Result of FASTA (omim) for
pFN21AB5246
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5246, 480 aa
1>>>pF1KB5246 480 - 480 aa - 480 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1363+/-0.000413; mu= 15.5995+/- 0.026
mean_var=130.9327+/-24.996, 0's: 0 Z-trim(115.8): 94 B-trim: 308 in 1/54
Lambda= 0.112086
statistics sampled from 26482 (26587) to 26482 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.676), E-opt: 0.2 (0.312), width: 16
Scan time: 10.220
The best scores are: opt bits E(85289)
NP_002766 (OMIM: 600142,602194,610149,616779) seri ( 480) 3174 524.9 1.9e-148
NP_710159 (OMIM: 610700) serine protease HTRA4 pre ( 476) 1613 272.5 1.8e-72
NP_444272 (OMIM: 608785) serine protease HTRA3 iso ( 453) 1547 261.8 2.9e-69
XP_011542733 (OMIM: 610700) PREDICTED: serine prot ( 380) 1295 221.0 4.7e-57
XP_011511898 (OMIM: 608785) PREDICTED: serine prot ( 373) 1260 215.3 2.3e-55
NP_001284488 (OMIM: 608785) serine protease HTRA3 ( 357) 1256 214.6 3.5e-55
XP_011542734 (OMIM: 610700) PREDICTED: serine prot ( 343) 1118 192.3 1.8e-48
NP_037379 (OMIM: 606441,610297) serine protease HT ( 458) 1107 190.7 7.5e-48
NP_001308657 (OMIM: 606441,610297) serine protease ( 426) 911 158.9 2.5e-38
NP_001308656 (OMIM: 606441,610297) serine protease ( 436) 711 126.6 1.4e-28
NP_001240764 (OMIM: 602867,614224) insulin-like gr ( 279) 377 72.4 1.8e-12
NP_001544 (OMIM: 602867,614224) insulin-like growt ( 282) 377 72.4 1.8e-12
NP_659540 (OMIM: 606441,610297) serine protease HT ( 361) 375 72.2 2.7e-12
XP_005270251 (OMIM: 609208) PREDICTED: kazal-type ( 230) 328 64.4 3.9e-10
XP_016872203 (OMIM: 609208) PREDICTED: kazal-type ( 304) 328 64.5 4.7e-10
XP_016872204 (OMIM: 609208) PREDICTED: kazal-type ( 304) 328 64.5 4.7e-10
NP_112191 (OMIM: 609208) kazal-type serine proteas ( 304) 328 64.5 4.7e-10
XP_016870188 (OMIM: 610413) PREDICTED: insulin-lik ( 174) 320 63.0 7.9e-10
NP_001007564 (OMIM: 610413) insulin-like growth fa ( 278) 320 63.2 1.1e-09
NP_000589 (OMIM: 146732) insulin-like growth facto ( 291) 216 46.4 0.00013
XP_016867641 (OMIM: 146732) PREDICTED: insulin-lik ( 291) 216 46.4 0.00013
NP_001013416 (OMIM: 146732) insulin-like growth fa ( 297) 216 46.4 0.00013
NP_000587 (OMIM: 146730) insulin-like growth facto ( 259) 196 43.1 0.0011
NP_001543 (OMIM: 146733) insulin-like growth facto ( 258) 194 42.8 0.0014
NP_001129076 (OMIM: 601521) endothelial cell-speci ( 134) 183 40.7 0.0031
NP_008967 (OMIM: 601521) endothelial cell-specific ( 184) 183 40.8 0.0038
NP_000590 (OMIM: 146734) insulin-like growth facto ( 272) 183 41.0 0.005
NP_002505 (OMIM: 164958) protein NOV homolog precu ( 357) 180 40.7 0.0085
>>NP_002766 (OMIM: 600142,602194,610149,616779) serine p (480 aa)
initn: 3174 init1: 3174 opt: 3174 Z-score: 2786.2 bits: 524.9 E(85289): 1.9e-148
Smith-Waterman score: 3174; 100.0% identity (100.0% similar) in 480 aa overlap (1-480:1-480)
10 20 30 40 50 60
pF1KB5 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 ACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 SDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 PAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 KIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 QRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 KKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 TPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
430 440 450 460 470 480
>>NP_710159 (OMIM: 610700) serine protease HTRA4 precurs (476 aa)
initn: 1618 init1: 1221 opt: 1613 Z-score: 1422.0 bits: 272.5 E(85289): 1.8e-72
Smith-Waterman score: 1628; 52.8% identity (77.5% similar) in 479 aa overlap (8-479:15-476)
10 20 30 40 50
pF1KB5 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHC
::: :::::. :. .. .. : .:: :.:.::: : :
NP_710 MIRPQLRTAGLGRCLLPGLLLLLV-PVLWAGAEKLHTQP---SCPAVCQPTRCPALPT-C
10 20 30 40 50
60 70 80 90 100
pF1KB5 EGGRAR--DACGCCEVCGAPEGAACGLQEG-PCGEGLQCVVPF--GVPASATVRRRAQAG
: . : : ::.:: : : .:: .: ::. ::::. :. : :..
NP_710 ALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPST----------
60 70 80 90 100
110 120 130 140 150 160
pF1KB5 LCVCAS-SEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQ-GQEDPNSLR
: : . . ::::: :: ..: ::: .: ..:: . :.. .: : ::. : .. . ::
NP_710 -CGCPTLGGAVCGSDRRTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLR
110 120 130 140 150 160
170 180 190 200 210 220
pF1KB5 HKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKH
..::::: ::::.::.:::..:. .: ..: ::: :::::::::::::.:::::: :..
NP_710 RNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQ
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB5 RVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPF
..: :.::: ::: .::.: : :.:.:::. ...::::.:::::.:: ::::::.::::
NP_710 WIEVVLQNGARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPF
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB5 SLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLK
:::::.:.::::: ::::::::...:::::.: :: :::::::::::::::.:::.:.:.
NP_710 SLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLR
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB5 VTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFP
:: :::::::::....::.: :..: ::::...:::.:..:.::: ..::: .. :::
NP_710 VTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFP
350 360 370 380 390 400
410 420 430 440 450 460
pF1KB5 DVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGN
:: ::.:. .:. : :...::...:::..:::. .....:: .. .: :.:.: ::.
NP_710 DVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDS-LSMAVLRGK
410 420 430 440 450 460
470 480
pF1KB5 EDIMITVIPEEIDP
.....::::: :.
NP_710 DNLLLTVIPETIN
470
>>NP_444272 (OMIM: 608785) serine protease HTRA3 isoform (453 aa)
initn: 1739 init1: 753 opt: 1547 Z-score: 1364.6 bits: 261.8 E(85289): 2.9e-69
Smith-Waterman score: 1716; 57.4% identity (78.0% similar) in 472 aa overlap (14-478:6-452)
10 20 30 40 50 60
pF1KB5 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD
::::: :. :.: : :: :: ::. .::: .:. : :: . :
NP_444 MQARALLLAALAALALARE----PPAAPCPARCDVSRCP-SPR-CPGGYVPD
10 20 30 40
70 80 90 100 110
pF1KB5 ACGCCEVCGAPEGAACGLQ-EGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVC
:.:: ::.: :: :: ..::::.:.:: ::: : :. ::
NP_444 LCNCCLVCAASEGEPCGGPLDSPCGESLECV----------------RGLCRCRWSHAVC
50 60 70 80 90
120 130 140 150 160 170
pF1KB5 GSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKI
:.:..::::.: :.:::::. .: :: ::.::: : .. .: :.:.::::::::::
NP_444 GTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKI
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB5 APAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTN------KHRVKVELK
:::::::::: . :. :.::..::::::.:: :::.::::::.. ....::.:.
NP_444 APAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQ
160 170 180 190 200 210
240 250 260 270 280 290
pF1KB5 NGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVT
:: .::: :::.:.:.::: ::: . ::::::::.:..::::::::::::::.::::::
NP_444 NGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVT
220 230 240 250 260 270
300 310 320 330 340 350
pF1KB5 TGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISF
::::::.:: :.:::::.::::::::::::::::::::::::::::::::::::::::::
NP_444 TGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISF
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB5 AIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAY
:::::.: .:::: .:.: : ::..::::: ..: : . ::: . :::.: :: :
NP_444 AIPSDRITRFLTEFQDKQIKDW---KKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIY
340 350 360 370 380
420 430 440 450 460 470
pF1KB5 IIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITV
. :: :..:.. ::....:.:...::. .:......... :: : . :::::.:.....
NP_444 VQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSI
390 400 410 420 430 440
480
pF1KB5 IPEEIDP
:: .
NP_444 APEVVM
450
>>XP_011542733 (OMIM: 610700) PREDICTED: serine protease (380 aa)
initn: 1317 init1: 969 opt: 1295 Z-score: 1145.3 bits: 221.0 E(85289): 4.7e-57
Smith-Waterman score: 1310; 55.2% identity (75.9% similar) in 373 aa overlap (8-373:15-371)
10 20 30 40 50
pF1KB5 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHC
::: :::::. :. .. .. : .:: :.:.::: : :
XP_011 MIRPQLRTAGLGRCLLPGLLLLLV-PVLWAGAEKLHTQP---SCPAVCQPTRCPALPT-C
10 20 30 40 50
60 70 80 90 100
pF1KB5 EGGRAR--DACGCCEVCGAPEGAACGLQEG-PCGEGLQCVVPF--GVPASATVRRRAQAG
: . : : ::.:: : : .:: .: ::. ::::. :. : :..
XP_011 ALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPST----------
60 70 80 90 100
110 120 130 140 150 160
pF1KB5 LCVCAS-SEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQ-GQEDPNSLR
: : . . ::::: :: ..: ::: .: ..:: . :.. .: : ::. : .. . ::
XP_011 -CGCPTLGGAVCGSDRRTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLR
110 120 130 140 150 160
170 180 190 200 210 220
pF1KB5 HKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKH
..::::: ::::.::.:::..:. .: ..: ::: :::::::::::::.:::::: :..
XP_011 RNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQ
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB5 RVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPF
..: :.::: ::: .::.: : :.:.:::. ...::::.:::::.:: ::::::.::::
XP_011 WIEVVLQNGARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPF
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB5 SLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLK
:::::.:.::::: ::::::::...:::::.: :: :::::::::::::::.:::.:.:.
XP_011 SLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLR
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB5 VTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFP
:: :::::::::....::.: :..: :
XP_011 VTDGISFAIPSDRVRQFLAEYHEHQMKEAKTIAAQS
350 360 370 380
>>XP_011511898 (OMIM: 608785) PREDICTED: serine protease (373 aa)
initn: 1446 init1: 759 opt: 1260 Z-score: 1114.8 bits: 215.3 E(85289): 2.3e-55
Smith-Waterman score: 1429; 62.6% identity (78.6% similar) in 369 aa overlap (14-375:6-352)
10 20 30 40 50 60
pF1KB5 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD
::::: :. :.: : :: :: ::. .::: .:. : :: . :
XP_011 MQARALLLAALAALALARE----PPAAPCPARCDVSRCP-SPR-CPGGYVPD
10 20 30 40
70 80 90 100 110
pF1KB5 ACGCCEVCGAPEGAACGLQ-EGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVC
:.:: ::.: :: :: ..::::.:.:: ::: : :. ::
XP_011 LCNCCLVCAASEGEPCGGPLDSPCGESLECV----------------RGLCRCRWSHAVC
50 60 70 80 90
120 130 140 150 160 170
pF1KB5 GSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKI
:.:..::::.: :.:::::. .: :: ::.::: : .. .: :.:.::::::::::
XP_011 GTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKI
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB5 APAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTN------KHRVKVELK
:::::::::: . :. :.::..::::::.:: :::.::::::.. ....::.:.
XP_011 APAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQ
160 170 180 190 200 210
240 250 260 270 280 290
pF1KB5 NGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVT
:: .::: :::.:.:.::: ::: . ::::::::.:..::::::::::::::.::::::
XP_011 NGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVT
220 230 240 250 260 270
300 310 320 330 340 350
pF1KB5 TGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISF
::::::.:: :.:::::.::::::::::::::::::::::::::::::::::::::::::
XP_011 TGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISF
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB5 AIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAY
:::::.: .:::: .:.: :.:
XP_011 AIPSDRITRFLTEFQDKQIKAKHMDPSAAKAGAMRAGHMKSCC
340 350 360 370
>>NP_001284488 (OMIM: 608785) serine protease HTRA3 isof (357 aa)
initn: 1442 init1: 755 opt: 1256 Z-score: 1111.6 bits: 214.6 E(85289): 3.5e-55
Smith-Waterman score: 1425; 62.0% identity (78.4% similar) in 371 aa overlap (14-377:6-354)
10 20 30 40 50 60
pF1KB5 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD
::::: :. :.: : :: :: ::. .::: .:. : :: . :
NP_001 MQARALLLAALAALALARE----PPAAPCPARCDVSRCP-SPR-CPGGYVPD
10 20 30 40
70 80 90 100 110
pF1KB5 ACGCCEVCGAPEGAACGLQ-EGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVC
:.:: ::.: :: :: ..::::.:.:: ::: : :. ::
NP_001 LCNCCLVCAASEGEPCGGPLDSPCGESLECV----------------RGLCRCRWSHAVC
50 60 70 80 90
120 130 140 150 160 170
pF1KB5 GSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKI
:.:..::::.: :.:::::. .: :: ::.::: : .. .: :.:.::::::::::
NP_001 GTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKI
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB5 APAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTN------KHRVKVELK
:::::::::: . :. :.::..::::::.:: :::.::::::.. ....::.:.
NP_001 APAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQ
160 170 180 190 200 210
240 250 260 270 280 290
pF1KB5 NGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVT
:: .::: :::.:.:.::: ::: . ::::::::.:..::::::::::::::.::::::
NP_001 NGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVT
220 230 240 250 260 270
300 310 320 330 340 350
pF1KB5 TGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISF
::::::.:: :.:::::.::::::::::::::::::::::::::::::::::::::::::
NP_001 TGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISF
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB5 AIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAY
:::::.: .:::: .:.: :. ..
NP_001 AIPSDRITRFLTEFQDKQIKAPSLAVH
340 350
>>XP_011542734 (OMIM: 610700) PREDICTED: serine protease (343 aa)
initn: 1145 init1: 797 opt: 1118 Z-score: 991.2 bits: 192.3 E(85289): 1.8e-48
Smith-Waterman score: 1133; 54.3% identity (74.0% similar) in 335 aa overlap (8-335:15-333)
10 20 30 40 50
pF1KB5 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHC
::: :::::. :. .. .. : .:: :.:.::: : :
XP_011 MIRPQLRTAGLGRCLLPGLLLLLV-PVLWAGAEKLHTQP---SCPAVCQPTRCPALPT-C
10 20 30 40 50
60 70 80 90 100
pF1KB5 EGGRAR--DACGCCEVCGAPEGAACGLQEG-PCGEGLQCVVPF--GVPASATVRRRAQAG
: . : : ::.:: : : .:: .: ::. ::::. :. : :..
XP_011 ALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPST----------
60 70 80 90 100
110 120 130 140 150 160
pF1KB5 LCVCAS-SEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQ-GQEDPNSLR
: : . . ::::: :: ..: ::: .: ..:: . :.. .: : ::. : .. . ::
XP_011 -CGCPTLGGAVCGSDRRTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLR
110 120 130 140 150 160
170 180 190 200 210 220
pF1KB5 HKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKH
..::::: ::::.::.:::..:. .: ..: ::: :::::::::::::.:::::: :..
XP_011 RNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQ
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB5 RVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPF
..: :.::: ::: .::.: : :.:.:::. ...::::.:::::.:: ::::::.::::
XP_011 WIEVVLQNGARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPF
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB5 SLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLK
:::::.:.::::: ::::::::...:::::.: :: :::::::::::::
XP_011 SLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLVFSLDLLTCL
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB5 VTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFP
>>NP_037379 (OMIM: 606441,610297) serine protease HTRA2, (458 aa)
initn: 1103 init1: 869 opt: 1107 Z-score: 980.0 bits: 190.7 E(85289): 7.5e-48
Smith-Waterman score: 1107; 53.8% identity (81.6% similar) in 316 aa overlap (162-476:140-455)
140 150 160 170 180 190
pF1KB5 LRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRK
: : : .:::::::::: :::::.::.. .
NP_037 ALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDR
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB5 LPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADI
:: ::::...::::.:. :::::::::::....::.:.: .: :::: . :: :::
NP_037 HPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADI
170 180 190 200 210 220
260 270 280 290 300 310
pF1KB5 ALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN
: ..:. . ::.: ::::...: ::::::.::::.::::.:.::::..:: ...::: .
NP_037 ATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQ
230 240 250 260 270 280
320 330 340 350 360 370
pF1KB5 SDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQ
....:::::: :..::::::::::::::::.::.:::::::::::::....:: ... ..
NP_037 TNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKN
290 300 310 320 330 340
380 390 400 410 420 430
pF1KB5 AK-GKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKE
.. : . ....:::. :..:. : ::. :. .:::: :. : .:: .::. .::.
NP_037 SSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRP
350 360 370 380 390 400
440 450 460 470 480
pF1KB5 NDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
.:::..:. : : .:.:: .... .: : . .::: : . . : ::
NP_037 GDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
410 420 430 440 450
>>NP_001308657 (OMIM: 606441,610297) serine protease HTR (426 aa)
initn: 984 init1: 869 opt: 911 Z-score: 809.1 bits: 158.9 E(85289): 2.5e-38
Smith-Waterman score: 966; 50.0% identity (75.3% similar) in 316 aa overlap (162-476:140-423)
140 150 160 170 180 190
pF1KB5 LRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRK
: : : .:::::::::: :::::.::.. .
NP_001 ALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDR
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB5 LPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADI
:: ::::...::::.:. :::::::::::....::.:.: .: :::: . :: :::
NP_001 HPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADI
170 180 190 200 210 220
260 270 280 290 300 310
pF1KB5 ALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN
: ..:. . ::.: ::::...: ::::::.::::.::::.:.::::..:: ...::: .
NP_001 ATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQ
230 240 250 260 270 280
320 330 340 350 360 370
pF1KB5 SDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQ
....:::::: :..::::::::::::::::.::.:::::::::::::....:: ... ..
NP_001 TNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKN
290 300 310 320 330 340
380 390 400 410 420 430
pF1KB5 AK-GKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKE
.. : . ....:::. :..: : .: ::.
NP_001 SSSGISGSQRRYIGVMMLTL-SPRA-------------------------------GLRP
350 360 370
440 450 460 470 480
pF1KB5 NDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
.:::..:. : : .:.:: .... .: : . .::: : . . : ::
NP_001 GDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
380 390 400 410 420
>>NP_001308656 (OMIM: 606441,610297) serine protease HTR (436 aa)
initn: 825 init1: 710 opt: 711 Z-score: 634.2 bits: 126.6 E(85289): 1.4e-28
Smith-Waterman score: 936; 48.5% identity (73.0% similar) in 326 aa overlap (162-476:140-433)
140 150 160 170 180 190
pF1KB5 LRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRK
: : : .:::::::::: :::::.::.. .
NP_001 ALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDR
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB5 LPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADI
:: ::::...::::.:. :::::::::::....::.:.: .: :::: . :: :::
NP_001 HPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADI
170 180 190 200 210 220
260 270 280 290 300 310
pF1KB5 ALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN
: ..:. . ::.: ::::...: ::::::.::::.::::.:.::::..:: ...::: .
NP_001 ATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQ
230 240 250 260 270 280
320 330 340 350 360
pF1KB5 SDMDYIQTDAIINYGNSGGPLVNL----------DGEVIGINTLKVTAGISFAIPSDKIK
....:::::: :..:::::::::: ::::::.::.:::::::::::::...
NP_001 TNVEYIQTDAAIDFGNSGGPLVNLARELGAVSLQDGEVIGVNTMKVTAGISFAIPSDRLR
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB5 KFLTESHDRQAK-GKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD
.:: ... .... : . ....:::. :..: : .:
NP_001 EFLHRGEKKNSSSGISGSQRRYIGVMMLTL-SPRA-------------------------
350 360 370 380
430 440 450 460 470 480
pF1KB5 TPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
::. .:::..:. : : .:.:: .... .: : . .::: : . . : ::
NP_001 ------GLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
390 400 410 420 430
480 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 20:20:34 2016 done: Sun Nov 6 20:20:35 2016
Total Scan time: 10.220 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]