Result of FASTA (omim) for
pFN21AB8898
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8898, 232 aa
1>>>pF1KB8898 232 - 232 aa - 232 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.3904+/-0.000367; mu= 0.6704+/- 0.023
mean_var=391.4021+/-80.234, 0's: 0 Z-trim(125.9): 112 B-trim: 877 in 2/58
Lambda= 0.064828
statistics sampled from 50453 (50585) to 50453 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.852), E-opt: 0.2 (0.593), width: 16
Scan time: 7.160
The best scores are: opt bits E(85289)
NP_114150 (OMIM: 609852) homeobox protein MIXL1 is ( 232) 1595 161.6 1e-39
NP_001269331 (OMIM: 609852) homeobox protein MIXL1 ( 240) 1569 159.2 5.6e-39
NP_001306003 (OMIM: 605726,610362,610381,613757) r ( 230) 351 45.3 0.00011
NP_038463 (OMIM: 601881,611038) retinal homeobox p ( 346) 326 43.2 0.00069
NP_852126 (OMIM: 122880,148820,193500,268220,60659 ( 403) 301 40.9 0.0038
NP_852125 (OMIM: 122880,148820,193500,268220,60659 ( 407) 301 40.9 0.0039
NP_006252 (OMIM: 262600,601538) homeobox protein p ( 226) 294 39.9 0.0042
NP_852122 (OMIM: 122880,148820,193500,268220,60659 ( 479) 301 41.0 0.0043
NP_116142 (OMIM: 605726,610362,610381,613757) reti ( 184) 292 39.6 0.0043
NP_001120838 (OMIM: 122880,148820,193500,268220,60 ( 483) 301 41.0 0.0043
NP_852123 (OMIM: 122880,148820,193500,268220,60659 ( 484) 301 41.0 0.0043
NP_852124 (OMIM: 122880,148820,193500,268220,60659 ( 505) 301 41.0 0.0044
NP_006483 (OMIM: 136760,606014) homeobox protein a ( 343) 286 39.4 0.0092
NP_115485 (OMIM: 604529) homeobox protein orthoped ( 325) 285 39.3 0.0095
XP_016883326 (OMIM: 122000,148300,605020,614195) P ( 280) 283 39.0 0.0099
>>NP_114150 (OMIM: 609852) homeobox protein MIXL1 isofor (232 aa)
initn: 1595 init1: 1595 opt: 1595 Z-score: 834.1 bits: 161.6 E(85289): 1e-39
Smith-Waterman score: 1595; 100.0% identity (100.0% similar) in 232 aa overlap (1-232:1-232)
10 20 30 40 50 60
pF1KB8 MATAESRALQFAEGAAFPAYRAPHAGGALLPPPSPAAALLPAPPAGPGPATFAGFLGRDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 MATAESRALQFAEGAAFPAYRAPHAGGALLPPPSPAAALLPAPPAGPGPATFAGFLGRDP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 GPAPPPPASLGSPAPPKGAAAPSASQRRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 GPAPPPPASLGSPAPPKGAAAPSASQRRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ALTLLPESRIQVWFQNRRAKSRRQSGKSFQPLARPEIILNHCAPGTETKCLKPQLPLEVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 ALTLLPESRIQVWFQNRRAKSRRQSGKSFQPLARPEIILNHCAPGTETKCLKPQLPLEVD
130 140 150 160 170 180
190 200 210 220 230
pF1KB8 VNCLPEPNGVGGGISDSSSQGQNFETCSPLSEDIGSKLDSWEEHIFSAFGNF
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 VNCLPEPNGVGGGISDSSSQGQNFETCSPLSEDIGSKLDSWEEHIFSAFGNF
190 200 210 220 230
>>NP_001269331 (OMIM: 609852) homeobox protein MIXL1 iso (240 aa)
initn: 1058 init1: 891 opt: 1569 Z-score: 820.8 bits: 159.2 E(85289): 5.6e-39
Smith-Waterman score: 1569; 96.7% identity (96.7% similar) in 240 aa overlap (1-232:1-240)
10 20 30 40 50 60
pF1KB8 MATAESRALQFAEGAAFPAYRAPHAGGALLPPPSPAAALLPAPPAGPGPATFAGFLGRDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MATAESRALQFAEGAAFPAYRAPHAGGALLPPPSPAAALLPAPPAGPGPATFAGFLGRDP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 GPAPPPPASLGSPAPPKGAAAPSASQRRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPAPPPPASLGSPAPPKGAAAPSASQRRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLA
70 80 90 100 110 120
130 140 150 160 170
pF1KB8 ALTLLPESRIQ--------VWFQNRRAKSRRQSGKSFQPLARPEIILNHCAPGTETKCLK
::::::::::: :::::::::::::::::::::::::::::::::::::::::
NP_001 ALTLLPESRIQLLFSPLFQVWFQNRRAKSRRQSGKSFQPLARPEIILNHCAPGTETKCLK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB8 PQLPLEVDVNCLPEPNGVGGGISDSSSQGQNFETCSPLSEDIGSKLDSWEEHIFSAFGNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQLPLEVDVNCLPEPNGVGGGISDSSSQGQNFETCSPLSEDIGSKLDSWEEHIFSAFGNF
190 200 210 220 230 240
>>NP_001306003 (OMIM: 605726,610362,610381,613757) retin (230 aa)
initn: 308 init1: 256 opt: 351 Z-score: 205.3 bits: 45.3 E(85289): 0.00011
Smith-Waterman score: 351; 40.4% identity (60.6% similar) in 193 aa overlap (13-197:6-191)
10 20 30 40 50
pF1KB8 MATAESRALQFAEGAAFP-AYRAPHAGGALLPPPSPAAALLPAPPAGPGPATFAGFLGRD
::. :: : : .. :: : .: :. .::. : :. .: . .
NP_001 MPAPVEGTDFPGAGRQAWGSPALSLPVAPPAV---SPPSVPLPSHQVGAMFLS
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 PGPAPPPPASLGSPAPPKGAAAPSASQRRKRTSFSAEQLQLLELVFRRTRYPDIHLRERL
:: . ::. :. : : ::. ..::.::.:.. ::. :: .:. ..:::.. ::.:
NP_001 PGEG---PATEGGGLGP-GEEAPKKKHRRNRTTFTTYQLHQLERAFEASHYPDVYSREEL
60 70 80 90 100
120 130 140 150 160 170
pF1KB8 AALTLLPESRIQVWFQNRRAKSRRQ----SGKSFQPLAR-PEI-ILNHCAPGTETKCLKP
:: . ::: :.:::::::::: ::: ::.. : :: : : . . :.:
NP_001 AAKVHLPEVRVQVWFQNRRAKWRRQERLESGSGAVAAPRLPEAPALPFARPPAMSLPLEP
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB8 QL-PLEVDVNCLPEPNGVGGGISDSSSQGQNFETCSPLSEDIGSKLDSWEEHIFSAFGNF
: : : ::. : : :.. :
NP_001 WLGPGPPAVPGLPRLLGPGPGLQASFGPHAFAPTFADGFALEEASLRLLAKEHAQALDRA
170 180 190 200 210 220
>>NP_038463 (OMIM: 601881,611038) retinal homeobox prote (346 aa)
initn: 251 init1: 251 opt: 326 Z-score: 190.8 bits: 43.2 E(85289): 0.00069
Smith-Waterman score: 326; 40.9% identity (63.1% similar) in 149 aa overlap (4-144:60-194)
10 20 30
pF1KB8 MATAESRALQFAEGAAFPAYRAPHAGGALLPPP
:. : ... : : .::. :. :::
NP_038 SRLHSIEAILGFTKDDGILGTFPAERGARGAKERDRRLGARPACP--KAPEEGSEPSPPP
30 40 50 60 70 80
40 50 60 70 80
pF1KB8 SPAAALLPAPP-AGPGPATFAGFLGRDPGPAPPPPASLGSPAPPKGAAA-------PSAS
.:: ::: .: : . ..:: : : : : :. : . : :. .
NP_038 APA----PAPEYEAPRP-----YCPKEPGEARPSP---GLPVGPATGEAKLSEEEQPKKK
90 100 110 120 130
90 100 110 120 130 140
pF1KB8 QRRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIQVWFQNRRAKSRRQS
.::.::.:.. ::. :: .:....:::.. ::.::. . ::: :.:::::::::: :::
NP_038 HRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQE
140 150 160 170 180 190
150 160 170 180 190 200
pF1KB8 GKSFQPLARPEIILNHCAPGTETKCLKPQLPLEVDVNCLPEPNGVGGGISDSSSQGQNFE
NP_038 KLEVSSMKLQDSPLLSFSRSPPSATLSPLGAGPGSGGGPAGGALPLESWLGPPLPGGGAT
200 210 220 230 240 250
>>NP_852126 (OMIM: 122880,148820,193500,268220,606597) p (403 aa)
initn: 302 init1: 251 opt: 301 Z-score: 177.4 bits: 40.9 E(85289): 0.0038
Smith-Waterman score: 301; 40.1% identity (62.8% similar) in 137 aa overlap (63-199:196-326)
40 50 60 70 80 90
pF1KB8 PSPAAALLPAPPAGPGPATFAGFLGRDPGPAPPPPASLGSPAPPKGAAAPSASQRRKRTS
: : .. :: . . .:::.::.
NP_852 EEEEADLERKEAEESEKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTT
170 180 190 200 210 220
100 110 120 130 140 150
pF1KB8 FSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIQVWFQNRRAKSRRQSGKSFQPL
:.::::. :: .:.::.::::. ::.:: . : :.:.::::.::::. :.:.: . : .
NP_852 FTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGAN-QLM
230 240 250 260 270 280
160 170 180 190 200 210
pF1KB8 ARPEIILNHCAPGTETKCLKPQLPLEVDVNCLPEPNGVGGGISDSSSQGQNFETCSPLSE
: .:: :: : :: . .:... ..:: ::
NP_852 A-----FNHLIPGGFPPTAMPTLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQPLPPSTV
290 300 310 320 330
220 230
pF1KB8 DIGSKLDSWEEHIFSAFGNF
NP_852 HQSTIPSNPDSSSAYCLPSTRHGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQVPFIISSQ
340 350 360 370 380 390
>>NP_852125 (OMIM: 122880,148820,193500,268220,606597) p (407 aa)
initn: 302 init1: 251 opt: 301 Z-score: 177.4 bits: 40.9 E(85289): 0.0039
Smith-Waterman score: 301; 40.1% identity (62.8% similar) in 137 aa overlap (63-199:196-326)
40 50 60 70 80 90
pF1KB8 PSPAAALLPAPPAGPGPATFAGFLGRDPGPAPPPPASLGSPAPPKGAAAPSASQRRKRTS
: : .. :: . . .:::.::.
NP_852 EEEEADLERKEAEESEKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTT
170 180 190 200 210 220
100 110 120 130 140 150
pF1KB8 FSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIQVWFQNRRAKSRRQSGKSFQPL
:.::::. :: .:.::.::::. ::.:: . : :.:.::::.::::. :.:.: . : .
NP_852 FTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGAN-QLM
230 240 250 260 270 280
160 170 180 190 200 210
pF1KB8 ARPEIILNHCAPGTETKCLKPQLPLEVDVNCLPEPNGVGGGISDSSSQGQNFETCSPLSE
: .:: :: : :: . .:... ..:: ::
NP_852 A-----FNHLIPGGFPPTAMPTLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQPLPPSTV
290 300 310 320 330
220 230
pF1KB8 DIGSKLDSWEEHIFSAFGNF
NP_852 HQSTIPSNPDSSSAYCLPSTRHGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQVPFIISSQ
340 350 360 370 380 390
>>NP_006252 (OMIM: 262600,601538) homeobox protein proph (226 aa)
initn: 254 init1: 254 opt: 294 Z-score: 176.6 bits: 39.9 E(85289): 0.0042
Smith-Waterman score: 294; 38.4% identity (56.2% similar) in 185 aa overlap (37-213:19-193)
10 20 30 40 50 60
pF1KB8 RALQFAEGAAFPAYRAPHAGGALLPPPSPAAALLPA-PPAGPGPATFAGFLGRDPGPAPP
..::: :: :.: . . :::
NP_006 MEAERRRQAEKPKKGRVGSSLLPERHPATGTPTTTVD------SSAPP
10 20 30 40
70 80 90 100 110
pF1KB8 ----PPASLGSP--APPKGAAAPSASQRRKRTSFSAEQLQLLELVFRRTRYPDIHLRERL
: :. : .: : . :.::.::.:: ::. :: .: :..:::: :: :
NP_006 CRRLPGAGGGRSRFSPQGGQRGRPHSRRRHRTTFSPVQLEQLESAFGRNQYPDIWARESL
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB8 AALTLLPESRIQVWFQNRRAKSRRQSGKSFQPLAR-PEIILNHCAPGTETKCLKPQLPLE
: : : :.::::::::::::.:.: . .::::. .. : . : :
NP_006 ARDTGLSEARIQVWFQNRRAKQRKQERSLLQPLAHLSPAAFSSFLPES-TACPYSYAAPP
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB8 VDVNCLPEPNGVGGGISDSSSQGQNFETCSPLSEDIGSKLDSWEEHIFSAFGNF
:.:.:.: . .. .. : : : . : :::
NP_006 PPVTCFPHP--YSHALPSQPSTGGAF-ALSHQSEDWYPTLHPAPAGHLPCPPPPPMLPLS
170 180 190 200 210
NP_006 LEPSKSWN
220
>>NP_852122 (OMIM: 122880,148820,193500,268220,606597) p (479 aa)
initn: 302 init1: 251 opt: 301 Z-score: 176.6 bits: 41.0 E(85289): 0.0043
Smith-Waterman score: 301; 40.1% identity (62.8% similar) in 137 aa overlap (63-199:196-326)
40 50 60 70 80 90
pF1KB8 PSPAAALLPAPPAGPGPATFAGFLGRDPGPAPPPPASLGSPAPPKGAAAPSASQRRKRTS
: : .. :: . . .:::.::.
NP_852 EEEEADLERKEAEESEKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTT
170 180 190 200 210 220
100 110 120 130 140 150
pF1KB8 FSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIQVWFQNRRAKSRRQSGKSFQPL
:.::::. :: .:.::.::::. ::.:: . : :.:.::::.::::. :.:.: . : .
NP_852 FTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGAN-QLM
230 240 250 260 270 280
160 170 180 190 200 210
pF1KB8 ARPEIILNHCAPGTETKCLKPQLPLEVDVNCLPEPNGVGGGISDSSSQGQNFETCSPLSE
: .:: :: : :: . .:... ..:: ::
NP_852 A-----FNHLIPGGFPPTAMPTLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQPLPPSTV
290 300 310 320 330
220 230
pF1KB8 DIGSKLDSWEEHIFSAFGNF
NP_852 HQSTIPSNPDSSSAYCLPSTRHGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQVMGLLTNH
340 350 360 370 380 390
>>NP_116142 (OMIM: 605726,610362,610381,613757) retina a (184 aa)
initn: 291 init1: 256 opt: 292 Z-score: 176.6 bits: 39.6 E(85289): 0.0043
Smith-Waterman score: 292; 42.8% identity (62.1% similar) in 145 aa overlap (60-197:5-145)
30 40 50 60 70 80
pF1KB8 LPPPSPAAALLPAPPAGPGPATFAGFLGRDPGPAPPPPASLGSPAPPKGAAAPSASQRRK
:: .: :. :. : : ::. ..::.
NP_116 MFLSPGEGP---ATEGGGLGP-GEEAPKKKHRRN
10 20 30
90 100 110 120 130 140
pF1KB8 RTSFSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIQVWFQNRRAKSRRQ----S
::.:.. ::. :: .:. ..:::.. ::.::: . ::: :.:::::::::: ::: :
NP_116 RTTFTTYQLHQLERAFEASHYPDVYSREELAAKVHLPEVRVQVWFQNRRAKWRRQERLES
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB8 GKSFQPLAR-PEI-ILNHCAPGTETKCLKPQL-PLEVDVNCLPEPNGVGGGISDSSSQGQ
:.. : :: : : . . :.: : : : ::. : : :.. :
NP_116 GSGAVAAPRLPEAPALPFARPPAMSLPLEPWLGPGPPAVPGLPRLLGPGPGLQASFGPHA
100 110 120 130 140 150
210 220 230
pF1KB8 NFETCSPLSEDIGSKLDSWEEHIFSAFGNF
NP_116 FAPTFADGFALEEASLRLLAKEHAQALDRAWPPA
160 170 180
>>NP_001120838 (OMIM: 122880,148820,193500,268220,606597 (483 aa)
initn: 302 init1: 251 opt: 301 Z-score: 176.5 bits: 41.0 E(85289): 0.0043
Smith-Waterman score: 301; 40.1% identity (62.8% similar) in 137 aa overlap (63-199:195-325)
40 50 60 70 80 90
pF1KB8 PSPAAALLPAPPAGPGPATFAGFLGRDPGPAPPPPASLGSPAPPKGAAAPSASQRRKRTS
: : .. :: . . .:::.::.
NP_001 EEEEADLERKEAEESEKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTT
170 180 190 200 210 220
100 110 120 130 140 150
pF1KB8 FSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIQVWFQNRRAKSRRQSGKSFQPL
:.::::. :: .:.::.::::. ::.:: . : :.:.::::.::::. :.:.: . : .
NP_001 FTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGAN-QLM
230 240 250 260 270 280
160 170 180 190 200 210
pF1KB8 ARPEIILNHCAPGTETKCLKPQLPLEVDVNCLPEPNGVGGGISDSSSQGQNFETCSPLSE
: .:: :: : :: . .:... ..:: ::
NP_001 A-----FNHLIPGGFPPTAMPTLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQPLPPSTV
290 300 310 320 330
220 230
pF1KB8 DIGSKLDSWEEHIFSAFGNF
NP_001 HQSTIPSNPDSSSAYCLPSTRHGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQVMGLLTNH
340 350 360 370 380 390
232 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 17:46:33 2016 done: Mon Nov 7 17:46:34 2016
Total Scan time: 7.160 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]