Result of FASTA (omim) for
pFN21AB8502
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8502, 864 aa
1>>>pF1KB8502 864 - 864 aa - 864 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.2037+/-0.000429; mu= 12.3553+/- 0.027
mean_var=554.0349+/-128.313, 0's: 0 Z-trim(122.2): 746 B-trim: 2210 in 1/58
Lambda= 0.054489
statistics sampled from 39194 (40064) to 39194 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.765), E-opt: 0.2 (0.47), width: 16
Scan time: 13.080
The best scores are: opt bits E(85289)
NP_002335 (OMIM: 151520) leukocyte tyrosine kinase ( 864) 6041 491.0 1e-137
NP_996844 (OMIM: 151520) leukocyte tyrosine kinase ( 803) 3779 313.1 3.3e-84
XP_011519858 (OMIM: 151520) PREDICTED: leukocyte t ( 880) 3138 262.8 5e-69
XP_016877672 (OMIM: 151520) PREDICTED: leukocyte t ( 800) 3114 260.8 1.8e-68
XP_016877671 (OMIM: 151520) PREDICTED: leukocyte t ( 837) 2940 247.2 2.4e-64
XP_016877670 (OMIM: 151520) PREDICTED: leukocyte t ( 885) 2938 247.1 2.7e-64
XP_011519859 (OMIM: 151520) PREDICTED: leukocyte t ( 824) 2928 246.2 4.6e-64
NP_004295 (OMIM: 105590,613014) ALK tyrosine kinas (1620) 2626 223.0 8.7e-57
NP_001129157 (OMIM: 151520) leukocyte tyrosine kin ( 734) 2276 194.9 1.2e-48
XP_011534355 (OMIM: 165020) PREDICTED: proto-oncog (2299) 974 93.4 1.3e-17
XP_016866662 (OMIM: 165020) PREDICTED: proto-oncog (2333) 974 93.5 1.3e-17
XP_016866661 (OMIM: 165020) PREDICTED: proto-oncog (2334) 974 93.5 1.3e-17
XP_006715611 (OMIM: 165020) PREDICTED: proto-oncog (2342) 974 93.5 1.3e-17
XP_011534354 (OMIM: 165020) PREDICTED: proto-oncog (2343) 974 93.5 1.3e-17
NP_002935 (OMIM: 165020) proto-oncogene tyrosine-p (2347) 974 93.5 1.3e-17
XP_011534353 (OMIM: 165020) PREDICTED: proto-oncog (2348) 974 93.5 1.3e-17
XP_011534352 (OMIM: 165020) PREDICTED: proto-oncog (2356) 974 93.5 1.3e-17
XP_011534351 (OMIM: 165020) PREDICTED: proto-oncog (2357) 974 93.5 1.3e-17
NP_055030 (OMIM: 147671) insulin receptor-related (1297) 931 89.6 1e-16
XP_011519819 (OMIM: 147370,270450) PREDICTED: insu ( 922) 889 86.0 8.6e-16
XP_011519818 (OMIM: 147370,270450) PREDICTED: insu (1064) 889 86.2 9.1e-16
XP_016877628 (OMIM: 147370,270450) PREDICTED: insu (1246) 889 86.3 9.8e-16
NP_001278787 (OMIM: 147370,270450) insulin-like gr (1366) 889 86.4 1e-15
NP_000866 (OMIM: 147370,270450) insulin-like growt (1367) 889 86.4 1e-15
XP_016877627 (OMIM: 147370,270450) PREDICTED: insu (1391) 889 86.4 1e-15
XP_016877626 (OMIM: 147370,270450) PREDICTED: insu (1392) 889 86.4 1e-15
XP_016877625 (OMIM: 147370,270450) PREDICTED: insu (1392) 889 86.4 1e-15
XP_011526291 (OMIM: 147670,246200,262190,609968,61 (1369) 885 86.0 1.3e-15
NP_001073285 (OMIM: 147670,246200,262190,609968,61 (1370) 885 86.0 1.3e-15
XP_011526290 (OMIM: 147670,246200,262190,609968,61 (1381) 885 86.0 1.3e-15
NP_000199 (OMIM: 147670,246200,262190,609968,61054 (1382) 885 86.0 1.3e-15
XP_011534356 (OMIM: 165020) PREDICTED: proto-oncog (2200) 859 84.4 6.5e-15
NP_001007793 (OMIM: 155240,191315,256800) high aff ( 760) 781 77.4 2.8e-13
NP_001012331 (OMIM: 155240,191315,256800) high aff ( 790) 781 77.4 2.9e-13
NP_002520 (OMIM: 155240,191315,256800) high affini ( 796) 781 77.4 2.9e-13
XP_016870243 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 761 75.9 8.7e-13
XP_011517020 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 761 75.9 8.7e-13
XP_016870241 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 761 75.9 8.7e-13
NP_001018074 (OMIM: 600456,613886) BDNF/NT-3 growt ( 822) 761 75.9 8.7e-13
XP_016870242 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 761 75.9 8.7e-13
XP_005252060 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 761 75.9 8.8e-13
XP_016870240 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 761 75.9 8.8e-13
XP_005252061 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 761 75.9 8.8e-13
NP_006171 (OMIM: 600456,613886) BDNF/NT-3 growth f ( 838) 761 75.9 8.8e-13
XP_005252058 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 761 75.9 8.8e-13
NP_001265528 (OMIM: 109135) tyrosine-protein kinas ( 626) 757 75.4 9.6e-13
NP_001690 (OMIM: 109135) tyrosine-protein kinase r ( 885) 757 75.6 1.1e-12
NP_068713 (OMIM: 109135) tyrosine-protein kinase r ( 894) 757 75.6 1.1e-12
XP_016877741 (OMIM: 191316) PREDICTED: NT-3 growth ( 448) 718 72.0 6.9e-12
XP_016877740 (OMIM: 191316) PREDICTED: NT-3 growth ( 456) 718 72.0 7e-12
>>NP_002335 (OMIM: 151520) leukocyte tyrosine kinase rec (864 aa)
initn: 6041 init1: 6041 opt: 6041 Z-score: 2593.6 bits: 491.0 E(85289): 1e-137
Smith-Waterman score: 6041; 100.0% identity (100.0% similar) in 864 aa overlap (1-864:1-864)
10 20 30 40 50 60
pF1KB8 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB8 TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL
790 800 810 820 830 840
850 860
pF1KB8 SSGLKPLKSRGLQPQNLWNPTYRS
::::::::::::::::::::::::
NP_002 SSGLKPLKSRGLQPQNLWNPTYRS
850 860
>>NP_996844 (OMIM: 151520) leukocyte tyrosine kinase rec (803 aa)
initn: 3749 init1: 3749 opt: 3779 Z-score: 1632.8 bits: 313.1 E(85289): 3.3e-84
Smith-Waterman score: 5455; 92.9% identity (92.9% similar) in 864 aa overlap (1-864:1-803)
10 20 30 40 50 60
pF1KB8 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
:::::::::::::::::::::::::::::::::
NP_996 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGG---------------------------
250 260 270
310 320 330 340 350 360
pF1KB8 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
::::::::::::::::::::::::::
NP_996 ----------------------------------DASETDNLWADGEDGVSFIHPSSELF
280 290
370 380 390 400 410 420
pF1KB8 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK
300 310 320 330 340 350
430 440 450 460 470 480
pF1KB8 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA
360 370 380 390 400 410
490 500 510 520 530 540
pF1KB8 PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ
420 430 440 450 460 470
550 560 570 580 590 600
pF1KB8 VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS
480 490 500 510 520 530
610 620 630 640 650 660
pF1KB8 FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA
540 550 560 570 580 590
670 680 690 700 710 720
pF1KB8 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG
600 610 620 630 640 650
730 740 750 760 770 780
pF1KB8 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC
660 670 680 690 700 710
790 800 810 820 830 840
pF1KB8 TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL
720 730 740 750 760 770
850 860
pF1KB8 SSGLKPLKSRGLQPQNLWNPTYRS
::::::::::::::::::::::::
NP_996 SSGLKPLKSRGLQPQNLWNPTYRS
780 790 800
>>XP_011519858 (OMIM: 151520) PREDICTED: leukocyte tyros (880 aa)
initn: 3131 init1: 3131 opt: 3138 Z-score: 1360.2 bits: 262.8 E(85289): 5e-69
Smith-Waterman score: 5995; 98.1% identity (98.2% similar) in 880 aa overlap (1-864:1-880)
10 20 30 40 50 60
pF1KB8 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK
370 380 390 400 410 420
430 440 450 460
pF1KB8 PPGPLVLMVAVVATSTLSLLMVCGVLIL----------------VKQKKWQGLQEMRLPS
:::::::::::::::::::::::::::: .:::::::::::::::
XP_011 PPGPLVLMVAVVATSTLSLLMVCGVLILGTKRLAGTVDSRLLLSMKQKKWQGLQEMRLPS
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB8 PELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEV
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB8 YEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRAT
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB8 PRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDI
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB8 AARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKT
670 680 690 700 710 720
710 720 730 740 750 760
pF1KB8 DSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEP
730 740 750 760 770 780
770 780 790 800 810 820
pF1KB8 ELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELS
790 800 810 820 830 840
830 840 850 860
pF1KB8 PEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS
::::::::::::::::::::::::::::::::::::::::
XP_011 PEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS
850 860 870 880
>>XP_016877672 (OMIM: 151520) PREDICTED: leukocyte tyros (800 aa)
initn: 4803 init1: 2555 opt: 3114 Z-score: 1350.3 bits: 260.8 E(85289): 1.8e-68
Smith-Waterman score: 5262; 89.6% identity (90.6% similar) in 869 aa overlap (1-864:1-800)
10 20 30 40 50 60
pF1KB8 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
310 320 330 340 350 360
370 380 390 400 410
pF1KB8 LQPLAV-----TENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTC
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQPLAVLLLTVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTC
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB8 MDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTS
::::::::::::::::::::::::::::::::: : :.: : .:
XP_016 MDLHKPPGPLVLMVAVVATSTLSLLMVCGVLIL--GGAW--------PGPVL------AS
430 440 450 460
480 490 500 510 520 530
pF1KB8 AIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGD
: : :. :. :.: .
XP_016 ATR-------CHRGF-PSQCY---------------------------------------
470
540 550 560 570 580 590
pF1KB8 SSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSG
. .:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ------SAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSG
480 490 500 510 520 530
600 610 620 630 640 650
pF1KB8 GDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAG
540 550 560 570 580 590
660 670 680 690 700 710
pF1KB8 PSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWE
600 610 620 630 640 650
720 730 740 750 760 770
pF1KB8 IFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILE
660 670 680 690 700 710
780 790 800 810 820 830
pF1KB8 RLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSP
720 730 740 750 760 770
840 850 860
pF1KB8 LGPWLSSGLKPLKSRGLQPQNLWNPTYRS
:::::::::::::::::::::::::::::
XP_016 LGPWLSSGLKPLKSRGLQPQNLWNPTYRS
780 790 800
>>XP_016877671 (OMIM: 151520) PREDICTED: leukocyte tyros (837 aa)
initn: 5461 init1: 2920 opt: 2940 Z-score: 1276.2 bits: 247.2 E(85289): 2.4e-64
Smith-Waterman score: 5745; 95.7% identity (95.7% similar) in 869 aa overlap (1-864:1-837)
10 20 30 40 50 60
pF1KB8 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
310 320 330 340 350 360
370 380 390 400 410
pF1KB8 LQPLAV-----TENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTC
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQPLAVLLLTVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTC
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB8 MDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTS
: :::::::::::::::::::::::::::
XP_016 M--------------------------------VKQKKWQGLQEMRLPSPELELSKLRTS
430 440
480 490 500 510 520 530
pF1KB8 AIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGD
450 460 470 480 490 500
540 550 560 570 580 590
pF1KB8 SSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSG
510 520 530 540 550 560
600 610 620 630 640 650
pF1KB8 GDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAG
570 580 590 600 610 620
660 670 680 690 700 710
pF1KB8 PSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWE
630 640 650 660 670 680
720 730 740 750 760 770
pF1KB8 IFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILE
690 700 710 720 730 740
780 790 800 810 820 830
pF1KB8 RLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSP
750 760 770 780 790 800
840 850 860
pF1KB8 LGPWLSSGLKPLKSRGLQPQNLWNPTYRS
:::::::::::::::::::::::::::::
XP_016 LGPWLSSGLKPLKSRGLQPQNLWNPTYRS
810 820 830
>>XP_016877670 (OMIM: 151520) PREDICTED: leukocyte tyros (885 aa)
initn: 5452 init1: 2911 opt: 2938 Z-score: 1275.2 bits: 247.1 E(85289): 2.7e-64
Smith-Waterman score: 5975; 97.5% identity (97.6% similar) in 885 aa overlap (1-864:1-885)
10 20 30 40 50 60
pF1KB8 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
310 320 330 340 350 360
370 380 390 400 410
pF1KB8 LQPLAV-----TENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTC
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQPLAVLLLTVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTC
370 380 390 400 410 420
420 430 440 450
pF1KB8 MDLHKPPGPLVLMVAVVATSTLSLLMVCGVLIL----------------VKQKKWQGLQE
::::::::::::::::::::::::::::::::: .::::::::::
XP_016 MDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILGTKRLAGTVDSRLLLSMKQKKWQGLQE
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB8 MRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHG
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB8 AFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGL
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB8 SLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHF
610 620 630 640 650 660
640 650 660 670 680 690
pF1KB8 IHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGI
670 680 690 700 710 720
700 710 720 730 740 750
pF1KB8 FTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQC
730 740 750 760 770 780
760 770 780 790 800 810
pF1KB8 WQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQ
790 800 810 820 830 840
820 830 840 850 860
pF1KB8 PQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS
850 860 870 880
>>XP_011519859 (OMIM: 151520) PREDICTED: leukocyte tyros (824 aa)
initn: 4783 init1: 2911 opt: 2928 Z-score: 1271.2 bits: 246.2 E(85289): 4.6e-64
Smith-Waterman score: 5389; 90.6% identity (90.7% similar) in 885 aa overlap (1-864:1-824)
10 20 30 40 50 60
pF1KB8 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
:::::::::::::::::::::::::::::::::
XP_011 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGG---------------------------
250 260 270
310 320 330 340 350 360
pF1KB8 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
::::::::::::::::::::::::::
XP_011 ----------------------------------DASETDNLWADGEDGVSFIHPSSELF
280 290
370 380 390 400 410
pF1KB8 LQPLAV-----TENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTC
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQPLAVLLLTVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTC
300 310 320 330 340 350
420 430 440 450
pF1KB8 MDLHKPPGPLVLMVAVVATSTLSLLMVCGVLIL----------------VKQKKWQGLQE
::::::::::::::::::::::::::::::::: .::::::::::
XP_011 MDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILGTKRLAGTVDSRLLLSMKQKKWQGLQE
360 370 380 390 400 410
460 470 480 490 500 510
pF1KB8 MRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHG
420 430 440 450 460 470
520 530 540 550 560 570
pF1KB8 AFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGL
480 490 500 510 520 530
580 590 600 610 620 630
pF1KB8 SLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHF
540 550 560 570 580 590
640 650 660 670 680 690
pF1KB8 IHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGI
600 610 620 630 640 650
700 710 720 730 740 750
pF1KB8 FTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQC
660 670 680 690 700 710
760 770 780 790 800 810
pF1KB8 WQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQ
720 730 740 750 760 770
820 830 840 850 860
pF1KB8 PQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS
780 790 800 810 820
>>NP_004295 (OMIM: 105590,613014) ALK tyrosine kinase re (1620 aa)
initn: 2767 init1: 2275 opt: 2626 Z-score: 1140.5 bits: 223.0 E(85289): 8.7e-57
Smith-Waterman score: 3136; 55.6% identity (75.9% similar) in 859 aa overlap (4-843:608-1450)
10 20 30
pF1KB8 MGCWGQLLVWFGAAGAILCSSPG---SQETFLR
: :...:.: .. . . . : . .:
NP_004 GRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLT
580 590 600 610 620 630
40 50 60 70 80
pF1KB8 SSP----LPLASPSPRDPKVSAPPSILEPA--SPLNSPGTEGS--WLFSTCGASGRHGPT
: : ..:. :. : . :.:. :: ..: . . :::.:::::: ::::
NP_004 ISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPT
640 650 660 670 680 690
90 100 110 120 130 140
pF1KB8 QTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGV
:.::..:: .... : ::. : :.:.:.:.::. : ::.::::::::.:: . :.:::
NP_004 QAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGV
700 710 720 730 740 750
150 160 170 180 190 200
pF1KB8 FVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCLGESRAVEEHAAMDGSEGVPGSR
: .::.: . ::::::::::::::. . : ::.::. ..::. .. : .
NP_004 SVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRS-----VH
760 770 780 790 800 810
210 220 230 240 250 260
pF1KB8 RWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAP
.:::::::::::::::... : ::..::::::::: : . ::.::: : .
NP_004 EWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFH----PERLENNSSVL
820 830 840 850 860
270 280 290 300 310 320
pF1KB8 GSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGCSEAWATLGWAAAGGFGGGGGAC
: .: .:::::::::.. . ::.:::::: ::..: .: :: . ::::::::.:
NP_004 GLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGC
870 880 890 900 910 920
330 340 350 360 370 380
pF1KB8 TAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCS
..::::::: ::.:. ... ::::::::: : . :. : : :.::::.:...::::
NP_004 SSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCS
930 940 950 960 970 980
390 400 410 420 430 440
pF1KB8 HCPLRDCQWQAELQLAECLCPEGMELAVDNVTCM--DLHKPPGPLVLMVAVVATSTLSLL
:: . .:. . : . . :.: .: :: :.:.:. .: :: :...::... .. :
NP_004 HCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAAL
990 1000 1010 1020 1030 1040
450 460 470 480 490
pF1KB8 MVC--GVLILVKQKKWQGLQ--EMRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSW
.. :..: : ..: : :: .:.: ::: .:::::::.: : :: :: .: . :
NP_004 VLAFSGIMI-VYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSIS-
1050 1060 1070 1080 1090 1100
500 510 520 530 540 550
pF1KB8 PLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDEL
. :: :.::.:.:::::::::::: : :.:.: ::::::.:::::.:: ::::
NP_004 ----DLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDEL
1110 1120 1130 1140 1150 1160
560 570 580 590 600 610
pF1KB8 DFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLV
:::::::::::: :::::::.:.::.. ::.::::::.:::.:::::..::. .::: :.
NP_004 DFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLA
1170 1180 1190 1200 1210 1220
620 630 640 650 660 670
pF1KB8 MRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASY
: :::..:.::: ::.:::::::::::::::::::.: ::.:::::::::::::::::::
NP_004 MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASY
1230 1240 1250 1260 1270 1280
680 690 700 710 720 730
pF1KB8 YRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFV
::.: :.:::::::::::.:::::::::.:::::::::::::::::::...:::::.::
NP_004 YRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV
1290 1300 1310 1320 1330 1340
740 750 760 770 780 790
pF1KB8 VGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELG
..:::::::..:::::::::::::::.:: ::.:: ::::..::::::::.:. ::.: :
NP_004 TSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYG
1350 1360 1370 1380 1390 1400
800 810 820 830 840 850
pF1KB8 PTPEEEGTSGLGNRSLECLRPPQ--PQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQP
: ::: . .. : . :: :. . :. .: .. : : :::
NP_004 PLVEEEEKVPVRPKDPEGV-PPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEI
1410 1420 1430 1440 1450 1460
860
pF1KB8 QNLWNPTYRS
NP_004 SVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNP
1470 1480 1490 1500 1510 1520
>>NP_001129157 (OMIM: 151520) leukocyte tyrosine kinase (734 aa)
initn: 4134 init1: 2262 opt: 2276 Z-score: 994.6 bits: 194.9 E(85289): 1.2e-48
Smith-Waterman score: 4696; 83.1% identity (84.0% similar) in 864 aa overlap (1-864:1-734)
10 20 30 40 50 60
pF1KB8 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
:::::::::::::::::::::::::::::::::
NP_001 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGG---------------------------
250 260 270
310 320 330 340 350 360
pF1KB8 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
::::::::::::::::::::::::::
NP_001 ----------------------------------DASETDNLWADGEDGVSFIHPSSELF
280 290
370 380 390 400 410 420
pF1KB8 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK
300 310 320 330 340 350
430 440 450 460 470 480
pF1KB8 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA
:::::::::::::::::::::::::::: : :.: : .:: :
NP_001 PPGPLVLMVAVVATSTLSLLMVCGVLIL--GGAW--------PGPVL------ASATR--
360 370 380 390 400
490 500 510 520 530 540
pF1KB8 PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ
:. :. :.: .
NP_001 -----CHRGF-PSQCY--------------------------------------------
410
550 560 570 580 590 600
pF1KB8 VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS
. .::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -SAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS
420 430 440 450 460 470
610 620 630 640 650 660
pF1KB8 FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA
480 490 500 510 520 530
670 680 690 700 710 720
pF1KB8 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG
540 550 560 570 580 590
730 740 750 760 770 780
pF1KB8 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC
600 610 620 630 640 650
790 800 810 820 830 840
pF1KB8 TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL
660 670 680 690 700 710
850 860
pF1KB8 SSGLKPLKSRGLQPQNLWNPTYRS
::::::::::::::::::::::::
NP_001 SSGLKPLKSRGLQPQNLWNPTYRS
720 730
>>XP_011534355 (OMIM: 165020) PREDICTED: proto-oncogene (2299 aa)
initn: 931 init1: 553 opt: 974 Z-score: 437.5 bits: 93.4 E(85289): 1.3e-17
Smith-Waterman score: 974; 46.9% identity (74.6% similar) in 307 aa overlap (510-813:1897-2196)
480 490 500 510 520 530
pF1KB8 APNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPG-DSSP
.:: :: ::::::::: .. . : :.
XP_011 GVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE
1870 1880 1890 1900 1910 1920
540 550 560 570 580 590
pF1KB8 LQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDM
..::.::: . . :....:: :: ..::: : ::.. .:. : :. :.:::: :::.
XP_011 IKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDL
1930 1940 1950 1960 1970 1980
600 610 620 630 640 650
pF1KB8 KSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPS-
..::..: :.. ::..: ::..:: :::. ::::::.::::::.: .
XP_011 LTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTS
1990 2000 2010 2020 2030 2040
660 670 680 690 700 710
pF1KB8 -RVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEI
:..::::::.:::::. .:::. ..::::.:: ::....::::...: ::::.:.:::
XP_011 PRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEI
2050 2060 2070 2080 2090 2100
720 730 740 750 760 770
pF1KB8 FSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILER
..::..:::...: .::..: :::..:::.:: .. .::::: .::. ::.: : ..
XP_011 LTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQ
2110 2120 2130 2140 2150 2160
780 790 800 810 820 830
pF1KB8 LQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPL
:: . :::. . .: ..::. :.:.:
XP_011 LQLFRN--FFLNSIYK-----SRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETK
2170 2180 2190 2200 2210
840 850 860
pF1KB8 GPWLSSGLKPLKSRGLQPQNLWNPTYRS
XP_011 NREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSG
2220 2230 2240 2250 2260 2270
864 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 02:18:27 2016 done: Tue Nov 8 02:18:29 2016
Total Scan time: 13.080 Total Display time: 0.240
Function used was FASTA [36.3.4 Apr, 2011]