Result of FASTA (omim) for
pFN21AB8529
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8529, 963 aa
1>>>pF1KB8529 963 - 963 aa - 963 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1156+/-0.000473; mu= 22.8016+/- 0.029
mean_var=78.2319+/-15.411, 0's: 0 Z-trim(109.6): 17 B-trim: 12 in 1/50
Lambda= 0.145005
statistics sampled from 17791 (17801) to 17791 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.568), E-opt: 0.2 (0.209), width: 16
Scan time: 10.080
The best scores are: opt bits E(85289)
NP_004127 (OMIM: 147582) iron-responsive element-b ( 963) 6374 1344.2 0
NP_001307871 (OMIM: 147582) iron-responsive elemen ( 906) 6000 1266.0 0
NP_001307870 (OMIM: 147582) iron-responsive elemen ( 713) 4662 986.0 0
XP_011516190 (OMIM: 100880) PREDICTED: cytoplasmic ( 889) 3302 701.5 4.8e-201
NP_001265281 (OMIM: 100880) cytoplasmic aconitate ( 889) 3302 701.5 4.8e-201
NP_002188 (OMIM: 100880) cytoplasmic aconitate hyd ( 889) 3302 701.5 4.8e-201
XP_005251533 (OMIM: 100880) PREDICTED: cytoplasmic ( 889) 3302 701.5 4.8e-201
NP_001307872 (OMIM: 147582) iron-responsive elemen ( 343) 2297 490.9 4.6e-138
XP_016884301 (OMIM: 100850,614559,616289) PREDICTE ( 747) 325 78.7 1.3e-13
NP_001089 (OMIM: 100850,614559,616289) aconitate h ( 780) 325 78.7 1.3e-13
>>NP_004127 (OMIM: 147582) iron-responsive element-bindi (963 aa)
initn: 6374 init1: 6374 opt: 6374 Z-score: 7203.1 bits: 1344.2 E(85289): 0
Smith-Waterman score: 6374; 100.0% identity (100.0% similar) in 963 aa overlap (1-963:1-963)
10 20 30 40 50 60
pF1KB8 MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 EDVMNILDWKTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EDVMNILDWKTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPAC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 PTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 GELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 NVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVGGIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVGGIE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 TEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 SQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 DQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 AEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 YIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 LVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGKNIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGKNIY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 LHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 PSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPRE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB8 FNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB8 LIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENAD
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB8 SLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVAR
910 920 930 940 950 960
pF1KB8 KFS
:::
NP_004 KFS
>>NP_001307871 (OMIM: 147582) iron-responsive element-bi (906 aa)
initn: 6000 init1: 6000 opt: 6000 Z-score: 6780.6 bits: 1266.0 E(85289): 0
Smith-Waterman score: 6000; 100.0% identity (100.0% similar) in 906 aa overlap (58-963:1-906)
30 40 50 60 70 80
pF1KB8 VSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKKEDVMNILDWKTKQSNVEVPFFPARVLL
::::::::::::::::::::::::::::::
NP_001 MKKEDVMNILDWKTKQSNVEVPFFPARVLL
10 20 30
90 100 110 120 130 140
pF1KB8 QDFTGIPAMVDFAAMREAVKTLGGDPEKVHPACPTDLTVDHSLQIDFSKCAIQNAPNPGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDFTGIPAMVDFAAMREAVKTLGGDPEKVHPACPTDLTVDHSLQIDFSKCAIQNAPNPGG
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB8 GDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDSGELGRNSGTFSSQIENTPILCPFHLQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDSGELGRNSGTFSSQIENTPILCPFHLQP
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB8 VPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQINLEYLSRVVFEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQINLEYLSRVVFEE
160 170 180 190 200 210
270 280 290 300 310 320
pF1KB8 KDLLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDLLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSN
220 230 240 250 260 270
330 340 350 360 370 380
pF1KB8 PFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPV
280 290 300 310 320 330
390 400 410 420 430 440
pF1KB8 DNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSG
340 350 360 370 380 390
450 460 470 480 490 500
pF1KB8 PKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIA
400 410 420 430 440 450
510 520 530 540 550 560
pF1KB8 AVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLS
460 470 480 490 500 510
570 580 590 600 610 620
pF1KB8 KLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGRLCDCVRANYLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGRLCDCVRANYLA
520 530 540 550 560 570
630 640 650 660 670 680
pF1KB8 SPPLVVAYAIAGTVNIDFQTEPLGTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPPLVVAYAIAGTVNIDFQTEPLGTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKAL
580 590 600 610 620 630
690 700 710 720 730 740
pF1KB8 KDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENAHVLLYLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENAHVLLYLG
640 650 660 670 680 690
750 760 770 780 790 800
pF1KB8 DSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNK
700 710 720 730 740 750
810 820 830 840 850 860
pF1KB8 FIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGV
760 770 780 790 800 810
870 880 890 900 910 920
pF1KB8 KAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRETFSLTFPEELSPGITLNIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRETFSLTFPEELSPGITLNIQ
820 830 840 850 860 870
930 940 950 960
pF1KB8 TSTGKVFSVIASFEDDVEITLYKHGGLLNFVARKFS
::::::::::::::::::::::::::::::::::::
NP_001 TSTGKVFSVIASFEDDVEITLYKHGGLLNFVARKFS
880 890 900
>>NP_001307870 (OMIM: 147582) iron-responsive element-bi (713 aa)
initn: 4662 init1: 4662 opt: 4662 Z-score: 5269.3 bits: 986.0 E(85289): 0
Smith-Waterman score: 4662; 100.0% identity (100.0% similar) in 713 aa overlap (251-963:1-713)
230 240 250 260 270 280
pF1KB8 EFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTD
::::::::::::::::::::::::::::::
NP_001 MAHQINLEYLSRVVFEEKDLLFPDSVVGTD
10 20 30
290 300 310 320 330 340
pF1KB8 SHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGIT
40 50 60 70 80 90
350 360 370 380 390 400
pF1KB8 KHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGF
100 110 120 130 140 150
410 420 430 440 450 460
pF1KB8 SKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDM
160 170 180 190 200 210
470 480 490 500 510 520
pF1KB8 KSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSV
220 230 240 250 260 270
530 540 550 560 570 580
pF1KB8 MLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCST
280 290 300 310 320 330
590 600 610 620 630 640
pF1KB8 CVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGT
340 350 360 370 380 390
650 660 670 680 690 700
pF1KB8 VNIDFQTEPLGTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNIDFQTEPLGTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNS
400 410 420 430 440 450
710 720 730 740 750 760
pF1KB8 LEAPDSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEAPDSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGS
460 470 480 490 500 510
770 780 790 800 810 820
pF1KB8 IARNSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IARNSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFP
520 530 540 550 560 570
830 840 850 860 870 880
pF1KB8 SGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHK
580 590 600 610 620 630
890 900 910 920 930 940
pF1KB8 DHLIGIGIAPLQFLPGENADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DHLIGIGIAPLQFLPGENADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASF
640 650 660 670 680 690
950 960
pF1KB8 EDDVEITLYKHGGLLNFVARKFS
:::::::::::::::::::::::
NP_001 EDDVEITLYKHGGLLNFVARKFS
700 710
>>XP_011516190 (OMIM: 100880) PREDICTED: cytoplasmic aco (889 aa)
initn: 3673 init1: 3299 opt: 3302 Z-score: 3730.4 bits: 701.5 E(85289): 4.8e-201
Smith-Waterman score: 3715; 57.3% identity (81.1% similar) in 957 aa overlap (10-963:5-888)
10 20 30 40 50
pF1KB8 MDAPKAGYAFEYLIETLND-SSHKKFFDVSKL-GTKYDVLPYSIRVLLEAAVRNCDGFLM
: .: : :. . ::::...:: ..: ::.:::::::::.:::: ::.
XP_011 MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLV
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 KKEDVMNILDWK-TKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVH
::.:. ::: :. :...:.:::: ::::.::::::.::.:::::::.::: :::::::..
XP_011 KKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKIN
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB8 PACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGS
:.::.::..:::.:.::.. :
XP_011 PVCPADLVIDHSIQVDFNRRA---------------------------------------
120 130
180 190 200 210 220 230
pF1KB8 CDSGELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSR
:: :: :::..:: :::::..:.::.:.
XP_011 -DS------------------------LQ---------KNQDLEFERNRERFEFLKWGSQ
140 150 160
240 250 260 270 280 290
pF1KB8 VFKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVG
.:.:. .::::.:. ::.:::::.::::.. .:::.:::::: ::..::::::::::
XP_011 AFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVG
170 180 190 200 210 220
300 310 320 330 340 350
pF1KB8 GIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFG
:::.:::::: :.:..::.:.: .: :. .:.::: :.:: ::::::::::.::::::::
XP_011 GIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFG
230 240 250 260 270 280
360 370 380 390 400 410
pF1KB8 SGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKL
::.::::.::.::::::::::: .:::::.:.. .: .:: .. ::. .. ::.:: .
XP_011 PGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGM
290 300 310 320 330 340
420 430 440 450 460 470
pF1KB8 FRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGF
::. .. : .:...::....:...:: ::::::::.:::.:::.::..::. : :::::
XP_011 FRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGF
350 360 370 380 390 400
480 490 500 510 520 530
pF1KB8 QIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLR
:.: :...: .. :...:. :.::::::::. ::::. ::::::.:::::::::.:::
XP_011 QVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLN
410 420 430 440 450 460
540 550 560 570 580 590
pF1KB8 VKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVK
: :::.::::::::.::.::. :::.::::.:::..::::: ::.::..:: . :..:.
XP_011 VMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAIT
470 480 490 500 510 520
600 610 620 630 640 650
pF1KB8 QGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGK
:::::. :.::::.:::::. .:::::::::::.:::::::. :::. ::::.. :.
XP_011 QGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQ
530 540 550 560 570 580
660 670 680 690 700 710
pF1KB8 NIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTY
...:.::::.:.:.. ::...:: .::: . .::: :. ::.: .:.. :: :. ::::
XP_011 QVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTY
590 600 610 620 630 640
720 730 740 750 760 770
pF1KB8 IRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLT
:. : ::..:: . ..: .:.::: ::::::::::::::.::::: ::.::::::::
XP_011 IKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLT
650 660 670 680 690 700
780 790 800 810 820 830
pF1KB8 PREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKE
::::::::.::::::::.:::::::.:.:.:..: ::.:::.:::. ::::.::: ::.
XP_011 PREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQA
710 720 730 740 750 760
840 850 860 870 880 890
pF1KB8 GIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGE
:.:::.::::.::.:.:::::::::.:::.:::::::::.::...:.:.:. ::..::::
XP_011 GLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGE
770 780 790 800 810 820
900 910 920 930 940 950
pF1KB8 NADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNF
:::.:::.:.: ... .::.:.: . .... .:::.:... :. :::.: . .::.::.
XP_011 NADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNY
830 840 850 860 870 880
960
pF1KB8 VARKFS
. ::..
XP_011 MIRKMAK
>>NP_001265281 (OMIM: 100880) cytoplasmic aconitate hydr (889 aa)
initn: 3673 init1: 3299 opt: 3302 Z-score: 3730.4 bits: 701.5 E(85289): 4.8e-201
Smith-Waterman score: 3715; 57.3% identity (81.1% similar) in 957 aa overlap (10-963:5-888)
10 20 30 40 50
pF1KB8 MDAPKAGYAFEYLIETLND-SSHKKFFDVSKL-GTKYDVLPYSIRVLLEAAVRNCDGFLM
: .: : :. . ::::...:: ..: ::.:::::::::.:::: ::.
NP_001 MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLV
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 KKEDVMNILDWK-TKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVH
::.:. ::: :. :...:.:::: ::::.::::::.::.:::::::.::: :::::::..
NP_001 KKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKIN
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB8 PACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGS
:.::.::..:::.:.::.. :
NP_001 PVCPADLVIDHSIQVDFNRRA---------------------------------------
120 130
180 190 200 210 220 230
pF1KB8 CDSGELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSR
:: :: :::..:: :::::..:.::.:.
NP_001 -DS------------------------LQ---------KNQDLEFERNRERFEFLKWGSQ
140 150 160
240 250 260 270 280 290
pF1KB8 VFKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVG
.:.:. .::::.:. ::.:::::.::::.. .:::.:::::: ::..::::::::::
NP_001 AFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVG
170 180 190 200 210 220
300 310 320 330 340 350
pF1KB8 GIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFG
:::.:::::: :.:..::.:.: .: :. .:.::: :.:: ::::::::::.::::::::
NP_001 GIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFG
230 240 250 260 270 280
360 370 380 390 400 410
pF1KB8 SGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKL
::.::::.::.::::::::::: .:::::.:.. .: .:: .. ::. .. ::.:: .
NP_001 PGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGM
290 300 310 320 330 340
420 430 440 450 460 470
pF1KB8 FRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGF
::. .. : .:...::....:...:: ::::::::.:::.:::.::..::. : :::::
NP_001 FRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGF
350 360 370 380 390 400
480 490 500 510 520 530
pF1KB8 QIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLR
:.: :...: .. :...:. :.::::::::. ::::. ::::::.:::::::::.:::
NP_001 QVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLN
410 420 430 440 450 460
540 550 560 570 580 590
pF1KB8 VKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVK
: :::.::::::::.::.::. :::.::::.:::..::::: ::.::..:: . :..:.
NP_001 VMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAIT
470 480 490 500 510 520
600 610 620 630 640 650
pF1KB8 QGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGK
:::::. :.::::.:::::. .:::::::::::.:::::::. :::. ::::.. :.
NP_001 QGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQ
530 540 550 560 570 580
660 670 680 690 700 710
pF1KB8 NIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTY
...:.::::.:.:.. ::...:: .::: . .::: :. ::.: .:.. :: :. ::::
NP_001 QVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTY
590 600 610 620 630 640
720 730 740 750 760 770
pF1KB8 IRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLT
:. : ::..:: . ..: .:.::: ::::::::::::::.::::: ::.::::::::
NP_001 IKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLT
650 660 670 680 690 700
780 790 800 810 820 830
pF1KB8 PREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKE
::::::::.::::::::.:::::::.:.:.:..: ::.:::.:::. ::::.::: ::.
NP_001 PREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQA
710 720 730 740 750 760
840 850 860 870 880 890
pF1KB8 GIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGE
:.:::.::::.::.:.:::::::::.:::.:::::::::.::...:.:.:. ::..::::
NP_001 GLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGE
770 780 790 800 810 820
900 910 920 930 940 950
pF1KB8 NADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNF
:::.:::.:.: ... .::.:.: . .... .:::.:... :. :::.: . .::.::.
NP_001 NADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNY
830 840 850 860 870 880
960
pF1KB8 VARKFS
. ::..
NP_001 MIRKMAK
>>NP_002188 (OMIM: 100880) cytoplasmic aconitate hydrata (889 aa)
initn: 3673 init1: 3299 opt: 3302 Z-score: 3730.4 bits: 701.5 E(85289): 4.8e-201
Smith-Waterman score: 3715; 57.3% identity (81.1% similar) in 957 aa overlap (10-963:5-888)
10 20 30 40 50
pF1KB8 MDAPKAGYAFEYLIETLND-SSHKKFFDVSKL-GTKYDVLPYSIRVLLEAAVRNCDGFLM
: .: : :. . ::::...:: ..: ::.:::::::::.:::: ::.
NP_002 MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLV
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 KKEDVMNILDWK-TKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVH
::.:. ::: :. :...:.:::: ::::.::::::.::.:::::::.::: :::::::..
NP_002 KKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKIN
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB8 PACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGS
:.::.::..:::.:.::.. :
NP_002 PVCPADLVIDHSIQVDFNRRA---------------------------------------
120 130
180 190 200 210 220 230
pF1KB8 CDSGELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSR
:: :: :::..:: :::::..:.::.:.
NP_002 -DS------------------------LQ---------KNQDLEFERNRERFEFLKWGSQ
140 150 160
240 250 260 270 280 290
pF1KB8 VFKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVG
.:.:. .::::.:. ::.:::::.::::.. .:::.:::::: ::..::::::::::
NP_002 AFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVG
170 180 190 200 210 220
300 310 320 330 340 350
pF1KB8 GIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFG
:::.:::::: :.:..::.:.: .: :. .:.::: :.:: ::::::::::.::::::::
NP_002 GIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFG
230 240 250 260 270 280
360 370 380 390 400 410
pF1KB8 SGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKL
::.::::.::.::::::::::: .:::::.:.. .: .:: .. ::. .. ::.:: .
NP_002 PGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGM
290 300 310 320 330 340
420 430 440 450 460 470
pF1KB8 FRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGF
::. .. : .:...::....:...:: ::::::::.:::.:::.::..::. : :::::
NP_002 FRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGF
350 360 370 380 390 400
480 490 500 510 520 530
pF1KB8 QIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLR
:.: :...: .. :...:. :.::::::::. ::::. ::::::.:::::::::.:::
NP_002 QVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLN
410 420 430 440 450 460
540 550 560 570 580 590
pF1KB8 VKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVK
: :::.::::::::.::.::. :::.::::.:::..::::: ::.::..:: . :..:.
NP_002 VMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAIT
470 480 490 500 510 520
600 610 620 630 640 650
pF1KB8 QGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGK
:::::. :.::::.:::::. .:::::::::::.:::::::. :::. ::::.. :.
NP_002 QGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQ
530 540 550 560 570 580
660 670 680 690 700 710
pF1KB8 NIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTY
...:.::::.:.:.. ::...:: .::: . .::: :. ::.: .:.. :: :. ::::
NP_002 QVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTY
590 600 610 620 630 640
720 730 740 750 760 770
pF1KB8 IRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLT
:. : ::..:: . ..: .:.::: ::::::::::::::.::::: ::.::::::::
NP_002 IKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLT
650 660 670 680 690 700
780 790 800 810 820 830
pF1KB8 PREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKE
::::::::.::::::::.:::::::.:.:.:..: ::.:::.:::. ::::.::: ::.
NP_002 PREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQA
710 720 730 740 750 760
840 850 860 870 880 890
pF1KB8 GIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGE
:.:::.::::.::.:.:::::::::.:::.:::::::::.::...:.:.:. ::..::::
NP_002 GLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGE
770 780 790 800 810 820
900 910 920 930 940 950
pF1KB8 NADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNF
:::.:::.:.: ... .::.:.: . .... .:::.:... :. :::.: . .::.::.
NP_002 NADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNY
830 840 850 860 870 880
960
pF1KB8 VARKFS
. ::..
NP_002 MIRKMAK
>>XP_005251533 (OMIM: 100880) PREDICTED: cytoplasmic aco (889 aa)
initn: 3673 init1: 3299 opt: 3302 Z-score: 3730.4 bits: 701.5 E(85289): 4.8e-201
Smith-Waterman score: 3715; 57.3% identity (81.1% similar) in 957 aa overlap (10-963:5-888)
10 20 30 40 50
pF1KB8 MDAPKAGYAFEYLIETLND-SSHKKFFDVSKL-GTKYDVLPYSIRVLLEAAVRNCDGFLM
: .: : :. . ::::...:: ..: ::.:::::::::.:::: ::.
XP_005 MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLV
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 KKEDVMNILDWK-TKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVH
::.:. ::: :. :...:.:::: ::::.::::::.::.:::::::.::: :::::::..
XP_005 KKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKIN
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB8 PACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGS
:.::.::..:::.:.::.. :
XP_005 PVCPADLVIDHSIQVDFNRRA---------------------------------------
120 130
180 190 200 210 220 230
pF1KB8 CDSGELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSR
:: :: :::..:: :::::..:.::.:.
XP_005 -DS------------------------LQ---------KNQDLEFERNRERFEFLKWGSQ
140 150 160
240 250 260 270 280 290
pF1KB8 VFKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVG
.:.:. .::::.:. ::.:::::.::::.. .:::.:::::: ::..::::::::::
XP_005 AFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVG
170 180 190 200 210 220
300 310 320 330 340 350
pF1KB8 GIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFG
:::.:::::: :.:..::.:.: .: :. .:.::: :.:: ::::::::::.::::::::
XP_005 GIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFG
230 240 250 260 270 280
360 370 380 390 400 410
pF1KB8 SGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKL
::.::::.::.::::::::::: .:::::.:.. .: .:: .. ::. .. ::.:: .
XP_005 PGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGM
290 300 310 320 330 340
420 430 440 450 460 470
pF1KB8 FRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGF
::. .. : .:...::....:...:: ::::::::.:::.:::.::..::. : :::::
XP_005 FRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGF
350 360 370 380 390 400
480 490 500 510 520 530
pF1KB8 QIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLR
:.: :...: .. :...:. :.::::::::. ::::. ::::::.:::::::::.:::
XP_005 QVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLN
410 420 430 440 450 460
540 550 560 570 580 590
pF1KB8 VKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVK
: :::.::::::::.::.::. :::.::::.:::..::::: ::.::..:: . :..:.
XP_005 VMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAIT
470 480 490 500 510 520
600 610 620 630 640 650
pF1KB8 QGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGK
:::::. :.::::.:::::. .:::::::::::.:::::::. :::. ::::.. :.
XP_005 QGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQ
530 540 550 560 570 580
660 670 680 690 700 710
pF1KB8 NIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTY
...:.::::.:.:.. ::...:: .::: . .::: :. ::.: .:.. :: :. ::::
XP_005 QVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTY
590 600 610 620 630 640
720 730 740 750 760 770
pF1KB8 IRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLT
:. : ::..:: . ..: .:.::: ::::::::::::::.::::: ::.::::::::
XP_005 IKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLT
650 660 670 680 690 700
780 790 800 810 820 830
pF1KB8 PREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKE
::::::::.::::::::.:::::::.:.:.:..: ::.:::.:::. ::::.::: ::.
XP_005 PREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQA
710 720 730 740 750 760
840 850 860 870 880 890
pF1KB8 GIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGE
:.:::.::::.::.:.:::::::::.:::.:::::::::.::...:.:.:. ::..::::
XP_005 GLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGE
770 780 790 800 810 820
900 910 920 930 940 950
pF1KB8 NADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNF
:::.:::.:.: ... .::.:.: . .... .:::.:... :. :::.: . .::.::.
XP_005 NADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNY
830 840 850 860 870 880
960
pF1KB8 VARKFS
. ::..
XP_005 MIRKMAK
>>NP_001307872 (OMIM: 147582) iron-responsive element-bi (343 aa)
initn: 2297 init1: 2297 opt: 2297 Z-score: 2599.7 bits: 490.9 E(85289): 4.6e-138
Smith-Waterman score: 2297; 100.0% identity (100.0% similar) in 341 aa overlap (1-341:1-341)
10 20 30 40 50 60
pF1KB8 MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 EDVMNILDWKTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDVMNILDWKTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPAC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 PTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 GELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 NVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVGGIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVGGIE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 TEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGV
:::::::::::::::::::::::::::::::::::::::::
NP_001 TEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKVS
310 320 330 340
370 380 390 400 410 420
pF1KB8 SQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRN
>>XP_016884301 (OMIM: 100850,614559,616289) PREDICTED: a (747 aa)
initn: 540 init1: 283 opt: 325 Z-score: 365.6 bits: 78.7 E(85289): 1.3e-13
Smith-Waterman score: 624; 27.3% identity (52.4% similar) in 740 aa overlap (225-956:114-740)
200 210 220 230 240 250
pF1KB8 ENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQ
:.: .:. .. . .:. ::.:. ::
XP_016 KVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKY-GVGFWKPGSGIIHQ
90 100 110 120 130 140
260 270 280 290 300 310
pF1KB8 INLEYLSRVVFEEKDLLFPDSV-VGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLT
: :: . .: . .::::: .::: . :::: .. :: :.: :
XP_016 IILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELK
150 160 170 180 190
320 330 340 350 360 370
pF1KB8 LPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIAN
:.:.: .:::: . . . ::.: .. : : .: .::. : ::...: . .:: :
XP_016 CPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICN
200 210 220 230 240 250
380 390 400 410 420 430
pF1KB8 MCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQV
: : :: : :: .. :.: .:: : . . :.. . .:.:.
XP_016 MGAEIGATTSVFPYNHRMKKYLSKTG--------REDIANLADEFKDHLVPDPGCHYDQL
260 270 280 290 300
440 450 460 470 480 490
pF1KB8 IQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYE
:.:::. . : ..:: : :. . : :: .::: :
XP_016 IEINLSELKPHINGPFTP-----------DLAHPVAE-VG-----KVAEK---------E
310 320 330
500 510 520 530 540 550
pF1KB8 GSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMV
: . :. . .. . ::::. .. .:.. ::.:. ::. : . ...::: ..
XP_016 G--WPLD---IRVGLIGSCTNSSYEDMGRSAAV-AKQALAHGLKCKSQF--TITPGSEQI
340 350 360 370 380 390
560 570 580 590 600 610
pF1KB8 THYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNF
. .: : :: ... .:. :.:. .: .:.:. : . : :.::
XP_016 RATIERDGYAQILRDLGGIVLANACGPCIGQW-DRKD-----IKKGEKNTI-VTSYNRNF
400 410 420 430 440
620 630 640 650 660 670
pF1KB8 EGRLCDCVRAN-YLASPPLVVAYAIAGTVNIDFQTEPL-GTDPTGKNIYLHDIWPSREEV
:: ... ...:: .:.: :::::.... .:. : ::: ::.. :. :. .:.
XP_016 TGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTD--GKKFRLEA--PDADEL
450 460 470 480 490
680 690 700 710 720
pF1KB8 HRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSF--FDKLTK
. : : .: . : :: :.. : : . :::
XP_016 PKGE--------FDPGQDTYQHPPK--------DSSGQHVDVSPTSQRLQLLEPFDKWDG
500 510 520 530 540
730 740 750 760 770 780
pF1KB8 EPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRG
. . :. ..:. . . :::::: :: .: ::
XP_016 KDL-----EDLQILIKVKGKCTTDHISAAGP---------WLKFRGHL------------
550 560 570
790 800 810 820 830 840
pF1KB8 NDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKY
: . . .. :.. : :: : .. . . . : ..:. :.:.:: .... ..:
XP_016 -DNISNNLLIGAINIEN---GK-ANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENY
580 590 600 610 620 630
850 860 870 880 890 900
pF1KB8 GSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRET
: :.::. :: : :: .:....:. .::. .: :. :: : .. :: . .
XP_016 GEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTF--ADPADYNKIHPVDK
640 650 660 670 680 690
910 920 930 940 950 960
pF1KB8 FSLTFPEELSPGITLN--IQTSTGKVFSVIASFE-DDVEITLYKHGGLLNFVARKFS
... ....:: :. :. .: ... . ....: .. :. ::
XP_016 LTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
700 710 720 730 740
>>NP_001089 (OMIM: 100850,614559,616289) aconitate hydra (780 aa)
initn: 540 init1: 283 opt: 325 Z-score: 365.4 bits: 78.7 E(85289): 1.3e-13
Smith-Waterman score: 624; 27.3% identity (52.4% similar) in 740 aa overlap (225-956:147-773)
200 210 220 230 240 250
pF1KB8 ENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQ
:.: .:. .. . .:. ::.:. ::
NP_001 KVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKY-GVGFWKPGSGIIHQ
120 130 140 150 160 170
260 270 280 290 300 310
pF1KB8 INLEYLSRVVFEEKDLLFPDSV-VGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLT
: :: . .: . .::::: .::: . :::: .. :: :.: :
NP_001 IILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELK
180 190 200 210 220
320 330 340 350 360 370
pF1KB8 LPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIAN
:.:.: .:::: . . . ::.: .. : : .: .::. : ::...: . .:: :
NP_001 CPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICN
230 240 250 260 270 280
380 390 400 410 420 430
pF1KB8 MCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQV
: : :: : :: .. :.: .:: : . . :.. . .:.:.
NP_001 MGAEIGATTSVFPYNHRMKKYLSKTG--------REDIANLADEFKDHLVPDPGCHYDQL
290 300 310 320 330
440 450 460 470 480 490
pF1KB8 IQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYE
:.:::. . : ..:: : :. . : :: .::: :
NP_001 IEINLSELKPHINGPFTP-----------DLAHPVAE-VG-----KVAEK---------E
340 350 360 370
500 510 520 530 540 550
pF1KB8 GSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMV
: . :. . .. . ::::. .. .:.. ::.:. ::. : . ...::: ..
NP_001 G--WPLD---IRVGLIGSCTNSSYEDMGRSAAV-AKQALAHGLKCKSQF--TITPGSEQI
380 390 400 410 420
560 570 580 590 600 610
pF1KB8 THYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNF
. .: : :: ... .:. :.:. .: .:.:. : . : :.::
NP_001 RATIERDGYAQILRDLGGIVLANACGPCIGQW-DRKD-----IKKGEKNTI-VTSYNRNF
430 440 450 460 470
620 630 640 650 660 670
pF1KB8 EGRLCDCVRAN-YLASPPLVVAYAIAGTVNIDFQTEPL-GTDPTGKNIYLHDIWPSREEV
:: ... ...:: .:.: :::::.... .:. : ::: ::.. :. :. .:.
NP_001 TGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTD--GKKFRLEA--PDADEL
480 490 500 510 520 530
680 690 700 710 720
pF1KB8 HRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSF--FDKLTK
. : : .: . : :: :.. : : . :::
NP_001 PKGE--------FDPGQDTYQHPPK--------DSSGQHVDVSPTSQRLQLLEPFDKWDG
540 550 560 570
730 740 750 760 770 780
pF1KB8 EPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRG
. . :. ..:. . . :::::: :: .: ::
NP_001 KDL-----EDLQILIKVKGKCTTDHISAAGP---------WLKFRGHL------------
580 590 600 610
790 800 810 820 830 840
pF1KB8 NDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKY
: . . .. :.. : :: : .. . . . : ..:. :.:.:: .... ..:
NP_001 -DNISNNLLIGAINIEN---GK-ANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENY
620 630 640 650 660
850 860 870 880 890 900
pF1KB8 GSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRET
: :.::. :: : :: .:....:. .::. .: :. :: : .. :: . .
NP_001 GEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTF--ADPADYNKIHPVDK
670 680 690 700 710 720
910 920 930 940 950 960
pF1KB8 FSLTFPEELSPGITLN--IQTSTGKVFSVIASFE-DDVEITLYKHGGLLNFVARKFS
... ....:: :. :. .: ... . ....: .. :. ::
NP_001 LTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
730 740 750 760 770 780
963 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 06:13:11 2016 done: Tue Nov 8 06:13:12 2016
Total Scan time: 10.080 Total Display time: 0.230
Function used was FASTA [36.3.4 Apr, 2011]