Result of FASTA (omim) for
pFN21AB5762
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5762, 751 aa
1>>>pF1KB5762 751 - 751 aa - 751 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7406+/-0.000385; mu= 18.2729+/- 0.024
mean_var=78.3204+/-15.248, 0's: 0 Z-trim(114.5): 25 B-trim: 33 in 1/54
Lambda= 0.144923
statistics sampled from 24412 (24436) to 24412 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.287), width: 16
Scan time: 9.270
The best scores are: opt bits E(85289)
XP_016867436 (OMIM: 104610) PREDICTED: amiloride-s ( 751) 5253 1108.3 0
NP_001082 (OMIM: 104610) amiloride-sensitive amine ( 751) 5253 1108.3 0
XP_016867434 (OMIM: 104610) PREDICTED: amiloride-s ( 770) 4303 909.6 0
NP_001259001 (OMIM: 104610) amiloride-sensitive am ( 770) 4303 909.6 0
XP_016867433 (OMIM: 104610) PREDICTED: amiloride-s ( 770) 4303 909.6 0
XP_016867435 (OMIM: 104610) PREDICTED: amiloride-s ( 770) 4303 909.6 0
NP_033720 (OMIM: 602268) retina-specific copper am ( 756) 1357 293.7 1.9e-78
NP_003725 (OMIM: 603735) membrane primary amine ox ( 763) 1346 291.4 9.3e-78
NP_001264660 (OMIM: 603735) membrane primary amine ( 634) 905 199.1 4.6e-50
NP_001149 (OMIM: 602268) retina-specific copper am ( 729) 872 192.3 6.1e-48
XP_011523722 (OMIM: 603735) PREDICTED: membrane pr ( 665) 702 156.7 2.8e-37
XP_011523721 (OMIM: 603735) PREDICTED: membrane pr ( 794) 702 156.8 3.3e-37
NP_001264661 (OMIM: 603735) membrane primary amine ( 220) 639 143.3 1e-33
>>XP_016867436 (OMIM: 104610) PREDICTED: amiloride-sensi (751 aa)
initn: 5253 init1: 5253 opt: 5253 Z-score: 5931.8 bits: 1108.3 E(85289): 0
Smith-Waterman score: 5253; 99.7% identity (99.9% similar) in 751 aa overlap (1-751:1-751)
10 20 30 40 50 60
pF1KB5 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
XP_016 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 ADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWDPPVVFEQFLHNNENI
:::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::
XP_016 ADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWHPPVVFEQFLHNNENI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 ENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRD
670 680 690 700 710 720
730 740 750
pF1KB5 NGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV
:::::::::::::::::::::::::::::::
XP_016 NGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV
730 740 750
>>NP_001082 (OMIM: 104610) amiloride-sensitive amine oxi (751 aa)
initn: 5253 init1: 5253 opt: 5253 Z-score: 5931.8 bits: 1108.3 E(85289): 0
Smith-Waterman score: 5253; 99.7% identity (99.9% similar) in 751 aa overlap (1-751:1-751)
10 20 30 40 50 60
pF1KB5 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
NP_001 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 ADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWDPPVVFEQFLHNNENI
:::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::
NP_001 ADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWHPPVVFEQFLHNNENI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 ENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRD
670 680 690 700 710 720
730 740 750
pF1KB5 NGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV
:::::::::::::::::::::::::::::::
NP_001 NGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV
730 740 750
>>XP_016867434 (OMIM: 104610) PREDICTED: amiloride-sensi (770 aa)
initn: 4303 init1: 4303 opt: 4303 Z-score: 4858.2 bits: 909.6 E(85289): 0
Smith-Waterman score: 5205; 97.3% identity (97.4% similar) in 770 aa overlap (1-751:1-770)
10 20 30 40 50 60
pF1KB5 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
XP_016 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSM
550 560 570 580 590 600
610 620 630 640
pF1KB5 ADQVLPPGWQEEQAITWAR-------------------YPLAVTKYRESELCSSSIYHQN
::::::::::::::::::: ::::::::::::::::::::::
XP_016 ADQVLPPGWQEEQAITWARTEGGQPRALSQAASPVPGRYPLAVTKYRESELCSSSIYHQN
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB5 DPWDPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNF
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNF
670 680 690 700 710 720
710 720 730 740 750
pF1KB5 FPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV
730 740 750 760 770
>>NP_001259001 (OMIM: 104610) amiloride-sensitive amine (770 aa)
initn: 4303 init1: 4303 opt: 4303 Z-score: 4858.2 bits: 909.6 E(85289): 0
Smith-Waterman score: 5205; 97.3% identity (97.4% similar) in 770 aa overlap (1-751:1-770)
10 20 30 40 50 60
pF1KB5 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
NP_001 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSM
550 560 570 580 590 600
610 620 630 640
pF1KB5 ADQVLPPGWQEEQAITWAR-------------------YPLAVTKYRESELCSSSIYHQN
::::::::::::::::::: ::::::::::::::::::::::
NP_001 ADQVLPPGWQEEQAITWARTEGGQPRALSQAASPVPGRYPLAVTKYRESELCSSSIYHQN
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB5 DPWDPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNF
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNF
670 680 690 700 710 720
710 720 730 740 750
pF1KB5 FPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV
730 740 750 760 770
>>XP_016867433 (OMIM: 104610) PREDICTED: amiloride-sensi (770 aa)
initn: 4303 init1: 4303 opt: 4303 Z-score: 4858.2 bits: 909.6 E(85289): 0
Smith-Waterman score: 5205; 97.3% identity (97.4% similar) in 770 aa overlap (1-751:1-770)
10 20 30 40 50 60
pF1KB5 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
XP_016 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSM
550 560 570 580 590 600
610 620 630 640
pF1KB5 ADQVLPPGWQEEQAITWAR-------------------YPLAVTKYRESELCSSSIYHQN
::::::::::::::::::: ::::::::::::::::::::::
XP_016 ADQVLPPGWQEEQAITWARTEGGQPRALSQAASPVPGRYPLAVTKYRESELCSSSIYHQN
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB5 DPWDPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNF
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNF
670 680 690 700 710 720
710 720 730 740 750
pF1KB5 FPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV
730 740 750 760 770
>>XP_016867435 (OMIM: 104610) PREDICTED: amiloride-sensi (770 aa)
initn: 4303 init1: 4303 opt: 4303 Z-score: 4858.2 bits: 909.6 E(85289): 0
Smith-Waterman score: 5205; 97.3% identity (97.4% similar) in 770 aa overlap (1-751:1-770)
10 20 30 40 50 60
pF1KB5 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
XP_016 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSM
550 560 570 580 590 600
610 620 630 640
pF1KB5 ADQVLPPGWQEEQAITWAR-------------------YPLAVTKYRESELCSSSIYHQN
::::::::::::::::::: ::::::::::::::::::::::
XP_016 ADQVLPPGWQEEQAITWARTEGGQPRALSQAASPVPGRYPLAVTKYRESELCSSSIYHQN
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB5 DPWDPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNF
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNF
670 680 690 700 710 720
710 720 730 740 750
pF1KB5 FPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV
730 740 750 760 770
>>NP_033720 (OMIM: 602268) retina-specific copper amine (756 aa)
initn: 1870 init1: 480 opt: 1357 Z-score: 1529.5 bits: 293.7 E(85289): 1.9e-78
Smith-Waterman score: 1915; 42.8% identity (68.9% similar) in 739 aa overlap (19-746:44-755)
10 20 30 40
pF1KB5 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFL
:.: : : .. .:.::: .:: :: ::
NP_033 LITIFALAYVLLTSPGGSSQPPHCPSVSHRAQPWPH--PGQSQLFADLSREELTAVMRFL
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB5 WSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEH
.. : .. . . : .: .:. :: : .: ::.: :.::: :...:: : .
NP_033 TQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPPAREALAIVLFGGQPQ
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB5 PNVTEFAVGPLPGPCYMRALS-PRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFL
:::.:..::::: : ::: .. : : . ::. ::.. ... :.:. : .::
NP_033 PNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMWRHLKEVELPKAPIFL
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB5 NTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVEGY--FLHPTGLELLVDHGS
..: :.. . :: . ..:::. ::.: .:. . . . : ::::.:::::.:: .
NP_033 SST-FNY---NGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFLHPVGLELLLDHRA
200 210 220 230 240
230 240 250 260 270 280
pF1KB5 TDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSH
: .::.:.::.: :..:.. .: :.. .:...:: . ::: .: .: : : .
NP_033 LDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRV--PLPPPNGASS-----LRSRN
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 KPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGER
.: : .: :.. : :.: .. ..:: :. . :::.: :::....:.: :::
NP_033 SP-GPLP-PLQFS------PQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGER
310 320 330 340 350
350 360 370 380 390 400
pF1KB5 IAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYD
::::::::: :..::. .: : :.::: ..::: .. :. :.::: ::..: .:
NP_033 IAYEVSVQECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVD-IHILV
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB5 ADDPVHY-PRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYI
. :. : :.:.:: :.::::: : ... .::.:: ...::.:..:.: :::::
NP_033 GKGAVQLLPGAVCVFEEAQGLPLRRHHNY-LQN--HFYGGLASSALVVRSVSSVGNYDYI
420 430 440 450 460
470 480 490 500 510 520
pF1KB5 WDFIFYPNGVMEAKMHATGYVHATFYT--PEGLRHGTRLHTHLIGNIHTHLVHYRVDLDV
:::..::::..:...:::::....: ::: :.:. ...:..::: :...::::
NP_033 WDFVLYPNGALEGRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDV
470 480 490 500 510 520
530 540 550 560 570 580
pF1KB5 AGTKNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSP
:: :: . .. .. .. ::.:.: . .: : . . : .:: . ::.:: ..:
NP_033 AGLKNWVVAEDVVFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASN
530 540 550 560 570 580
590 600 610 620 630 640
pF1KB5 QENPWGHKRSYRLQIHSMADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQND
: : :::.:.::.:::: .: . :.:..:.:: :.::. .: : :::::::::
NP_033 QTNAWGHQRGYRIQIHSPLGIHIPLESDMERALSWGRYQLVVTQRKEEESQSSSIYHQND
590 600 610 620 630 640
650 660 670 680 690 700
pF1KB5 PWDPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFF
: : :.: .:. :::.. .::::::::..::::::.::::::.: :: :::::::.:::
NP_033 IWTPTVTFADFI-NNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFF
650 660 670 680 690 700
710 720 730 740 750
pF1KB5 PEDPSLASRDTVIVWP-RDNGPNYVQRW--IPEDRDCSMP--PPFSYNGTYRPV
::::. : .: .: : .. .:. : .: :::::.:
NP_033 DEDPSIFSPGSVYFEKGQDAGLCSINPVACLPDLAAC-VPDLPPFSYHGF
710 720 730 740 750
>>NP_003725 (OMIM: 603735) membrane primary amine oxidas (763 aa)
initn: 1438 init1: 633 opt: 1346 Z-score: 1517.0 bits: 291.4 E(85289): 9.3e-78
Smith-Waterman score: 1852; 40.1% identity (66.2% similar) in 736 aa overlap (21-746:46-759)
10 20 30 40
pF1KB5 MPALGWAVAAILMLQTAMAEPS--PGTLPRKAGVFSDLSNQELKAVHSFL
:: : : : .. .:.::: .:: :: ::
NP_003 TIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLFADLSREELTAVMRFL
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB5 WSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEH
.. : .. . . : :: .:. :: : .: ::.: :.::: :..::: : .
NP_003 TQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPPAREALAIVFFGRQPQ
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB5 PNVTEFAVGPLPGPCYMRALS-PRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFL
:::.:..::::: : ::: .. : : . ::. :: . . . . : . .:
NP_003 PNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDIDQMIFNRELPQASGLL
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB5 NTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVEG--YFLHPTGLELLVDHGS
. : . : :. .::::. ::.: .:. . . : .::: .::::::.: .
NP_003 HHC--CFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFLHHVGLELLVNHKA
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB5 TDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSH
: ..:....:.:.:..: : .: .. : :.::.. : ::. .. ::
NP_003 LDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSWSLKSPVPP-----
260 270 280 290 300
290 300 310 320 330 340
pF1KB5 KPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGER
: :.: : :.:::: ..:. : . :.:.: : . :: ....:.: :::
NP_003 ---G--PAP-----PLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGER
310 320 330 340 350
350 360 370 380 390 400
pF1KB5 IAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYD
..::.:.:::.:.:::..::.: :.:.: :.:.:. : :. :.::: ::..: .
NP_003 LVYEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLE
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB5 ADDPVHYPRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIW
.. : :.:.::. :.::::: .. .. ....:: :::.:. ::. ::::.:
NP_003 SQAPKTIRDAFCVFEQNQGLPLRRHHSDLYS---HYFGGLAETVLVVRSMSTLLNYDYVW
420 430 440 450 460 470
470 480 490 500 510 520
pF1KB5 DFIFYPNGVMEAKMHATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGT
: .:.:.:..: ...::::. ..: ..:... : .:..::: .:..:::::::
NP_003 DTVFHPSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGL
480 490 500 510 520 530
530 540 550 560 570 580
pF1KB5 KNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQEN
.: . .: . .. ::::.:.. . . . :.:::: :.:: ..: . :
NP_003 ENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSN
540 550 560 570 580 590
590 600 610 620 630 640
pF1KB5 PWGHKRSYRLQIHSMADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWD
::: :.::.:. :.: . :: . . ....: :: ::::. .: : :::...:::::
NP_003 KWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWA
600 610 620 630 640 650
650 660 670 680 690 700
pF1KB5 PPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPED
: : : .:. :::.: ..:::::::.:::::::.::::::.: ::.:::.:::.::: ::
NP_003 PTVDFSDFI-NNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDED
660 670 680 690 700 710
710 720 730 740 750
pF1KB5 PSLASRDTVIVW-PRDNGPNYVQRW--IPEDRDCSMP--PPFSYNGTYRPV
::. : :.. .: : :. .:. :. : : ::..:
NP_003 PSFYSADSIYFRGDQDAGACEVNPLACLPQAAACA-PDLPAFSHGGFSHN
720 730 740 750 760
>>NP_001264660 (OMIM: 603735) membrane primary amine oxi (634 aa)
initn: 1395 init1: 476 opt: 905 Z-score: 1019.9 bits: 199.1 E(85289): 4.6e-50
Smith-Waterman score: 1411; 37.1% identity (64.6% similar) in 604 aa overlap (21-619:46-629)
10 20 30 40
pF1KB5 MPALGWAVAAILMLQTAMAEPS--PGTLPRKAGVFSDLSNQELKAVHSFL
:: : : : .. .:.::: .:: :: ::
NP_001 TIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLFADLSREELTAVMRFL
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB5 WSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEH
.. : .. . . : :: .:. :: : .: ::.: :.::: :..::: : .
NP_001 TQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPPAREALAIVFFGRQPQ
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB5 PNVTEFAVGPLPGPCYMRALS-PRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFL
:::.:..::::: : ::: .. : : . ::. :: . . . . : . .:
NP_001 PNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDIDQMIFNRELPQASGLL
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB5 NTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVEG--YFLHPTGLELLVDHGS
. : . : :. .::::. ::.: .:. . . : .::: .::::::.: .
NP_001 HHC--CFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFLHHVGLELLVNHKA
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB5 TDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSH
: ..:....:.:.:..: : .: .. : :.::.. : ::. .. ::
NP_001 LDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSWSLKSPVPP-----
260 270 280 290 300
290 300 310 320 330 340
pF1KB5 KPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGER
: :.: : :.:::: ..:. : . :.:.: : . :: ....:.: :::
NP_001 ---G--PAP-----PLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGER
310 320 330 340 350
350 360 370 380 390 400
pF1KB5 IAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYD
..::.:.:::.:.:::..::.: :.:.: :.:.:. : :. :.::: ::..: .
NP_001 LVYEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLE
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB5 ADDPVHYPRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIW
.. : :.:.::. :.::::: .. .. ....:: :::.:. ::. ::::.:
NP_001 SQAPKTIRDAFCVFEQNQGLPLRRHHSDLYS---HYFGGLAETVLVVRSMSTLLNYDYVW
420 430 440 450 460 470
470 480 490 500 510 520
pF1KB5 DFIFYPNGVMEAKMHATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGT
: .:.:.:..: ...::::. ..: ..:... : .:..::: .:..:::::::
NP_001 DTVFHPSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGL
480 490 500 510 520 530
530 540 550 560 570 580
pF1KB5 KNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQEN
.: . .: . .. ::::.:.. . . . :.:::: :.:: ..: . :
NP_001 ENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSN
540 550 560 570 580 590
590 600 610 620 630 640
pF1KB5 PWGHKRSYRLQIHSMADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWD
::: :.::.:. :.: . :: . . ....: :
NP_001 KWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWERIWWPG
600 610 620 630
650 660 670 680 690 700
pF1KB5 PPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPED
>>NP_001149 (OMIM: 602268) retina-specific copper amine (729 aa)
initn: 1766 init1: 354 opt: 872 Z-score: 981.7 bits: 192.3 E(85289): 6.1e-48
Smith-Waterman score: 1785; 41.3% identity (66.6% similar) in 739 aa overlap (19-746:44-728)
10 20 30 40
pF1KB5 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFL
:.: : : .. .:.::: .:: :: ::
NP_001 LITIFALAYVLLTSPGGSSQPPHCPSVSHRAQPWPH--PGQSQLFADLSREELTAVMRFL
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB5 WSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEH
.. : .. . . : .: .:. :: : .: ::.: :.::: :...:: : .
NP_001 TQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPPAREALAIVLFGGQPQ
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB5 PNVTEFAVGPLPGPCYMRALS-PRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFL
:::.:..::::: : ::: .. : : . ::. ::.. ... :.:. : .::
NP_001 PNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMWRHLKEVELPKAPIFL
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB5 NTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVEGY--FLHPTGLELLVDHGS
..: :.. . :: . ..:::. ::.: .:. . . . : ::::.:::::.:: .
NP_001 SST-FNY---NGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFLHPVGLELLLDHRA
200 210 220 230 240
230 240 250 260 270 280
pF1KB5 TDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSH
: .::.:.::.: :..:.. .: :.. .:...:: . ::: .: .: : : .
NP_001 LDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRV--PLPPPNGASS-----LRSRN
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 KPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGER
.: : .: :.. : :.: .. ..:: :. . :::.: :::....:.: :::
NP_001 SP-GPLP-PLQFS------PQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGER
310 320 330 340 350
350 360 370 380 390 400
pF1KB5 IAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYD
::::::::: :..::. .: : :.::: ..::: .. :. :.::: ::..: .:
NP_001 IAYEVSVQECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVD-IHILV
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB5 ADDPVHY-PRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYI
. :. : :.:.:: :.::::: : ... .::.:: ...::.:..:.: :::::
NP_001 GKGAVQLLPGAVCVFEEAQGLPLRRHHNY-LQN--HFYGGLASSALVVRSVSSVGNYDYI
420 430 440 450 460
470 480 490 500 510 520
pF1KB5 WDFIFYPNGVMEAKMHATGYVHATFYT--PEGLRHGTRLHTHLIGNIHTHLVHYRVDLDV
:::..::::..:...:::::....: ::: :.:. ...:..::: :...::::
NP_001 WDFVLYPNGALEGRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDV
470 480 490 500 510 520
530 540 550 560 570 580
pF1KB5 AGTKNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSP
:: :: . .. .. .. ::.:.: . .: : . . : .:: . ::.:: ..:
NP_001 AGLKNWVVAEDVVFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASN
530 540 550 560 570 580
590 600 610 620 630 640
pF1KB5 QENPWGHKRSYRLQIHSMADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQND
: : :::.:.:.: .::. .: : :::::::::
NP_001 QTNAWGHQRGYQL---------------------------VVTQRKEEESQSSSIYHQND
590 600 610 620
650 660 670 680 690 700
pF1KB5 PWDPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFF
: : :.: .:. :::.. .::::::::..::::::.::::::.: :: :::::::.:::
NP_001 IWTPTVTFADFI-NNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFF
630 640 650 660 670 680
710 720 730 740 750
pF1KB5 PEDPSLASRDTVIVWP-RDNGPNYVQRW--IPEDRDCSMP--PPFSYNGTYRPV
::::. : .: .: : .. .:. : .: :::::.:
NP_001 DEDPSIFSPGSVYFEKGQDAGLCSINPVACLPDLAAC-VPDLPPFSYHGF
690 700 710 720
751 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 06:17:36 2016 done: Tue Nov 8 06:17:37 2016
Total Scan time: 9.270 Total Display time: 0.190
Function used was FASTA [36.3.4 Apr, 2011]