Result of FASTA (omim) for
pFN21AB8401
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8401, 953 aa
1>>>pF1KB8401 953 - 953 aa - 953 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5308+/-0.000495; mu= 20.4497+/- 0.031
mean_var=73.7745+/-15.032, 0's: 0 Z-trim(107.3): 59 B-trim: 444 in 1/54
Lambda= 0.149321
statistics sampled from 15307 (15361) to 15307 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.521), E-opt: 0.2 (0.18), width: 16
Scan time: 13.350
The best scores are: opt bits E(85289)
NP_057535 (OMIM: 600959) coatomer subunit beta [Ho ( 953) 6121 1329.1 0
NP_001137534 (OMIM: 600959) coatomer subunit beta ( 953) 6121 1329.1 0
NP_001137533 (OMIM: 600959) coatomer subunit beta ( 953) 6121 1329.1 0
XP_005257998 (OMIM: 601025) PREDICTED: AP-2 comple ( 733) 266 67.8 2.4e-10
XP_016879776 (OMIM: 601025) PREDICTED: AP-2 comple ( 733) 266 67.8 2.4e-10
NP_001273 (OMIM: 601025) AP-2 complex subunit beta ( 937) 266 67.8 2.9e-10
XP_016879773 (OMIM: 601025) PREDICTED: AP-2 comple ( 937) 266 67.8 2.9e-10
XP_005257995 (OMIM: 601025) PREDICTED: AP-2 comple ( 951) 266 67.8 3e-10
XP_005257994 (OMIM: 601025) PREDICTED: AP-2 comple ( 951) 266 67.8 3e-10
NP_001025177 (OMIM: 601025) AP-2 complex subunit b ( 951) 266 67.8 3e-10
XP_011522753 (OMIM: 601025) PREDICTED: AP-2 comple ( 969) 266 67.8 3e-10
XP_011522752 (OMIM: 601025) PREDICTED: AP-2 comple ( 983) 266 67.8 3e-10
XP_011522750 (OMIM: 601025) PREDICTED: AP-2 comple ( 983) 266 67.8 3e-10
XP_011522751 (OMIM: 601025) PREDICTED: AP-2 comple ( 983) 266 67.8 3e-10
NP_001159491 (OMIM: 600157) AP-1 complex subunit b ( 919) 257 65.9 1.1e-09
NP_663782 (OMIM: 600157) AP-1 complex subunit beta ( 939) 257 65.9 1.1e-09
NP_001118 (OMIM: 600157) AP-1 complex subunit beta ( 949) 257 65.9 1.1e-09
XP_011522757 (OMIM: 601025) PREDICTED: AP-2 comple ( 880) 220 57.9 2.7e-07
XP_016879775 (OMIM: 601025) PREDICTED: AP-2 comple ( 880) 220 57.9 2.7e-07
XP_016879774 (OMIM: 601025) PREDICTED: AP-2 comple ( 894) 220 57.9 2.7e-07
XP_011522756 (OMIM: 601025) PREDICTED: AP-2 comple ( 926) 220 57.9 2.8e-07
XP_011522754 (OMIM: 601025) PREDICTED: AP-2 comple ( 926) 220 57.9 2.8e-07
XP_011522755 (OMIM: 601025) PREDICTED: AP-2 comple ( 926) 220 57.9 2.8e-07
XP_005248676 (OMIM: 603401,608233) PREDICTED: AP-3 ( 871) 189 51.2 2.7e-05
XP_005248675 (OMIM: 603401,608233) PREDICTED: AP-3 (1053) 189 51.3 3.2e-05
NP_003655 (OMIM: 603401,608233) AP-3 complex subun (1094) 189 51.3 3.3e-05
XP_016865490 (OMIM: 603401,608233) PREDICTED: AP-3 (1004) 182 49.7 8.7e-05
NP_001258698 (OMIM: 603401,608233) AP-3 complex su (1045) 182 49.8 9e-05
XP_016878130 (OMIM: 602166) PREDICTED: AP-3 comple ( 629) 170 47.0 0.00035
XP_016878129 (OMIM: 602166) PREDICTED: AP-3 comple (1058) 170 47.2 0.00054
NP_004635 (OMIM: 602166) AP-3 complex subunit beta (1082) 170 47.2 0.00055
NP_001265441 (OMIM: 602166) AP-3 complex subunit b (1101) 170 47.2 0.00056
XP_016855582 (OMIM: 607245,614066) PREDICTED: AP-4 ( 405) 163 45.4 0.0007
XP_016855578 (OMIM: 607245,614066) PREDICTED: AP-4 ( 635) 163 45.5 0.001
NP_001240781 (OMIM: 607245,614066) AP-4 complex su ( 739) 163 45.6 0.0011
NP_006585 (OMIM: 607245,614066) AP-4 complex subun ( 739) 163 45.6 0.0011
>>NP_057535 (OMIM: 600959) coatomer subunit beta [Homo s (953 aa)
initn: 6121 init1: 6121 opt: 6121 Z-score: 7121.8 bits: 1329.1 E(85289): 0
Smith-Waterman score: 6121; 100.0% identity (100.0% similar) in 953 aa overlap (1-953:1-953)
10 20 30 40 50 60
pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB8 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB8 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI
850 860 870 880 890 900
910 920 930 940 950
pF1KB8 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI
910 920 930 940 950
>>NP_001137534 (OMIM: 600959) coatomer subunit beta [Hom (953 aa)
initn: 6121 init1: 6121 opt: 6121 Z-score: 7121.8 bits: 1329.1 E(85289): 0
Smith-Waterman score: 6121; 100.0% identity (100.0% similar) in 953 aa overlap (1-953:1-953)
10 20 30 40 50 60
pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB8 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB8 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI
850 860 870 880 890 900
910 920 930 940 950
pF1KB8 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI
910 920 930 940 950
>>NP_001137533 (OMIM: 600959) coatomer subunit beta [Hom (953 aa)
initn: 6121 init1: 6121 opt: 6121 Z-score: 7121.8 bits: 1329.1 E(85289): 0
Smith-Waterman score: 6121; 100.0% identity (100.0% similar) in 953 aa overlap (1-953:1-953)
10 20 30 40 50 60
pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB8 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB8 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI
850 860 870 880 890 900
910 920 930 940 950
pF1KB8 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI
910 920 930 940 950
>>XP_005257998 (OMIM: 601025) PREDICTED: AP-2 complex su (733 aa)
initn: 183 init1: 105 opt: 266 Z-score: 306.8 bits: 67.8 E(85289): 2.4e-10
Smith-Waterman score: 296; 19.8% identity (52.1% similar) in 606 aa overlap (26-604:18-577)
10 20 30 40 50 60
pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
:: .:.. ... ::.:::: . :. . .:.
XP_005 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFP
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
.. . .. .:::. .. :. :: :.. ... :: . :: .::. .
XP_005 DVVN-CMQTDNLELKKLVYLYLMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALA
60 70 80 90 100
130 140 150 160 170
pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IH
.: . .. .. : : .: ::. . :::..:.. . .. ... : : ..
XP_005 VRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLR
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB8 DFLVNEKDASCKRNAFMMLIHADQDRA----LDYLSTCIDQVQT-FGDILQLVIVELIYK
: :. ... :: : . .... :: :... : ... . . ..
XP_005 D-LIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDC
170 180 190 200 210 220
240 250 260 270 280
pF1KB8 VCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIK-----AAAQCYIDL
. . ::.. : .. . .: ... :.. :.::.. . .: . : ..
XP_005 LSNYNPKDD----REAQSICERVTPRLSH--ANSAVVLSAVKVLMKFLELLPKDSDYYNM
230 240 250 260 270
290 300 310 320 330
pF1KB8 IIKE----------SDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRK
..:. .. .:. ..: : :.: . : . :.. .. : . . :.
XP_005 LLKKLAPPLVTLLSGEPEVQYVAL-RNINLIVQKRPEILKQEI--KVFFVKYNDPIYVKL
280 290 300 310 320 330
340 350 360 370 380 390
pF1KB8 KTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMA
. :.. . :.:. :. ... ::. . .. :.: :. ::.. :... . :
XP_005 EKLDIMIRLASQANIAQVLAELKEYATEV-------DVDFVRKA-VRAIGRCAIKVEQSA
340 350 360 370 380
400 410 420 430 440 450
pF1KB8 ANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGA
. .:..... . . .. ... .:. .... : :. . : . .. .
XP_005 ERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAM
390 400 410 420 430 440
460 470 480 490 500 510
pF1KB8 LWILGEYCSTKEDIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKL
.::.::: .. . .. . ... : :. . .: :: : .:.:
XP_005 IWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQEL
450 460 470 480 490 500
520 530 540 550 560 570
pF1KB8 VTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQE
: .. . :::. :. : . :: . ::. : .: ...: :..:
XP_005 VQQVLSLATQD---SDNPDLR--DRGYIYWRLLSTD-------PVTAKEVVLSEKPLISE
510 520 530 540 550
580 590 600 610 620 630
pF1KB8 KKKQNSFVAEAMLLMATILHLGK-SSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNK
. . : :: : :.:. .:. .::
XP_005 ETD----LIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSP
560 570 580 590 600
640 650 660 670 680 690
pF1KB8 ECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSL
XP_005 VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLPQK
610 620 630 640 650 660
>>XP_016879776 (OMIM: 601025) PREDICTED: AP-2 complex su (733 aa)
initn: 183 init1: 105 opt: 266 Z-score: 306.8 bits: 67.8 E(85289): 2.4e-10
Smith-Waterman score: 296; 19.8% identity (52.1% similar) in 606 aa overlap (26-604:18-577)
10 20 30 40 50 60
pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
:: .:.. ... ::.:::: . :. . .:.
XP_016 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFP
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
.. . .. .:::. .. :. :: :.. ... :: . :: .::. .
XP_016 DVVN-CMQTDNLELKKLVYLYLMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALA
60 70 80 90 100
130 140 150 160 170
pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IH
.: . .. .. : : .: ::. . :::..:.. . .. ... : : ..
XP_016 VRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLR
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB8 DFLVNEKDASCKRNAFMMLIHADQDRA----LDYLSTCIDQVQT-FGDILQLVIVELIYK
: :. ... :: : . .... :: :... : ... . . ..
XP_016 D-LIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDC
170 180 190 200 210 220
240 250 260 270 280
pF1KB8 VCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIK-----AAAQCYIDL
. . ::.. : .. . .: ... :.. :.::.. . .: . : ..
XP_016 LSNYNPKDD----REAQSICERVTPRLSH--ANSAVVLSAVKVLMKFLELLPKDSDYYNM
230 240 250 260 270
290 300 310 320 330
pF1KB8 IIKE----------SDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRK
..:. .. .:. ..: : :.: . : . :.. .. : . . :.
XP_016 LLKKLAPPLVTLLSGEPEVQYVAL-RNINLIVQKRPEILKQEI--KVFFVKYNDPIYVKL
280 290 300 310 320 330
340 350 360 370 380 390
pF1KB8 KTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMA
. :.. . :.:. :. ... ::. . .. :.: :. ::.. :... . :
XP_016 EKLDIMIRLASQANIAQVLAELKEYATEV-------DVDFVRKA-VRAIGRCAIKVEQSA
340 350 360 370 380
400 410 420 430 440 450
pF1KB8 ANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGA
. .:..... . . .. ... .:. .... : :. . : . .. .
XP_016 ERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAM
390 400 410 420 430 440
460 470 480 490 500 510
pF1KB8 LWILGEYCSTKEDIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKL
.::.::: .. . .. . ... : :. . .: :: : .:.:
XP_016 IWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQEL
450 460 470 480 490 500
520 530 540 550 560 570
pF1KB8 VTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQE
: .. . :::. :. : . :: . ::. : .: ...: :..:
XP_016 VQQVLSLATQD---SDNPDLR--DRGYIYWRLLSTD-------PVTAKEVVLSEKPLISE
510 520 530 540 550
580 590 600 610 620 630
pF1KB8 KKKQNSFVAEAMLLMATILHLGK-SSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNK
. . : :: : :.:. .:. .::
XP_016 ETD----LIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSP
560 570 580 590 600
640 650 660 670 680 690
pF1KB8 ECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSL
XP_016 VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLPQK
610 620 630 640 650 660
>>NP_001273 (OMIM: 601025) AP-2 complex subunit beta iso (937 aa)
initn: 183 init1: 105 opt: 266 Z-score: 305.2 bits: 67.8 E(85289): 2.9e-10
Smith-Waterman score: 296; 19.8% identity (52.1% similar) in 606 aa overlap (26-604:18-577)
10 20 30 40 50 60
pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
:: .:.. ... ::.:::: . :. . .:.
NP_001 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFP
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
.. . .. .:::. .. :. :: :.. ... :: . :: .::. .
NP_001 DVVN-CMQTDNLELKKLVYLYLMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALA
60 70 80 90 100
130 140 150 160 170
pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IH
.: . .. .. : : .: ::. . :::..:.. . .. ... : : ..
NP_001 VRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLR
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB8 DFLVNEKDASCKRNAFMMLIHADQDRA----LDYLSTCIDQVQT-FGDILQLVIVELIYK
: :. ... :: : . .... :: :... : ... . . ..
NP_001 D-LIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDC
170 180 190 200 210 220
240 250 260 270 280
pF1KB8 VCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIK-----AAAQCYIDL
. . ::.. : .. . .: ... :.. :.::.. . .: . : ..
NP_001 LSNYNPKDD----REAQSICERVTPRLSH--ANSAVVLSAVKVLMKFLELLPKDSDYYNM
230 240 250 260 270
290 300 310 320 330
pF1KB8 IIKE----------SDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRK
..:. .. .:. ..: : :.: . : . :.. .. : . . :.
NP_001 LLKKLAPPLVTLLSGEPEVQYVAL-RNINLIVQKRPEILKQEI--KVFFVKYNDPIYVKL
280 290 300 310 320 330
340 350 360 370 380 390
pF1KB8 KTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMA
. :.. . :.:. :. ... ::. . .. :.: :. ::.. :... . :
NP_001 EKLDIMIRLASQANIAQVLAELKEYATEV-------DVDFVRKA-VRAIGRCAIKVEQSA
340 350 360 370 380
400 410 420 430 440 450
pF1KB8 ANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGA
. .:..... . . .. ... .:. .... : :. . : . .. .
NP_001 ERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAM
390 400 410 420 430 440
460 470 480 490 500 510
pF1KB8 LWILGEYCSTKEDIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKL
.::.::: .. . .. . ... : :. . .: :: : .:.:
NP_001 IWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQEL
450 460 470 480 490 500
520 530 540 550 560 570
pF1KB8 VTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQE
: .. . :::. :. : . :: . ::. : .: ...: :..:
NP_001 VQQVLSLATQD---SDNPDLR--DRGYIYWRLLSTD-------PVTAKEVVLSEKPLISE
510 520 530 540 550
580 590 600 610 620 630
pF1KB8 KKKQNSFVAEAMLLMATILHLGK-SSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNK
. . : :: : :.:. .:. .::
NP_001 ETD----LIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSP
560 570 580 590 600
640 650 660 670 680 690
pF1KB8 ECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSL
NP_001 VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLVGQ
610 620 630 640 650 660
>>XP_016879773 (OMIM: 601025) PREDICTED: AP-2 complex su (937 aa)
initn: 183 init1: 105 opt: 266 Z-score: 305.2 bits: 67.8 E(85289): 2.9e-10
Smith-Waterman score: 296; 19.8% identity (52.1% similar) in 606 aa overlap (26-604:18-577)
10 20 30 40 50 60
pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
:: .:.. ... ::.:::: . :. . .:.
XP_016 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFP
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
.. . .. .:::. .. :. :: :.. ... :: . :: .::. .
XP_016 DVVN-CMQTDNLELKKLVYLYLMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALA
60 70 80 90 100
130 140 150 160 170
pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IH
.: . .. .. : : .: ::. . :::..:.. . .. ... : : ..
XP_016 VRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLR
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB8 DFLVNEKDASCKRNAFMMLIHADQDRA----LDYLSTCIDQVQT-FGDILQLVIVELIYK
: :. ... :: : . .... :: :... : ... . . ..
XP_016 D-LIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDC
170 180 190 200 210 220
240 250 260 270 280
pF1KB8 VCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIK-----AAAQCYIDL
. . ::.. : .. . .: ... :.. :.::.. . .: . : ..
XP_016 LSNYNPKDD----REAQSICERVTPRLSH--ANSAVVLSAVKVLMKFLELLPKDSDYYNM
230 240 250 260 270
290 300 310 320 330
pF1KB8 IIKE----------SDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRK
..:. .. .:. ..: : :.: . : . :.. .. : . . :.
XP_016 LLKKLAPPLVTLLSGEPEVQYVAL-RNINLIVQKRPEILKQEI--KVFFVKYNDPIYVKL
280 290 300 310 320 330
340 350 360 370 380 390
pF1KB8 KTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMA
. :.. . :.:. :. ... ::. . .. :.: :. ::.. :... . :
XP_016 EKLDIMIRLASQANIAQVLAELKEYATEV-------DVDFVRKA-VRAIGRCAIKVEQSA
340 350 360 370 380
400 410 420 430 440 450
pF1KB8 ANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGA
. .:..... . . .. ... .:. .... : :. . : . .. .
XP_016 ERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAM
390 400 410 420 430 440
460 470 480 490 500 510
pF1KB8 LWILGEYCSTKEDIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKL
.::.::: .. . .. . ... : :. . .: :: : .:.:
XP_016 IWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQEL
450 460 470 480 490 500
520 530 540 550 560 570
pF1KB8 VTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQE
: .. . :::. :. : . :: . ::. : .: ...: :..:
XP_016 VQQVLSLATQD---SDNPDLR--DRGYIYWRLLSTD-------PVTAKEVVLSEKPLISE
510 520 530 540 550
580 590 600 610 620 630
pF1KB8 KKKQNSFVAEAMLLMATILHLGK-SSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNK
. . : :: : :.:. .:. .::
XP_016 ETD----LIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSP
560 570 580 590 600
640 650 660 670 680 690
pF1KB8 ECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSL
XP_016 VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLVGQ
610 620 630 640 650 660
>>XP_005257995 (OMIM: 601025) PREDICTED: AP-2 complex su (951 aa)
initn: 183 init1: 105 opt: 266 Z-score: 305.1 bits: 67.8 E(85289): 3e-10
Smith-Waterman score: 296; 19.8% identity (52.1% similar) in 606 aa overlap (26-604:18-577)
10 20 30 40 50 60
pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
:: .:.. ... ::.:::: . :. . .:.
XP_005 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFP
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
.. . .. .:::. .. :. :: :.. ... :: . :: .::. .
XP_005 DVVN-CMQTDNLELKKLVYLYLMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALA
60 70 80 90 100
130 140 150 160 170
pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IH
.: . .. .. : : .: ::. . :::..:.. . .. ... : : ..
XP_005 VRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLR
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB8 DFLVNEKDASCKRNAFMMLIHADQDRA----LDYLSTCIDQVQT-FGDILQLVIVELIYK
: :. ... :: : . .... :: :... : ... . . ..
XP_005 D-LIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDC
170 180 190 200 210 220
240 250 260 270 280
pF1KB8 VCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIK-----AAAQCYIDL
. . ::.. : .. . .: ... :.. :.::.. . .: . : ..
XP_005 LSNYNPKDD----REAQSICERVTPRLSH--ANSAVVLSAVKVLMKFLELLPKDSDYYNM
230 240 250 260 270
290 300 310 320 330
pF1KB8 IIKE----------SDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRK
..:. .. .:. ..: : :.: . : . :.. .. : . . :.
XP_005 LLKKLAPPLVTLLSGEPEVQYVAL-RNINLIVQKRPEILKQEI--KVFFVKYNDPIYVKL
280 290 300 310 320 330
340 350 360 370 380 390
pF1KB8 KTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMA
. :.. . :.:. :. ... ::. . .. :.: :. ::.. :... . :
XP_005 EKLDIMIRLASQANIAQVLAELKEYATEV-------DVDFVRKA-VRAIGRCAIKVEQSA
340 350 360 370 380
400 410 420 430 440 450
pF1KB8 ANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGA
. .:..... . . .. ... .:. .... : :. . : . .. .
XP_005 ERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAM
390 400 410 420 430 440
460 470 480 490 500 510
pF1KB8 LWILGEYCSTKEDIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKL
.::.::: .. . .. . ... : :. . .: :: : .:.:
XP_005 IWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQEL
450 460 470 480 490 500
520 530 540 550 560 570
pF1KB8 VTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQE
: .. . :::. :. : . :: . ::. : .: ...: :..:
XP_005 VQQVLSLATQD---SDNPDLR--DRGYIYWRLLSTD-------PVTAKEVVLSEKPLISE
510 520 530 540 550
580 590 600 610 620 630
pF1KB8 KKKQNSFVAEAMLLMATILHLGK-SSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNK
. . : :: : :.:. .:. .::
XP_005 ETD----LIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSP
560 570 580 590 600
640 650 660 670 680 690
pF1KB8 ECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSL
XP_005 VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLLGS
610 620 630 640 650 660
>>XP_005257994 (OMIM: 601025) PREDICTED: AP-2 complex su (951 aa)
initn: 183 init1: 105 opt: 266 Z-score: 305.1 bits: 67.8 E(85289): 3e-10
Smith-Waterman score: 296; 19.8% identity (52.1% similar) in 606 aa overlap (26-604:18-577)
10 20 30 40 50 60
pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
:: .:.. ... ::.:::: . :. . .:.
XP_005 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFP
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
.. . .. .:::. .. :. :: :.. ... :: . :: .::. .
XP_005 DVVN-CMQTDNLELKKLVYLYLMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALA
60 70 80 90 100
130 140 150 160 170
pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IH
.: . .. .. : : .: ::. . :::..:.. . .. ... : : ..
XP_005 VRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLR
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB8 DFLVNEKDASCKRNAFMMLIHADQDRA----LDYLSTCIDQVQT-FGDILQLVIVELIYK
: :. ... :: : . .... :: :... : ... . . ..
XP_005 D-LIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDC
170 180 190 200 210 220
240 250 260 270 280
pF1KB8 VCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIK-----AAAQCYIDL
. . ::.. : .. . .: ... :.. :.::.. . .: . : ..
XP_005 LSNYNPKDD----REAQSICERVTPRLSH--ANSAVVLSAVKVLMKFLELLPKDSDYYNM
230 240 250 260 270
290 300 310 320 330
pF1KB8 IIKE----------SDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRK
..:. .. .:. ..: : :.: . : . :.. .. : . . :.
XP_005 LLKKLAPPLVTLLSGEPEVQYVAL-RNINLIVQKRPEILKQEI--KVFFVKYNDPIYVKL
280 290 300 310 320 330
340 350 360 370 380 390
pF1KB8 KTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMA
. :.. . :.:. :. ... ::. . .. :.: :. ::.. :... . :
XP_005 EKLDIMIRLASQANIAQVLAELKEYATEV-------DVDFVRKA-VRAIGRCAIKVEQSA
340 350 360 370 380
400 410 420 430 440 450
pF1KB8 ANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGA
. .:..... . . .. ... .:. .... : :. . : . .. .
XP_005 ERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAM
390 400 410 420 430 440
460 470 480 490 500 510
pF1KB8 LWILGEYCSTKEDIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKL
.::.::: .. . .. . ... : :. . .: :: : .:.:
XP_005 IWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQEL
450 460 470 480 490 500
520 530 540 550 560 570
pF1KB8 VTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQE
: .. . :::. :. : . :: . ::. : .: ...: :..:
XP_005 VQQVLSLATQD---SDNPDLR--DRGYIYWRLLSTD-------PVTAKEVVLSEKPLISE
510 520 530 540 550
580 590 600 610 620 630
pF1KB8 KKKQNSFVAEAMLLMATILHLGK-SSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNK
. . : :: : :.:. .:. .::
XP_005 ETD----LIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSP
560 570 580 590 600
640 650 660 670 680 690
pF1KB8 ECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSL
XP_005 VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLLGS
610 620 630 640 650 660
>>NP_001025177 (OMIM: 601025) AP-2 complex subunit beta (951 aa)
initn: 183 init1: 105 opt: 266 Z-score: 305.1 bits: 67.8 E(85289): 3e-10
Smith-Waterman score: 296; 19.8% identity (52.1% similar) in 606 aa overlap (26-604:18-577)
10 20 30 40 50 60
pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
:: .:.. ... ::.:::: . :. . .:.
NP_001 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFP
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
.. . .. .:::. .. :. :: :.. ... :: . :: .::. .
NP_001 DVVN-CMQTDNLELKKLVYLYLMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALA
60 70 80 90 100
130 140 150 160 170
pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IH
.: . .. .. : : .: ::. . :::..:.. . .. ... : : ..
NP_001 VRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLR
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB8 DFLVNEKDASCKRNAFMMLIHADQDRA----LDYLSTCIDQVQT-FGDILQLVIVELIYK
: :. ... :: : . .... :: :... : ... . . ..
NP_001 D-LIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDC
170 180 190 200 210 220
240 250 260 270 280
pF1KB8 VCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIK-----AAAQCYIDL
. . ::.. : .. . .: ... :.. :.::.. . .: . : ..
NP_001 LSNYNPKDD----REAQSICERVTPRLSH--ANSAVVLSAVKVLMKFLELLPKDSDYYNM
230 240 250 260 270
290 300 310 320 330
pF1KB8 IIKE----------SDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRK
..:. .. .:. ..: : :.: . : . :.. .. : . . :.
NP_001 LLKKLAPPLVTLLSGEPEVQYVAL-RNINLIVQKRPEILKQEI--KVFFVKYNDPIYVKL
280 290 300 310 320 330
340 350 360 370 380 390
pF1KB8 KTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMA
. :.. . :.:. :. ... ::. . .. :.: :. ::.. :... . :
NP_001 EKLDIMIRLASQANIAQVLAELKEYATEV-------DVDFVRKA-VRAIGRCAIKVEQSA
340 350 360 370 380
400 410 420 430 440 450
pF1KB8 ANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGA
. .:..... . . .. ... .:. .... : :. . : . .. .
NP_001 ERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAM
390 400 410 420 430 440
460 470 480 490 500 510
pF1KB8 LWILGEYCSTKEDIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKL
.::.::: .. . .. . ... : :. . .: :: : .:.:
NP_001 IWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQEL
450 460 470 480 490 500
520 530 540 550 560 570
pF1KB8 VTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQE
: .. . :::. :. : . :: . ::. : .: ...: :..:
NP_001 VQQVLSLATQD---SDNPDLR--DRGYIYWRLLSTD-------PVTAKEVVLSEKPLISE
510 520 530 540 550
580 590 600 610 620 630
pF1KB8 KKKQNSFVAEAMLLMATILHLGK-SSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNK
. . : :: : :.:. .:. .::
NP_001 ETD----LIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSP
560 570 580 590 600
640 650 660 670 680 690
pF1KB8 ECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSL
NP_001 VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLLGS
610 620 630 640 650 660
953 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 22:17:14 2016 done: Sun Nov 6 22:17:16 2016
Total Scan time: 13.350 Total Display time: 0.290
Function used was FASTA [36.3.4 Apr, 2011]