Result of FASTA (omim) for
pFN21AB7761
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7761, 448 aa
1>>>pF1KB7761 448 - 448 aa - 448 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.2437+/-0.000379; mu= 5.4605+/- 0.024
mean_var=193.7824+/-40.528, 0's: 0 Z-trim(119.8): 78 B-trim: 883 in 2/56
Lambda= 0.092133
statistics sampled from 34213 (34294) to 34213 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.735), E-opt: 0.2 (0.402), width: 16
Scan time: 10.390
The best scores are: opt bits E(85289)
NP_005140 (OMIM: 201400,604614) T-box transcriptio ( 448) 3093 423.5 5.7e-118
XP_011534382 (OMIM: 182940,601397,615709) PREDICTE ( 436) 1601 225.1 2.8e-58
NP_003172 (OMIM: 182940,601397,615709) brachyury p ( 435) 1582 222.6 1.6e-57
NP_001257413 (OMIM: 182940,601397,615709) brachyur ( 377) 1247 178.0 3.7e-44
XP_011544228 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 671 101.5 4.6e-21
NP_004599 (OMIM: 122600,602427) T-box transcriptio ( 436) 671 101.5 4.6e-21
XP_016879103 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 671 101.5 4.6e-21
XP_005255580 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 671 101.5 4.6e-21
NP_060958 (OMIM: 147891,601719) T-box transcriptio ( 545) 653 99.2 2.8e-20
XP_011523793 (OMIM: 147891,601719) PREDICTED: T-bo ( 608) 653 99.2 3.1e-20
NP_001308049 (OMIM: 147891,601719) T-box transcrip ( 546) 648 98.5 4.5e-20
XP_011523792 (OMIM: 147891,601719) PREDICTED: T-bo ( 609) 648 98.6 4.9e-20
XP_011523797 (OMIM: 147891,601719) PREDICTED: T-bo ( 417) 634 96.6 1.3e-19
NP_542448 (OMIM: 142900,601620) T-box transcriptio ( 468) 632 96.4 1.7e-19
NP_000183 (OMIM: 142900,601620) T-box transcriptio ( 518) 632 96.4 1.9e-19
NP_852259 (OMIM: 142900,601620) T-box transcriptio ( 518) 632 96.4 1.9e-19
XP_016875401 (OMIM: 142900,601620) PREDICTED: T-bo ( 534) 632 96.4 1.9e-19
NP_005985 (OMIM: 600747) T-box transcription facto ( 712) 597 91.9 6.1e-18
NP_005987 (OMIM: 181450,601621) T-box transcriptio ( 723) 567 87.9 9.7e-17
XP_016877522 (OMIM: 616061) PREDICTED: MAX gene-as (1439) 558 86.9 3.8e-16
XP_011519703 (OMIM: 616061) PREDICTED: MAX gene-as (1549) 558 86.9 4e-16
XP_016877519 (OMIM: 616061) PREDICTED: MAX gene-as (2207) 558 87.1 5.2e-16
NP_001074010 (OMIM: 616061) MAX gene-associated pr (2856) 558 87.2 6.3e-16
XP_005254310 (OMIM: 616061) PREDICTED: MAX gene-as (2906) 558 87.2 6.4e-16
XP_005254309 (OMIM: 616061) PREDICTED: MAX gene-as (2956) 558 87.2 6.5e-16
XP_011519700 (OMIM: 616061) PREDICTED: MAX gene-as (3004) 558 87.2 6.6e-16
XP_011519699 (OMIM: 616061) PREDICTED: MAX gene-as (3005) 558 87.2 6.6e-16
NP_001157745 (OMIM: 616061) MAX gene-associated pr (3065) 558 87.2 6.7e-16
XP_005254306 (OMIM: 616061) PREDICTED: MAX gene-as (3066) 558 87.2 6.7e-16
XP_005254305 (OMIM: 616061) PREDICTED: MAX gene-as (3114) 558 87.2 6.7e-16
XP_005254300 (OMIM: 616061) PREDICTED: MAX gene-as (3115) 558 87.2 6.7e-16
XP_005254304 (OMIM: 616061) PREDICTED: MAX gene-as (3115) 558 87.2 6.7e-16
XP_005254301 (OMIM: 616061) PREDICTED: MAX gene-as (3115) 558 87.2 6.7e-16
XP_005254303 (OMIM: 616061) PREDICTED: MAX gene-as (3115) 558 87.2 6.7e-16
XP_005254302 (OMIM: 616061) PREDICTED: MAX gene-as (3115) 558 87.2 6.7e-16
XP_006720506 (OMIM: 616061) PREDICTED: MAX gene-as (3115) 558 87.2 6.7e-16
NP_037483 (OMIM: 208550,604895) T-box transcriptio ( 535) 537 83.8 1.2e-15
XP_006724720 (OMIM: 300307,302905,303400) PREDICTE ( 350) 487 77.0 8.9e-14
NP_058650 (OMIM: 300307,302905,303400) T-box trans ( 520) 487 77.1 1.2e-13
NP_001103348 (OMIM: 300307,302905,303400) T-box tr ( 520) 487 77.1 1.2e-13
XP_005262193 (OMIM: 300307,302905,303400) PREDICTE ( 521) 487 77.1 1.2e-13
NP_006584 (OMIM: 604616) T-box brain protein 1 [Ho ( 682) 489 77.5 1.2e-13
XP_006715665 (OMIM: 143100,143400,604613) PREDICTE ( 364) 480 76.1 1.7e-13
XP_011534551 (OMIM: 143100,143400,604613) PREDICTE ( 372) 480 76.1 1.8e-13
XP_016866962 (OMIM: 143100,143400,604613) PREDICTE ( 376) 480 76.1 1.8e-13
XP_011534550 (OMIM: 143100,143400,604613) PREDICTE ( 377) 480 76.1 1.8e-13
XP_011534549 (OMIM: 143100,143400,604613) PREDICTE ( 379) 480 76.1 1.8e-13
NP_001073977 (OMIM: 143100,143400,604613) T-box tr ( 607) 480 76.3 2.6e-13
NP_005986 (OMIM: 604648) T-box transcription facto ( 385) 470 74.8 4.6e-13
XP_011543294 (OMIM: 604648) PREDICTED: T-box trans ( 430) 470 74.8 5e-13
>>NP_005140 (OMIM: 201400,604614) T-box transcription fa (448 aa)
initn: 3093 init1: 3093 opt: 3093 Z-score: 2238.9 bits: 423.5 E(85289): 5.7e-118
Smith-Waterman score: 3093; 100.0% identity (100.0% similar) in 448 aa overlap (1-448:1-448)
10 20 30 40 50 60
pF1KB7 MAMSELGTRKPSDGTVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MAMSELGTRKPSDGTVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 MIVTKNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MIVTKNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 CVYIHPDSPNFGAHWMKAPISFSKVKLTNKLNGGGQIMLNSLHKYEPQVHIVRVGSAHRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CVYIHPDSPNFGAHWMKAPISFSKVKLTNKLNGGGQIMLNSLHKYEPQVHIVRVGSAHRM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 VTNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQHVTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VTNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQHVTY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 SHLGGWIFSNPDGVCTAGNSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPYPSAYMHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SHLGGWIFSNPDGVCTAGNSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPYPSAYMHR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 NHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPINPGPSPYPCLWTIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPINPGPSPYPCLWTIS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 NGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVLGEPSLTSIAVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVLGEPSLTSIAVST
370 380 390 400 410 420
430 440
pF1KB7 WTAVASHPFAGWGGPGAGGHHSPSSLDG
::::::::::::::::::::::::::::
NP_005 WTAVASHPFAGWGGPGAGGHHSPSSLDG
430 440
>>XP_011534382 (OMIM: 182940,601397,615709) PREDICTED: b (436 aa)
initn: 1479 init1: 1294 opt: 1601 Z-score: 1167.3 bits: 225.1 E(85289): 2.8e-58
Smith-Waterman score: 1601; 56.6% identity (78.6% similar) in 435 aa overlap (3-432:1-428)
10 20 30 40 50
pF1KB7 MAMSELGTR---KPSDGTVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEV
:: ::. : . :.:::..::.::::: :::::::..:.. ::.. :: ::::.
XP_011 MSSPGTESAGKSLQYRVDHLLSAVENELQAGSEKGDPTERELRVGLEESELWLRFKEL
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 TNEMIVTKNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVS
::::::::::::::::::..:.:::::::::.::::: .:.::::::::::::.:::: .
XP_011 TNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQ
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 SHSCVYIHPDSPNFGAHWMKAPISFSKVKLTNKLNGGGQIMLNSLHKYEPQVHIVRVGSA
. ::::::::::::::::::::.:::::::::::::::::::::::::::..::::::.
XP_011 APSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGP
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 HRMVTNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH
.::.:. :::::::::::::::::::::::::::::::::::::. ... : ..::.
XP_011 QRMITSHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERSDHKEMMEEPGDSQQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 VTYSHLGGWIFSNPDGVCTAGNSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPYPSAY
::. :::.. . . .: .: . :... : ::. :. :..: ::.::..:::: :
XP_011 PGYSQSGGWLLPGTSTLCPPANPHPQFGGALSLPSTHS---CDRYPTLRSHRSSPYPSPY
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB7 MHRNHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPINPGPSPYPCLW
:::.::. . ..: :..... :.:.::. : :.: : :. .: . . : :: ::
XP_011 AHRNNSPTYS--DNSPACLSMLQSHDNWSSLGMPAHPSMLPVSHNASPPTSS-SQYPSLW
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB7 TISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVL-GEPSLTSI
..:::: :.. . : . . :. :.:: .: . ..::.:.: . : . :.:
XP_011 SVSNGAVTPGSQAAAVSNGLGAQFFRGSPAHYTPLT-HPVSAPSSSGSPLYEGAAAATDI
360 370 380 390 400 410
420 430 440
pF1KB7 AVSTWTAVASHPF-AGWGGPGAGGHHSPSSLDG
. : . :.:. . :.:
XP_011 VDSQYDAAAQGRLIASWTPVSPPSM
420 430
>>NP_003172 (OMIM: 182940,601397,615709) brachyury prote (435 aa)
initn: 1401 init1: 1216 opt: 1582 Z-score: 1153.7 bits: 222.6 E(85289): 1.6e-57
Smith-Waterman score: 1582; 56.3% identity (78.4% similar) in 435 aa overlap (3-432:1-427)
10 20 30 40 50
pF1KB7 MAMSELGTR---KPSDGTVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEV
:: ::. : . :.:::..::.::::: :::::::..:.. ::.. :: ::::.
NP_003 MSSPGTESAGKSLQYRVDHLLSAVENELQAGSEKGDPTERELRVGLEESELWLRFKEL
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 TNEMIVTKNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVS
::::::::::::::::::..:.:::::::::.::::: .:.::::::::::::.:::: .
NP_003 TNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQ
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 SHSCVYIHPDSPNFGAHWMKAPISFSKVKLTNKLNGGGQIMLNSLHKYEPQVHIVRVGSA
. ::::::::::::::::::::.:::::::::::::::::::::::::::..::::::.
NP_003 APSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGP
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 HRMVTNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH
.::.:. :::::::::::::::::::::::::::::::::::::. ... : ..::.
NP_003 QRMITSHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERSDHKEMMEEPGDSQQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 VTYSHLGGWIFSNPDGVCTAGNSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPYPSAY
::. : :.. . . .: .: . :... : ::. :. :..: ::.::..:::: :
NP_003 PGYSQWG-WLLPGTSTLCPPANPHPQFGGALSLPSTHS---CDRYPTLRSHRSSPYPSPY
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB7 MHRNHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPINPGPSPYPCLW
:::.::. . ..: :..... :.:.::. : :.: : :. .: . . : :: ::
NP_003 AHRNNSPTYS--DNSPACLSMLQSHDNWSSLGMPAHPSMLPVSHNASPPTSS-SQYPSLW
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB7 TISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVL-GEPSLTSI
..:::: :.. . : . . :. :.:: .: . ..::.:.: . : . :.:
NP_003 SVSNGAVTPGSQAAAVSNGLGAQFFRGSPAHYTPLT-HPVSAPSSSGSPLYEGAAAATDI
360 370 380 390 400 410
420 430 440
pF1KB7 AVSTWTAVASHPF-AGWGGPGAGGHHSPSSLDG
. : . :.:. . :.:
NP_003 VDSQYDAAAQGRLIASWTPVSPPSM
420 430
>>NP_001257413 (OMIM: 182940,601397,615709) brachyury pr (377 aa)
initn: 1293 init1: 1205 opt: 1247 Z-score: 913.8 bits: 178.0 E(85289): 3.7e-44
Smith-Waterman score: 1286; 52.4% identity (68.7% similar) in 435 aa overlap (3-432:1-369)
10 20 30 40 50
pF1KB7 MAMSELGTR---KPSDGTVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEV
:: ::. : . :.:::..::.::::: :::::::..:.. ::.. :: ::::.
NP_001 MSSPGTESAGKSLQYRVDHLLSAVENELQAGSEKGDPTERELRVGLEESELWLRFKEL
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 TNEMIVTKNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVS
::::::::::::::::::..:.:::::::::.::::: .:.::::::::::::.:::: .
NP_001 TNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQ
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 SHSCVYIHPDSPNFGAHWMKAPISFSKVKLTNKLNGGGQIMLNSLHKYEPQVHIVRVGSA
. ::::::::::::::::::::.:::::::::::::::::::::::::::..::::::.
NP_001 APSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGP
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 HRMVTNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH
.::.:. :::::::::::::::::::::::::::::::::::::. ... : ..::.
NP_001 QRMITSHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERSDHKEMMEEPGDSQQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 VTYSHLGGWIFSNPDGVCTAGNSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPYPSAY
::. : : :: :: : : :..:
NP_001 PGYSQ------SYSD------NS----------PA------C--LSMLQSH---------
240 250
300 310 320 330 340 350
pF1KB7 MHRNHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPINPGPSPYPCLW
:.:.::. : :.: : :. .: . . : :: ::
NP_001 -------------------------DNWSSLGMPAHPSMLPVSHNASPPTSS-SQYPSLW
260 270 280 290
360 370 380 390 400 410
pF1KB7 TISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVL-GEPSLTSI
..:::: :.. . : . . :. :.:: .: . ..::.:.: . : . :.:
NP_001 SVSNGAVTPGSQAAAVSNGLGAQFFRGSPAHYTPLT-HPVSAPSSSGSPLYEGAAAATDI
300 310 320 330 340 350
420 430 440
pF1KB7 AVSTWTAVASHPF-AGWGGPGAGGHHSPSSLDG
. : . :.:. . :.:
NP_001 VDSQYDAAAQGRLIASWTPVSPPSM
360 370
>>XP_011544228 (OMIM: 122600,602427) PREDICTED: T-box tr (436 aa)
initn: 574 init1: 417 opt: 671 Z-score: 499.2 bits: 101.5 E(85289): 4.6e-21
Smith-Waterman score: 672; 38.3% identity (60.6% similar) in 358 aa overlap (45-382:95-428)
20 30 40 50 60 70
pF1KB7 TVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNEMIVTKNGRRMFPVL
::. ::..:. : .:::.:: ::::::.
XP_011 PLPLLPPAMGTEPAPSAPEALHSLPGVSLSLENRELWKEFSSVGTEMIITKAGRRMFPAC
70 80 90 100 110 120
80 90 100 110 120 130
pF1KB7 KISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHSCVYIHPDSPNFGAH
..:::::::.: : .::: .:.:. :... . .: :.:: : . :::::::: :::
XP_011 RVSVTGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPDSPATGAH
130 140 150 160 170 180
140 150 160 170 180
pF1KB7 WMKAPISFSKVKLTNK-LNGGGQIMLNSLHKYEPQVHIVRVG---SAHRM-VTNCSFPET
::. :.:: .:::::. :. :...:.:.:::.:..:.::.. : : ... ::::
XP_011 WMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRFPET
190 200 210 220 230 240
190 200 210 220 230 240
pF1KB7 QFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH-----VTYSHLG
::.:::::: .:: ::: :::::.: . :: :. .... . .: .. .
XP_011 TFISVTAYQNPQITQLKIAANPFAKGFRENG-RNCKRERDARVKRKLRGPEPAATEAYGS
250 260 270 280 290 300
250 260 270 280 290 300
pF1KB7 GWIFSNPDGVCTAG-NSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPY---PSAYMHR
: ..: : : . ... . . : ::: : :: ::: .
XP_011 G---DTPGGPCDSTLGGDIRESDPEQAPAP----------GEATAAPAPLCGGPSAEAYL
310 320 330 340 350
310 320 330 340 350
pF1KB7 NHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPH-ASILSVPHTNG----PINPGPSPY-P
: :.. : . : :.. : :.:. :..: .:: .: : : :. :
XP_011 LH-PAAFHGAPSHLPTRSPSFPEAPDSGRSAPYSAAFLELPHGSGGSGYPAAPPAVPFAP
360 370 380 390 400
360 370 380 390 400 410
pF1KB7 CLWTISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVLGEPSLT
. ::: : : ..::..:
XP_011 HFLQ-----GGPF-PLPY---TAPGGYLDVGSKPMY
410 420 430
>>NP_004599 (OMIM: 122600,602427) T-box transcription fa (436 aa)
initn: 574 init1: 417 opt: 671 Z-score: 499.2 bits: 101.5 E(85289): 4.6e-21
Smith-Waterman score: 672; 38.3% identity (60.6% similar) in 358 aa overlap (45-382:95-428)
20 30 40 50 60 70
pF1KB7 TVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNEMIVTKNGRRMFPVL
::. ::..:. : .:::.:: ::::::.
NP_004 PLPLLPPAMGTEPAPSAPEALHSLPGVSLSLENRELWKEFSSVGTEMIITKAGRRMFPAC
70 80 90 100 110 120
80 90 100 110 120 130
pF1KB7 KISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHSCVYIHPDSPNFGAH
..:::::::.: : .::: .:.:. :... . .: :.:: : . :::::::: :::
NP_004 RVSVTGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPDSPATGAH
130 140 150 160 170 180
140 150 160 170 180
pF1KB7 WMKAPISFSKVKLTNK-LNGGGQIMLNSLHKYEPQVHIVRVG---SAHRM-VTNCSFPET
::. :.:: .:::::. :. :...:.:.:::.:..:.::.. : : ... ::::
NP_004 WMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRFPET
190 200 210 220 230 240
190 200 210 220 230 240
pF1KB7 QFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH-----VTYSHLG
::.:::::: .:: ::: :::::.: . :: :. .... . .: .. .
NP_004 TFISVTAYQNPQITQLKIAANPFAKGFRENG-RNCKRERDARVKRKLRGPEPAATEAYGS
250 260 270 280 290 300
250 260 270 280 290 300
pF1KB7 GWIFSNPDGVCTAG-NSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPY---PSAYMHR
: ..: : : . ... . . : ::: : :: ::: .
NP_004 G---DTPGGPCDSTLGGDIRESDPEQAPAP----------GEATAAPAPLCGGPSAEAYL
310 320 330 340 350
310 320 330 340 350
pF1KB7 NHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPH-ASILSVPHTNG----PINPGPSPY-P
: :.. : . : :.. : :.:. :..: .:: .: : : :. :
NP_004 LH-PAAFHGAPSHLPTRSPSFPEAPDSGRSAPYSAAFLELPHGSGGSGYPAAPPAVPFAP
360 370 380 390 400
360 370 380 390 400 410
pF1KB7 CLWTISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVLGEPSLT
. ::: : : ..::..:
NP_004 HFLQ-----GGPF-PLPY---TAPGGYLDVGSKPMY
410 420 430
>>XP_016879103 (OMIM: 122600,602427) PREDICTED: T-box tr (436 aa)
initn: 574 init1: 417 opt: 671 Z-score: 499.2 bits: 101.5 E(85289): 4.6e-21
Smith-Waterman score: 672; 38.3% identity (60.6% similar) in 358 aa overlap (45-382:95-428)
20 30 40 50 60 70
pF1KB7 TVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNEMIVTKNGRRMFPVL
::. ::..:. : .:::.:: ::::::.
XP_016 PLPLLPPAMGTEPAPSAPEALHSLPGVSLSLENRELWKEFSSVGTEMIITKAGRRMFPAC
70 80 90 100 110 120
80 90 100 110 120 130
pF1KB7 KISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHSCVYIHPDSPNFGAH
..:::::::.: : .::: .:.:. :... . .: :.:: : . :::::::: :::
XP_016 RVSVTGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPDSPATGAH
130 140 150 160 170 180
140 150 160 170 180
pF1KB7 WMKAPISFSKVKLTNK-LNGGGQIMLNSLHKYEPQVHIVRVG---SAHRM-VTNCSFPET
::. :.:: .:::::. :. :...:.:.:::.:..:.::.. : : ... ::::
XP_016 WMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRFPET
190 200 210 220 230 240
190 200 210 220 230 240
pF1KB7 QFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH-----VTYSHLG
::.:::::: .:: ::: :::::.: . :: :. .... . .: .. .
XP_016 TFISVTAYQNPQITQLKIAANPFAKGFRENG-RNCKRERDARVKRKLRGPEPAATEAYGS
250 260 270 280 290 300
250 260 270 280 290 300
pF1KB7 GWIFSNPDGVCTAG-NSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPY---PSAYMHR
: ..: : : . ... . . : ::: : :: ::: .
XP_016 G---DTPGGPCDSTLGGDIRESDPEQAPAP----------GEATAAPAPLCGGPSAEAYL
310 320 330 340 350
310 320 330 340 350
pF1KB7 NHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPH-ASILSVPHTNG----PINPGPSPY-P
: :.. : . : :.. : :.:. :..: .:: .: : : :. :
XP_016 LH-PAAFHGAPSHLPTRSPSFPEAPDSGRSAPYSAAFLELPHGSGGSGYPAAPPAVPFAP
360 370 380 390 400
360 370 380 390 400 410
pF1KB7 CLWTISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVLGEPSLT
. ::: : : ..::..:
XP_016 HFLQ-----GGPF-PLPY---TAPGGYLDVGSKPMY
410 420 430
>>XP_005255580 (OMIM: 122600,602427) PREDICTED: T-box tr (436 aa)
initn: 574 init1: 417 opt: 671 Z-score: 499.2 bits: 101.5 E(85289): 4.6e-21
Smith-Waterman score: 672; 38.3% identity (60.6% similar) in 358 aa overlap (45-382:95-428)
20 30 40 50 60 70
pF1KB7 TVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNEMIVTKNGRRMFPVL
::. ::..:. : .:::.:: ::::::.
XP_005 PLPLLPPAMGTEPAPSAPEALHSLPGVSLSLENRELWKEFSSVGTEMIITKAGRRMFPAC
70 80 90 100 110 120
80 90 100 110 120 130
pF1KB7 KISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHSCVYIHPDSPNFGAH
..:::::::.: : .::: .:.:. :... . .: :.:: : . :::::::: :::
XP_005 RVSVTGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPDSPATGAH
130 140 150 160 170 180
140 150 160 170 180
pF1KB7 WMKAPISFSKVKLTNK-LNGGGQIMLNSLHKYEPQVHIVRVG---SAHRM-VTNCSFPET
::. :.:: .:::::. :. :...:.:.:::.:..:.::.. : : ... ::::
XP_005 WMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRFPET
190 200 210 220 230 240
190 200 210 220 230 240
pF1KB7 QFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH-----VTYSHLG
::.:::::: .:: ::: :::::.: . :: :. .... . .: .. .
XP_005 TFISVTAYQNPQITQLKIAANPFAKGFRENG-RNCKRERDARVKRKLRGPEPAATEAYGS
250 260 270 280 290 300
250 260 270 280 290 300
pF1KB7 GWIFSNPDGVCTAG-NSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPY---PSAYMHR
: ..: : : . ... . . : ::: : :: ::: .
XP_005 G---DTPGGPCDSTLGGDIRESDPEQAPAP----------GEATAAPAPLCGGPSAEAYL
310 320 330 340 350
310 320 330 340 350
pF1KB7 NHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPH-ASILSVPHTNG----PINPGPSPY-P
: :.. : . : :.. : :.:. :..: .:: .: : : :. :
XP_005 LH-PAAFHGAPSHLPTRSPSFPEAPDSGRSAPYSAAFLELPHGSGGSGYPAAPPAVPFAP
360 370 380 390 400
360 370 380 390 400 410
pF1KB7 CLWTISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVLGEPSLT
. ::: : : ..::..:
XP_005 HFLQ-----GGPF-PLPY---TAPGGYLDVGSKPMY
410 420 430
>>NP_060958 (OMIM: 147891,601719) T-box transcription fa (545 aa)
initn: 666 init1: 415 opt: 653 Z-score: 485.0 bits: 99.2 E(85289): 2.8e-20
Smith-Waterman score: 662; 35.4% identity (59.3% similar) in 413 aa overlap (35-429:61-442)
10 20 30 40 50 60
pF1KB7 ELGTRKPSDGTVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNEMIVT
. : ..... :.. ::..:.:. .:::.:
NP_060 EPALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIIT
40 50 60 70 80 90
70 80 90 100 110 120
pF1KB7 KNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHSCVYI
: :::::: :..:::..:.. : ::.:.::.:.::.:. ...:. ::: : . . .:.
NP_060 KAGRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYV
100 110 120 130 140 150
130 140 150 160 170
pF1KB7 HPDSPNFGAHWMKAPISFSKVKLTNK-LNGGGQIMLNSLHKYEPQVHIVRV------GSA
::::: :::::. .::.:.::::. :. :.:.:::.:::.:..:::.. ::
NP_060 HPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSK
160 170 180 190 200 210
180 190 200 210 220 230
pF1KB7 HRMVTNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH
. . ::::.::.::.:::..:: :::. :::::.: . . . :: : . :.
NP_060 NTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSD-LR-VARLQSKEYP
220 230 240 250 260
240 250 260 270 280 290
pF1KB7 VTYSHLGGWIFSNPDGVCTAGNSNYQYAAPLPLPAPHTHHGCEHYSGLRG-HRQAPYPSA
: . . . .:. :.: : ::.. .::. : : : :.
NP_060 VISKSIMRQRLISPQ----------LSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQD
270 280 290 300 310
300 310 320 330 340 350
pF1KB7 YMHRNHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPIN----PGP--
. . :. ..:: . .. :. :. . : : .: . : . : :
NP_060 -LPLSTFPT---QRDSSLFYHCLKRRDGTRHLDLPCKRSYLEAPSSVGEDHYFRSPPPYD
320 330 340 350 360 370
360 370 380 390 400
pF1KB7 ----SPYPCLWTISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVE
:: : . : :: :::. :.. :. : :: :: . ::..
NP_060 QQMLSPSYCSEVTPREACMYSGSGPEI-AGVSGVDDL-------PPPPLSCNMWTSVS--
380 390 400 410 420
410 420 430 440
pF1KB7 VLGEPSLTSIAVSTWTAVASHPFAGWGGPGAGGHHSPSSLDG
: :: .:.: .: .::
NP_060 ----P-YTSYSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLSQ
430 440 450 460 470
>>XP_011523793 (OMIM: 147891,601719) PREDICTED: T-box tr (608 aa)
initn: 666 init1: 415 opt: 653 Z-score: 484.3 bits: 99.2 E(85289): 3.1e-20
Smith-Waterman score: 662; 35.4% identity (59.3% similar) in 413 aa overlap (35-429:124-505)
10 20 30 40 50 60
pF1KB7 ELGTRKPSDGTVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNEMIVT
. : ..... :.. ::..:.:. .:::.:
XP_011 EPALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIIT
100 110 120 130 140 150
70 80 90 100 110 120
pF1KB7 KNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHSCVYI
: :::::: :..:::..:.. : ::.:.::.:.::.:. ...:. ::: : . . .:.
XP_011 KAGRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYV
160 170 180 190 200 210
130 140 150 160 170
pF1KB7 HPDSPNFGAHWMKAPISFSKVKLTNK-LNGGGQIMLNSLHKYEPQVHIVRV------GSA
::::: :::::. .::.:.::::. :. :.:.:::.:::.:..:::.. ::
XP_011 HPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSK
220 230 240 250 260 270
180 190 200 210 220 230
pF1KB7 HRMVTNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH
. . ::::.::.::.:::..:: :::. :::::.: . . . :: : . :.
XP_011 NTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSD-LR-VARLQSKEYP
280 290 300 310 320 330
240 250 260 270 280 290
pF1KB7 VTYSHLGGWIFSNPDGVCTAGNSNYQYAAPLPLPAPHTHHGCEHYSGLRG-HRQAPYPSA
: . . . .:. :.: : ::.. .::. : : : :.
XP_011 VISKSIMRQRLISPQ----------LSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQD
340 350 360 370 380
300 310 320 330 340 350
pF1KB7 YMHRNHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPIN----PGP--
. . :. ..:: . .. :. :. . : : .: . : . : :
XP_011 -LPLSTFPT---QRDSSLFYHCLKRRDGTRHLDLPCKRSYLEAPSSVGEDHYFRSPPPYD
390 400 410 420 430
360 370 380 390 400
pF1KB7 ----SPYPCLWTISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVE
:: : . : :: :::. :.. :. : :: :: . ::..
XP_011 QQMLSPSYCSEVTPREACMYSGSGPEI-AGVSGVDDL-------PPPPLSCNMWTSVS--
440 450 460 470 480
410 420 430 440
pF1KB7 VLGEPSLTSIAVSTWTAVASHPFAGWGGPGAGGHHSPSSLDG
: :: .:.: .: .::
XP_011 ----P-YTSYSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLSQ
490 500 510 520 530 540
448 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 18:48:24 2016 done: Sun Nov 6 18:48:26 2016
Total Scan time: 10.390 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]