Result of FASTA (omim) for
pFN21AB6945
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6945, 211 aa
1>>>pF1KB6945 211 - 211 aa - 211 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5550+/-0.000296; mu= 13.2858+/- 0.019
mean_var=74.3523+/-14.919, 0's: 0 Z-trim(118.7): 35 B-trim: 330 in 1/53
Lambda= 0.148740
statistics sampled from 31900 (31935) to 31900 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.745), E-opt: 0.2 (0.374), width: 16
Scan time: 5.960
The best scores are: opt bits E(85289)
NP_001179 (OMIM: 600516) bcl-2 homologous antagoni ( 211) 1422 313.6 1.5e-85
XP_011513081 (OMIM: 600516) PREDICTED: bcl-2 homol ( 211) 1422 313.6 1.5e-85
XP_011513082 (OMIM: 600516) PREDICTED: bcl-2 homol ( 152) 1014 226.0 2.6e-59
NP_000648 (OMIM: 151430) apoptosis regulator Bcl-2 ( 205) 233 58.5 9.4e-09
NP_000624 (OMIM: 151430) apoptosis regulator Bcl-2 ( 239) 227 57.2 2.6e-08
XP_016881406 (OMIM: 151430) PREDICTED: apoptosis r ( 198) 219 55.4 7.3e-08
XP_011524437 (OMIM: 151430) PREDICTED: apoptosis r ( 224) 219 55.5 8.1e-08
NP_001309169 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 215 54.6 1.5e-07
XP_016883482 (OMIM: 600039) PREDICTED: bcl-2-like ( 233) 215 54.6 1.5e-07
XP_011527266 (OMIM: 600039) PREDICTED: bcl-2-like ( 233) 215 54.6 1.5e-07
NP_001304849 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 215 54.6 1.5e-07
NP_612815 (OMIM: 600039) bcl-2-like protein 1 isof ( 233) 215 54.6 1.5e-07
NP_001304848 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 215 54.6 1.5e-07
NP_001309171 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 215 54.6 1.5e-07
NP_001304850 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 215 54.6 1.5e-07
NP_001309168 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 215 54.6 1.5e-07
NP_001186768 (OMIM: 601931) bcl-2-like protein 2 [ ( 193) 210 53.5 2.7e-07
NP_004041 (OMIM: 601931) bcl-2-like protein 2 [Hom ( 193) 210 53.5 2.7e-07
NP_620116 (OMIM: 600040) apoptosis regulator BAX i ( 192) 206 52.6 4.9e-07
NP_004315 (OMIM: 600040) apoptosis regulator BAX i ( 218) 205 52.5 6.3e-07
XP_016882566 (OMIM: 600040) PREDICTED: apoptosis r ( 173) 202 51.8 8.2e-07
NP_620119 (OMIM: 600040) apoptosis regulator BAX i ( 179) 201 51.6 9.8e-07
NP_001278357 (OMIM: 600040) apoptosis regulator BA ( 221) 199 51.2 1.6e-06
NP_001278358 (OMIM: 600040) apoptosis regulator BA ( 181) 196 50.5 2.1e-06
NP_068779 (OMIM: 159552) induced myeloid leukemia ( 350) 196 50.6 3.6e-06
NP_001184249 (OMIM: 159552) induced myeloid leukem ( 197) 186 48.4 9.8e-06
NP_115904 (OMIM: 605404) bcl-2-related ovarian kil ( 212) 170 44.9 0.00011
XP_011509998 (OMIM: 605404) PREDICTED: bcl-2-relat ( 212) 170 44.9 0.00011
NP_001108207 (OMIM: 601056) bcl-2-related protein ( 163) 164 43.6 0.00022
NP_004040 (OMIM: 601056) bcl-2-related protein A1 ( 175) 164 43.6 0.00024
NP_001278360 (OMIM: 600040) apoptosis regulator BA ( 114) 156 41.8 0.00054
NP_620118 (OMIM: 600040) apoptosis regulator BAX i ( 143) 156 41.8 0.00065
NP_001278359 (OMIM: 600040) apoptosis regulator BA ( 140) 155 41.6 0.00075
XP_016860264 (OMIM: 605404) PREDICTED: bcl-2-relat ( 134) 148 40.1 0.002
XP_016860265 (OMIM: 605404) PREDICTED: bcl-2-relat ( 134) 148 40.1 0.002
>>NP_001179 (OMIM: 600516) bcl-2 homologous antagonist/k (211 aa)
initn: 1422 init1: 1422 opt: 1422 Z-score: 1656.9 bits: 313.6 E(85289): 1.5e-85
Smith-Waterman score: 1422; 100.0% identity (100.0% similar) in 211 aa overlap (1-211:1-211)
10 20 30 40 50 60
pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 SGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAA
130 140 150 160 170 180
190 200 210
pF1KB6 LNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
:::::::::::::::::::::::::::::::
NP_001 LNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
190 200 210
>>XP_011513081 (OMIM: 600516) PREDICTED: bcl-2 homologou (211 aa)
initn: 1422 init1: 1422 opt: 1422 Z-score: 1656.9 bits: 313.6 E(85289): 1.5e-85
Smith-Waterman score: 1422; 100.0% identity (100.0% similar) in 211 aa overlap (1-211:1-211)
10 20 30 40 50 60
pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 SGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAA
130 140 150 160 170 180
190 200 210
pF1KB6 LNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
:::::::::::::::::::::::::::::::
XP_011 LNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
190 200 210
>>XP_011513082 (OMIM: 600516) PREDICTED: bcl-2 homologou (152 aa)
initn: 1014 init1: 1014 opt: 1014 Z-score: 1185.8 bits: 226.0 E(85289): 2.6e-59
Smith-Waterman score: 1014; 100.0% identity (100.0% similar) in 152 aa overlap (60-211:1-152)
30 40 50 60 70 80
pF1KB6 DTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRY
::::::::::::::::::::::::::::::
XP_011 MVTLPLQPSSTMGQVGRQLAIIGDDINRRY
10 20 30
90 100 110 120 130 140
pF1KB6 DSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTG
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB6 FLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFF
100 110 120 130 140 150
210
pF1KB6 KS
::
XP_011 KS
>>NP_000648 (OMIM: 151430) apoptosis regulator Bcl-2 bet (205 aa)
initn: 275 init1: 160 opt: 233 Z-score: 278.2 bits: 58.5 E(85289): 9.4e-09
Smith-Waterman score: 240; 30.5% identity (61.7% similar) in 141 aa overlap (53-181:60-199)
30 40 50 60 70 80
pF1KB6 SEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQ-PSSTMGQVGRQLAII
:: :: : ::: :.. . .: :. .
NP_000 WDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPV
30 40 50 60 70 80
90 100 110 120 130
pF1KB6 -----------GDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVA
:::..::: .: : ..:. : .: :. .. ::..:.::::.::
NP_000 PPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVA
90 100 110 120 130 140
140 150 160 170 180 190
pF1KB6 LLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILN
.. :: . .. .. .. .. ... ...... .: . :: . ::::.::
NP_000 FFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRH-LHTWIQDNGGWVGALGDVSLG
150 160 170 180 190 200
200 210
pF1KB6 VLVVLGVVLLGQFVVRRFFKS
>>NP_000624 (OMIM: 151430) apoptosis regulator Bcl-2 alp (239 aa)
initn: 262 init1: 160 opt: 227 Z-score: 270.2 bits: 57.2 E(85289): 2.6e-08
Smith-Waterman score: 234; 29.6% identity (59.9% similar) in 152 aa overlap (53-192:60-209)
30 40 50 60 70 80
pF1KB6 SEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQ-PSSTMGQVGRQLAII
:: :: : ::: :.. . .: :. .
NP_000 WDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPV
30 40 50 60 70 80
90 100 110 120 130
pF1KB6 -----------GDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVA
:::..::: .: : ..:. : .: :. .. ::..:.::::.::
NP_000 PPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVA
90 100 110 120 130 140
140 150 160 170 180 190
pF1KB6 LLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILN
.. :: . .. .. .. .. ... ...... .: . :: . ::: : ..: :: .
NP_000 FFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRH-LHTWIQDNGGWDAFVEL-YGPSMR
150 160 170 180 190 200
200 210
pF1KB6 VLVVLGVVLLGQFVVRRFFKS
:
NP_000 PLFDFSWLSLKTLLSLALVGACITLGAYLGHK
210 220 230
>>XP_016881406 (OMIM: 151430) PREDICTED: apoptosis regul (198 aa)
initn: 259 init1: 160 opt: 219 Z-score: 262.2 bits: 55.4 E(85289): 7.3e-08
Smith-Waterman score: 226; 29.0% identity (60.9% similar) in 138 aa overlap (53-178:60-196)
30 40 50 60 70 80
pF1KB6 SEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQ-PSSTMGQVGRQLAII
:: :: : ::: :.. . .: :. .
XP_016 WDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPV
30 40 50 60 70 80
90 100 110 120 130
pF1KB6 -----------GDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVA
:::..::: .: : ..:. : .: :. .. ::..:.::::.::
XP_016 PPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVA
90 100 110 120 130 140
140 150 160 170 180 190
pF1KB6 LLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILN
.. :: . .. .. .. .. ... ...... .: . :: . :::.
XP_016 FFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRH-LHTWIQDNGGWLYM
150 160 170 180 190
200 210
pF1KB6 VLVVLGVVLLGQFVVRRFFKS
>>XP_011524437 (OMIM: 151430) PREDICTED: apoptosis regul (224 aa)
initn: 259 init1: 160 opt: 219 Z-score: 261.4 bits: 55.5 E(85289): 8.1e-08
Smith-Waterman score: 226; 29.5% identity (60.4% similar) in 139 aa overlap (53-179:60-197)
30 40 50 60 70 80
pF1KB6 SEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQ-PSSTMGQVGRQLAII
:: :: : ::: :.. . .: :. .
XP_011 WDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPV
30 40 50 60 70 80
90 100 110 120 130
pF1KB6 -----------GDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVA
:::..::: .: : ..:. : .: :. .. ::..:.::::.::
XP_011 PPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVA
90 100 110 120 130 140
140 150 160 170 180 190
pF1KB6 LLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILN
.. :: . .. .. .. .. ... ...... .: . :: . ::: :
XP_011 FFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRH-LHTWIQDNGGWDALVLFAGLREFQ
150 160 170 180 190 200
200 210
pF1KB6 VLVVLGVVLLGQFVVRRFFKS
XP_011 HGPGNYFLKRNLNAKF
210 220
>>NP_001309169 (OMIM: 600039) bcl-2-like protein 1 isofo (233 aa)
initn: 236 init1: 169 opt: 215 Z-score: 256.5 bits: 54.6 E(85289): 1.5e-07
Smith-Waterman score: 227; 28.3% identity (62.5% similar) in 152 aa overlap (71-207:83-233)
50 60 70 80 90 100
pF1KB6 YRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHL
:. : . : ::... :: :. . ..:
NP_001 GNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB6 QPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVD
. : .::. : .... ::..:.::::.::...:: : .. .. . ...... ...
NP_001 HITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMAT
120 130 140 150 160 170
170 180 190 200
pF1KB6 FMLHHCIARWIAQRGGWVAALNL-GNGP--------------ILNVLVVLGVVLLGQFVV
.. : . :: . ::: . ..: ::. .:. ..: ::::::..
NP_001 YLNDH-LEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFS
180 190 200 210 220 230
210
pF1KB6 RRFFKS
:.
NP_001 RK
>>XP_016883482 (OMIM: 600039) PREDICTED: bcl-2-like prot (233 aa)
initn: 236 init1: 169 opt: 215 Z-score: 256.5 bits: 54.6 E(85289): 1.5e-07
Smith-Waterman score: 227; 28.3% identity (62.5% similar) in 152 aa overlap (71-207:83-233)
50 60 70 80 90 100
pF1KB6 YRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHL
:. : . : ::... :: :. . ..:
XP_016 GNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB6 QPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVD
. : .::. : .... ::..:.::::.::...:: : .. .. . ...... ...
XP_016 HITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMAT
120 130 140 150 160 170
170 180 190 200
pF1KB6 FMLHHCIARWIAQRGGWVAALNL-GNGP--------------ILNVLVVLGVVLLGQFVV
.. : . :: . ::: . ..: ::. .:. ..: ::::::..
XP_016 YLNDH-LEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFS
180 190 200 210 220 230
210
pF1KB6 RRFFKS
:.
XP_016 RK
>>XP_011527266 (OMIM: 600039) PREDICTED: bcl-2-like prot (233 aa)
initn: 236 init1: 169 opt: 215 Z-score: 256.5 bits: 54.6 E(85289): 1.5e-07
Smith-Waterman score: 227; 28.3% identity (62.5% similar) in 152 aa overlap (71-207:83-233)
50 60 70 80 90 100
pF1KB6 YRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHL
:. : . : ::... :: :. . ..:
XP_011 GNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB6 QPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVD
. : .::. : .... ::..:.::::.::...:: : .. .. . ...... ...
XP_011 HITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMAT
120 130 140 150 160 170
170 180 190 200
pF1KB6 FMLHHCIARWIAQRGGWVAALNL-GNGP--------------ILNVLVVLGVVLLGQFVV
.. : . :: . ::: . ..: ::. .:. ..: ::::::..
XP_011 YLNDH-LEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFS
180 190 200 210 220 230
210
pF1KB6 RRFFKS
:.
XP_011 RK
211 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 02:26:41 2016 done: Mon Nov 7 02:26:42 2016
Total Scan time: 5.960 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]