Result of FASTA (omim) for
pFN21AB8975
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8975, 371 aa
1>>>pF1KB8975 371 - 371 aa - 371 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.0666+/-0.000347; mu= 6.7305+/- 0.022
mean_var=237.8697+/-49.240, 0's: 0 Z-trim(122.3): 228 B-trim: 687 in 2/57
Lambda= 0.083158
statistics sampled from 39967 (40243) to 39967 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.778), E-opt: 0.2 (0.472), width: 16
Scan time: 9.890
The best scores are: opt bits E(85289)
NP_003308 (OMIM: 118700,188550,600635,610978) home ( 371) 2542 317.4 3.3e-86
NP_001073136 (OMIM: 118700,188550,600635,610978) h ( 401) 2542 317.5 3.5e-86
NP_149416 (OMIM: 607808) homeobox protein Nkx-2.4 ( 354) 882 118.2 2.8e-26
NP_660328 (OMIM: 606727) homeobox protein Nkx-2.3 ( 364) 409 61.5 3.5e-09
NP_001129743 (OMIM: 217095,611770) homeobox protei ( 301) 373 57.1 6.1e-08
NP_002500 (OMIM: 604612) homeobox protein Nkx-2.2 ( 273) 368 56.5 8.7e-08
XP_006723629 (OMIM: 604612) PREDICTED: homeobox pr ( 202) 362 55.6 1.2e-07
NP_055175 (OMIM: 603245) homeobox protein Nkx-2.8 ( 239) 358 55.2 1.8e-07
NP_004378 (OMIM: 108900,187500,217095,225250,60058 ( 324) 334 52.5 1.7e-06
NP_005506 (OMIM: 142994,176450) motor neuron and p ( 401) 319 50.8 6.6e-06
NP_001180 (OMIM: 602183,613330) homeobox protein N ( 333) 300 48.4 2.8e-05
XP_016880046 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 301 48.8 3.8e-05
XP_011523009 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 301 48.8 3.8e-05
XP_016880051 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 301 48.8 3.8e-05
XP_016880050 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 301 48.8 3.8e-05
XP_016880048 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 301 48.8 3.8e-05
XP_016880047 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 301 48.8 3.8e-05
XP_016880052 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 301 48.8 3.8e-05
XP_016880049 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 301 48.8 3.8e-05
NP_001243268 (OMIM: 602041) homeobox protein Nkx-3 ( 159) 283 46.0 7.1e-05
XP_011523023 (OMIM: 142966) PREDICTED: homeobox pr ( 430) 291 47.4 7.1e-05
XP_011523022 (OMIM: 142966) PREDICTED: homeobox pr ( 431) 290 47.3 7.8e-05
XP_006721917 (OMIM: 142966) PREDICTED: homeobox pr ( 431) 290 47.3 7.8e-05
XP_005257334 (OMIM: 142966) PREDICTED: homeobox pr ( 431) 290 47.3 7.8e-05
XP_011523012 (OMIM: 142966) PREDICTED: homeobox pr ( 431) 290 47.3 7.8e-05
XP_011523021 (OMIM: 142966) PREDICTED: homeobox pr ( 431) 290 47.3 7.8e-05
NP_002137 (OMIM: 142966) homeobox protein Hox-B3 i ( 431) 290 47.3 7.8e-05
NP_001158727 (OMIM: 142994,176450) motor neuron an ( 189) 281 45.8 9.5e-05
XP_011523028 (OMIM: 142966) PREDICTED: homeobox pr ( 358) 286 46.7 9.6e-05
NP_001317251 (OMIM: 142966) homeobox protein Hox-B ( 358) 286 46.7 9.6e-05
NP_001317252 (OMIM: 142966) homeobox protein Hox-B ( 299) 284 46.4 0.0001
NP_057254 (OMIM: 604240) T-cell leukemia homeobox ( 284) 282 46.2 0.00011
XP_011523010 (OMIM: 142966) PREDICTED: homeobox pr ( 488) 284 46.7 0.00014
NP_006158 (OMIM: 602041) homeobox protein Nkx-3.1 ( 234) 278 45.6 0.00014
NP_068777 (OMIM: 142995) H2.0-like homeobox protei ( 488) 279 46.1 0.00021
XP_006712540 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 266 44.4 0.00057
NP_008829 (OMIM: 142980) homeobox protein Hox-D3 [ ( 432) 266 44.4 0.00057
XP_005246566 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 266 44.4 0.00057
XP_005246568 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 266 44.4 0.00057
XP_005246570 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 266 44.4 0.00057
XP_011509368 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 266 44.4 0.00057
XP_005246567 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 266 44.4 0.00057
XP_011509367 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 266 44.4 0.00057
NP_066305 (OMIM: 604640) T-cell leukemia homeobox ( 291) 260 43.5 0.00072
NP_000545 (OMIM: 120970,268000,602225,613829) cone ( 299) 256 43.1 0.001
XP_005249788 (OMIM: 142954) PREDICTED: homeobox pr ( 443) 251 42.7 0.002
XP_011513645 (OMIM: 142954) PREDICTED: homeobox pr ( 443) 251 42.7 0.002
XP_005249789 (OMIM: 142954) PREDICTED: homeobox pr ( 443) 251 42.7 0.002
NP_705895 (OMIM: 142954) homeobox protein Hox-A3 i ( 443) 251 42.7 0.002
XP_005249787 (OMIM: 142954) PREDICTED: homeobox pr ( 443) 251 42.7 0.002
>>NP_003308 (OMIM: 118700,188550,600635,610978) homeobox (371 aa)
initn: 2542 init1: 2542 opt: 2542 Z-score: 1668.7 bits: 317.4 E(85289): 3.3e-86
Smith-Waterman score: 2542; 100.0% identity (100.0% similar) in 371 aa overlap (1-371:1-371)
10 20 30 40 50 60
pF1KB8 MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVGH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 HGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 HGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 RFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 KQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 GTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQAAQAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQAAQAA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 AAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTM
310 320 330 340 350 360
370
pF1KB8 SCSTLLYGRTW
:::::::::::
NP_003 SCSTLLYGRTW
370
>>NP_001073136 (OMIM: 118700,188550,600635,610978) homeo (401 aa)
initn: 2542 init1: 2542 opt: 2542 Z-score: 1668.3 bits: 317.5 E(85289): 3.5e-86
Smith-Waterman score: 2542; 100.0% identity (100.0% similar) in 371 aa overlap (1-371:31-401)
10 20 30
pF1KB8 MSMSPKHTTPFSVSDILSPLEESYKKVGME
::::::::::::::::::::::::::::::
NP_001 MWSGGSGKARGWEAAAGGRSSPGRLSRRRIMSMSPKHTTPFSVSDILSPLEESYKKVGME
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB8 GGGLGAPLAAYRQGQAAPPTAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGLGAPLAAYRQGQAAPPTAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGN
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB8 LGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB8 KNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQ
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB8 NHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPC
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB8 QAGAPAPGAASLQGHAQQQAQHQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAGAPAPGAASLQGHAQQQAQHQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDL
310 320 330 340 350 360
340 350 360 370
pF1KB8 AHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW
:::::::::::::::::::::::::::::::::::::::::
NP_001 AHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW
370 380 390 400
>>NP_149416 (OMIM: 607808) homeobox protein Nkx-2.4 [Hom (354 aa)
initn: 953 init1: 470 opt: 882 Z-score: 592.7 bits: 118.2 E(85289): 2.8e-26
Smith-Waterman score: 1207; 54.0% identity (69.3% similar) in 404 aa overlap (1-371:1-354)
10 20 30 40
pF1KB8 MSMSPKHTTPFSVSDILSPLEESYKKVG--MEGG--GLGAPLAAYRQGQAAPP-------
::.::::::::::::::::.::.::: . :.:. ::::::.: .: ::
NP_149 MSLSPKHTTPFSVSDILSPIEETYKKFSGAMDGAPPGLGAPLGAAAAYRAPPPGPSSQAA
10 20 30 40 50 60
50 60 70 80 90
pF1KB8 -TAAMQ-QHAV-GHHGAVTAA-----------YHMTAAGVPQLSHSAVGGYCNGNLGNMS
.:.:: .::. ::..:..:: ::: :: :. :.:.:.::::.::::.
NP_149 TVAGMQPSHAMAGHNAAAAAAAAAAAAAAAATYHMPP-GVSQFPHGAMGSYCNGGLGNMG
70 80 90 100 110
100 110 120 130 140 150
pF1KB8 ELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAP
::: : : ::..:. ::::::::::. .:::::::..:.:..:::.: ...:..:...:
NP_149 ELPAYTDGMRGGAA-TGWYGANPDPRYSSISRFMGPSAGVNVAGMGSLTGIADAAKSLGP
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB8 L-----PSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQ
: .::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 LHAAAAAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQ
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB8 NHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPC
::::::::::::::::: :::. :: : : :::::::::::::::::
NP_149 NHRYKMKRQAKDKAAQQ-LQQE-------GGLGPPPPP---PPSPRRVAVPVLVKDGKPC
240 250 260 270 280
280 290 300 310 320
pF1KB8 QAGA--PAPGAASLQGHAQQQAQHQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSP
: :: :.:: : : :: . .:
NP_149 QNGASTPTPGQA-------------------------------------GPQPPAPTPAP
290 300 310
330 340 350 360 370
pF1KB8 DLAHHAASPAALQGQVSSLSHLNSSGSDY-GTMSCSTLLYGRTW
.: . . :: ::.: ..:. :......: : . ..:::::::
NP_149 ELEELSPSPPALHGPGGGLAALDAAAGEYSGGVLGANLLYGRTW
320 330 340 350
>>NP_660328 (OMIM: 606727) homeobox protein Nkx-2.3 [Hom (364 aa)
initn: 538 init1: 342 opt: 409 Z-score: 285.8 bits: 61.5 E(85289): 3.5e-09
Smith-Waterman score: 523; 38.1% identity (57.6% similar) in 370 aa overlap (1-355:2-336)
10 20 30 40 50
pF1KB8 MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVG
: :: .:::::.:::. ::..... ..:. : : : .. ..:: : : :
NP_660 MMLPSPVTSTPFSVKDILN-LEQQHQH--FHGAHLQADLE--HHFHSAP---CMLAAAEG
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 HHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPP-YQDT-MRNSASGPGWYGAN
. . . : .::. . .:. :. . : : : .:.: : : . .
NP_660 TQFSDGGEEDEEDEG-EKLSYLNSLAAADGH-GDSGLCPQGYVHTVLRDSCSEPKEHEEE
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB8 PDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELE
:. . : . : . ... :. . .. : : . ::: :::::::::.:::
NP_660 PE-----VVRDRSQKSCQLKKSLETAGDCKAAEESERPKPRS-RRKPRVLFSQAQVFELE
120 130 140 150 160
180 190 200 210 220 230
pF1KB8 RRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGG
::::::.:::::::::::: ..:: :::::::::.::: ::: .::. .
NP_660 RRFKQQRYLSAPEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLEL----------
170 180 190 200 210
240 250 260 270 280
pF1KB8 GGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPC-----QA-GAPAPGAASLQGH----AQ
:. : ::::::::::.::::: :: ::: .:: .. :
NP_660 ---GAHAPPPP------PRRVAVPVLVRDGKPCVTPSAQAYGAPYSVGASAYSYNSFPAY
220 230 240 250 260
290 300 310 320 330 340
pF1KB8 QQAQHQAQAAQAAAAAISVGSGGAGLG-AHP-GHQPGSAGQSP-DLAHHAASPAALQGQV
.. : :: ::::: .... ... : :.: : :..: : : . : :: :
NP_660 GYGNSAAAAAAAAAAAAAAAAYSSSYGCAYPAGGGGGGGGTSAATTAMQPACSAAGGGPF
270 280 290 300 310 320
350 360 370
pF1KB8 SSLSHLNSSGSDYGTMSCSTLLYGRTW
..:.:.. ::
NP_660 VNVSNLGGFGSGGSAQPLHQGTAAGAACAQGTLQGIRAW
330 340 350 360
>>NP_001129743 (OMIM: 217095,611770) homeobox protein Nk (301 aa)
initn: 496 init1: 332 opt: 373 Z-score: 263.5 bits: 57.1 E(85289): 6.1e-08
Smith-Waterman score: 498; 36.8% identity (54.1% similar) in 353 aa overlap (1-342:1-297)
10 20 30 40 50 60
pF1KB8 MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVGH
: .:: .:::::.::: ::. :. :: : ... .
NP_001 MLLSPVTSTPFSVKDILR-LERE------------------RSCPAASPHPRVRKSPENF
10 20 30 40
70 80 90 100 110
pF1KB8 HGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELP--PYQDTMRNSASGPGWYGANP
. .: : . :.: :: . .: . :: : : . ... .: : .:
NP_001 Q-----YLRMDAEPRGSEVHNAGGGGGDRKL-DGSEPPGGPCEAVLEMDAERMG----EP
50 60 70 80 90
120 130 140 150 160 170
pF1KB8 DPRFPAISRFMGPASGMNMSGMGGLGSLGD-VSKNMAPLPSA-PRRKRRVLFSQAQVYEL
.: . : : : .: . :.:. :: : . . :.: ::: ::::::::: :
NP_001 QPGLNAAS----PLGGGTRVPERGVGNSGDSVRGGRSEQPKARQRRKPRVLFSQAQVLAL
100 110 120 130 140
180 190 200 210 220 230
pF1KB8 ERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGG
:::::::.:::::::::::: ..:: :::::::::.::: ::: .::. .
NP_001 ERRFKQQRYLSAPEREHLASALQLTSTQVKIWFQNRRYKCKRQRQDKSLEL---------
150 160 170 180 190
240 250 260 270 280 290
pF1KB8 GGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQA
.: : .::::::::::.::::: . :.::: .. . . .. .
NP_001 -----AGHPL-------TPRRVAVPVLVRDGKPCLG--PGPGAPAFPSPYSAAVSPYSCY
200 210 220 230 240
300 310 320 330 340
pF1KB8 AQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAH--HAASP-----AALQGQVSSLSH
. ..: ..: : :: : : . : ..: . :.: :.:::
NP_001 GGYSGAPYGAGYGTCYAGAPSGPAPHTPLASAGFGHGGQNATPQGHLAATLQGVRAW
250 260 270 280 290 300
350 360 370
pF1KB8 LNSSGSDYGTMSCSTLLYGRTW
>>NP_002500 (OMIM: 604612) homeobox protein Nkx-2.2 [Hom (273 aa)
initn: 491 init1: 357 opt: 368 Z-score: 260.8 bits: 56.5 E(85289): 8.7e-08
Smith-Waterman score: 456; 38.9% identity (59.1% similar) in 257 aa overlap (62-303:26-255)
40 50 60 70 80 90
pF1KB8 GGLGAPLAAYRQGQAAPPTAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNL
:.:. . . : :. .. : : .: :
NP_002 MSLTNTKTGFSVKDILDLPDTNDEEGSVAEGPEEENEG-PEPAKRA-GPLGQGAL
10 20 30 40 50
100 110 120 130 140
pF1KB8 GNMSELP---PYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGD
.. :: :. :. : . : ... .. .. . . : .. :. . : .
NP_002 DAVQSLPLKNPFYDSSDNPYT--RWLASTEGLQY-SLHGLAAGAPPQDSSSKSPEPSADE
60 70 80 90 100 110
150 160 170 180 190 200
pF1KB8 VSKNMAPLP-----SAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPT
: : .. .::::::::.::.:::::::.::.::::::::::::.:.::::
NP_002 SPDNDKETPGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPT
120 130 140 150 160 170
210 220 230 240 250 260
pF1KB8 QVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVL
::::::::::::::: .:. . : : ::::::::::
NP_002 QVKIWFQNHRYKMKRARAEKGMEV--------------TPLP--------SPRRVAVPVL
180 190 200
270 280 290 300 310
pF1KB8 VKDGKPCQA-GAPAPGAASLQG------HAQQQAQHQAQAAQAAAAAISVGSGGAGLGAH
:.:::::.: : .::..:. .. :. ::. :: ..:.
NP_002 VRDGKPCHALKAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSASTPQYPTAHPLVQA
210 220 230 240 250 260
320 330 340 350 360 370
pF1KB8 PGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW
NP_002 QQWTW
270
>>XP_006723629 (OMIM: 604612) PREDICTED: homeobox protei (202 aa)
initn: 466 init1: 357 opt: 362 Z-score: 258.4 bits: 55.6 E(85289): 1.2e-07
Smith-Waterman score: 450; 44.7% identity (63.1% similar) in 206 aa overlap (114-303:3-184)
90 100 110 120 130
pF1KB8 GGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRF-PAISRFMGPASG---MNMSG
..:. :.: :.. . : :.: .. :.
XP_006 MIFSATSPPKFSPTL--LHGLAAGAPPQDSSS
10 20 30
140 150 160 170 180 190
pF1KB8 MGGLGSLGDVSKNMAPLP-----SAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHL
. : . : : .. .::::::::.::.:::::::.::.::::::::::
XP_006 KSPEPSADESPDNDKETPGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHL
40 50 60 70 80 90
200 210 220 230 240 250
pF1KB8 ASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQS
::.:.::::::::::::::::::: .:. . : : :
XP_006 ASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEV--------------TPLP--------S
100 110 120
260 270 280 290 300
pF1KB8 PRRVAVPVLVKDGKPCQA-GAPAPGAASLQG------HAQQQAQHQAQAAQAAAAAISVG
::::::::::.:::::.: : .::..:. .. :. ::. :: ..:.
XP_006 PRRVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSASTPQY
130 140 150 160 170 180
310 320 330 340 350 360
pF1KB8 SGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLY
XP_006 PTAHPLVQAQQWTW
190 200
>>NP_055175 (OMIM: 603245) homeobox protein Nkx-2.8 [Hom (239 aa)
initn: 452 init1: 325 opt: 358 Z-score: 255.0 bits: 55.2 E(85289): 1.8e-07
Smith-Waterman score: 446; 39.0% identity (58.3% similar) in 264 aa overlap (82-338:2-233)
60 70 80 90 100 110
pF1KB8 AMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGP
:..: . .. .. .:: ::... :
NP_055 MATSGRLSFTVRSLLDLPE-QDAQHLPRREP
10 20 30
120 130 140 150 160
pF1KB8 GWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAP------RRKRR
. .::: .. : . . :.. : : :. . :..: :.:::
NP_055 EPRAPQPDPCAAWLDSERGHYPSSDESSLE--TSPPDSSQRPSARPASPGSDAEKRKKRR
40 50 60 70 80
170 180 190 200 210 220
pF1KB8 VLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAA
::::.::. ::::::.::.::::::::.:::...::::::::::::::::.:: ::
NP_055 VLFSKAQTLELERRFRQQRYLSAPEREQLASLLRLTPTQVKIWFQNHRYKLKRARAPGAA
90 100 110 120 130 140
230 240 250 260 270 280
pF1KB8 QQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGH
.. :. . .: :::.:::::.::.:: .: :.. . :
NP_055 ESPDLAASA------------ELHAAPGLLRRVVVPVLVRDGQPCGGG----GGGEV-GT
150 160 170 180 190
290 300 310 320 330 340
pF1KB8 AQQQAQHQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSA-GQSPDLAHHAASPAALQGQV
: ::.. : ::: : ..:. :::: : : .: ::::
NP_055 A--AAQEKCGAPPAAACP---------LPGYPAFGPGSALGLFPAY-QHLASPALVSWNW
200 210 220 230
350 360 370
pF1KB8 SSLSHLNSSGSDYGTMSCSTLLYGRTW
>>NP_004378 (OMIM: 108900,187500,217095,225250,600584,61 (324 aa)
initn: 484 init1: 331 opt: 334 Z-score: 237.8 bits: 52.5 E(85289): 1.7e-06
Smith-Waterman score: 474; 35.0% identity (52.9% similar) in 374 aa overlap (1-371:1-324)
10 20 30 40 50
pF1KB8 MSMSPKHT-TPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVG
: :: : :::::.:::. ::.. .... : :.: .. :: . .
NP_004 MFPSPALTPTPFSVKDILN-LEQQQRSLAAAG-----ELSARLEATLAPSSCMLAAFKPE
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 HHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPD
... :: : :.:.: : : . : .: . . : : :
NP_004 AYAGPEAA----APGLPELR--AELGRAPSPAKCASAFPAAPAFYPRAYSDPD---PAKD
60 70 80 90 100
120 130 140 150 160 170
pF1KB8 PRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKR-RVLFSQAQVYELER
:: : .. .. : . . : : : ::.. ::::::::::::::
NP_004 PR----------AEKKELCALQKAVELEKTEADNAERPRARRRRKPRVLFSQAQVYELER
110 120 130 140 150
180 190 200 210 220 230
pF1KB8 RFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGG
:::::.:::::::..:::...:: :::::::::.::: ::: .: : :.
NP_004 RFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQD----QTLEL-------
160 170 180 190 200
240 250 260 270 280 290
pF1KB8 GGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQAAQ
.: : ::.::::::.::::: : :: : . : . . ..: :
NP_004 ---VGLPPPPPPP---ARRIAVPVLVRDGKPCL-GDSAPYAPAY-GVGLNPYGYNAYPAY
210 220 230 240 250
300 310 320 330 340 350
pF1KB8 AAAAAISVGSGGAGLGAHPGHQPGSAGQSPDL-AHHAASPAALQGQVSSLSHLNSSGSDY
. .. . . : . .:.: :: :: : ::. .. :..:. ..: :
NP_004 PGYGGAACSPGYSCTAAYP------AGPSPAQPATAAANNNFVNFGVGDLNAVQSPGIPQ
260 270 280 290 300 310
360 370
pF1KB8 GTMSCSTLLYGRTW
.. . ::: :.:
NP_004 SNSGVSTLHGIRAW
320
>>NP_005506 (OMIM: 142994,176450) motor neuron and pancr (401 aa)
initn: 326 init1: 269 opt: 319 Z-score: 227.0 bits: 50.8 E(85289): 6.6e-06
Smith-Waterman score: 319; 34.9% identity (59.1% similar) in 235 aa overlap (28-249:104-332)
10 20 30 40 50
pF1KB8 MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHA
: ::: :.: . : :: .:: :
NP_005 RAESPSPPRLLAAHCALLPKPGFLGAGGGGGGTGGGHGGPHHHAHPGAAAAAAAAAAAAA
80 90 100 110 120 130
60 70 80 90 100 110
pF1KB8 VGHHG-AVTAAYHMTAAGVPQLSHSAVGG---YCNGNLGNMSELPPYQDTMRNSASGPGW
.: . .. . . .::.: ...:. : : . . . : . .. : : :
NP_005 AGGLALGLHPGGAQGGAGLP--AQAALYGHPVYGYSAAAAAAALAGQHPAL--SYSYPQV
140 150 160 170 180
120 130 140 150 160
pF1KB8 YGANP----DP-RFPAISRFMGPASGMNMSGMGGLGSLGDV-SKNMAPLPSAPRRKRRVL
::.: :: .. : . . . .:: : .. : :. .. : . :: : ..
NP_005 QGAHPAHPADPIKLGAGTFQLDQWLRASTAGMI-LPKMPDFNSQAQSNLLGKCRRPRTAF
190 200 210 220 230 240
170 180 190 200 210 220
pF1KB8 FSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR--QAKDKAA
:: :. :::..:: .:::: :.: ..:. . :: :::::::::.:.: :: .::..::
NP_005 TSQ-QLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKAKEQAA
250 260 270 280 290 300
230 240 250 260 270 280
pF1KB8 QQQLQQDSGGGGGG-GGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQG
:. .: .::::.: ::. : ..
NP_005 QEAEKQKGGGGGAGKGGAEEPGAEELLGPPAPGDKGSGRRLRDLRDSDPEEDEDEDDEDH
310 320 330 340 350 360
371 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 21:26:10 2016 done: Sun Nov 6 21:26:12 2016
Total Scan time: 9.890 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]