Result of FASTA (omim) for
pFN21AB6149
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6149, 596 aa
1>>>pF1KB6149 596 - 596 aa - 596 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.2538+/-0.000552; mu= -0.1687+/- 0.033
mean_var=414.2426+/-103.038, 0's: 0 Z-trim(115.2): 250 B-trim: 1205 in 1/52
Lambda= 0.063015
statistics sampled from 25160 (25442) to 25160 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.298), width: 16
Scan time: 11.110
The best scores are: opt bits E(85289)
NP_009130 (OMIM: 604459,611064) interleukin-1 rece ( 596) 4055 384.3 6.2e-106
NP_001135995 (OMIM: 604459,611064) interleukin-1 r ( 535) 3335 318.8 3e-86
NP_001020413 (OMIM: 300283) interleukin-1 receptor ( 682) 586 69.0 5.8e-11
XP_005274725 (OMIM: 300283) PREDICTED: interleukin ( 708) 586 69.0 6e-11
NP_001560 (OMIM: 300283) interleukin-1 receptor-as ( 712) 586 69.0 6e-11
NP_001020414 (OMIM: 300283) interleukin-1 receptor ( 633) 574 67.9 1.2e-10
XP_011529460 (OMIM: 300283) PREDICTED: interleukin ( 603) 567 67.2 1.8e-10
NP_001561 (OMIM: 603304) interleukin-1 receptor-as ( 625) 451 56.7 2.7e-07
XP_006719502 (OMIM: 606883,607676,610799) PREDICTE ( 336) 435 54.9 5.2e-07
NP_001138729 (OMIM: 606883,607676,610799) interleu ( 336) 435 54.9 5.2e-07
XP_016874880 (OMIM: 606883,607676,610799) PREDICTE ( 336) 435 54.9 5.2e-07
XP_005269005 (OMIM: 606883,607676,610799) PREDICTE ( 336) 435 54.9 5.2e-07
NP_001138728 (OMIM: 606883,607676,610799) interleu ( 336) 435 54.9 5.2e-07
XP_005269006 (OMIM: 606883,607676,610799) PREDICTE ( 336) 435 54.9 5.2e-07
NP_001138730 (OMIM: 606883,607676,610799) interleu ( 336) 435 54.9 5.2e-07
XP_005269004 (OMIM: 606883,607676,610799) PREDICTE ( 336) 435 54.9 5.2e-07
NP_001107654 (OMIM: 606883,607676,610799) interleu ( 460) 435 55.0 6.3e-07
XP_011536733 (OMIM: 606883,607676,610799) PREDICTE ( 460) 435 55.0 6.3e-07
NP_057207 (OMIM: 606883,607676,610799) interleukin ( 460) 435 55.0 6.3e-07
XP_006719501 (OMIM: 606883,607676,610799) PREDICTE ( 460) 435 55.0 6.3e-07
XP_005269002 (OMIM: 606883,607676,610799) PREDICTE ( 460) 435 55.0 6.3e-07
XP_005269001 (OMIM: 606883,607676,610799) PREDICTE ( 460) 435 55.0 6.3e-07
XP_005269000 (OMIM: 606883,607676,610799) PREDICTE ( 460) 435 55.0 6.3e-07
XP_011536735 (OMIM: 606883,607676,610799) PREDICTE ( 460) 435 55.0 6.3e-07
XP_016874879 (OMIM: 606883,607676,610799) PREDICTE ( 460) 435 55.0 6.3e-07
XP_011536734 (OMIM: 606883,607676,610799) PREDICTE ( 460) 435 55.0 6.3e-07
XP_006719505 (OMIM: 606883,607676,610799) PREDICTE ( 257) 390 50.6 7.6e-06
XP_006719503 (OMIM: 606883,607676,610799) PREDICTE ( 257) 390 50.6 7.6e-06
XP_006719506 (OMIM: 606883,607676,610799) PREDICTE ( 257) 390 50.6 7.6e-06
XP_006719504 (OMIM: 606883,607676,610799) PREDICTE ( 257) 390 50.6 7.6e-06
>>NP_009130 (OMIM: 604459,611064) interleukin-1 receptor (596 aa)
initn: 4055 init1: 4055 opt: 4055 Z-score: 2022.8 bits: 384.3 E(85289): 6.2e-106
Smith-Waterman score: 4055; 99.8% identity (100.0% similar) in 596 aa overlap (1-596:1-596)
10 20 30 40 50 60
pF1KB6 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 YVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 YVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 FPNILFKETANVTVDNVLIPEHNEKGVLLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVY
::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::
NP_009 FPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 RVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 RVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 YPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 YPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANIL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 LDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 GIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 GIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 LAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 DDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 DDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCE
490 500 510 520 530 540
550 560 570 580 590
pF1KB6 ESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 ESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE
550 560 570 580 590
>>NP_001135995 (OMIM: 604459,611064) interleukin-1 recep (535 aa)
initn: 3335 init1: 3335 opt: 3335 Z-score: 1669.5 bits: 318.8 E(85289): 3e-86
Smith-Waterman score: 3514; 89.6% identity (89.8% similar) in 596 aa overlap (1-596:1-535)
10 20 30 40 50 60
pF1KB6 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEK
::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGL----------------
10 20 30 40
70 80 90 100 110 120
pF1KB6 YVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGG
:::::::::::::::
NP_001 ---------------------------------------------GAVLSPSEKSYQEGG
50
130 140 150 160 170 180
pF1KB6 FPNILFKETANVTVDNVLIPEHNEKGVLLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVY
::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::
NP_001 FPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVY
60 70 80 90 100 110
190 200 210 220 230 240
pF1KB6 RVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLI
120 130 140 150 160 170
250 260 270 280 290 300
pF1KB6 YPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANIL
180 190 200 210 220 230
310 320 330 340 350 360
pF1KB6 LDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSF
240 250 260 270 280 290
370 380 390 400 410 420
pF1KB6 GIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFC
300 310 320 330 340 350
430 440 450 460 470 480
pF1KB6 LAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVE
360 370 380 390 400 410
490 500 510 520 530 540
pF1KB6 DDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCE
420 430 440 450 460 470
550 560 570 580 590
pF1KB6 ESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE
480 490 500 510 520 530
>>NP_001020413 (OMIM: 300283) interleukin-1 receptor-ass (682 aa)
initn: 646 init1: 321 opt: 586 Z-score: 317.8 bits: 69.0 E(85289): 5.8e-11
Smith-Waterman score: 668; 28.8% identity (53.8% similar) in 626 aa overlap (16-549:18-632)
10 20 30 40 50
pF1KB6 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHI
.:...:: .. .. :.:. . : : .: . . ..:
NP_001 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPA-DWCQFAALIVRDQTELRLC
10 20 30 40 50
60 70 80 90 100
pF1KB6 EKYVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNY-------------
:. .:. : .:: : ..: ..::...: .. :: .:: .
NP_001 ER---SGQR-TASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTA
60 70 80 90 100 110
110 120 130 140
pF1KB6 ---GAVLSPSE-------------KSYQEGGFPNILFK---ETANVTVDNVLIPEHN---
... .:.: ... .::. . : . : : :
NP_001 PRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPA
120 130 140 150 160 170
150 160 170 180
pF1KB6 --------EKGV-LLKSSISFQ------NIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLT
:..: ::... : .: .::.:: ... :::: . :::. ..: .
NP_001 PSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTV
180 190 200 210 220 230
190 200 210 220 230 240
pF1KB6 YAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGT
:::: .:.. .. . ::.:.: : :.::::...:.: ... .::.: .. ::.
NP_001 YAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGS
240 250 260 270 280 290
250 260 270 280 290 300
pF1KB6 LFDRLQCVGDTAP-LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQP
: :::.: .. : : : :. ::.: ..::..::. .: :.: :.:.:.:.:::... :
NP_001 LEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTP
300 310 320 330 340 350
310 320 330 340 350 360
pF1KB6 KLTDFAMAHFRSHL---EHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVI
:: ::..:.: :: . :.. : :.:::::. :.:.. ::..:::.:.
NP_001 KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVV
360 370 380 390 400 410
370 380 390 400
pF1KB6 MEVLTGCRVVLDDPKHIQ-LRDLLRELMEKRG--LDSCLS--------------------
.:.:.: :.: . . :.::..: :. : : : :
NP_001 LETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIY
420 430 440 450 460 470
410 420 430 440 450
pF1KB6 --FLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTS
:: . ::: ... : :: : ::: :: : . :. :. . . . :
NP_001 KKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQE-NSYVSSTGRAHSGAAPWQP
480 490 500 510 520 530
460 470 480 490 500
pF1KB6 LKSFRCPSPLFLENV---PSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFE--------
: . : :.. :. :::.::: : . .:: ..: . :..
NP_001 LAAPSGASAQAAEQLQRGPNQPVESDES----LGGLSAALRSWHLTPSCPLDPAPLREAG
540 550 560 570 580
510 520 530 540 550 560
pF1KB6 CSQSEVM-FLSLDKKPESKRNE-EACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSE
: :... : . : :. . :. . ::. : :. :.
NP_001 CPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDG
590 600 610 620 630 640
570 580 590
pF1KB6 APGHSCRSRPVESSCSSKFSWDEYEQYKKE
NP_001 ALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
650 660 670 680
>>XP_005274725 (OMIM: 300283) PREDICTED: interleukin-1 r (708 aa)
initn: 646 init1: 321 opt: 586 Z-score: 317.6 bits: 69.0 E(85289): 6e-11
Smith-Waterman score: 641; 33.2% identity (58.1% similar) in 434 aa overlap (158-549:231-658)
130 140 150 160 170 180
pF1KB6 ETANVTVDNVLIPEHNEKGVLLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVYRVEIQNL
: .::.:: ... :::: . :::. ..:
XP_005 APSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNT
210 220 230 240 250 260
190 200 210 220 230 240
pF1KB6 TYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNG
.:::: .:.. .. . ::.:.: : :.::::...:.: ... .::.: .. ::
XP_005 VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNG
270 280 290 300 310 320
250 260 270 280 290 300
pF1KB6 TLFDRLQCVGDTAP-LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQ
.: :::.: .. : : : :. ::.: ..::..::. .: :.: :.:.:.:.:::...
XP_005 SLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLT
330 340 350 360 370
310 320 330 340 350 360
pF1KB6 PKLTDFAMAHFRSHL---EHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIV
::: ::..:.: :: . :.. : :.:::::. :.:.. ::..:::.:
XP_005 PKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVV
380 390 400 410 420 430
370 380 390 400
pF1KB6 IMEVLTGCRVVLDDPKHIQ-LRDLLRELMEKRG--LDSCLS-------------------
..:.:.: :.: . . :.::..: :. : : : :
XP_005 VLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQI
440 450 460 470 480 490
410 420 430 440 450
pF1KB6 ---FLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPT
:: . ::: ... : :: : ::: :: : . :. :. . . . :
XP_005 YKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQE-NSYVSSTGRAHSGAAPWQ
500 510 520 530 540 550
460 470 480 490 500
pF1KB6 SLKSFRCPSPLFLENV---PSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFE-------
: . : :.. :. :::.::: : . .:: ..: . :..
XP_005 PLAAPSGASAQAAEQLQRGPNQPVESDES----LGGLSAALRSWHLTPSCPLDPAPLREA
560 570 580 590 600 610
510 520 530 540 550 560
pF1KB6 -CSQSEVM-FLSLDKKPESKRNE-EACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSS
: :... : . : :. . :. . ::. : :. :.
XP_005 GCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYED
620 630 640 650 660 670
570 580 590
pF1KB6 EAPGHSCRSRPVESSCSSKFSWDEYEQYKKE
XP_005 GALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
680 690 700
>>NP_001560 (OMIM: 300283) interleukin-1 receptor-associ (712 aa)
initn: 669 init1: 321 opt: 586 Z-score: 317.6 bits: 69.0 E(85289): 6e-11
Smith-Waterman score: 673; 28.2% identity (54.1% similar) in 614 aa overlap (16-546:18-622)
10 20 30 40 50
pF1KB6 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHI
.:...:: .. .. :.:. . : : .: . . ..:
NP_001 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPA-DWCQFAALIVRDQTELRLC
10 20 30 40 50
60 70 80 90 100
pF1KB6 EKYVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNY-------------
:. .:. : .:: : ..: ..::...: .. :: .:: .
NP_001 ER---SGQR-TASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTA
60 70 80 90 100 110
110 120 130 140
pF1KB6 ---GAVLSPSE-------------KSYQEGGFPNILFK---ETANVTVDNVLIPEHN---
... .:.: ... .::. . : . : : :
NP_001 PRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPA
120 130 140 150 160 170
150 160 170 180
pF1KB6 --------EKGV-LLKSSISFQ------NIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLT
:..: ::... : .: .::.:: ... :::: . :::. ..: .
NP_001 PSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTV
180 190 200 210 220 230
190 200 210 220 230 240
pF1KB6 YAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGT
:::: .:.. .. . ::.:.: : :.::::...:.: ... .::.: .. ::.
NP_001 YAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGS
240 250 260 270 280 290
250 260 270 280 290 300
pF1KB6 LFDRLQCVGDTAP-LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQP
: :::.: .. : : : :. ::.: ..::..::. .: :.: :.:.:.:.:::... :
NP_001 LEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTP
300 310 320 330 340 350
310 320 330 340 350 360
pF1KB6 KLTDFAMAHFRSHL---EHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVI
:: ::..:.: :: . :.. : :.:::::. :.:.. ::..:::.:.
NP_001 KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVV
360 370 380 390 400 410
370 380 390 400
pF1KB6 MEVLTGCRVVLDDPKHIQ-LRDLLRELMEKRGL-----DSCLS-----------------
.:.:.: :.: . . :.::..: :. :. .: :.
NP_001 LETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIY
420 430 440 450 460 470
410 420 430 440 450
pF1KB6 --FLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTS
:: . ::: ... : :: : ::: :: : .: . ::. :: . :
NP_001 KKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVV---AGVPGH
480 490 500 510 520 530
460 470 480 490 500 510
pF1KB6 LKSFRC--PSPLFLENVPSIPVEDDESQNNNLL--PSDEGLRIDRMTQKTPFECSQSEVM
.. : ::: : : . . . : :: . . .. :. : . .:.
NP_001 SEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDES
540 550 560 570 580 590
520 530 540 550 560 570
pF1KB6 FLSLDKKPESKRNEEACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSR
. .:. .: . .: . . .:. :.
NP_001 LGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSA
600 610 620 630 640 650
580 590
pF1KB6 PVESSCSSKFSWDEYEQYKKE
NP_001 SSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQ
660 670 680 690 700 710
>>NP_001020414 (OMIM: 300283) interleukin-1 receptor-ass (633 aa)
initn: 573 init1: 321 opt: 574 Z-score: 312.2 bits: 67.9 E(85289): 1.2e-10
Smith-Waterman score: 602; 28.0% identity (53.7% similar) in 603 aa overlap (16-549:18-583)
10 20 30 40 50
pF1KB6 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHI
.:...:: .. .. :.:. . : : .: . . ..:
NP_001 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPA-DWCQFAALIVRDQTELRLC
10 20 30 40 50
60 70 80 90 100
pF1KB6 EKYVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNY-------------
:. .:. : .:: : ..: ..::...: .. :: .:: .
NP_001 ER---SGQR-TASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTA
60 70 80 90 100 110
110 120 130 140
pF1KB6 ---GAVLSPSE-------------KSYQEGGFPNILFK---ETANVTVDNVLIPEHN---
... .:.: ... .::. . : . : : :
NP_001 PRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPA
120 130 140 150 160 170
150 160 170 180
pF1KB6 --------EKGV-LLKSSISFQ------NIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLT
:..: ::... : .: .::.:: ... :::: . :::. ..: .
NP_001 PSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTV
180 190 200 210 220 230
190 200 210 220 230 240
pF1KB6 YAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGT
:::: .:.. .. . ::.:.: : :.::::...:.: ... .::.: .. ::.
NP_001 YAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGS
240 250 260 270 280 290
250 260 270 280 290 300
pF1KB6 LFDRLQCVGDTAP-LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQP
: :::.: .. : : : :. ::.: ..::..::. .: :.: :.:.:.:.:::... :
NP_001 LEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTP
300 310 320 330 340 350
310 320 330 340 350 360
pF1KB6 KLTDFAMAHFRSHL---EHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVI
:: ::..:.: :: . :.. : :.:::::. :.:.. ::..:::.:.
NP_001 KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVV
360 370 380 390 400 410
370 380 390 400 410
pF1KB6 MEVLTGCRVVLDDPKHIQLRDLLRELMEK-----RGLDSCLSFLDKKVPPCPRNFSAKLF
.:.:.: :.: . . . :. : .:: :. . : . .:: :.. :
NP_001 LETLAGQRAV--KTHGARTKYLVYERLEKLQAVVAGVPGH-SEAASCIPPSPQENS--YV
420 430 440 450 460
420 430 440 450 460 470
pF1KB6 CLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPV
.:: . : .: . :: ::. :. :. ::
NP_001 SSTGRAHSGAAPWQP-------LAAPSGASAQAAEQ---------------LQRGPNQPV
470 480 490 500
480 490 500 510 520
pF1KB6 EDDESQNNNLLPSDEGLRIDRMTQKTPFE--------CSQSEVM-FLSLDKKPESKRNE-
:.::: : . .:: ..: . :.. : :... : . : :. .
NP_001 ESDES----LGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAV
510 520 530 540 550 560
530 540 550 560 570 580
pF1KB6 EACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDE
:. . ::. : :. :.
NP_001 EGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQ
570 580 590 600 610 620
>>XP_011529460 (OMIM: 300283) PREDICTED: interleukin-1 r (603 aa)
initn: 573 init1: 321 opt: 567 Z-score: 309.0 bits: 67.2 E(85289): 1.8e-10
Smith-Waterman score: 594; 30.8% identity (59.3% similar) in 413 aa overlap (16-374:18-424)
10 20 30 40 50
pF1KB6 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHI
.:...:: .. .. :.:. . : : .: . . ..:
XP_011 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPA-DWCQFAALIVRDQTELRLC
10 20 30 40 50
60 70 80 90 100
pF1KB6 EKYVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNY-------------
:. .:. : .:: : ..: ..::...: .. :: .:: .
XP_011 ER---SGQR-TASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTA
60 70 80 90 100 110
110 120 130 140
pF1KB6 ---GAVLSPSE-------------KSYQEGGFPNILFK---ETANVTVDNVLIPEHN---
... .:.: ... .::. . : . : : :
XP_011 PRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPA
120 130 140 150 160 170
150 160 170 180
pF1KB6 --------EKGV-LLKSSISFQ------NIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLT
:..: ::... : .: .::.:: ... :::: . :::. ..: .
XP_011 PSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTV
180 190 200 210 220 230
190 200 210 220 230 240
pF1KB6 YAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGT
:::: .:.. .. . ::.:.: : :.::::...:.: ... .::.: .. ::.
XP_011 YAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGS
240 250 260 270 280 290
250 260 270 280 290 300
pF1KB6 LFDRLQCVGDTAP-LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQP
: :::.: .. : : : :. ::.: ..::..::. .: :.: :.:.:.:.:::... :
XP_011 LEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTP
300 310 320 330 340 350
310 320 330 340 350 360
pF1KB6 KLTDFAMAHFRSHL---EHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVI
:: ::..:.: :: . :.. : :.:::::. :.:.. ::..:::.:.
XP_011 KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVV
360 370 380 390 400 410
370 380 390 400 410 420
pF1KB6 MEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGR
.:.:.: :.:
XP_011 LETLAGQRAVKTHGARTKYLENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPN
420 430 440 450 460 470
>>NP_001561 (OMIM: 603304) interleukin-1 receptor-associ (625 aa)
initn: 511 init1: 231 opt: 451 Z-score: 251.8 bits: 56.7 E(85289): 2.7e-07
Smith-Waterman score: 492; 25.6% identity (52.3% similar) in 606 aa overlap (27-543:15-594)
10 20 30 40 50 60
pF1KB6 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEK
.:: .:. . : .: . .. ..:.:..
NP_001 MACYIYQLPSWVLDDLCRNMDALS-EWDWMEFASYVITDLTQLRKIKS
10 20 30 40
70 80 90 100
pF1KB6 YVD-QGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNY--------------
. :: : :::::: :.... :. .:...: .. :: ..: :.
NP_001 MERVQGVSITRELLWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFP
50 60 70 80 90 100
110 120
pF1KB6 ---------GAVLSPSEKSYQEG---------------------GF--------PNILFK
.: . .: .:: .: :. : .
NP_001 DSVKPEKPLAASVRKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRS
110 120 130 140 150 160
130 140 150 160 170 180
pF1KB6 E--TANVTVD-NVLIPEHNEKGVLLKSSI--SFQNIIEGTRNFHKDFLIGEGEIFEVYRV
. :.. . : .. ::.... : .:. : .....: .:... :..: . .:::
NP_001 DLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRG
170 180 190 200 210 220
190 200 210 220 230
pF1KB6 EIQNLTYAVKLFKQEKKMQCKK--HWKRFL-SELEVLLLFHHPNILELAAYFTETEKFCL
. .. . .::. .. :.. .::. .::.. : :::.: . .. . . .
NP_001 HRHGKPF---VFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSF
230 240 250 260 270 280
240 250 260 270 280 290
pF1KB6 IYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANI
::::: ::.: :::: : . :::: :..: :. :..:::... .: ....:.:.
NP_001 IYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLE---IIHSNVKSSNV
290 300 310 320 330 340
300 310 320 330 340 350
pF1KB6 LLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSS---KHLW-----YMPEEYIRQGKL
:::... ::: :: .:: : .: :. . :: :.::..:: :.:
NP_001 LLDQNLTPKL-----AHPMAHL----CPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQL
350 360 370 380 390
360 370 380 390
pF1KB6 SIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELM---------EKRGLDS----
. ..:..: :::. ::::: .. .. . . :.::: . .: :...
NP_001 TKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAK
400 410 420 430 440 450
400 410 420 430 440 450
pF1KB6 --CLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAED-
: ..:.: . :.. . : : : : :..:: ... ... : :
NP_001 EICQKYLEKGAGRLPEDCAEALATAACLCLRRRN---TSLQEVCGSVAAVEERLRGRETL
460 470 480 490 500
460 470 480 490 500 510
pF1KB6 -PPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEV
: ..:. : . : : :. .:..: :. ::. ...
NP_001 LPWSGLSEGTGSSS-------NTPEETDDVDNSSLDASSSMSVAPWAGAATPLLPTENGE
510 520 530 540 550 560
520 530 540 550 560 570
pF1KB6 MFLSLDKKPESKRNEEAC---NMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHS
: . :. . ::: . :.. : ::
NP_001 GRLRVIVGREADSSSEACVGLEPPQDVTETSWQIEINEAKRKLMENILLYKEEKVDSIEL
570 580 590 600 610 620
580 590
pF1KB6 CRSRPVESSCSSKFSWDEYEQYKKE
NP_001 FGP
>>XP_006719502 (OMIM: 606883,607676,610799) PREDICTED: i (336 aa)
initn: 473 init1: 266 opt: 435 Z-score: 246.8 bits: 54.9 E(85289): 5.2e-07
Smith-Waterman score: 491; 32.2% identity (62.2% similar) in 304 aa overlap (152-449:43-336)
130 140 150 160 170
pF1KB6 PNILFKETANVTVDNVLIPEHNEKGVLLKSSISFQNIIEGTRNFHKDFL------IGEGE
:.:: .. . : :: . . .:::
XP_006 PVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGG
20 30 40 50 60 70
180 190 200 210 220 230
pF1KB6 IFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETE
. ::. ..: : ::: . . .. ..: .:..:. .: :..:: .. .. .
XP_006 FGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGD
80 90 100 110 120 130
240 250 260 270 280 290
pF1KB6 KFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSIS
.::.: :: ::.:.:::.:. : :: ::.: : : ...:..::. . : .:.
XP_006 DLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH---IHRDIK
140 150 160 170 180
300 310 320 330 340 350
pF1KB6 SANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKT
:::::::. : :..::..: :. :. . :. ::: :: : .: :... :.
XP_006 SANILLDEAFTAKISDFGLA--RAS-EKFAQTV-MTSRIVGTTAYMAPEALR-GEITPKS
190 200 210 220 230 240
360 370 380 390 400 410
pF1KB6 DVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFS
:.::::.:..:..:: .: :. .. :: ..: .: . . ...:::. .
XP_006 DIYSFGVVLLEIITGLPAV-DEHREPQLLLDIKEEIEDEE-KTIEDYIDKKMNDADSTSV
250 260 270 280 290 300
420 430 440 450 460 470
pF1KB6 AKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVP
.. .:..: . . ::.. .: . :. ::
XP_006 EAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
310 320 330
480 490 500 510 520 530
pF1KB6 SIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMP
>>NP_001138729 (OMIM: 606883,607676,610799) interleukin- (336 aa)
initn: 473 init1: 266 opt: 435 Z-score: 246.8 bits: 54.9 E(85289): 5.2e-07
Smith-Waterman score: 491; 32.2% identity (62.2% similar) in 304 aa overlap (152-449:43-336)
130 140 150 160 170
pF1KB6 PNILFKETANVTVDNVLIPEHNEKGVLLKSSISFQNIIEGTRNFHKDFL------IGEGE
:.:: .. . : :: . . .:::
NP_001 PVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGG
20 30 40 50 60 70
180 190 200 210 220 230
pF1KB6 IFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETE
. ::. ..: : ::: . . .. ..: .:..:. .: :..:: .. .. .
NP_001 FGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGD
80 90 100 110 120 130
240 250 260 270 280 290
pF1KB6 KFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSIS
.::.: :: ::.:.:::.:. : :: ::.: : : ...:..::. . : .:.
NP_001 DLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH---IHRDIK
140 150 160 170 180
300 310 320 330 340 350
pF1KB6 SANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKT
:::::::. : :..::..: :. :. . :. ::: :: : .: :... :.
NP_001 SANILLDEAFTAKISDFGLA--RAS-EKFAQTV-MTSRIVGTTAYMAPEALR-GEITPKS
190 200 210 220 230 240
360 370 380 390 400 410
pF1KB6 DVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFS
:.::::.:..:..:: .: :. .. :: ..: .: . . ...:::. .
NP_001 DIYSFGVVLLEIITGLPAV-DEHREPQLLLDIKEEIEDEE-KTIEDYIDKKMNDADSTSV
250 260 270 280 290 300
420 430 440 450 460 470
pF1KB6 AKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVP
.. .:..: . . ::.. .: . :. ::
NP_001 EAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
310 320 330
480 490 500 510 520 530
pF1KB6 SIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMP
596 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 14:47:38 2016 done: Sun Nov 6 14:47:40 2016
Total Scan time: 11.110 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]