Result of FASTA (omim) for
pFN21AB7036
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7036, 397 aa
1>>>pF1KB7036 397 - 397 aa - 397 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0897+/-0.000471; mu= 18.6611+/- 0.029
mean_var=104.7866+/-27.145, 0's: 0 Z-trim(110.0): 731 B-trim: 771 in 1/48
Lambda= 0.125291
statistics sampled from 17447 (18286) to 17447 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.569), E-opt: 0.2 (0.214), width: 16
Scan time: 6.970
The best scores are: opt bits E(85289)
NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 2642 489.0 8.4e-138
XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 2362 438.4 1.5e-122
XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 2362 438.4 1.5e-122
XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 2362 438.4 1.5e-122
XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 2362 438.4 1.5e-122
XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 2362 438.4 1.5e-122
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 2352 436.5 4.7e-122
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 2352 436.5 4.8e-122
NP_003958 (OMIM: 607405) trace amine-associated re ( 337) 538 108.6 2.3e-23
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 522 105.9 2.1e-22
NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 520 105.4 2.3e-22
NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 520 105.4 2.4e-22
NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 520 105.4 2.4e-22
NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 520 105.4 2.4e-22
NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 520 105.5 2.5e-22
NP_001028252 (OMIM: 604849) trace amine-associated ( 351) 519 105.2 2.6e-22
NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 520 105.5 2.6e-22
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 513 104.1 5.2e-22
NP_055441 (OMIM: 604849) trace amine-associated re ( 306) 512 103.9 5.7e-22
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 511 103.7 6.4e-22
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 511 103.7 6.6e-22
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 511 103.7 6.9e-22
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 511 103.8 7.2e-22
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 511 103.8 7.3e-22
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 510 103.5 7.6e-22
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 510 103.5 7.6e-22
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 511 103.8 7.9e-22
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 511 103.8 7.9e-22
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 510 103.6 8.1e-22
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 511 103.9 8.3e-22
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 511 103.9 8.4e-22
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 510 103.6 8.5e-22
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 511 103.9 8.5e-22
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 511 103.9 8.5e-22
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 511 103.9 8.5e-22
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 511 103.9 8.5e-22
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 510 103.6 8.6e-22
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 510 103.8 1e-21
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 510 103.8 1.1e-21
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 509 103.5 1.1e-21
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 509 103.6 1.2e-21
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 490 100.0 1.1e-20
NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamin ( 422) 483 98.8 2.6e-20
NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 477 97.7 5.5e-20
NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 453 93.4 1.2e-18
NP_612200 (OMIM: 609333) trace amine-associated re ( 339) 450 92.7 1.4e-18
NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 444 91.7 3.5e-18
NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 444 91.8 3.6e-18
NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 444 91.8 3.8e-18
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 441 91.2 5.4e-18
>>NP_001124527 (OMIM: 142703) histamine H2 receptor isof (397 aa)
initn: 2642 init1: 2642 opt: 2642 Z-score: 2595.0 bits: 489.0 E(85289): 8.4e-138
Smith-Waterman score: 2642; 100.0% identity (100.0% similar) in 397 aa overlap (1-397:1-397)
10 20 30 40 50 60
pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRP
310 320 330 340 350 360
370 380 390
pF1KB7 WLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL
:::::::::::::::::::::::::::::::::::::
NP_001 WLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL
370 380 390
>>XP_011532850 (OMIM: 142703) PREDICTED: histamine H2 re (422 aa)
initn: 2352 init1: 2352 opt: 2362 Z-score: 2321.1 bits: 438.4 E(85289): 1.5e-122
Smith-Waterman score: 2362; 97.3% identity (97.6% similar) in 374 aa overlap (1-373:1-374)
10 20 30 40 50 60
pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
250 260 270 280 290 300
310 320 330 340 350
pF1KB7 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR-
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRK
310 320 330 340 350 360
360 370 380 390
pF1KB7 PWLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL
: : : : :.
XP_011 PALSCTTCSSNLLSCCKSLWGLRFLQRHMGGPSEELSGEPLSEEPQKRPPQKAVRTLPSE
370 380 390 400 410 420
>>XP_006714927 (OMIM: 142703) PREDICTED: histamine H2 re (422 aa)
initn: 2352 init1: 2352 opt: 2362 Z-score: 2321.1 bits: 438.4 E(85289): 1.5e-122
Smith-Waterman score: 2362; 97.3% identity (97.6% similar) in 374 aa overlap (1-373:1-374)
10 20 30 40 50 60
pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
250 260 270 280 290 300
310 320 330 340 350
pF1KB7 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR-
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRK
310 320 330 340 350 360
360 370 380 390
pF1KB7 PWLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL
: : : : :.
XP_006 PALSCTTCSSNLLSCCKSLWGLRFLQRHMGGPSEELSGEPLSEEPQKRPPQKAVRTLPSE
370 380 390 400 410 420
>>XP_011532851 (OMIM: 142703) PREDICTED: histamine H2 re (422 aa)
initn: 2352 init1: 2352 opt: 2362 Z-score: 2321.1 bits: 438.4 E(85289): 1.5e-122
Smith-Waterman score: 2362; 97.3% identity (97.6% similar) in 374 aa overlap (1-373:1-374)
10 20 30 40 50 60
pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
250 260 270 280 290 300
310 320 330 340 350
pF1KB7 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR-
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRK
310 320 330 340 350 360
360 370 380 390
pF1KB7 PWLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL
: : : : :.
XP_011 PALSCTTCSSNLLSCCKSLWGLRFLQRHMGGPSEELSGEPLSEEPQKRPPQKAVRTLPSE
370 380 390 400 410 420
>>XP_005265961 (OMIM: 142703) PREDICTED: histamine H2 re (422 aa)
initn: 2352 init1: 2352 opt: 2362 Z-score: 2321.1 bits: 438.4 E(85289): 1.5e-122
Smith-Waterman score: 2362; 97.3% identity (97.6% similar) in 374 aa overlap (1-373:1-374)
10 20 30 40 50 60
pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
250 260 270 280 290 300
310 320 330 340 350
pF1KB7 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR-
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRK
310 320 330 340 350 360
360 370 380 390
pF1KB7 PWLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL
: : : : :.
XP_005 PALSCTTCSSNLLSCCKSLWGLRFLQRHMGGPSEELSGEPLSEEPQKRPPQKAVRTLPSE
370 380 390 400 410 420
>>XP_016864915 (OMIM: 142703) PREDICTED: histamine H2 re (422 aa)
initn: 2352 init1: 2352 opt: 2362 Z-score: 2321.1 bits: 438.4 E(85289): 1.5e-122
Smith-Waterman score: 2362; 97.3% identity (97.6% similar) in 374 aa overlap (1-373:1-374)
10 20 30 40 50 60
pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
250 260 270 280 290 300
310 320 330 340 350
pF1KB7 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR-
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRK
310 320 330 340 350 360
360 370 380 390
pF1KB7 PWLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL
: : : : :.
XP_016 PALSCTTCSSNLLSCCKSLWGLRFLQRHMGGPSEELSGEPLSEEPQKRPPQKAVRTLPSE
370 380 390 400 410 420
>>NP_071640 (OMIM: 142703) histamine H2 receptor isoform (359 aa)
initn: 2352 init1: 2352 opt: 2352 Z-score: 2312.2 bits: 436.5 E(85289): 4.7e-122
Smith-Waterman score: 2352; 100.0% identity (100.0% similar) in 359 aa overlap (1-359:1-359)
10 20 30 40 50 60
pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
310 320 330 340 350
370 380 390
pF1KB7 WLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL
>>XP_006714928 (OMIM: 142703) PREDICTED: histamine H2 re (362 aa)
initn: 2352 init1: 2352 opt: 2352 Z-score: 2312.1 bits: 436.5 E(85289): 4.8e-122
Smith-Waterman score: 2352; 100.0% identity (100.0% similar) in 359 aa overlap (1-359:1-359)
10 20 30 40 50 60
pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRN
310 320 330 340 350 360
370 380 390
pF1KB7 WLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL
XP_006 SS
>>NP_003958 (OMIM: 607405) trace amine-associated recept (337 aa)
initn: 432 init1: 321 opt: 538 Z-score: 540.4 bits: 108.6 E(85289): 2.3e-23
Smith-Waterman score: 538; 35.3% identity (66.4% similar) in 283 aa overlap (18-296:34-313)
10 20 30 40
pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNR
...: .. :. .:: : ::: : .::. .
NP_003 VFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVSYFK
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB7 RLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASIL
:.. :: ...:::..:..:::::::.:.: .. : :: .: ..: ::...: .::.
NP_003 ALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIF
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB7 NLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLI-WVISITLS--FLSIHLGWNSRNET
.: .::.::.::. ::: :: : ::::. .: : . . . :: . . ..
NP_003 HLCFISIDRHCAICDPLLYPSKFT-VRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQW
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB7 SKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHIS-SWK
. ...:.. .:. .: .. . :..: ::: : .:: :: ::..:. .: :
NP_003 LEEMPCVGSCQLLLNKFWGWLN-FPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSLA
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB7 AATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSAL
.:. .:.::. ::. ..: ...::.:. . .: . :.. : .:..: :::
NP_003 GAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFD-IFIWFAYFNSAC
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB7 NPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQ
:::.:. . ::
NP_003 NPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE
310 320 330
>>NP_000785 (OMIM: 126449) D(1A) dopamine receptor [Homo (446 aa)
initn: 448 init1: 270 opt: 522 Z-score: 523.4 bits: 105.9 E(85289): 2.1e-22
Smith-Waterman score: 689; 35.1% identity (64.7% similar) in 368 aa overlap (18-342:23-387)
10 20 30 40 50
pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRN-LTN
.: . :..::: :. ::..:: :: :.::. .::
NP_000 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 CFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISL
:..:::..:::...::.:..:. ... : ::. ::::....:.: ::::::: .::.
NP_000 FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISV
70 80 90 100 110
120 130 140 150 160 170
pF1KB7 DRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSK--GNHTT-
::: :. .:.:: .:: . : . . :..:. .::. ..:.:.. . :: :: :.
NP_000 DRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSL
120 130 140 150 160 170
180 190 200 210
pF1KB7 ----SKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHI--------
..: .....:.. .....::.:. :: .:: ::...:. : .:: .
NP_000 AETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAK
180 190 200 210 220 230
220 230 240 250
pF1KB7 ------------------SSWKAATIREHKATVTLAAVMGAFIICWFPYFT-----AFVY
::.: . :: :. ::...::.:. ::.:.: :
NP_000 NCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCG
240 250 260 270 280 290
260 270 280 290 300 310
pF1KB7 RGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCC-RL--ANRNSH
: :. . .:.:.:::.::::.:: .: ::: ... :. : :: :. :.
NP_000 SGETQPFCIDSNTFDVFVWFGWANSSLNPIIYA-FNADFRKAFSTLLGCYRLCPATNNAI
300 310 320 330 340 350
320 330 340 350 360 370
pF1KB7 KT-SLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRPWLCLPECWSVEL
.: :. .:.. . .. .::: . : .:
NP_000 ETVSINNNGAAMFSSH-HEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLS
360 370 380 390 400 410
397 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 17:02:02 2016 done: Sun Nov 6 17:02:04 2016
Total Scan time: 6.970 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]