Result of FASTA (omim) for
pFN21AB8954
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8954, 330 aa
1>>>pF1KB8954 330 - 330 aa - 330 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.0344+/-0.000377; mu= 2.9305+/- 0.024
mean_var=345.0164+/-70.232, 0's: 0 Z-trim(124.3): 88 B-trim: 1068 in 1/57
Lambda= 0.069049
statistics sampled from 45720 (45850) to 45720 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.829), E-opt: 0.2 (0.538), width: 16
Scan time: 8.790
The best scores are: opt bits E(85289)
NP_059106 (OMIM: 142976,614931) homeobox protein H ( 330) 2320 244.1 3.2e-64
NP_006352 (OMIM: 604607) homeobox protein Hox-B13 ( 284) 848 97.3 4e-20
NP_000514 (OMIM: 113200,113300,142989,186000,18630 ( 343) 814 94.1 4.7e-19
NP_000513 (OMIM: 140000,142959,176305) homeobox pr ( 388) 804 93.1 1e-18
XP_011509370 (OMIM: 113200,113300,142989,186000,18 ( 324) 392 52.0 2e-06
NP_776272 (OMIM: 142975) homeobox protein Hox-C12 ( 282) 282 41.0 0.0037
NP_055027 (OMIM: 605559) homeobox protein Hox-C11 ( 304) 277 40.5 0.0055
NP_067016 (OMIM: 142988) homeobox protein Hox-D12 ( 270) 275 40.2 0.0059
>>NP_059106 (OMIM: 142976,614931) homeobox protein Hox-C (330 aa)
initn: 2320 init1: 2320 opt: 2320 Z-score: 1274.1 bits: 244.1 E(85289): 3.2e-64
Smith-Waterman score: 2320; 100.0% identity (100.0% similar) in 330 aa overlap (1-330:1-330)
10 20 30 40 50 60
pF1KB8 MTTSLLLHPRWPESLMYVYEDSAAESGIGGGGGGGGGGTGGAGGGCSGASPGKAPSMDGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 MTTSLLLHPRWPESLMYVYEDSAAESGIGGGGGGGGGGTGGAGGGCSGASPGKAPSMDGL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 GSSCPASHCRDLLPHPVLGRPPAPLGAPQGAVYTDIPAPEAARQCAPPPAPPTSSSATLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 GSSCPASHCRDLLPHPVLGRPPAPLGAPQGAVYTDIPAPEAARQCAPPPAPPTSSSATLG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 YGYPFGGSYYGCRLSHNVNLQQKPCAYHPGDKYPEPSGALPGDDLSSRAKEFAFYPSFAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 YGYPFGGSYYGCRLSHNVNLQQKPCAYHPGDKYPEPSGALPGDDLSSRAKEFAFYPSFAS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 SYQAMPGYLDVSVVPGISGHPEPRHDALIPVEGYQHWALSNGWDSQVYCSKEQSQSAHLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 SYQAMPGYLDVSVVPGISGHPEPRHDALIPVEGYQHWALSNGWDSQVYCSKEQSQSAHLW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 KSPFPDVVPLQPEVSSYRRGRKKRVPYTKVQLKELEKEYAASKFITKEKRRRISATTNLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 KSPFPDVVPLQPEVSSYRRGRKKRVPYTKVQLKELEKEYAASKFITKEKRRRISATTNLS
250 260 270 280 290 300
310 320 330
pF1KB8 ERQVTIWFQNRRVKEKKVVSKSKAPHLHST
::::::::::::::::::::::::::::::
NP_059 ERQVTIWFQNRRVKEKKVVSKSKAPHLHST
310 320 330
>>NP_006352 (OMIM: 604607) homeobox protein Hox-B13 [Hom (284 aa)
initn: 787 init1: 351 opt: 848 Z-score: 482.3 bits: 97.3 E(85289): 4e-20
Smith-Waterman score: 848; 48.2% identity (71.6% similar) in 282 aa overlap (51-323:3-279)
30 40 50 60 70
pF1KB8 DSAAESGIGGGGGGGGGGTGGAGGGCSGASPGKAPSMDG---LGSSCPASHCRDLLPH-P
::. ..:: . . :. :.:. : :
NP_006 MEPGNYATLDGAKDIEGLLGAGGGRNLVAHSP
10 20 30
80 90 100 110 120 130
pF1KB8 VLGRPPAPLGAPQ-GAVYTDIP-APEAARQCAP-PPAPPTSSSATLGYGYPFGGSYYGCR
. ..: :: : . . :.: . : .:: : : .: .: : . ::: :::.::.::
NP_006 LTSHPAAPTLMPAVNYAPLDLPGSAEPPKQCHPCPGVPQGTSPAPVPYGY-FGGGYYSCR
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB8 LSHNVNLQQKPCAYHPG-DKYPEPSGALPGDDLSSRAKEFAFYPSFASSYQAMPGYLDVS
.:.. . :::: :: . :.. :: ::::::.. ..:: : .:::::
NP_006 VSRS---SLKPCAQAATLAAYPAET-PTAGEEYPSRPTEFAFYPGYPGTYQPMASYLDVS
100 110 120 130 140
200 210 220 230 240 250
pF1KB8 VVPGISGHPEPRHDALIPVEGYQHWALSNGWDSQVYCSKEQSQSAHLWKSPFPDVVPLQP
:: ... :::::.:.::..:: :::..::.::. :. ::. . .::. : : .:
NP_006 VVQTLGAPGEPRHDSLLPVDSYQSWALAGGWNSQMCCQGEQNPPGPFWKAAFADSSGQHP
150 160 170 180 190 200
260 270 280 290 300 310
pF1KB8 -EVSSYRRGRKKRVPYTKVQLKELEKEYAASKFITKEKRRRISATTNLSERQVTIWFQNR
.. ..:::::::.::.: ::.:::.::::.:::::.:::.:::.:.:::::.:::::::
NP_006 PDACAFRRGRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNR
210 220 230 240 250 260
320 330
pF1KB8 RVKEKKVVSKSKAPHLHST
:::::::..: :
NP_006 RVKEKKVLAKVKNSATP
270 280
>>NP_000514 (OMIM: 113200,113300,142989,186000,186300,19 (343 aa)
initn: 888 init1: 392 opt: 814 Z-score: 463.1 bits: 94.1 E(85289): 4.7e-19
Smith-Waterman score: 898; 48.3% identity (70.8% similar) in 329 aa overlap (29-323:16-339)
10 20 30 40 50
pF1KB8 MTTSLLLHPRWPESLMYVYEDSAAESGIGGGGGGGGGGTGG-------AGGGCSG--ASP
:::.::. ..... :.: : : ..:
NP_000 MSRAGSWDMDGLRADGGGAGGAPASSSSSSVAAAAASGQCRGFLSAP
10 20 30 40
60 70 80 90 100
pF1KB8 GKAPSMDGLGSSCPASHCRDLLPHPVLGRPPAP--LGAPQGAVYTDIPA--PEA--ARQC
: . .: ... :. .. : . :. ... . . : ::: :..:
NP_000 VFAGTHSGRAAAAAAAAAAAAAAASGFAYPGTSERTGSSSSSSSSAVVAARPEAPPAKEC
50 60 70 80 90 100
110 120 130 140 150
pF1KB8 -APPPA-----PPTSSSATLGYGYPFGGSYYGCRLSHNVNLQQK-----PCAY---HPGD
:: :: :: :. .::::: ::..::.::.::.:.:::. : : : .
NP_000 PAPTPAAAAAAPP--SAPALGYGYHFGNGYYSCRMSHGVGLQQNALKSSPHASLGGFPVE
110 120 130 140 150 160
160 170 180 190 200
pF1KB8 KYPEPSG----ALPGDDLSSRAKEFAFYPSFASSYQAMPGYLDVSVVPGISGHPEPRHDA
:: . :: ..:.... .:::: .:: ...: :: .:::.:. . : :: ::::.:
NP_000 KYMDVSGLASSSVPANEVPARAKEVSFYQGYTSPYQHVPGYIDMVSTFG-SG--EPRHEA
170 180 190 200 210 220
210 220 230 240 250 260
pF1KB8 LIPVEGYQHWALSNGWDSQVYCSKEQSQSAHLWKSPFP-DVVPLQPEVSSYRRGRKKRVP
: .:::: :.:.:::.:::::.:.: :..:.::: :: ::. ::.. ::::::::::
NP_000 YISMEGYQSWTLANGWNSQVYCTKDQPQGSHFWKSSFPGDVALNQPDMCVYRRGRKKRVP
230 240 250 260 270 280
270 280 290 300 310 320
pF1KB8 YTKVQLKELEKEYAASKFITKEKRRRISATTNLSERQVTIWFQNRRVKEKKVVSKSKAPH
:::.::::::.::: .:::.:.:::::::.::::::::::::::::::.::.::: :
NP_000 YTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTIWFQNRRVKDKKIVSKLKDTV
290 300 310 320 330 340
330
pF1KB8 LHST
NP_000 S
>>NP_000513 (OMIM: 140000,142959,176305) homeobox protei (388 aa)
initn: 941 init1: 585 opt: 804 Z-score: 457.1 bits: 93.1 E(85289): 1e-18
Smith-Waterman score: 907; 48.6% identity (67.1% similar) in 350 aa overlap (22-323:45-385)
10 20 30 40 50
pF1KB8 MTTSLLLHPRWPESLMYVYEDSAAESGIGGGGGGGGGGTGGAGGGCSGASP
.:: .. :.:::: ...:.:: ...
NP_000 TVMFLYDNGGGLVADELNKNMEGAAAAAAAAAAAAAAGAGGGGFPHPAAAAAGGNFSVAA
20 30 40 50 60 70
60 70 80 90
pF1KB8 GKAPSMDGLGSSCPASHCRDLLPHPVLGRP-------PAPLGAPQGAVYTDI--------
. : . .. :..::.:. ::. : :: :: .:. .
NP_000 AAAAA-----AAAAANQCRNLMAHPAPLAPGAASAYSSAPGEAPPSAAAAAAAAAAAAAA
80 90 100 110 120
100 110 120 130
pF1KB8 ---------PAP------EAARQCAPPPAPPTSSS--ATLGYGYPFGGSYYGC-RLSHNV
:.: :::.::.: : ::: :.: ::: ::..:: : :.. .
NP_000 AAAASSSGGPGPAGPAGAEAAKQCSPCSAAAQSSSGPAALPYGY-FGSGYYPCARMGPHP
130 140 150 160 170 180
140 150 160 170 180
pF1KB8 NLQQKPCAYHPG---------DKYPEPSGALPGDDLSSRAKEFAFY-PSFASS----YQA
: : :: .:. ::: . .: ....:::::::::: ..:.. .:
NP_000 N-AIKSCA-QPASAAAAAAFADKYMDTAGP-AAEEFSSRAKEFAFYHQGYAAGPYHHHQP
190 200 210 220 230 240
190 200 210 220 230 240
pF1KB8 MPGYLDVSVVPGISGHPEPRHDAL-IPVEGYQHWALSNGWDSQVYCSKEQSQSAHLWKSP
::::::. ::::..: : ::. : .:.:.:: ::: :::..:.:: :::.: :::::
NP_000 MPGYLDMPVVPGLGGPGESRHEPLGLPMESYQPWALPNGWNGQMYCPKEQAQPPHLWKST
250 260 270 280 290 300
250 260 270 280 290 300
pF1KB8 FPDVVPLQPEVSSYRRGRKKRVPYTKVQLKELEKEYAASKFITKEKRRRISATTNLSERQ
.:::: ..::::::::::::::::::::::.:::..:::::.:::::::::::::::
NP_000 LPDVVSHPSDASSYRRGRKKRVPYTKVQLKELEREYATNKFITKDKRRRISATTNLSERQ
310 320 330 340 350 360
310 320 330
pF1KB8 VTIWFQNRRVKEKKVVSKSKAPHLHST
:::::::::::::::..: :
NP_000 VTIWFQNRRVKEKKVINKLKTTS
370 380
>>XP_011509370 (OMIM: 113200,113300,142989,186000,186300 (324 aa)
initn: 454 init1: 392 opt: 392 Z-score: 236.2 bits: 52.0 E(85289): 2e-06
Smith-Waterman score: 422; 36.3% identity (54.3% similar) in 289 aa overlap (41-323:63-320)
20 30 40 50 60 70
pF1KB8 WPESLMYVYEDSAAESGIGGGGGGGGGGTGGAGGGCSGASPGKAPSMDGLGSSCPASHCR
::.: :::. . :.. . ::
XP_011 SLALLLRGGLRAIGADNLRSRLGTHACSRAGAAG-CSGTVGPRKPGLRASGS--------
40 50 60 70 80
80 90 100 110 120
pF1KB8 DLLPHPVLGRPPAPLGAPQGAV-YTDIPAPEAARQCAPPPAPP--TSSSATLGYGYPFGG
: . : . .. .: . . . : .. : . ::: . : ::
XP_011 --LSSGEVRFPRVQVSLHKGRLRFRALGRPASSSLSLPGLSGCFCLSSSHSRRNPAPHGG
90 100 110 120 130 140
130 140 150 160 170 180
pF1KB8 SYYGCRLSHNVNLQQKPCAYHPGDKYPEPS---GALPGDDLSSRAKEFAFYPSFASSYQA
. : .. . : . : :: : : : . . :.. : : .:. .
XP_011 RSW-CGSWGILSSWARSTQTHRLPRVPVPSDATGKLAGTSSARRGELRAAGP--GSGAEH
150 160 170 180 190
190 200 210 220 230 240
pF1KB8 MPGYLDVSVVPGISGHPEPRHDALIPVEGYQHWALSNGWDSQVYCSKEQSQSAHLWKSPF
:. ..:. : . :: : .::. . .:: :. : .
XP_011 CPSA-SLSAPPFVLGHFPHLHPFALPVRTMWIPHRDNG-----LCGME-----------I
200 210 220 230 240
250 260 270 280 290 300
pF1KB8 PDVVPLQPEVSSYRRGRKKRVPYTKVQLKELEKEYAASKFITKEKRRRISATTNLSERQV
::. ::.. :::::::::::::.::::::.::: .:::.:.:::::::.::::::::
XP_011 GDVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQV
250 260 270 280 290 300
310 320 330
pF1KB8 TIWFQNRRVKEKKVVSKSKAPHLHST
::::::::::.::.::: :
XP_011 TIWFQNRRVKDKKIVSKLKDTVS
310 320
>>NP_776272 (OMIM: 142975) homeobox protein Hox-C12 [Hom (282 aa)
initn: 448 init1: 241 opt: 282 Z-score: 177.6 bits: 41.0 E(85289): 0.0037
Smith-Waterman score: 282; 30.2% identity (53.7% similar) in 255 aa overlap (81-324:37-278)
60 70 80 90 100
pF1KB8 PGKAPSMDGLGSSCPASHCRDLLPHPVLGRPPAP-LGAPQGAVYTDIPAPEAARQCAPPP
: : :. :. .. : .:. : :
NP_776 LNPGFVGPLVNIHTGDTFYFPNFRASGAQLPGLPSLSYPRRDNVCSLSWP-SAEPCNGYP
10 20 30 40 50 60
110 120 130 140 150 160
pF1KB8 APPTSSSATLGYGYPFGGSYYGCRLSHNVNLQQKPCAYHPGDKYP-EPSGALPGDDLSSR
: .: ..:. ::: . :. . . ..::: : : : :: ..
NP_776 QPYLGSPVSLNP--PFGRTCELARVEDGKGYYREPCAEGGGGGLKREERGRDPGAGPGA-
70 80 90 100 110 120
170 180 190 200 210 220
pF1KB8 AKEFAFYPSFASSYQAMPGYLDVSVVPGIS---GHPEPRHD--ALIPVEGYQHWALSNGW
:. : :. :. : .. : . : : :: . .:. . .: :
NP_776 ----ALLPLEPSGPPALGFKYDYAAGGGGGDGGGGAGPPHDPPSCQSLESDSSSSLLNEG
130 140 150 160 170
230 240 250 260 270
pF1KB8 DSQVYCSKEQSQSAHLWKSPFPDV----VPLQPEVSSYRRGRKKRVPYTKVQLKELEKEY
.. . . : . : .: . .: : ..: :.:::: ::.:.:: ::: :.
NP_776 NKGAGAGDPGSLVSPL--NPGGGLSASGAPWYP-INS--RSRKKRKPYSKLQLAELEGEF
180 190 200 210 220 230
280 290 300 310 320 330
pF1KB8 AASKFITKEKRRRISATTNLSERQVTIWFQNRRVKEKKVVSKSKAPHLHST
...:::...::..: :::..:: :::::::.:.:... . .:
NP_776 LVNEFITRQRRRELSDRLNLSDQQVKIWFQNRRMKKKRLLLREQALSFF
240 250 260 270 280
>>NP_055027 (OMIM: 605559) homeobox protein Hox-C11 [Hom (304 aa)
initn: 324 init1: 235 opt: 277 Z-score: 174.6 bits: 40.5 E(85289): 0.0055
Smith-Waterman score: 282; 30.8% identity (53.0% similar) in 247 aa overlap (99-318:52-290)
70 80 90 100 110 120
pF1KB8 CRDLLPHPVLGRPPAPLGAPQGAVYTDIPAPEA-ARQCAPPPAPPTSSSATLGYGY-PFG
:.: .:: . : . . ..:: : :
NP_055 FGERGSCASNLYLPSCTYYMPEFSTVSSFLPQAPSRQISYPYSAQVPPVREVSYGLEPSG
30 40 50 60 70 80
130 140 150 160
pF1KB8 -----GSYYGCRLSHNVNLQQKPC--------------AYHPGDKYPEPSGALPGDDLSS
.:: .: . . .:... : . . : ..: : :. ::
NP_055 KWHHRNSYSSCYAAAD-ELMHRECLPPSTVTEILMKNEGSYGGHHHPSAPHATPAGFYSS
90 100 110 120 130 140
170 180 190 200 210 220
pF1KB8 RAKEFAFYPSFASSYQ-AMPGYLDVSVVPGISGHPEPRHDALIP-VEGYQHWALSNGWDS
:. .. .: .. :. : : . : ::. : . . : . : : : ..
NP_055 VNKNSVLPQAFDRFFDNAYCGGGDPPAEPPCSGKGEAKGEPEAPPASGLASRA-EAGAEA
150 160 170 180 190
230 240 250 260 270 280
pF1KB8 QVY---CSKEQSQSAH-LWKSPFPDVVPLQPEVSSYRRGRKKRVPYTKVQLKELEKEYAA
.. . .: ::: . : : ..: : : :::: ::.: :..:::.:.
NP_055 EAEEENTNPSSSGSAHSVAKEPAKGAAPNAP------RTRKKRCPYSKFQIRELEREFFF
200 210 220 230 240 250
290 300 310 320 330
pF1KB8 SKFITKEKRRRISATTNLSERQVTIWFQNRRVKEKKVVSKSKAPHLHST
. .:.:::: ..: ::..::: :::::::.::::.
NP_055 NVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLSRDRLQYFSGNPLL
260 270 280 290 300
>>NP_067016 (OMIM: 142988) homeobox protein Hox-D12 [Hom (270 aa)
initn: 321 init1: 242 opt: 275 Z-score: 174.1 bits: 40.2 E(85289): 0.0059
Smith-Waterman score: 293; 29.4% identity (56.9% similar) in 255 aa overlap (84-328:41-270)
60 70 80 90 100 110
pF1KB8 APSMDGLGSSCPASHCRDLLPHPVLGRPPAPLGAPQGAVYTDIPAPEAARQCAPPPAPPT
:.. :.:: .: . .::: : :.
NP_067 YVGSLLNLQSPDSFYFSNLRPNGGQLAALPPISYPRGA----LPWAATPASCAP--AQPA
20 30 40 50 60
120 130 140 150 160 170
pF1KB8 SSSATLGYGYPFGGSYYGCRLSHNVNLQQKPCAYHPGD--KYPEPSGALPGDDLSSRAKE
...: :.. :. .. : ..:: : . :. : .: : . .:..
NP_067 GATAFGGFSQPYLAG------SGPLGLQPPTAKDGPEEQAKFYAPEAA-AGPEERGRTR-
70 80 90 100 110
180 190 200 210 220
pF1KB8 FAFYPSFASSYQAMPGYLDVSVVP----GISGHPEPRHDALI---P-VEGYQHWALSNGW
:::: . :. .... :. :. : .:. : . :.. ..:
NP_067 ----PSFAPESSLAPAVAALKAAKYDYAGV-GRATPGSTTLLQGAPCAPGFKD--DTKG-
120 130 140 150 160
230 240 250 260 270 280
pF1KB8 DSQVYCSKEQSQSAHLWKSPFPDVVPLQPEVSSYRRGRKKRVPYTKVQLKELEKEYAASK
.. . . . : . .:: .: .. :.:::: :::: :. :::.:. ...
NP_067 PLNLNMTVQAAGVASCLRPSLPDGLPWG---AAPGRARKKRKPYTKQQIAELENEFLVNE
170 180 190 200 210 220
290 300 310 320 330
pF1KB8 FITKEKRRRISATTNLSERQVTIWFQNRRVKEKKVVSKSKAPHLHST
::...::...: :::..:: :::::::.:.:.:: . .: :.
NP_067 FINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKRVVLREQALALY
230 240 250 260 270
330 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 04:23:21 2016 done: Tue Nov 8 04:23:22 2016
Total Scan time: 8.790 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]