Result of FASTA (omim) for
pFN21AB7933
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7933, 367 aa
1>>>pF1KB7933 367 - 367 aa - 367 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.0365+/-0.000379; mu= -10.0039+/- 0.024
mean_var=523.2271+/-107.186, 0's: 0 Z-trim(126.6): 76 B-trim: 0 in 0/62
Lambda= 0.056070
statistics sampled from 52809 (52920) to 52809 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.851), E-opt: 0.2 (0.62), width: 16
Scan time: 11.700
The best scores are: opt bits E(85289)
NP_006159 (OMIM: 602563) homeobox protein Nkx-6.1 ( 367) 2428 210.0 6.9e-54
NP_796374 (OMIM: 605955) homeobox protein Nkx-6.2 ( 277) 969 91.9 1.9e-18
XP_016872278 (OMIM: 605955) PREDICTED: homeobox pr ( 277) 964 91.5 2.5e-18
XP_016868632 (OMIM: 610772) PREDICTED: homeobox pr ( 265) 595 61.6 2.4e-09
NP_066305 (OMIM: 604640) T-cell leukemia homeobox ( 291) 348 41.7 0.0026
NP_057254 (OMIM: 604240) T-cell leukemia homeobox ( 284) 326 39.9 0.0088
>>NP_006159 (OMIM: 602563) homeobox protein Nkx-6.1 [Hom (367 aa)
initn: 2428 init1: 2428 opt: 2428 Z-score: 1088.5 bits: 210.0 E(85289): 6.9e-54
Smith-Waterman score: 2428; 100.0% identity (100.0% similar) in 367 aa overlap (1-367:1-367)
10 20 30 40 50 60
pF1KB7 MLAVGAMEGTRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MLAVGAMEGTRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 SPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 SGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 AAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 PTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 TAKKKQDSETERLKGASENEEEDDDYNKPLDPNSDDEKITQLLKKHKSSSGGGGGLLLHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TAKKKQDSETERLKGASENEEEDDDYNKPLDPNSDDEKITQLLKKHKSSSGGGGGLLLHA
310 320 330 340 350 360
pF1KB7 SEPESSS
:::::::
NP_006 SEPESSS
>>NP_796374 (OMIM: 605955) homeobox protein Nkx-6.2 [Hom (277 aa)
initn: 1064 init1: 699 opt: 969 Z-score: 452.1 bits: 91.9 E(85289): 1.9e-18
Smith-Waterman score: 1075; 55.3% identity (67.4% similar) in 356 aa overlap (7-355:1-274)
10 20 30 40 50 60
pF1KB7 MLAVGAMEGTRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSP
:. .: .::.::: ::::::.:::::: :.: :
NP_796 MDTNRPGAFVLSSAPLAALHNMAEMKTSLFPYAL--------------------
10 20 30
70 80 90 100 110 120
pF1KB7 SPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASP
..:.:.: :: :::.. :: .:::::.:::.:: :::
NP_796 ------QGPAGFKAPALGGLGA------QLPLGTPHGISDILGRPV-----GAA------
40 50 60 70
130 140 150 160 170 180
pF1KB7 SGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPS
:. :::.::::...:. :.::.:
NP_796 -GG-------------------------------GLLGGLPRLNGLASSA---GVYFGP-
80 90
190 200 210 220 230 240
pF1KB7 AAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTR
::::: : ::::::::::: :::::::.:. :::: ::: :..: :::::.::.:
NP_796 AAAVAR-G-YPKPLAELPGRPPIFWPGVVQGAPWRDPRLAGPAPAGGVL-DKDGKKKHSR
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB7 PTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMA
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
NP_796 PTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAAEMA
160 170 180 190 200 210
310 320 330 340 350
pF1KB7 TAKKKQDSETERLKGASENEEEDDDYNKPLDPNSDDEKITQLLKKHKSSS-------GGG
.:::::::..:.:: .. . :.::.::.::::::::::::.:::::: :. :::
NP_796 SAKKKQDSDAEKLKVGGSDAEDDDEYNRPLDPNSDDEKITRLLKKHKPSNLALVSPCGGG
220 230 240 250 260 270
360
pF1KB7 GGLLLHASEPESSS
.:
NP_796 AGDAL
>>XP_016872278 (OMIM: 605955) PREDICTED: homeobox protei (277 aa)
initn: 1059 init1: 694 opt: 964 Z-score: 449.9 bits: 91.5 E(85289): 2.5e-18
Smith-Waterman score: 1070; 55.1% identity (67.4% similar) in 356 aa overlap (7-355:1-274)
10 20 30 40 50 60
pF1KB7 MLAVGAMEGTRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSP
:. .: .::.::: ::::::.:::::: :.: :
XP_016 MDTNRPGAFVLSSAPLAALHNMAEMKTSLFPYAL--------------------
10 20 30
70 80 90 100 110 120
pF1KB7 SPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASP
..:.:.: :: :::.. :: .:::::.:::.:: :::
XP_016 ------QGPAGFKAPALGGLGA------QLPLGTPHGISDILGRPV-----GAA------
40 50 60 70
130 140 150 160 170 180
pF1KB7 SGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPS
:. :::.::::...:. :.::.:
XP_016 -GG-------------------------------GLLGGLPRLNGLASSA---GVYFGP-
80 90
190 200 210 220 230 240
pF1KB7 AAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTR
::::: : ::::::::::: :::::::.:. :::: ::: :..: :::::.::.:
XP_016 AAAVAR-G-YPKPLAELPGRPPIFWPGVVQGAPWRDPRLAGPAPAGGVL-DKDGKKKHSR
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB7 PTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMA
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::.:::
XP_016 PTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAVEMA
160 170 180 190 200 210
310 320 330 340 350
pF1KB7 TAKKKQDSETERLKGASENEEEDDDYNKPLDPNSDDEKITQLLKKHKSSS-------GGG
.:::::::..:.:: .. . :.::.::.::::::::::::.:::::: :. :::
XP_016 SAKKKQDSDAEKLKVGGSDAEDDDEYNRPLDPNSDDEKITRLLKKHKPSNLALVSPCGGG
220 230 240 250 260 270
360
pF1KB7 GGLLLHASEPESSS
.:
XP_016 AGDAL
>>XP_016868632 (OMIM: 610772) PREDICTED: homeobox protei (265 aa)
initn: 653 init1: 390 opt: 595 Z-score: 288.9 bits: 61.6 E(85289): 2.4e-09
Smith-Waterman score: 634; 41.7% identity (57.5% similar) in 348 aa overlap (7-349:1-254)
10 20 30 40 50 60
pF1KB7 MLAVGAMEGTRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSP
::.. :..:::.. ::: .. :::.:. . : ..: .
XP_016 MESNLQGTFLLNNTPLA---QFPEMKAPV-------------CQYSVQNSFYKL
10 20 30
70 80 90 100 110 120
pF1KB7 SPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASP
::: :: : ::.:.:::::.:::::: :.:
XP_016 SPP-------GLGP--------------QLAAGTPHGITDILSRPV-----------AAP
40 50 60
130 140 150 160 170
pF1KB7 SGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPR---FSSLSPPPPPPGLYF
..: ::.: :. :..:: :.:.
XP_016 NNS--------------------------------LLSGYPHVAGFGGLS----SQGVYY
70 80 90
180 190 200 210 220 230
pF1KB7 SPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRK
::. :: . : : : :: : . :. :: .: :. . . : :. :.:
XP_016 SPQ------VGNFSKAGNEYPTRTRNCWADTGQD--WRGGR-QCS-NTPDPLSDSIHKKK
100 110 120 130 140
240 250 260 270 280 290
pF1KB7 HTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAA
::::::.:.:::::::::::::::::::::::::::::::::::::::::::::::: :
XP_016 HTRPTFTGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKSAL
150 160 170 180 190 200
300 310 320 330 340 350
pF1KB7 EMATAKKKQDSETERLKGASE--NEEEDDDYNKPLDPNSDDEKITQLLKKHKSSSGGGGG
: ... . . . :... .:.:::.:::::::.:::::: ::.::...
XP_016 EPSSSTPRAPGGAGAGAGGDRAPSENEDDEYNKPLDPDSDDEKIRLLLRKHRAAFSVLSL
210 220 230 240 250 260
360
pF1KB7 LLLHASEPESSS
XP_016 GAHSV
>>NP_066305 (OMIM: 604640) T-cell leukemia homeobox prot (291 aa)
initn: 376 init1: 254 opt: 348 Z-score: 180.4 bits: 41.7 E(85289): 0.0026
Smith-Waterman score: 358; 34.2% identity (56.7% similar) in 263 aa overlap (91-333:6-259)
70 80 90 100 110
pF1KB7 SPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPH-------GINDILSRP---SMPVA
:: ::: ::..::. : : :.
NP_066 MEAPASAQTPHPHEPISFGIDQILNSPDQDSAPAP
10 20 30
120 130 140 150 160
pF1KB7 ---SGAALPSASPSGSSSSSSSSASASSASAAAAAAAAAAAAAS---SPAGLLAGLPRFS
.::. .. :.: ... : :: :. .: :.. ... .:::.. .:
NP_066 RGPDGASYLGGPPGGRPGATYPSLPASFAGLGAPFEDAGSYSVNLSLAPAGVIR-VPAHR
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB7 SLS---PPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGR-TPIFWPGVMQSPPWRDARLA
: ::: : .: ::. .:...: : : : . . .. :. .:
NP_066 PLPGAVPPPLPSALPAMPSVPTVSSLGGLNFPWMESSRRFVKDRFTAAAALTPFTVTRRI
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB7 CTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQV
:.:. :::. : .:: :: ::: :.. ::::. ::: :: :: ::..::
NP_066 GHPYQNRT----PPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQV
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB7 KVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKGASENEEEDDDYNKPLDPNSDDEKIT
:.::::::::::.. .:: :...: : :: ... . . : ..:.
NP_066 KTWFQNRRTKWRRQ-TAEEREAERQQAS---RLMLQLQHDAFQKSLNDSIQPDPLCLHNS
220 230 240 250 260
350 360
pF1KB7 QLLKKHKSSSGGGGGLLLHASEPESSS
NP_066 SLFALQNLQPWEEDSSKVPAVTSLV
270 280 290
>>NP_057254 (OMIM: 604240) T-cell leukemia homeobox prot (284 aa)
initn: 339 init1: 247 opt: 326 Z-score: 170.9 bits: 39.9 E(85289): 0.0088
Smith-Waterman score: 326; 32.8% identity (58.6% similar) in 256 aa overlap (87-332:8-245)
60 70 80 90 100 110
pF1KB7 SSSPSPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATP--HGINDILSRPSMPVASGAA
:..: : ::..::: : : ..: .
NP_057 MEPGMLGPHNLPHHEPISFGIDQILSGPETP-GGGLG
10 20 30
120 130 140 150 160 170
pF1KB7 LPSASPSGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPG
: .. .: . ... :.. .::. . :.. : .:: .: .:. : . : : ::
NP_057 LGRGG-QGHGENGAFSGGYHGASGYGPAGSLAPLPGSSGVGP-GGVIRVPAHRPLPVPP-
40 50 60 70 80 90
180 190 200 210 220 230
pF1KB7 LYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARL--ACTPHQGSILLDK
:...: :. : :. :. : . . .: . .. . :: : .: .:. . .
NP_057 ----PAGGAPAVPG--PSGLGGAGGLAGLTFPWMDSGRRFAKDRLTAALSPFSGTRRIGH
100 110 120 130 140
240 250 260 270 280
pF1KB7 D------GKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQN
:::. : .:: .:.. ::. : . ::::. ::: :: .: ::..:::.::::
NP_057 PYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQN
150 160 170 180 190 200
290 300 310 320 330 340
pF1KB7 RRTKWRKKHAAEMATAKKKQDSETERLKGASENEEEDDDYNKPLDPNSDDEKITQLLKKH
::::::.. : : ...: .: : . ..: .:: :
NP_057 RRTKWRRQTAEE-------REAERHR-AGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSL
210 220 230 240 250
350 360
pF1KB7 KSSSGGGGGLLLHASEPESSS
NP_057 FALQNLQPWAEDNKVASVSGLASVV
260 270 280
367 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 17:50:13 2016 done: Mon Nov 7 17:50:15 2016
Total Scan time: 11.700 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]