Result of FASTA (omim) for
pFN21AB5860
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5860, 490 aa
1>>>pF1KB5860 490 - 490 aa - 490 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0754+/-0.000372; mu= 15.0182+/- 0.023
mean_var=92.0901+/-18.878, 0's: 0 Z-trim(115.4): 70 B-trim: 873 in 1/49
Lambda= 0.133650
statistics sampled from 25844 (25915) to 25844 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.674), E-opt: 0.2 (0.304), width: 16
Scan time: 7.280
The best scores are: opt bits E(85289)
NP_002384 (OMIM: 602704) protein Mdm4 isoform 1 [H ( 490) 3293 645.2 1.2e-184
XP_016856800 (OMIM: 602704) PREDICTED: protein Mdm ( 508) 3293 645.2 1.2e-184
XP_016856801 (OMIM: 602704) PREDICTED: protein Mdm ( 503) 3243 635.6 9.9e-182
NP_001265446 (OMIM: 602704) protein Mdm4 isoform 5 ( 392) 2498 491.9 1.4e-138
NP_001265448 (OMIM: 602704) protein Mdm4 isoform 7 ( 267) 1502 299.7 6.7e-81
NP_001191100 (OMIM: 602704) protein Mdm4 isoform 2 ( 440) 1497 298.9 2e-80
XP_016856802 (OMIM: 602704) PREDICTED: protein Mdm ( 458) 1497 298.9 2e-80
NP_001191101 (OMIM: 602704) protein Mdm4 isoform 3 ( 164) 950 193.2 4.9e-49
XP_005268929 (OMIM: 164785,614401) PREDICTED: E3 u ( 491) 886 181.1 6.2e-45
NP_002383 (OMIM: 164785,614401) E3 ubiquitin-prote ( 497) 886 181.1 6.3e-45
NP_001265447 (OMIM: 602704) protein Mdm4 isoform 6 ( 116) 751 154.7 1.3e-37
NP_001265445 (OMIM: 602704) protein Mdm4 isoform 4 ( 140) 751 154.7 1.5e-37
XP_006719462 (OMIM: 164785,614401) PREDICTED: E3 u ( 430) 752 155.2 3.3e-37
XP_006719463 (OMIM: 164785,614401) PREDICTED: E3 u ( 390) 592 124.4 6e-28
NP_001265391 (OMIM: 164785,614401) E3 ubiquitin-pr ( 321) 558 117.7 4.8e-26
NP_001138812 (OMIM: 164785,614401) E3 ubiquitin-pr ( 295) 501 106.7 9.1e-23
NP_001138809 (OMIM: 164785,614401) E3 ubiquitin-pr ( 444) 352 78.1 5.7e-14
NP_001138811 (OMIM: 164785,614401) E3 ubiquitin-pr ( 442) 325 72.9 2.1e-12
>>NP_002384 (OMIM: 602704) protein Mdm4 isoform 1 [Homo (490 aa)
initn: 3293 init1: 3293 opt: 3293 Z-score: 3435.9 bits: 645.2 E(85289): 1.2e-184
Smith-Waterman score: 3293; 100.0% identity (100.0% similar) in 490 aa overlap (1-490:1-490)
10 20 30 40 50 60
pF1KB5 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
430 440 450 460 470 480
490
pF1KB5 IQLVIKVFIA
::::::::::
NP_002 IQLVIKVFIA
490
>>XP_016856800 (OMIM: 602704) PREDICTED: protein Mdm4 is (508 aa)
initn: 3293 init1: 3293 opt: 3293 Z-score: 3435.7 bits: 645.2 E(85289): 1.2e-184
Smith-Waterman score: 3293; 100.0% identity (100.0% similar) in 490 aa overlap (1-490:19-508)
10 20 30 40
pF1KB5 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGA
::::::::::::::::::::::::::::::::::::::::::
XP_016 MQNLSKVLPTDCSFFTTKMTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 QGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDML
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB5 RKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSE
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 HKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQT
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 NQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKND
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 DLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLS
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 TSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSE
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB5 SQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFH
430 440 450 460 470 480
470 480 490
pF1KB5 CARRLKKAGASCPICKKEIQLVIKVFIA
::::::::::::::::::::::::::::
XP_016 CARRLKKAGASCPICKKEIQLVIKVFIA
490 500
>>XP_016856801 (OMIM: 602704) PREDICTED: protein Mdm4 is (503 aa)
initn: 1773 init1: 1773 opt: 3243 Z-score: 3383.7 bits: 635.6 E(85289): 9.9e-182
Smith-Waterman score: 3243; 99.0% identity (99.0% similar) in 490 aa overlap (1-490:19-503)
10 20 30 40
pF1KB5 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGA
::::::::::::::::::::::::::::::::::::::::::
XP_016 MQNLSKVLPTDCSFFTTKMTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 QGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDML
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB5 RKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSE
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 HKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQT
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 NQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKND
:::::::::::::::::::::::::::::::::::::::::::::::: :::::::
XP_016 NQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKV-----IEVGKND
250 260 270 280 290
290 300 310 320 330 340
pF1KB5 DLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLS
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB5 TSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSE
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB5 SQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFH
420 430 440 450 460 470
470 480 490
pF1KB5 CARRLKKAGASCPICKKEIQLVIKVFIA
::::::::::::::::::::::::::::
XP_016 CARRLKKAGASCPICKKEIQLVIKVFIA
480 490 500
>>NP_001265446 (OMIM: 602704) protein Mdm4 isoform 5 [Ho (392 aa)
initn: 2493 init1: 2493 opt: 2498 Z-score: 2608.9 bits: 491.9 E(85289): 1.4e-138
Smith-Waterman score: 2498; 96.9% identity (98.4% similar) in 382 aa overlap (112-490:11-392)
90 100 110 120 130
pF1KB5 GELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLA---LAQDHSMDIPSQDQLKQ
.:.:.: .. . :::::::::::::::
NP_001 MTSFSTSAQCSTSDSACRISPGQINQDHSMDIPSQDQLKQ
10 20 30 40
140 150 160 170 180 190
pF1KB5 SAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGL
50 60 70 80 90 100
200 210 220 230 240 250
pF1KB5 PWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAA
110 120 130 140 150 160
260 270 280 290 300 310
pF1KB5 DTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKR
170 180 190 200 210 220
320 330 340 350 360 370
pF1KB5 YCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYI
230 240 250 260 270 280
380 390 400 410 420 430
pF1KB5 KKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCS
290 300 310 320 330 340
440 450 460 470 480 490
pF1KB5 LCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
350 360 370 380 390
>>NP_001265448 (OMIM: 602704) protein Mdm4 isoform 7 [Ho (267 aa)
initn: 1502 init1: 1502 opt: 1502 Z-score: 1573.4 bits: 299.7 E(85289): 6.7e-81
Smith-Waterman score: 1502; 99.5% identity (100.0% similar) in 218 aa overlap (273-490:50-267)
250 260 270 280 290 300
pF1KB5 ESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSED
:.::::::::::::::::::::::::::::
NP_001 SPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVIEVGKNDDLEDSKSLSDDTDVEVTSED
20 30 40 50 60 70
310 320 330 340 350 360
pF1KB5 EWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDC
80 90 100 110 120 130
370 380 390 400 410 420
pF1KB5 RRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRT
140 150 160 170 180 190
430 440 450 460 470 480
pF1KB5 DTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQ
200 210 220 230 240 250
490
pF1KB5 LVIKVFIA
::::::::
NP_001 LVIKVFIA
260
>--
initn: 320 init1: 320 opt: 320 Z-score: 341.7 bits: 71.8 E(85289): 2.7e-12
Smith-Waterman score: 320; 100.0% identity (100.0% similar) in 49 aa overlap (1-49:1-49)
10 20 30 40 50 60
pF1KB5 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVIEVGKNDD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
NP_001 LEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLST
70 80 90 100 110 120
>>NP_001191100 (OMIM: 602704) protein Mdm4 isoform 2 [Ho (440 aa)
initn: 1497 init1: 1497 opt: 1497 Z-score: 1565.1 bits: 298.9 E(85289): 2e-80
Smith-Waterman score: 2874; 89.8% identity (89.8% similar) in 490 aa overlap (1-490:1-440)
10 20 30 40 50 60
pF1KB5 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
::::::::::::::::::::::::::::::::::::::::::::
NP_001 DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQ----------------
190 200 210 220
250 260 270 280 290 300
pF1KB5 LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
::::::::::::::::::::::::::
NP_001 ----------------------------------VIEVGKNDDLEDSKSLSDDTDVEVTS
230 240 250
310 320 330 340 350 360
pF1KB5 EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
260 270 280 290 300 310
370 380 390 400 410 420
pF1KB5 DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB5 RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
380 390 400 410 420 430
490
pF1KB5 IQLVIKVFIA
::::::::::
NP_001 IQLVIKVFIA
440
>>XP_016856802 (OMIM: 602704) PREDICTED: protein Mdm4 is (458 aa)
initn: 1497 init1: 1497 opt: 1497 Z-score: 1564.8 bits: 298.9 E(85289): 2e-80
Smith-Waterman score: 2874; 89.8% identity (89.8% similar) in 490 aa overlap (1-490:19-458)
10 20 30 40
pF1KB5 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGA
::::::::::::::::::::::::::::::::::::::::::
XP_016 MQNLSKVLPTDCSFFTTKMTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 QGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDML
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB5 RKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSE
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 HKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQT
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 NQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKND
:: ::::::::
XP_016 NQ--------------------------------------------------VIEVGKND
250
290 300 310 320 330 340
pF1KB5 DLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLS
260 270 280 290 300 310
350 360 370 380 390 400
pF1KB5 TSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSE
320 330 340 350 360 370
410 420 430 440 450 460
pF1KB5 SQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFH
380 390 400 410 420 430
470 480 490
pF1KB5 CARRLKKAGASCPICKKEIQLVIKVFIA
::::::::::::::::::::::::::::
XP_016 CARRLKKAGASCPICKKEIQLVIKVFIA
440 450
>>NP_001191101 (OMIM: 602704) protein Mdm4 isoform 3 [Ho (164 aa)
initn: 950 init1: 950 opt: 950 Z-score: 1001.3 bits: 193.2 E(85289): 4.9e-49
Smith-Waterman score: 950; 99.3% identity (100.0% similar) in 139 aa overlap (352-490:26-164)
330 340 350 360 370 380
pF1KB5 RCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKE
.:::::::::::::::::::::::::::::
NP_001 MTSFSTSAQCSTSDSACRISPGQINQENEGNDVPDCRRTISAPVVRPKDAYIKKE
10 20 30 40 50
390 400 410 420 430 440
pF1KB5 NSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCE
60 70 80 90 100 110
450 460 470 480 490
pF1KB5 KRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
120 130 140 150 160
>>XP_005268929 (OMIM: 164785,614401) PREDICTED: E3 ubiqu (491 aa)
initn: 512 init1: 346 opt: 886 Z-score: 927.7 bits: 181.1 E(85289): 6.2e-45
Smith-Waterman score: 886; 33.9% identity (64.2% similar) in 481 aa overlap (23-488:24-489)
10 20 30 40 50
pF1KB5 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQY
: . :::: :::.:...::: . .:.:::. :::::
XP_005 MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 IMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATA-TTDAAQ
::.:.:::...::.:::..::::.:.: :::::. .: :. .:::.. ..:..
XP_005 IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 TLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENL
... . : .: .: : .: . : .. . :. . .. ...:. : . .
XP_005 SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSR--PSTSSRRRAISETEENSDELSGE
130 140 150 160 170
180 190 200 210 220 230
pF1KB5 AQDETSRLD---LGFEEWDVAGLPWWFLGNLRSNYTPRSNGS--TDLQTNQDVGTAIVSD
: . . : :.:.: ..: : .: ::..: : .: :. : ::.
XP_005 RQRKRHKSDSISLSFDE-SLA------LCVIREICCERSSSSESTGTPSNPDLD-AGVSE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 TTDDLWFLNESVSEQLGVGIKVEAADTEQ--TSEEVGKVSDKKVIEVGKNDDLEDSKSLS
. : :. ..:::.:..: ..::. :.:. ::: ..::. :: . . ..: .
XP_005 HSGD-WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDD-EVYQVTVYQAGESDT
240 250 260 270 280
300 310 320 330 340
pF1KB5 D--DTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYS-DCSKLTHSLSTSDITA
: . : :.. : :.:: :...: : .: ::::::..: : .: .: .
XP_005 DSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLE
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB5 IPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETIS
. .:: :::::..:: : ... ......:. . .: : : .. : :. :
XP_005 NSTQAEEGFDVPDCKKTI---VNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIY
350 360 370 380 390 400
410 420 430 440 450 460
pF1KB5 SMGEQLDNLSEQRTDT--ENMEDCQ--NLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCA
: :.. .. ...:. :..:. : ..:: .:. ::..: :.::.::::..:: ::
XP_005 SSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCA
410 420 430 440 450 460
470 480 490
pF1KB5 RRLKKAGASCPICKKEIQLVIKVFIA
..::: . ::.:.. ::... ..
XP_005 KKLKKRNKPCPVCRQPIQMIVLTYFP
470 480 490
>>NP_002383 (OMIM: 164785,614401) E3 ubiquitin-protein l (497 aa)
initn: 512 init1: 346 opt: 886 Z-score: 927.6 bits: 181.1 E(85289): 6.3e-45
Smith-Waterman score: 886; 33.9% identity (64.2% similar) in 481 aa overlap (23-488:30-495)
10 20 30 40 50
pF1KB5 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVM
: . :::: :::.:...::: . .:.:::.
NP_002 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 HYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATA-
:::::::.:.:::...::.:::..::::.:.: :::::. .: :. .:::..
NP_002 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 TTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDE
..:.. ... . : .: .: : .: . : .. . :. . .. ...:.
NP_002 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSR--PSTSSRRRAISETEENS
130 140 150 160 170
180 190 200 210 220
pF1KB5 DLIENLAQDETSRLD---LGFEEWDVAGLPWWFLGNLRSNYTPRSNGS--TDLQTNQDVG
: . . : . . : :.:.: ..: : .: ::..: : .: :.
NP_002 DELSGERQRKRHKSDSISLSFDE-SLA------LCVIREICCERSSSSESTGTPSNPDLD
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB5 TAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQ--TSEEVGKVSDKKVIEVGKNDDLE
: ::. . : :. ..:::.:..: ..::. :.:. ::: ..::. :: . .
NP_002 -AGVSEHSGD-WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDD-EVYQVTVYQ
240 250 260 270 280
290 300 310 320 330 340
pF1KB5 DSKSLSD--DTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYS-DCSKLTHSLS
..: .: . : :.. : :.:: :...: : .: ::::::..: : .: .:
NP_002 AGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEIS
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB5 TSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSE
. . .:: :::::..:: : ... ......:. . .: : : .. :
NP_002 EKAKLENSTQAEEGFDVPDCKKTI---VNDSRESCVEENDDKITQASQSQESEDYSQPST
350 360 370 380 390 400
410 420 430 440 450
pF1KB5 SQETISSMGEQLDNLSEQRTDT--ENMEDCQ--NLLKPCSLCEKRPRDGNIIHGRTGHLV
:. : : :.. .. ...:. :..:. : ..:: .:. ::..: :.::.::::.
NP_002 SSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLM
410 420 430 440 450 460
460 470 480 490
pF1KB5 TCFHCARRLKKAGASCPICKKEIQLVIKVFIA
.:: ::..::: . ::.:.. ::... ..
NP_002 ACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
470 480 490
490 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 18:52:30 2016 done: Mon Nov 7 18:52:31 2016
Total Scan time: 7.280 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]