Result of FASTA (omim) for
pFN21AB5802
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5802, 471 aa
1>>>pF1KB5802 471 - 471 aa - 471 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7894+/-0.000534; mu= 21.4684+/- 0.033
mean_var=109.6630+/-28.684, 0's: 0 Z-trim(107.6): 666 B-trim: 732 in 1/54
Lambda= 0.122474
statistics sampled from 14867 (15666) to 14867 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.527), E-opt: 0.2 (0.184), width: 16
Scan time: 8.200
The best scores are: opt bits E(85289)
NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471) 3069 554.3 2.6e-157
NP_001159419 (OMIM: 103780,164230,181500,182135,60 ( 387) 2195 399.8 7.1e-111
NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 939 177.9 5e-44
NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 939 177.9 5e-44
NP_001307687 (OMIM: 601122) 5-hydroxytryptamine re ( 439) 782 150.2 1.1e-35
XP_006712545 (OMIM: 601122) PREDICTED: 5-hydroxytr ( 456) 782 150.2 1.1e-35
NP_000858 (OMIM: 601122) 5-hydroxytryptamine recep ( 481) 782 150.2 1.2e-35
NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 626 122.6 2.2e-27
NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 626 122.6 2.2e-27
NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 626 122.7 2.3e-27
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 620 121.6 5e-27
NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 562 111.3 5.3e-24
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 541 107.6 7.5e-23
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 540 107.4 8.1e-23
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 540 107.4 8.1e-23
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 540 107.4 8.4e-23
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 540 107.5 8.6e-23
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 540 107.5 8.6e-23
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 540 107.5 8.6e-23
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 540 107.5 8.6e-23
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 537 107.0 1.4e-22
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 525 104.7 4.8e-22
NP_076917 (OMIM: 601305) 5-hydroxytryptamine recep ( 357) 523 104.3 5.8e-22
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 521 103.9 7.1e-22
NP_001243690 (OMIM: 312861) 5-hydroxytryptamine re ( 248) 519 103.4 7.7e-22
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 520 103.7 8e-22
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 520 103.8 8.5e-22
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 520 103.8 9e-22
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 520 104.0 1.1e-21
XP_005246577 (OMIM: 601122) PREDICTED: 5-hydroxytr ( 362) 510 102.0 2.9e-21
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 507 101.6 4.7e-21
NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 489 98.4 4.2e-20
NP_000786 (OMIM: 126450,159900) D(2) dopamine rece ( 443) 463 93.8 1e-18
XP_016872785 (OMIM: 126450,159900) PREDICTED: D(2) ( 443) 463 93.8 1e-18
NP_057658 (OMIM: 126450,159900) D(2) dopamine rece ( 414) 462 93.6 1.1e-18
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 456 92.5 2.2e-18
XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 455 92.3 2.4e-18
NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 455 92.3 2.4e-18
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 454 92.0 2.5e-18
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 454 92.0 2.5e-18
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 454 92.0 2.6e-18
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 454 92.1 2.7e-18
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 454 92.1 2.8e-18
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 454 92.3 3.2e-18
NP_000788 (OMIM: 126452,143465,601696) D(4) dopami ( 419) 439 89.5 1.9e-17
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 412 84.7 4.7e-16
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 412 84.7 4.7e-16
NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 412 84.7 5e-16
XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 412 84.8 5.2e-16
XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 412 84.8 5.2e-16
>>NP_000612 (OMIM: 103780,164230,181500,182135,606788,60 (471 aa)
initn: 3069 init1: 3069 opt: 3069 Z-score: 2945.2 bits: 554.3 E(85289): 2.6e-157
Smith-Waterman score: 3069; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471)
10 20 30 40 50 60
pF1KB5 MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
370 380 390 400 410 420
430 440 450 460 470
pF1KB5 SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
430 440 450 460 470
>>NP_001159419 (OMIM: 103780,164230,181500,182135,606788 (387 aa)
initn: 2195 init1: 2195 opt: 2195 Z-score: 2111.5 bits: 399.8 E(85289): 7.1e-111
Smith-Waterman score: 2195; 100.0% identity (100.0% similar) in 333 aa overlap (139-471:55-387)
110 120 130 140 150 160
pF1KB5 TNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCA
::::::::::::::::::::::::::::::
NP_001 GTLHQFNYCERCSESQNNKCISCVDPEDKWYRWPLPSKLCAVWIYLDVLFSTASIMHLCA
30 40 50 60 70 80
170 180 190 200 210 220
pF1KB5 ISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCL
90 100 110 120 130 140
230 240 250 260 270 280
pF1KB5 LADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSS
150 160 170 180 190 200
290 300 310 320 330 340
pF1KB5 LSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVI
210 220 230 240 250 260
350 360 370 380 390 400
pF1KB5 CKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQL
270 280 290 300 310 320
410 420 430 440 450 460
pF1KB5 ILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKV
330 340 350 360 370 380
470
pF1KB5 SCV
:::
NP_001 SCV
>>NP_000859 (OMIM: 312861) 5-hydroxytryptamine receptor (458 aa)
initn: 1240 init1: 769 opt: 939 Z-score: 911.4 bits: 177.9 E(85289): 5e-44
Smith-Waterman score: 1413; 55.0% identity (78.0% similar) in 409 aa overlap (74-471:53-458)
50 60 70 80 90 100
pF1KB5 NWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEK
.:: :: ...::.::.::::::::::.::
NP_000 CDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEK
30 40 50 60 70 80
110 120 130 140 150 160
pF1KB5 KLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASI
::.::::::::::::::::.:.::::.:.:.::: : :::: :: ::: ::::::::::
NP_000 KLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASI
90 100 110 120 130 140
170 180 190 200 210 220
pF1KB5 MHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVF-
::::::::::::::.:::.::::::::::..:: ::.::.:.:.::::.::.:. :::
NP_000 MHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFV
150 160 170 180 190 200
230 240 250 260 270 280
pF1KB5 KEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFS
.. .:.: : :::::::::.:::::::::::: ::: :...: . . . :..
NP_000 NNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLD
210 220 230 240 250 260
290 300 310 320 330
pF1KB5 FLP--------QSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVV
:: . . .. . : . .:. : :::.:.::.:: ::::::::.:..
NP_000 FLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLI
270 280 290 300 310 320
340 350 360 370 380 390
pF1KB5 MWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY
::::::::::..:.:..:::. .. ::::::::::. :..:::::::::: :: ::: :
NP_000 MWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNY
330 340 350 360 370 380
400 410 420 430 440 450
pF1KB5 IQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDA--KTTDNDCSMVALGKQH
..:.:: .::: . . . : : .. .:... ..... . :..::. .. . .
NP_000 LRCNYKVEKKP-PVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEM--QVE
390 400 410 420 430
460 470
pF1KB5 SEEASKDNSDGVNEKVSCV
. : . :. :.:..: :
NP_000 NLELPVNPSSVVSERISSV
440 450
>>NP_001243689 (OMIM: 312861) 5-hydroxytryptamine recept (458 aa)
initn: 1240 init1: 769 opt: 939 Z-score: 911.4 bits: 177.9 E(85289): 5e-44
Smith-Waterman score: 1413; 55.0% identity (78.0% similar) in 409 aa overlap (74-471:53-458)
50 60 70 80 90 100
pF1KB5 NWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEK
.:: :: ...::.::.::::::::::.::
NP_001 CDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEK
30 40 50 60 70 80
110 120 130 140 150 160
pF1KB5 KLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASI
::.::::::::::::::::.:.::::.:.:.::: : :::: :: ::: ::::::::::
NP_001 KLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASI
90 100 110 120 130 140
170 180 190 200 210 220
pF1KB5 MHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVF-
::::::::::::::.:::.::::::::::..:: ::.::.:.:.::::.::.:. :::
NP_001 MHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFV
150 160 170 180 190 200
230 240 250 260 270 280
pF1KB5 KEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFS
.. .:.: : :::::::::.:::::::::::: ::: :...: . . . :..
NP_001 NNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLD
210 220 230 240 250 260
290 300 310 320 330
pF1KB5 FLP--------QSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVV
:: . . .. . : . .:. : :::.:.::.:: ::::::::.:..
NP_001 FLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLI
270 280 290 300 310 320
340 350 360 370 380 390
pF1KB5 MWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY
::::::::::..:.:..:::. .. ::::::::::. :..:::::::::: :: ::: :
NP_001 MWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNY
330 340 350 360 370 380
400 410 420 430 440 450
pF1KB5 IQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDA--KTTDNDCSMVALGKQH
..:.:: .::: . . . : : .. .:... ..... . :..::. .. . .
NP_001 LRCNYKVEKKP-PVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEM--QVE
390 400 410 420 430
460 470
pF1KB5 SEEASKDNSDGVNEKVSCV
. : . :. :.:..: :
NP_001 NLELPVNPSSVVSERISSV
440 450
>>NP_001307687 (OMIM: 601122) 5-hydroxytryptamine recept (439 aa)
initn: 1182 init1: 628 opt: 782 Z-score: 761.6 bits: 150.2 E(85289): 1.1e-35
Smith-Waterman score: 1200; 53.4% identity (78.0% similar) in 350 aa overlap (75-403:13-361)
50 60 70 80 90 100
pF1KB5 WTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKK
.:.::: .::: ::.:: :::.:::::::
NP_001 MKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKK
10 20 30 40
110 120 130 140 150 160
pF1KB5 LQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIM
:: ::::::::::.::.:.:..:::...:::.. :::: :: .:..:::::::::::
NP_001 LQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIM
50 60 70 80 90 100
170 180 190 200 210 220
pF1KB5 HLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKE
::::::.:::.::..::. ...:::. ::.:: .:: ::.::..:.:. :.. : ..
NP_001 HLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNN
110 120 130 140 150 160
230 240 250 260 270 280
pF1KB5 GSCLLADD---NFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASF
.:.:. . .:.:.::...:: ::.::..::::::..:::.: : . : .
NP_001 ITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTV
170 180 190 200 210 220
290 300 310 320
pF1KB5 SFLPQSSL----SSEKLFQRSIHRE----PGS----------YTGRRTMQSISNEQKACK
: . : . : ::. . . :. :.: :....:.:::::.: :
NP_001 STVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASK
230 240 250 260 270 280
330 340 350 360 370 380
pF1KB5 VLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLF
:::::::::..:::::::::: :.: .:::. .. ::..::::::.::.:::::::::
NP_001 VLGIVFFLFLLMWCPFFITNITLVLC-DSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLF
290 300 310 320 330 340
390 400 410 420 430 440
pF1KB5 NKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDC
:::.:.::.::: :.:. .:
NP_001 NKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQ
350 360 370 380 390 400
>>XP_006712545 (OMIM: 601122) PREDICTED: 5-hydroxytrypta (456 aa)
initn: 1182 init1: 628 opt: 782 Z-score: 761.5 bits: 150.2 E(85289): 1.1e-35
Smith-Waterman score: 1200; 53.4% identity (78.0% similar) in 350 aa overlap (75-403:30-378)
50 60 70 80 90 100
pF1KB5 WTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKK
.:.::: .::: ::.:: :::.:::::::
XP_006 MLSKITTKPETESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKK
10 20 30 40 50
110 120 130 140 150 160
pF1KB5 LQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIM
:: ::::::::::.::.:.:..:::...:::.. :::: :: .:..:::::::::::
XP_006 LQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIM
60 70 80 90 100 110
170 180 190 200 210 220
pF1KB5 HLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKE
::::::.:::.::..::. ...:::. ::.:: .:: ::.::..:.:. :.. : ..
XP_006 HLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNN
120 130 140 150 160 170
230 240 250 260 270 280
pF1KB5 GSCLLADD---NFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASF
.:.:. . .:.:.::...:: ::.::..::::::..:::.: : . : .
XP_006 ITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTV
180 190 200 210 220 230
290 300 310 320
pF1KB5 SFLPQSSL----SSEKLFQRSIHRE----PGS----------YTGRRTMQSISNEQKACK
: . : . : ::. . . :. :.: :....:.:::::.: :
XP_006 STVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASK
240 250 260 270 280 290
330 340 350 360 370 380
pF1KB5 VLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLF
:::::::::..:::::::::: :.: .:::. .. ::..::::::.::.:::::::::
XP_006 VLGIVFFLFLLMWCPFFITNITLVLC-DSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLF
300 310 320 330 340 350
390 400 410 420 430 440
pF1KB5 NKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDC
:::.:.::.::: :.:. .:
XP_006 NKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQ
360 370 380 390 400 410
>>NP_000858 (OMIM: 601122) 5-hydroxytryptamine receptor (481 aa)
initn: 1182 init1: 628 opt: 782 Z-score: 761.2 bits: 150.2 E(85289): 1.2e-35
Smith-Waterman score: 1200; 53.4% identity (78.0% similar) in 350 aa overlap (75-403:55-403)
50 60 70 80 90 100
pF1KB5 WTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKK
.:.::: .::: ::.:: :::.:::::::
NP_000 HVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKK
30 40 50 60 70 80
110 120 130 140 150 160
pF1KB5 LQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIM
:: ::::::::::.::.:.:..:::...:::.. :::: :: .:..:::::::::::
NP_000 LQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIM
90 100 110 120 130 140
170 180 190 200 210 220
pF1KB5 HLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKE
::::::.:::.::..::. ...:::. ::.:: .:: ::.::..:.:. :.. : ..
NP_000 HLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNN
150 160 170 180 190 200
230 240 250 260 270 280
pF1KB5 GSCLLADD---NFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASF
.:.:. . .:.:.::...:: ::.::..::::::..:::.: : . : .
NP_000 ITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTV
210 220 230 240 250 260
290 300 310 320
pF1KB5 SFLPQSSL----SSEKLFQRSIHRE----PGS----------YTGRRTMQSISNEQKACK
: . : . : ::. . . :. :.: :....:.:::::.: :
NP_000 STVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASK
270 280 290 300 310 320
330 340 350 360 370 380
pF1KB5 VLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLF
:::::::::..:::::::::: :.: .:::. .. ::..::::::.::.:::::::::
NP_000 VLGIVFFLFLLMWCPFFITNITLVLC-DSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLF
330 340 350 360 370 380
390 400 410 420 430 440
pF1KB5 NKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDC
:::.:.::.::: :.:. .:
NP_000 NKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQ
390 400 410 420 430 440
>>NP_062874 (OMIM: 182137) 5-hydroxytryptamine receptor (432 aa)
initn: 528 init1: 326 opt: 626 Z-score: 612.7 bits: 122.6 E(85289): 2.2e-27
Smith-Waterman score: 634; 31.8% identity (64.7% similar) in 380 aa overlap (36-404:51-409)
10 20 30 40 50 60
pF1KB5 EENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSC
:...: : .: . .: . ::
NP_062 LPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNAS-----GCGEQ--
30 40 50 60 70
70 80 90 100 110 120
pF1KB5 LSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGF
.. .... ...:: .. .:::::: ::...: . :::.. .::...:::.::. ..
NP_062 INYGRVEKVVIGSILT-LITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV
80 90 100 110 120 130
130 140 150 160 170 180
pF1KB5 LVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHS-
::: .: : : .: . .: :.: .::. ::::: ::.::.:::..: :. .
NP_062 AVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPV
140 150 160 170 180 190
190 200 210 220 230 240
pF1KB5 RFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADD-NFVLIGSFVSF
: :.. : . :..:: .:..:..: :.:: .. : . ::...: .... .. :.:
NP_062 RQNGKCMAKM-ILSVWLLSASITLP-PLFGWAQN--VNDDKVCLISQDFGYTIYSTAVAF
200 210 220 230 240
250 260 270 280 290 300
pF1KB5 FIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFL-PQSSLSSEKL--FQRSIH
.::...:.. :. :. .: :. . :. .: . :.: .. . . .:. ..
NP_062 YIPMSVMLFMYYQIYKAARKSAA--------KHKFPGFPRVEPDSVIALNGIVKLQKEVE
250 260 270 280 290 300
310 320 330 340 350
pF1KB5 REPG-SYTGRRTMQSIS---NEQKACKVLGIVFFLFVVMWCPFFI-TNIMAVICKESCNE
. . : .. ..:: :::: .:::. :.: : :::. .. :: ::.
NP_062 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 DVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKE-NKKPLQLILVNTI
. . .:.:.:: .: .::..:..::. :... .::::.. :.:
NP_062 -IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEAL
370 380 390 400 410
420 430 440 450 460 470
pF1KB5 PALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
NP_062 KLAERPERPEFVL
420 430
>>NP_000863 (OMIM: 182137) 5-hydroxytryptamine receptor (445 aa)
initn: 528 init1: 326 opt: 626 Z-score: 612.6 bits: 122.6 E(85289): 2.2e-27
Smith-Waterman score: 634; 31.8% identity (64.7% similar) in 380 aa overlap (36-404:51-409)
10 20 30 40 50 60
pF1KB5 EENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSC
:...: : .: . .: . ::
NP_000 LPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNAS-----GCGEQ--
30 40 50 60 70
70 80 90 100 110 120
pF1KB5 LSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGF
.. .... ...:: .. .:::::: ::...: . :::.. .::...:::.::. ..
NP_000 INYGRVEKVVIGSILT-LITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV
80 90 100 110 120 130
130 140 150 160 170 180
pF1KB5 LVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHS-
::: .: : : .: . .: :.: .::. ::::: ::.::.:::..: :. .
NP_000 AVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPV
140 150 160 170 180 190
190 200 210 220 230 240
pF1KB5 RFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADD-NFVLIGSFVSF
: :.. : . :..:: .:..:..: :.:: .. : . ::...: .... .. :.:
NP_000 RQNGKCMAKM-ILSVWLLSASITLP-PLFGWAQN--VNDDKVCLISQDFGYTIYSTAVAF
200 210 220 230 240
250 260 270 280 290 300
pF1KB5 FIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFL-PQSSLSSEKL--FQRSIH
.::...:.. :. :. .: :. . :. .: . :.: .. . . .:. ..
NP_000 YIPMSVMLFMYYQIYKAARKSAA--------KHKFPGFPRVEPDSVIALNGIVKLQKEVE
250 260 270 280 290 300
310 320 330 340 350
pF1KB5 REPG-SYTGRRTMQSIS---NEQKACKVLGIVFFLFVVMWCPFFI-TNIMAVICKESCNE
. . : .. ..:: :::: .:::. :.: : :::. .. :: ::.
NP_000 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 DVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKE-NKKPLQLILVNTI
. . .:.:.:: .: .::..:..::. :... .::::.. :.:
NP_000 -IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEAL
370 380 390 400 410
420 430 440 450 460 470
pF1KB5 PALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
NP_000 KLAERPERPEFVLQNADYCRKKGHDS
420 430 440
>>NP_062873 (OMIM: 182137) 5-hydroxytryptamine receptor (479 aa)
initn: 528 init1: 326 opt: 626 Z-score: 612.3 bits: 122.7 E(85289): 2.3e-27
Smith-Waterman score: 634; 31.8% identity (64.7% similar) in 380 aa overlap (36-404:51-409)
10 20 30 40 50 60
pF1KB5 EENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSC
:...: : .: . .: . ::
NP_062 LPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNAS-----GCGEQ--
30 40 50 60 70
70 80 90 100 110 120
pF1KB5 LSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGF
.. .... ...:: .. .:::::: ::...: . :::.. .::...:::.::. ..
NP_062 INYGRVEKVVIGSILT-LITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV
80 90 100 110 120 130
130 140 150 160 170 180
pF1KB5 LVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHS-
::: .: : : .: . .: :.: .::. ::::: ::.::.:::..: :. .
NP_062 AVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPV
140 150 160 170 180 190
190 200 210 220 230 240
pF1KB5 RFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADD-NFVLIGSFVSF
: :.. : . :..:: .:..:..: :.:: .. : . ::...: .... .. :.:
NP_062 RQNGKCMAKM-ILSVWLLSASITLP-PLFGWAQN--VNDDKVCLISQDFGYTIYSTAVAF
200 210 220 230 240
250 260 270 280 290 300
pF1KB5 FIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFL-PQSSLSSEKL--FQRSIH
.::...:.. :. :. .: :. . :. .: . :.: .. . . .:. ..
NP_062 YIPMSVMLFMYYQIYKAARKSAA--------KHKFPGFPRVEPDSVIALNGIVKLQKEVE
250 260 270 280 290 300
310 320 330 340 350
pF1KB5 REPG-SYTGRRTMQSIS---NEQKACKVLGIVFFLFVVMWCPFFI-TNIMAVICKESCNE
. . : .. ..:: :::: .:::. :.: : :::. .. :: ::.
NP_062 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 DVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKE-NKKPLQLILVNTI
. . .:.:.:: .: .::..:..::. :... .::::.. :.:
NP_062 -IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEAL
370 380 390 400 410
420 430 440 450 460 470
pF1KB5 PALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
NP_062 KLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
420 430 440 450 460 470
471 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 14:36:11 2016 done: Sun Nov 6 14:36:13 2016
Total Scan time: 8.200 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]