Result of FASTA (omim) for
pFN21AB8888
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8888, 201 aa
1>>>pF1KB8888 201 - 201 aa - 201 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.1511+/-0.000269; mu= 3.6195+/- 0.017
mean_var=200.9329+/-40.808, 0's: 0 Z-trim(125.8): 56 B-trim: 2639 in 1/59
Lambda= 0.090479
statistics sampled from 50417 (50481) to 50417 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.842), E-opt: 0.2 (0.592), width: 16
Scan time: 6.550
The best scores are: opt bits E(85289)
XP_006716679 (OMIM: 609067) PREDICTED: basic helix ( 201) 1405 194.2 1.2e-49
NP_001073983 (OMIM: 609067) basic helix-loop-helix ( 201) 1405 194.2 1.2e-49
NP_004600 (OMIM: 601010) transcription factor 15 [ ( 199) 520 78.7 7.2e-15
XP_011513798 (OMIM: 101400,123100,180750,601622) P ( 202) 261 44.8 0.00011
NP_000465 (OMIM: 101400,123100,180750,601622) twis ( 202) 261 44.8 0.00011
NP_068808 (OMIM: 602407) heart- and neural crest d ( 217) 253 43.8 0.00024
NP_005089 (OMIM: 603628) musculin [Homo sapiens] ( 206) 242 42.4 0.00062
NP_803238 (OMIM: 608606) class A basic helix-loop- ( 189) 239 42.0 0.00076
NP_001157877 (OMIM: 607539,609432,615416) class A ( 235) 235 41.5 0.0013
NP_476527 (OMIM: 200110,209885,227260,607556) twis ( 160) 230 40.7 0.0015
NP_001258822 (OMIM: 200110,209885,227260,607556) t ( 160) 230 40.7 0.0015
XP_005268588 (OMIM: 602406) PREDICTED: heart- and ( 214) 224 40.0 0.0032
NP_004812 (OMIM: 602406) heart- and neural crest d ( 215) 224 40.0 0.0033
NP_938206 (OMIM: 603306) transcription factor 21 [ ( 179) 222 39.7 0.0034
NP_003197 (OMIM: 603306) transcription factor 21 [ ( 179) 222 39.7 0.0034
XP_016871769 (OMIM: 604882,610370) PREDICTED: neur ( 214) 219 39.4 0.0051
NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo ( 214) 219 39.4 0.0051
NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapien ( 272) 219 39.5 0.0061
NP_660161 (OMIM: 609875) protein atonal homolog 7 ( 152) 213 38.5 0.0068
>>XP_006716679 (OMIM: 609067) PREDICTED: basic helix-loo (201 aa)
initn: 1405 init1: 1405 opt: 1405 Z-score: 1012.2 bits: 194.2 E(85289): 1.2e-49
Smith-Waterman score: 1405; 100.0% identity (100.0% similar) in 201 aa overlap (1-201:1-201)
10 20 30 40 50 60
pF1KB8 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEKPCRVHAARCGLQGARRRAGGRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEKPCRVHAARCGLQGARRRAGGRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 AGGGGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIETLRLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AGGGGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIETLRLA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 SSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPPPPARDGENTQPKQICT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPPPPARDGENTQPKQICT
130 140 150 160 170 180
190 200
pF1KB8 FCLSNQRKLSKDRDRKTAIRS
:::::::::::::::::::::
XP_006 FCLSNQRKLSKDRDRKTAIRS
190 200
>>NP_001073983 (OMIM: 609067) basic helix-loop-helix tra (201 aa)
initn: 1405 init1: 1405 opt: 1405 Z-score: 1012.2 bits: 194.2 E(85289): 1.2e-49
Smith-Waterman score: 1405; 100.0% identity (100.0% similar) in 201 aa overlap (1-201:1-201)
10 20 30 40 50 60
pF1KB8 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEKPCRVHAARCGLQGARRRAGGRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEKPCRVHAARCGLQGARRRAGGRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 AGGGGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIETLRLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGGGGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIETLRLA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 SSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPPPPARDGENTQPKQICT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPPPPARDGENTQPKQICT
130 140 150 160 170 180
190 200
pF1KB8 FCLSNQRKLSKDRDRKTAIRS
:::::::::::::::::::::
NP_001 FCLSNQRKLSKDRDRKTAIRS
190 200
>>NP_004600 (OMIM: 601010) transcription factor 15 [Homo (199 aa)
initn: 513 init1: 413 opt: 520 Z-score: 387.9 bits: 78.7 E(85289): 7.2e-15
Smith-Waterman score: 616; 59.3% identity (73.4% similar) in 199 aa overlap (1-194:1-180)
10 20 30 40 50
pF1KB8 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEK-PCRVHAARC-GLQGARRR---
:.:: :::. .. :::.: :::::. :.:..::.. : : : ..:::
NP_004 MAFALLRPVG-AHVLYPDVRLLSEDEENRSESDASDQSFGC------CEGPEAARRGPGP
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 AGGRRAGGGGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIE
.::::::::: .: : :::..:::::::::.:::::::::::::::::.::::::::
NP_004 GGGRRAGGGGGAG-PVVVVRQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIE
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB8 TLRLASSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPPPPARDGENTQP
:::::::::.::.:::: :.. ::::: :.:: :: : : :: . ::
NP_004 TLRLASSYIAHLANVLLLGDSADDGQPC------FRAA--GSAKGAVPA--AADG-GRQP
120 130 140 150 160
180 190 200
pF1KB8 KQICTFCLSNQRKLSKDRDRKTAIRS
..::::::::::: . ::
NP_004 RSICTFCLSNQRKGGGRRDLGGSCLKVRGVAPLRGPRR
170 180 190
>>XP_011513798 (OMIM: 101400,123100,180750,601622) PREDI (202 aa)
initn: 304 init1: 155 opt: 261 Z-score: 205.1 bits: 44.8 E(85289): 0.00011
Smith-Waterman score: 261; 44.8% identity (65.5% similar) in 116 aa overlap (29-143:62-175)
10 20 30 40 50
pF1KB8 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEKPCR-VHAARCGLQGARRRAG
:.: :: . : ..: :: :. .:
XP_011 GKRGGRKRRSSRRSAGGGAGPGGAAGGGVGGGDEPGSPAQGKRGKKSAGCGGGGGAGGGG
40 50 60 70 80 90
60 70 80 90 100 110
pF1KB8 GRRAGGGGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIETL
: .:::.: . . :: ::.:::.::.:.: ::.::: .::: :.: :::::.::
XP_011 GSSSGGGSPQSYEELQT-QRVMANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTL
100 110 120 130 140
120 130 140 150 160 170
pF1KB8 RLASSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPPPPARDGENTQPKQ
.::. ::. : .:: . : . :
XP_011 KLAARYIDFLYQVLQSDELDSKMASCSYVAHERLSYAFSVWRMEGAWSMSASH
150 160 170 180 190 200
>>NP_000465 (OMIM: 101400,123100,180750,601622) twist-re (202 aa)
initn: 304 init1: 155 opt: 261 Z-score: 205.1 bits: 44.8 E(85289): 0.00011
Smith-Waterman score: 261; 44.8% identity (65.5% similar) in 116 aa overlap (29-143:62-175)
10 20 30 40 50
pF1KB8 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEKPCR-VHAARCGLQGARRRAG
:.: :: . : ..: :: :. .:
NP_000 GKRGGRKRRSSRRSAGGGAGPGGAAGGGVGGGDEPGSPAQGKRGKKSAGCGGGGGAGGGG
40 50 60 70 80 90
60 70 80 90 100 110
pF1KB8 GRRAGGGGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIETL
: .:::.: . . :: ::.:::.::.:.: ::.::: .::: :.: :::::.::
NP_000 GSSSGGGSPQSYEELQT-QRVMANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTL
100 110 120 130 140
120 130 140 150 160 170
pF1KB8 RLASSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPPPPARDGENTQPKQ
.::. ::. : .:: . : . :
NP_000 KLAARYIDFLYQVLQSDELDSKMASCSYVAHERLSYAFSVWRMEGAWSMSASH
150 160 170 180 190 200
>>NP_068808 (OMIM: 602407) heart- and neural crest deriv (217 aa)
initn: 244 init1: 244 opt: 253 Z-score: 199.1 bits: 43.8 E(85289): 0.00024
Smith-Waterman score: 254; 42.5% identity (63.8% similar) in 127 aa overlap (16-141:50-165)
10 20 30 40
pF1KB8 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEKPCRVHAA
.::.:: : . : : : ..
NP_068 FAAAAAAAAAAAASRCSHEENPYFHGWLIGHPEMSP----PDYSMALSYSPEYA----SG
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB8 RCGLQGARRRAGGRRAGGGGPG-GRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPT
::. .. :: :.: :: : : : ..: ::: .:: ::.:.:.::. :: ::.
NP_068 AAGLDHSHY--GGVPPGAGPPGLGGP-RPVKRRGTANRKERRRTQSINSAFAELRECIPN
80 90 100 110 120
110 120 130 140 150 160
pF1KB8 EPADRKLSKIETLRLASSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPP
::: :::::.:::::.:::..: ..: . :...
NP_068 VPADTKLSKIKTLRLATSYIAYLMDLLAKDDQNGEAEAFKAEIKKTDVKEEKRKKELNEI
130 140 150 160 170 180
170 180 190 200
pF1KB8 PPARDGENTQPKQICTFCLSNQRKLSKDRDRKTAIRS
NP_068 LKSTVSSNDKKTKGRTGWPQHVWALELKQ
190 200 210
>>NP_005089 (OMIM: 603628) musculin [Homo sapiens] (206 aa)
initn: 309 init1: 197 opt: 242 Z-score: 191.6 bits: 42.4 E(85289): 0.00062
Smith-Waterman score: 252; 37.5% identity (57.6% similar) in 144 aa overlap (8-131:22-163)
10 20 30 40
pF1KB8 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEKPCRVHAAR
:.: .. : . . .. ::.:...:. . :
NP_005 MSTGSVSDPEEMELRGLQREYPVPASKR--PPLRGVERSYASPSDNSSAEEEDPDGEEER
10 20 30 40 50
50 60 70 80
pF1KB8 CGLQGARRRAGGRR-----AGGGGPGGRPG---REP------------RQRHTANARERD
:.: : : .: ::::: :: : ..: ::..::::::
NP_005 CALGTAGSAEGCKRKRPRVAGGGGAGGSAGGGGKKPLPAKGSAAECKQSQRNAANARERA
60 70 80 90 100 110
90 100 110 120 130 140
pF1KB8 RTNSVNTAFTALRTLIPTEPADRKLSKIETLRLASSYISHLGNVLLAGEACGDGQPCHSG
: .. ::. :.: .: : : ::::..:::::::::.:: ..:
NP_005 RMRVLSKAFSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLRQLLQEDRYENGYVHPVNL
120 130 140 150 160 170
150 160 170 180 190 200
pF1KB8 PAFFHAARAGSPPPPPPPPPARDGENTQPKQICTFCLSNQRKLSKDRDRKTAIRS
NP_005 TWPFVVSGRPDSDTKEVSAANRLCGTTA
180 190 200
>>NP_803238 (OMIM: 608606) class A basic helix-loop-heli (189 aa)
initn: 224 init1: 224 opt: 239 Z-score: 190.0 bits: 42.0 E(85289): 0.00076
Smith-Waterman score: 241; 41.6% identity (61.6% similar) in 125 aa overlap (9-132:19-132)
10 20 30 40
pF1KB8 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSD-SSGSDEKPCRVHAARCGL
: :: : .: . . : . ..: .: :. :::
NP_803 MKTKNRPPRRRAPVQDTEATPG-----EGTPDGSLPNPGPEPAKGLRSRPARA-AARAPG
10 20 30 40 50
50 60 70 80 90 100
pF1KB8 QGARRRAGGRRAGGGGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADR
.: ::: : .::::: ..: .: :::.: ...:.:: ::: .:: ::.
NP_803 EGRRRRPG-----PSGPGGRRDSSIQRRLESNERERQRMHKLNNAFQALREVIPHVRADK
60 70 80 90 100
110 120 130 140 150 160
pF1KB8 KLSKIETLRLASSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPPPPARD
:::::::: ::..::. : ..:
NP_803 KLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQQQQQVAGGALGATEA
110 120 130 140 150 160
>>NP_001157877 (OMIM: 607539,609432,615416) class A basi (235 aa)
initn: 194 init1: 156 opt: 235 Z-score: 185.9 bits: 41.5 E(85289): 0.0013
Smith-Waterman score: 240; 34.9% identity (52.9% similar) in 189 aa overlap (6-182:2-179)
10 20 30 40 50
pF1KB8 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSS--GSDEKPCRVHAARCGLQGARRRAGG
:: :: : : . . . :: :. :.: ...: :. :.. ::
NP_001 MLRGAP-GLGLTARKGAEDSAEDLGGPCPEPGGDSGVLGANGASCSRGEAEEPAGR
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 RRAGGGGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIETLR
::: :: : .: .::.::: : . : ::.::: . . . ..:::: :::
NP_001 RRA-------RPVRSKARRMAANVRERKRILDYNEAFNALRRALRHDLGGKRLSKIATLR
60 70 80 90 100
120 130 140 150 160
pF1KB8 LASSYISHLGNVLLAGEA----CGDGQPCHSGPAFFHAARAGSPPPPP--P----PPPAR
: :. :. :: :. : :: . ::. : .. .:. :::: : : ::
NP_001 RAIHRIAALSLVLRASPAPRGPCGHLE-CHGPAARGDTGDTGASPPPPAGPSLARPDAAR
110 120 130 140 150 160
170 180 190 200
pF1KB8 DGENTQPKQICTFCLSNQRKLSKDRDRKTAIRS
. . :. :. :
NP_001 PSVPSAPR--CASCPPHAPLARPSAVAEGPGLAQASGGSWRRCPGASSAGPPPWPRGYLR
170 180 190 200 210 220
>>NP_476527 (OMIM: 200110,209885,227260,607556) twist-re (160 aa)
initn: 201 init1: 135 opt: 230 Z-score: 184.6 bits: 40.7 E(85289): 0.0015
Smith-Waterman score: 230; 38.3% identity (64.8% similar) in 128 aa overlap (20-143:7-133)
10 20 30 40 50
pF1KB8 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEKPCRVHAARCGLQGARRRAG---
::.: .. :.. ...: : : . . . ..
NP_476 MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTP
10 20 30 40
60 70 80 90 100 110
pF1KB8 GRRAGGGGPGGRPGRE-PRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIET
:.:. :.:... .: :: ::.:::.::.:.: ::.::: .::: :.: :::::.:
NP_476 GKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQT
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB8 LRLASSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPPPPARDGENTQPK
:.::. ::. : .:: . : . :
NP_476 LKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH
110 120 130 140 150 160
201 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 04:48:50 2016 done: Tue Nov 8 04:48:51 2016
Total Scan time: 6.550 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]