Result of FASTA (omim) for
pFN21AB7764
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7764, 501 aa
1>>>pF1KB7764 501 - 501 aa - 501 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.8347+/-0.000412; mu= -13.4729+/- 0.026
mean_var=531.5318+/-106.250, 0's: 0 Z-trim(125.7): 24 B-trim: 0 in 0/60
Lambda= 0.055630
statistics sampled from 49863 (49887) to 49863 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.835), E-opt: 0.2 (0.585), width: 16
Scan time: 9.290
The best scores are: opt bits E(85289)
NP_077312 (OMIM: 612985) iroquois-class homeodomai ( 501) 3370 284.7 4.3e-76
XP_005256196 (OMIM: 612985) PREDICTED: iroquois-cl ( 529) 3279 277.4 7e-74
XP_016865334 (OMIM: 606197) PREDICTED: iroquois-cl ( 449) 941 89.7 1.9e-17
NP_077313 (OMIM: 606197) iroquois-class homeodomai ( 480) 941 89.7 2e-17
NP_005844 (OMIM: 606195,611174) iroquois-class hom ( 483) 797 78.2 6.1e-14
NP_001239126 (OMIM: 606195,611174) iroquois-class ( 482) 795 78.0 6.8e-14
XP_011521111 (OMIM: 606195,611174) PREDICTED: iroq ( 413) 757 74.9 5e-13
NP_150366 (OMIM: 606198) iroquois-class homeodomai ( 471) 727 72.5 2.9e-12
NP_001127694 (OMIM: 606198) iroquois-class homeodo ( 471) 727 72.5 2.9e-12
XP_011512281 (OMIM: 606198) PREDICTED: iroquois-cl ( 471) 727 72.5 2.9e-12
NP_057442 (OMIM: 606199) iroquois-class homeodomai ( 519) 703 70.7 1.2e-11
NP_001265561 (OMIM: 606199) iroquois-class homeodo ( 519) 703 70.7 1.2e-11
NP_001265563 (OMIM: 606199) iroquois-class homeodo ( 519) 703 70.7 1.2e-11
XP_005256194 (OMIM: 606196) PREDICTED: iroquois-cl ( 445) 626 64.4 7.7e-10
NP_077311 (OMIM: 606196) iroquois-class homeodomai ( 446) 626 64.4 7.8e-10
NP_001265562 (OMIM: 606199) iroquois-class homeodo ( 545) 603 62.7 3.2e-09
NP_001265564 (OMIM: 606199) iroquois-class homeodo ( 545) 603 62.7 3.2e-09
>>NP_077312 (OMIM: 612985) iroquois-class homeodomain pr (501 aa)
initn: 3370 init1: 3370 opt: 3370 Z-score: 1487.1 bits: 284.7 E(85289): 4.3e-76
Smith-Waterman score: 3370; 99.8% identity (99.8% similar) in 501 aa overlap (1-501:1-501)
10 20 30 40 50 60
pF1KB7 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 YAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 YAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYPY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 GQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 GQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFAN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 ARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEEEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 ARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEEEDT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 GGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSEDSSEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 GGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSEDSSEGL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 EDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAETATSPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 EDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAETATSPD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 NPRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFPGPPPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 NPRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFPGPPPGP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 RPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALEVEKKLLKTAFQP
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 RLHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALEVEKKLLKTAFQP
430 440 450 460 470 480
490 500
pF1KB7 VPRRPQNHLDAALVLSALSSS
:::::::::::::::::::::
NP_077 VPRRPQNHLDAALVLSALSSS
490 500
>>XP_005256196 (OMIM: 612985) PREDICTED: iroquois-class (529 aa)
initn: 3490 init1: 3279 opt: 3279 Z-score: 1447.4 bits: 277.4 E(85289): 7e-74
Smith-Waterman score: 3279; 99.6% identity (99.8% similar) in 486 aa overlap (1-486:1-486)
10 20 30 40 50 60
pF1KB7 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 YAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYPY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 GQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFAN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 ARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEEEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEEEDT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 GGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSEDSSEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSEDSSEGL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 EDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAETATSPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAETATSPD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 NPRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFPGPPPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NPRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFPGPPPGP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 RPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALEVEKKLLKTAFQP
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALEVEKKLLKTAFQP
430 440 450 460 470 480
490 500
pF1KB7 VPRRPQNHLDAALVLSALSSS
:::::.
XP_005 VPRRPRPRVLTPRAHPTVKPQHTHLQLDIILHCDTFLTIGPNPSRISPP
490 500 510 520
>>XP_016865334 (OMIM: 606197) PREDICTED: iroquois-class (449 aa)
initn: 759 init1: 592 opt: 941 Z-score: 434.2 bits: 89.7 E(85289): 1.9e-17
Smith-Waterman score: 1098; 47.3% identity (64.4% similar) in 463 aa overlap (1-457:1-415)
10 20 30 40 50
pF1KB7 MSFPQLGY-QYIRPLYPS----ERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSS
:::::::: ::. :. ::::. ......:.: .. ::.::.. :. . ...:
XP_016 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGG-GAGAAAVTS
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 VYGAPYAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHP
: : ::::. :.: .:.:::::::.: .: :.:.::::::.::: :::. :: : :
XP_016 VLGM-YAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGV-HPATFAA--HTAP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 AFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVS
:.:::::.:.:::.::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 TWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGG
:::::::::::::::.::. ::. .:.: .::. : : :. :.: .:..:: ..
XP_016 TWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEG-DPEKAEDD--EEIDLESIDIDK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 EEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSED
.: : .. .::::. . : . : .. :: .:. :.. . .:
XP_016 IDEHDGDQS-NEDDEDK----AEAPHAPAAP----SALARDQGS----PLAAADVLKPQD
240 250 260 270
300 310 320 330 340 350
pF1KB7 SSEGLEDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAET
: :: . . :: : .: : :: .. :: ::::::::::
XP_016 S-------PLGLAKEAPEP-----GSTRLLSPGAAAGGLQGAPHG-----KPKIWSLAET
280 290 300 310 320
360 370 380 390 400 410
pF1KB7 ATSPDN-PRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFP
:::::. :. ::: .: : :: .::: : .: : . .::: ::: :
XP_016 ATSPDGAPKASPPPPAGHP-GAH-GPSAGAPLQHPAFLPSHGLYTCHIGKFSNWTNSAFL
330 340 350 360 370 380
420 430 440 450 460 470
pF1KB7 GPPPGPRPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALEVEKKLL
. : . :.:: . :: :: : : : :
XP_016 A--QGSLLNMRSFLGVGAPH------AAPHGPHLPAPPPPQPPVAIAPGALNGDKASVRS
390 400 410 420 430
480 490 500
pF1KB7 KTAFQPVPRRPQNHLDAALVLSALSSS
XP_016 SPTLPALWPRRRERRGS
440
>>NP_077313 (OMIM: 606197) iroquois-class homeodomain pr (480 aa)
initn: 759 init1: 592 opt: 941 Z-score: 433.8 bits: 89.7 E(85289): 2e-17
Smith-Waterman score: 1118; 44.8% identity (61.7% similar) in 525 aa overlap (1-501:1-480)
10 20 30 40 50
pF1KB7 MSFPQLGY-QYIRPLYPS----ERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSS
:::::::: ::. :. ::::. ......:.: .. ::.::.. :. . ...:
NP_077 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGG-GAGAAAVTS
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 VYGAPYAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHP
: : ::::. :.: .:.:::::::.: .: :.:.::::::.::: :::. :: : :
NP_077 VLGM-YAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGV-HPATFAA--HTAP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 AFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVS
:.:::::.:.:::.::::::::::::::::::::::::::::::::::::::::::::::
NP_077 AYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 TWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGG
:::::::::::::::.::. ::. .:.: .::. : : :. :.: .:..:: ..
NP_077 TWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEG-DPEKAEDD--EEIDLESIDIDK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 EEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSED
.: : .. .::::. : :. : .: : : .:.. . .:
NP_077 IDEHDGDQS-NEDDEDK----------AEAPHAPAAPSALAR-DQG-SPLAAADVLKPQD
240 250 260 270
300 310 320 330 340 350
pF1KB7 SSEGLEDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAET
: :: . . :: : .: : :: .. :: ::::::::::
NP_077 S-------PLGLAKEAPEP-----GSTRLLSPGAAAGGLQGAPHG-----KPKIWSLAET
280 290 300 310 320
360 370 380 390 400 410
pF1KB7 ATSPDN-PRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTN----
:::::. :. ::: .: : .: .::: : .: : . .::: :::
NP_077 ATSPDGAPKASPPPPAGHP--GAHGPSAGAPLQHPAFLPSHGLYTCHIGKFSNWTNSAFL
330 340 350 360 370 380
420 430 440 450
pF1KB7 --------RPFPG-PPPGPRPHPLSLLGSAPPH--LLGLPGAAGHPAAAAAFARPAEPEG
: : : : :: : . ::. . ::: . :.. . :. ::
NP_077 AQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAPGALNGDKASVR-SSPTLPE-
390 400 410 420 430
460 470 480 490 500
pF1KB7 GTDRCSALEVEKKLLKTAFQPVPRR---PQNHLDAALVLSALSSS
: . . ::. :::: ::. . .:.:: :.
NP_077 -RDLVPRPDSPAQQLKSPFQPVRDNSLAPQE--GTPRILAALPSA
440 450 460 470 480
>>NP_005844 (OMIM: 606195,611174) iroquois-class homeodo (483 aa)
initn: 758 init1: 522 opt: 797 Z-score: 371.3 bits: 78.2 E(85289): 6.1e-14
Smith-Waterman score: 806; 38.3% identity (57.0% similar) in 491 aa overlap (1-479:1-465)
10 20 30 40 50 60
pF1KB7 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP
::.:: :: : :: . . . :... . : ..::. :.: : .:
NP_005 MSYPQ-GYLY----QPSASLALYSCPAYSTSVIS--GPRTDELGRSSSGSAF------SP
10 20 30 40
70 80 90 100 110
pF1KB7 YAAAAA-AAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYP
::...: .: . ::.. : :.:. : .: :: . :. :... . :: :
NP_005 YAGSTAFTAPSPGYNSHLQYGAD-PAAAAAAAFSSYVGSPYDHTPGMAGSLGY-HPYAAP
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB7 YGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFA
:.: .:::. :::::..:.:::::::::::::::::::::::::::::::::::::::
NP_005 LGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFA
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB7 NARRRLKKENKMTWAPRSRTD--EEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEE
::::::::::::::.::.:.. :: . :...::: . :: . . : : :: :
NP_005 NARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPED---KGDPEGPEAGGAE
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB7 ED--TGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSED
. .: : : . : :. .. ... . : : :: . : .
NP_005 QKAASGCERLQGPPTPAGKETE---GSLSDSDFKEPPSEGRLDALQ-GPPRTGGPSPAGP
230 240 250 260 270
300 310 320 330 340 350
pF1KB7 SSEGLEDRP---LPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSL
.. : . : :. . ::.: :.: : :. : :. : : : ..: :::.:::
NP_005 AAARLAEDPAPHYPAGAPAPGPHPAAGEVPPGPGGP-SVIHSPPPPPPPAVLAKPKLWSL
280 290 300 310 320 330
360 370 380 390 400
pF1KB7 AETATSPDNPRRSPPGAGGSP----PGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAW
:: ::: :. . . : ::: :: .: .:: : :. : : : :: ::.
NP_005 AEIATSSDKVKDGGGGNEGSPCPPCPGP-IAGQALGGSRASPAPAPSRSPSAQC-PFPGG
340 350 360 370 380 390
410 420 430 440 450 460
pF1KB7 TNRPFPGPPPGPRPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALE
: : .: . :: :: : :: . :... . . . .: .::
NP_005 TVLSRPLYYTAPFYPGYTNYGSFG-HLHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALA
400 410 420 430 440 450
470 480 490 500
pF1KB7 VEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS
. :.:.. :
NP_005 KDPKMLRSQSQLDLCKDSPYELKKGMSDI
460 470 480
>>NP_001239126 (OMIM: 606195,611174) iroquois-class home (482 aa)
initn: 751 init1: 515 opt: 795 Z-score: 370.5 bits: 78.0 E(85289): 6.8e-14
Smith-Waterman score: 804; 38.1% identity (56.6% similar) in 491 aa overlap (1-479:1-464)
10 20 30 40 50 60
pF1KB7 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP
::.:: :: : :: . . . :... . : ..::. :.: : .:
NP_001 MSYPQ-GYLY----QPSASLALYSCPAYSTSVIS--GPRTDELGRSSSGSAF------SP
10 20 30 40
70 80 90 100 110
pF1KB7 YAAAAA-AAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYP
::...: .: . ::.. : :.:. : .: :: . :. :... . :: :
NP_001 YAGSTAFTAPSPGYNSHLQYGAD-PAAAAAAAFSSYVGSPYDHTPGMAGSLGY-HPYAAP
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB7 YGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFA
:.: .:::. :::::..:.:::::::::::::::::::::::::::::::::::::::
NP_001 LGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFA
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB7 NARRRLKKENKMTWAPRSRTD--EEGNAYGSEREEEDEEEDEEDGKR----ELELEEEEL
::::::::::::::.::.:.. :: . :...::: . :: : :..
NP_001 NARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEAGAEQKAA
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB7 GGEEEDTGGEGLADDDEDEEIDLENLDGAATEPEL-SLAGAARRDGDLGLGPISDSKNSD
.: :. : : . . .. .. .: .: .: : : : :: .
NP_001 SGCERLQGPPTPAGKETEGSLSDSDFKEPPSEGRLDALQGPPRTGGPSPAGP---AAARL
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB7 SEDSSEGLEDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSL
.:: . :. . ::.: :.: : :. : :. : : : ..: :::.:::
NP_001 AEDPAPHY-----PAGAPAPGPHPAAGEVPPGPGGP-SVIHSPPPPPPPAVLAKPKLWSL
290 300 310 320 330
360 370 380 390 400
pF1KB7 AETATSPDNPRRSPPGAGGSP----PGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAW
:: ::: :. . . : ::: :: .: .:: : :. : : : :: ::.
NP_001 AEIATSSDKVKDGGGGNEGSPCPPCPGP-IAGQALGGSRASPAPAPSRSPSAQC-PFPGG
340 350 360 370 380 390
410 420 430 440 450 460
pF1KB7 TNRPFPGPPPGPRPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALE
: : .: . :: :: : :: . :... . . . .: .::
NP_001 TVLSRPLYYTAPFYPGYTNYGSFG-HLHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALA
400 410 420 430 440 450
470 480 490 500
pF1KB7 VEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS
. :.:.. :
NP_001 KDPKMLRSQSQLDLCKDSPYELKKGMSDI
460 470 480
>>XP_011521111 (OMIM: 606195,611174) PREDICTED: iroquois (413 aa)
initn: 717 init1: 522 opt: 757 Z-score: 354.8 bits: 74.9 E(85289): 5e-13
Smith-Waterman score: 757; 40.7% identity (58.3% similar) in 393 aa overlap (98-479:15-395)
70 80 90 100 110 120
pF1KB7 AAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYPYGQYQFGD
:: . :. :... . :: : :.: .::
XP_011 MEGRAAVARSAHGGSPYDHTPGMAGSLGY-HPYAAPLGSYPYGD
10 20 30 40
130 140 150 160 170 180
pF1KB7 PSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKK
:. :::::..:.:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKK
50 60 70 80 90 100
190 200 210 220 230 240
pF1KB7 ENKMTWAPRSRTD--EEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEEED--TGGE
::::::.::.:.. :: . :...::: . :: . . : : :: :. .: :
XP_011 ENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPED---KGDPEGPEAGGAEQKAASGCE
110 120 130 140 150 160
250 260 270 280 290 300
pF1KB7 GLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSEDSSEGLEDR
: . : :. .. ... . : : :: . : . .. : .
XP_011 RLQGPPTPAGKETE---GSLSDSDFKEPPSEGRL-DALQGPPRTGGPSPAGPAAARLAED
170 180 190 200 210
310 320 330 340 350 360
pF1KB7 P---LPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAETATSPD
: :. . ::.: :.: : :. : :. : : : ..: :::.::::: ::: :
XP_011 PAPHYPAGAPAPGPHPAAGEVPPGPGGP-SVIHSPPPPPPPAVLAKPKLWSLAEIATSSD
220 230 240 250 260 270
370 380 390 400 410
pF1KB7 NPRRSPPGAGGSP----PGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFPGP
. . . : ::: :: .: .:: : :. : : : :: ::. : :
XP_011 KVKDGGGGNEGSPCPPCPGP-IAGQALGGSRASPAPAPSRSPSAQC-PFPGGTVLSRPLY
280 290 300 310 320 330
420 430 440 450 460 470
pF1KB7 PPGPRPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALEVEKKLLKT
.: . :: :: : :: . :... . . . .: .:: . :.:..
XP_011 YTAPFYPGYTNYGSFG-HLHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRS
340 350 360 370 380 390
480 490 500
pF1KB7 AFQPVPRRPQNHLDAALVLSALSSS
:
XP_011 QSQLDLCKDSPYELKKGMSDI
400 410
>>NP_150366 (OMIM: 606198) iroquois-class homeodomain pr (471 aa)
initn: 650 init1: 513 opt: 727 Z-score: 341.1 bits: 72.5 E(85289): 2.9e-12
Smith-Waterman score: 782; 38.2% identity (58.4% similar) in 497 aa overlap (1-480:1-452)
10 20 30 40 50 60
pF1KB7 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP
::.:: :: : . ::. . . : . ..:.: :: : .. ....: :
NP_150 MSYPQ-GYLY-------QAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPY---P
10 20 30 40
70 80 90 100 110
pF1KB7 YAAAAAAAAAQGYGAFLPYAAELPI----FPQ-LGAQYELKDSPGVQHPAAAAAFPHPH-
.:: .: :: :.:. : :.:. ::. .:: :. . :. ..: .. ::.
NP_150 GSAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYD-AHTTGM---TGAISY-HPYG
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB7 PAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
: ::: :..::. :::::..:.::::::::::::::::::::::::::::::::::
NP_150 SAAYPY---QLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB7 STWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELG
::::::::::::::::::::::.....: . :. . .:: :. . : :.: ..
NP_150 STWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGIS
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB7 GEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSE
..:.: . . : : :.: : .: : .:. .: . :....: :
NP_150 -----LHVDSLTDHSCSAESDGEKLPCRAGDP-LCESGSECKDK---YDDLEDDEDDD-E
230 240 250 260 270
300 310 320 330 340
pF1KB7 DSSEGLEDRPLPVLSL------AP--APPPVAVASPSLPSPPVS-LDPCAPAPAPASALQ
.. .:: : :: : :: .::: :. . .: : .: :: :: .
NP_150 EGERGLAP-PKPVTSSPLTGLEAPLLSPPPEAAPRGGRKTPQGSRTSPGAPPPA-----S
280 290 300 310 320
350 360 370 380 390 400
pF1KB7 KPKIWSLAETATSPDNPRRSPPGAGGSPPG--AAVAPSALQLSPAAAAAAAHRLVSAPLG
:::.::::: ::: . :: : ::: ::.::.. :... : : ::
NP_150 KPKLWSLAEIATSDLKQPSLGPGCG--PPGLPAAAAPASTGAPPGGSPYPASPL----LG
330 340 350 360 370
410 420 430 440 450 460
pF1KB7 KFPAWTNRPFPGPPPGPRPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDR
. : . . :: : . .: :.. :: .::. :. : : : ..:
NP_150 R-PLYYTSPFYGNYTNYGNLNAALQGQG---LLRYNSAAAAPGEALHTAPKAASDAGKAG
380 390 400 410 420 430
470 480 490 500
pF1KB7 CSALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS
:: . . ...:
NP_150 AHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL
440 450 460 470
>>NP_001127694 (OMIM: 606198) iroquois-class homeodomain (471 aa)
initn: 650 init1: 513 opt: 727 Z-score: 341.1 bits: 72.5 E(85289): 2.9e-12
Smith-Waterman score: 782; 38.2% identity (58.4% similar) in 497 aa overlap (1-480:1-452)
10 20 30 40 50 60
pF1KB7 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP
::.:: :: : . ::. . . : . ..:.: :: : .. ....: :
NP_001 MSYPQ-GYLY-------QAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPY---P
10 20 30 40
70 80 90 100 110
pF1KB7 YAAAAAAAAAQGYGAFLPYAAELPI----FPQ-LGAQYELKDSPGVQHPAAAAAFPHPH-
.:: .: :: :.:. : :.:. ::. .:: :. . :. ..: .. ::.
NP_001 GSAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYD-AHTTGM---TGAISY-HPYG
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB7 PAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
: ::: :..::. :::::..:.::::::::::::::::::::::::::::::::::
NP_001 SAAYPY---QLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB7 STWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELG
::::::::::::::::::::::.....: . :. . .:: :. . : :.: ..
NP_001 STWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGIS
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB7 GEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSE
..:.: . . : : :.: : .: : .:. .: . :....: :
NP_001 -----LHVDSLTDHSCSAESDGEKLPCRAGDP-LCESGSECKDK---YDDLEDDEDDD-E
230 240 250 260 270
300 310 320 330 340
pF1KB7 DSSEGLEDRPLPVLSL------AP--APPPVAVASPSLPSPPVS-LDPCAPAPAPASALQ
.. .:: : :: : :: .::: :. . .: : .: :: :: .
NP_001 EGERGLAP-PKPVTSSPLTGLEAPLLSPPPEAAPRGGRKTPQGSRTSPGAPPPA-----S
280 290 300 310 320
350 360 370 380 390 400
pF1KB7 KPKIWSLAETATSPDNPRRSPPGAGGSPPG--AAVAPSALQLSPAAAAAAAHRLVSAPLG
:::.::::: ::: . :: : ::: ::.::.. :... : : ::
NP_001 KPKLWSLAEIATSDLKQPSLGPGCG--PPGLPAAAAPASTGAPPGGSPYPASPL----LG
330 340 350 360 370
410 420 430 440 450 460
pF1KB7 KFPAWTNRPFPGPPPGPRPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDR
. : . . :: : . .: :.. :: .::. :. : : : ..:
NP_001 R-PLYYTSPFYGNYTNYGNLNAALQGQG---LLRYNSAAAAPGEALHTAPKAASDAGKAG
380 390 400 410 420 430
470 480 490 500
pF1KB7 CSALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS
:: . . ...:
NP_001 AHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL
440 450 460 470
>>XP_011512281 (OMIM: 606198) PREDICTED: iroquois-class (471 aa)
initn: 650 init1: 513 opt: 727 Z-score: 341.1 bits: 72.5 E(85289): 2.9e-12
Smith-Waterman score: 782; 38.2% identity (58.4% similar) in 497 aa overlap (1-480:1-452)
10 20 30 40 50 60
pF1KB7 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP
::.:: :: : . ::. . . : . ..:.: :: : .. ....: :
XP_011 MSYPQ-GYLY-------QAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPY---P
10 20 30 40
70 80 90 100 110
pF1KB7 YAAAAAAAAAQGYGAFLPYAAELPI----FPQ-LGAQYELKDSPGVQHPAAAAAFPHPH-
.:: .: :: :.:. : :.:. ::. .:: :. . :. ..: .. ::.
XP_011 GSAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYD-AHTTGM---TGAISY-HPYG
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB7 PAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
: ::: :..::. :::::..:.::::::::::::::::::::::::::::::::::
XP_011 SAAYPY---QLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB7 STWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELG
::::::::::::::::::::::.....: . :. . .:: :. . : :.: ..
XP_011 STWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGIS
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB7 GEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSE
..:.: . . : : :.: : .: : .:. .: . :....: :
XP_011 -----LHVDSLTDHSCSAESDGEKLPCRAGDP-LCESGSECKDK---YDDLEDDEDDD-E
230 240 250 260 270
300 310 320 330 340
pF1KB7 DSSEGLEDRPLPVLSL------AP--APPPVAVASPSLPSPPVS-LDPCAPAPAPASALQ
.. .:: : :: : :: .::: :. . .: : .: :: :: .
XP_011 EGERGLAP-PKPVTSSPLTGLEAPLLSPPPEAAPRGGRKTPQGSRTSPGAPPPA-----S
280 290 300 310 320
350 360 370 380 390 400
pF1KB7 KPKIWSLAETATSPDNPRRSPPGAGGSPPG--AAVAPSALQLSPAAAAAAAHRLVSAPLG
:::.::::: ::: . :: : ::: ::.::.. :... : : ::
XP_011 KPKLWSLAEIATSDLKQPSLGPGCG--PPGLPAAAAPASTGAPPGGSPYPASPL----LG
330 340 350 360 370
410 420 430 440 450 460
pF1KB7 KFPAWTNRPFPGPPPGPRPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDR
. : . . :: : . .: :.. :: .::. :. : : : ..:
XP_011 R-PLYYTSPFYGNYTNYGNLNAALQGQG---LLRYNSAAAAPGEALHTAPKAASDAGKAG
380 390 400 410 420 430
470 480 490 500
pF1KB7 CSALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS
:: . . ...:
XP_011 AHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL
440 450 460 470
501 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:13:50 2016 done: Tue Nov 8 05:13:51 2016
Total Scan time: 9.290 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]