300 310 320 330 340
340 350 360 370 380 390
pF1KB9 SRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQT
NP_003 SSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFC
350 360 370 380 390 400
>>NP_848605 (OMIM: 608774) ankyrin repeat and protein ki (765 aa)
initn: 487 init1: 181 opt: 479 Z-score: 205.2 bits: 48.1 E(85289): 0.00011
Smith-Waterman score: 479; 31.2% identity (62.5% similar) in 288 aa overlap (14-292:14-294)
10 20 30 40 50
pF1KB9 MSCVKLWPSGAPAPLVSIEELE-NQELVGKGGFGTVFRAQHRKWGYDVAVKI---VNSKA
:. . ...: . .::..:::. ::.:.::.: . :.: . :
NP_848 MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 ISREVKAMASLDNEFV-LRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLL--QSQCPRP
: .:. . .. .... .. . ..: ..: .:: :::: .: .: :
NP_848 ASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPL-GIVMEFMANGSLEKVLSTHSLC---
70 80 90 100 110
120 130 140 150 160 170
pF1KB9 WPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF--QGGSQ
: : :...:. :.: .::. .: ::: ::::.:.::: ..:::..::::: . :. .
NP_848 WKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRM
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 SGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYE
. . : :.:. ::.:.. :. . :::::.:..: .:. .. . ..
NP_848 QYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNMMMIII
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB9 AVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVE
: . :::: . . : . . .::. ::...:: :: : . .:: ......
NP_848 RVAAGM-RPSLQPVSDQWPSEA--QQMVDLMKRCWDQDPKKRPCFLDITIETDILLSLLQ
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB9 NNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNK
.
NP_848 SRVAVPESKALARKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRD
300 310 320 330 340 350
>>XP_011541039 (OMIM: 608774) PREDICTED: ankyrin repeat (766 aa)
initn: 487 init1: 181 opt: 479 Z-score: 205.1 bits: 48.1 E(85289): 0.00011
Smith-Waterman score: 479; 31.2% identity (62.5% similar) in 288 aa overlap (14-292:14-294)
10 20 30 40 50
pF1KB9 MSCVKLWPSGAPAPLVSIEELE-NQELVGKGGFGTVFRAQHRKWGYDVAVKI---VNSKA
:. . ...: . .::..:::. ::.:.::.: . :.: . :
XP_011 MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 ISREVKAMASLDNEFV-LRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLL--QSQCPRP
: .:. . .. .... .. . ..: ..: .:: :::: .: .: :
XP_011 ASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPL-GIVMEFMANGSLEKVLSTHSLC---
70 80 90 100 110
120 130 140 150 160 170
pF1KB9 WPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF--QGGSQ
: : :...:. :.: .::. .: ::: ::::.:.::: ..:::..::::: . :. .
XP_011 WKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRM
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 SGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYE
. . : :.:. ::.:.. :. . :::::.:..: .:. .. . ..
XP_011 QYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNMMMIII
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB9 AVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVE
: . :::: . . : . . .::. ::...:: :: : . .:: ......
XP_011 RVAAGM-RPSLQPVSDQWPSEA--QQMVDLMKRCWDQDPKKRPCFLDITIETDILLSLLQ
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB9 NNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNK
.
XP_011 SRVAVPESKALARKVSCKLSLRQPGEVNEDISQELMDSADSGNYLKRALQLSDRKNLVPR
300 310 320 330 340 350
>>XP_016872964 (OMIM: 608774) PREDICTED: ankyrin repeat (775 aa)
initn: 487 init1: 181 opt: 399 Z-score: 176.0 bits: 42.8 E(85289): 0.0046
Smith-Waterman score: 469; 30.6% identity (61.6% similar) in 297 aa overlap (14-292:14-304)
10 20 30 40 50
pF1KB9 MSCVKLWPSGAPAPLVSIEELE-NQELVGKGGFGTVFRAQHRKWGYDVAVKI---VNSKA
:. . ...: . .::..:::. ::.:.::.: . :.: . :
XP_016 MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 ISREVKAMASLDNEFV-LRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLL--QSQCPRP
: .:. . .. .... .. . ..: ..: .:: :::: .: .: :
XP_016 ASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPL-GIVMEFMANGSLEKVLSTHSLC---
70 80 90 100 110
120 130 140 150 160 170
pF1KB9 WPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF--QGGSQ
: : :...:. :.: .::. .: ::: ::::.:.::: ..:::..::::: . :. .
XP_016 WKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRM
120 130 140 150 160 170
180 190 200 210 220
pF1KB9 SGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGRE------VELPTE
. . : :.:. ::.:.. :. . :::::.:..: .:. .. .: .
XP_016 QYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSELTSQLKER
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB9 PSLVYEAVCNRQN---RPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPK
.. . . : :::: . . : . . .::. ::...:: :: : . .
XP_016 KGFNMMMIIIRVAAGMRPSLQPVSDQWPSEA--QQMVDLMKRCWDQDPKKRPCFLDITIE
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB9 TDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRND
:: .......
XP_016 TDILLSLLQSRVAVPESKALARKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRALQLS
300 310 320 330 340 350
>>XP_011541038 (OMIM: 608774) PREDICTED: ankyrin repeat (776 aa)
initn: 487 init1: 181 opt: 399 Z-score: 176.0 bits: 42.8 E(85289): 0.0046
Smith-Waterman score: 469; 30.6% identity (61.6% similar) in 297 aa overlap (14-292:14-304)
10 20 30 40 50
pF1KB9 MSCVKLWPSGAPAPLVSIEELE-NQELVGKGGFGTVFRAQHRKWGYDVAVKI---VNSKA
:. . ...: . .::..:::. ::.:.::.: . :.: . :
XP_011 MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 ISREVKAMASLDNEFV-LRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLL--QSQCPRP
: .:. . .. .... .. . ..: ..: .:: :::: .: .: :
XP_011 ASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPL-GIVMEFMANGSLEKVLSTHSLC---
70 80 90 100 110
120 130 140 150 160 170
pF1KB9 WPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF--QGGSQ
: : :...:. :.: .::. .: ::: ::::.:.::: ..:::..::::: . :. .
XP_011 WKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRM
120 130 140 150 160 170
180 190 200 210 220
pF1KB9 SGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGRE------VELPTE
. . : :.:. ::.:.. :. . :::::.:..: .:. .. .: .
XP_011 QYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSELTSQLKER
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB9 PSLVYEAVCNRQN---RPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPK
.. . . : :::: . . : . . .::. ::...:: :: : . .
XP_011 KGFNMMMIIIRVAAGMRPSLQPVSDQWPSEA--QQMVDLMKRCWDQDPKKRPCFLDITIE
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB9 TDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRND
:: .......
XP_011 TDILLSLLQSRVAVPESKALARKVSCKLSLRQPGEVNEDISQELMDSADSGNYLKRALQL
300 310 320 330 340 350
518 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 16:05:03 2016 done: Mon Nov 7 16:05:05 2016
Total Scan time: 11.930 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]