Result of FASTA (omim) for
pFN21AB4048
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4048, 596 aa
1>>>pF1KB4048 596 - 596 aa - 596 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 15.5674+/-0.000612; mu= -35.3323+/- 0.036
mean_var=712.3095+/-155.469, 0's: 0 Z-trim(115.4): 1576 B-trim: 0 in 0/57
Lambda= 0.048055
statistics sampled from 23877 (25886) to 23877 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.304), width: 16
Scan time: 6.490
The best scores are: opt bits E(85289)
NP_002731 (OMIM: 600539) protein kinase C iota typ ( 596) 4128 302.7 2.2e-81
XP_016862349 (OMIM: 600539) PREDICTED: protein kin ( 464) 3064 228.9 3e-59
NP_002735 (OMIM: 176982) protein kinase C zeta typ ( 592) 2960 221.8 5.3e-57
XP_011540075 (OMIM: 176982) PREDICTED: protein kin ( 595) 2612 197.6 9.7e-50
NP_001229803 (OMIM: 176982) protein kinase C zeta ( 488) 2528 191.7 4.7e-48
XP_016857280 (OMIM: 176982) PREDICTED: protein kin ( 510) 2513 190.7 1e-47
XP_011540076 (OMIM: 176982) PREDICTED: protein kin ( 491) 2180 167.6 8.7e-41
XP_016857290 (OMIM: 176982) PREDICTED: protein kin ( 405) 2103 162.2 3.1e-39
NP_001028754 (OMIM: 176982) protein kinase C zeta ( 409) 2103 162.2 3.1e-39
XP_016857288 (OMIM: 176982) PREDICTED: protein kin ( 409) 2103 162.2 3.1e-39
NP_001028753 (OMIM: 176982) protein kinase C zeta ( 409) 2103 162.2 3.1e-39
XP_016857294 (OMIM: 176982) PREDICTED: protein kin ( 355) 2073 160.1 1.2e-38
XP_016857293 (OMIM: 176982) PREDICTED: protein kin ( 355) 2073 160.1 1.2e-38
XP_016857287 (OMIM: 176982) PREDICTED: protein kin ( 417) 2052 158.7 3.6e-38
XP_016857285 (OMIM: 176982) PREDICTED: protein kin ( 417) 2052 158.7 3.6e-38
XP_016857289 (OMIM: 176982) PREDICTED: protein kin ( 408) 1755 138.1 5.6e-32
XP_011540078 (OMIM: 176982) PREDICTED: protein kin ( 412) 1755 138.1 5.7e-32
XP_011540080 (OMIM: 176982) PREDICTED: protein kin ( 412) 1755 138.1 5.7e-32
XP_016857291 (OMIM: 176982) PREDICTED: protein kin ( 358) 1725 136.0 2.2e-31
XP_016857286 (OMIM: 176982) PREDICTED: protein kin ( 416) 1704 134.5 6.6e-31
XP_016857283 (OMIM: 176982) PREDICTED: protein kin ( 420) 1704 134.6 6.7e-31
XP_016857281 (OMIM: 176982) PREDICTED: protein kin ( 420) 1704 134.6 6.7e-31
XP_016857282 (OMIM: 176982) PREDICTED: protein kin ( 420) 1704 134.6 6.7e-31
XP_016857284 (OMIM: 176982) PREDICTED: protein kin ( 420) 1704 134.6 6.7e-31
XP_016857292 (OMIM: 176982) PREDICTED: protein kin ( 358) 1380 112.0 3.4e-24
XP_011540077 (OMIM: 176982) PREDICTED: protein kin ( 416) 1375 111.7 4.9e-24
XP_016857279 (OMIM: 176982) PREDICTED: protein kin ( 600) 1380 112.2 5e-24
XP_016857278 (OMIM: 176982) PREDICTED: protein kin ( 603) 1380 112.2 5.1e-24
XP_011531285 (OMIM: 176975) PREDICTED: protein kin ( 436) 1184 98.5 4.9e-20
XP_006712113 (OMIM: 176975) PREDICTED: protein kin ( 460) 1184 98.5 5.1e-20
XP_011531284 (OMIM: 176975) PREDICTED: protein kin ( 497) 1184 98.6 5.4e-20
XP_011531283 (OMIM: 176975) PREDICTED: protein kin ( 587) 1184 98.6 6.1e-20
XP_011531282 (OMIM: 176975) PREDICTED: protein kin ( 587) 1184 98.6 6.1e-20
XP_016859980 (OMIM: 176975) PREDICTED: protein kin ( 587) 1184 98.6 6.1e-20
XP_016859978 (OMIM: 176975) PREDICTED: protein kin ( 587) 1184 98.6 6.1e-20
XP_016859979 (OMIM: 176975) PREDICTED: protein kin ( 587) 1184 98.6 6.1e-20
XP_016859976 (OMIM: 176975) PREDICTED: protein kin ( 623) 1184 98.6 6.4e-20
XP_011531280 (OMIM: 176975) PREDICTED: protein kin ( 623) 1184 98.6 6.4e-20
XP_016859977 (OMIM: 176975) PREDICTED: protein kin ( 623) 1184 98.6 6.4e-20
XP_016859975 (OMIM: 176975) PREDICTED: protein kin ( 641) 1184 98.7 6.5e-20
XP_011531273 (OMIM: 176975) PREDICTED: protein kin ( 641) 1184 98.7 6.5e-20
XP_011531277 (OMIM: 176975) PREDICTED: protein kin ( 641) 1184 98.7 6.5e-20
XP_005264485 (OMIM: 176975) PREDICTED: protein kin ( 737) 1184 98.7 7.2e-20
NP_005391 (OMIM: 176975) protein kinase C epsilon ( 737) 1184 98.7 7.2e-20
XP_016876947 (OMIM: 601367,605437) PREDICTED: prot ( 522) 1027 87.7 1.1e-16
XP_011535257 (OMIM: 601367,605437) PREDICTED: prot ( 603) 1027 87.7 1.2e-16
XP_011535256 (OMIM: 601367,605437) PREDICTED: prot ( 604) 1027 87.7 1.2e-16
NP_006246 (OMIM: 601367,605437) protein kinase C e ( 683) 1027 87.8 1.3e-16
NP_872198 (OMIM: 603607) ribosomal protein S6 kina ( 549) 911 79.7 2.9e-14
NP_001309158 (OMIM: 603607) ribosomal protein S6 k ( 795) 911 79.8 3.8e-14
>>NP_002731 (OMIM: 600539) protein kinase C iota type [H (596 aa)
initn: 4128 init1: 4128 opt: 4128 Z-score: 1582.0 bits: 302.7 E(85289): 2.2e-81
Smith-Waterman score: 4128; 100.0% identity (100.0% similar) in 596 aa overlap (1-596:1-596)
10 20 30 40 50 60
pF1KB4 MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB4 IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK
490 500 510 520 530 540
550 560 570 580 590
pF1KB4 PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV
550 560 570 580 590
>>XP_016862349 (OMIM: 600539) PREDICTED: protein kinase (464 aa)
initn: 3064 init1: 3064 opt: 3064 Z-score: 1184.8 bits: 228.9 E(85289): 3e-59
Smith-Waterman score: 3064; 100.0% identity (100.0% similar) in 446 aa overlap (151-596:19-464)
130 140 150 160 170 180
pF1KB4 DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK
::::::::::::::::::::::::::::::
XP_016 MCSLVYQNVLGCLVQEKIRAHCAICTDRIWGLGRQGYKCINCKLLVHK
10 20 30 40
190 200 210 220 230 240
pF1KB4 KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR
50 60 70 80 90 100
250 260 270 280 290 300
pF1KB4 ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ
110 120 130 140 150 160
310 320 330 340 350 360
pF1KB4 TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA
170 180 190 200 210 220
370 380 390 400 410 420
pF1KB4 EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI
230 240 250 260 270 280
430 440 450 460 470 480
pF1KB4 APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR
290 300 310 320 330 340
490 500 510 520 530 540
pF1KB4 IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK
350 360 370 380 390 400
550 560 570 580 590
pF1KB4 PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV
410 420 430 440 450 460
>>NP_002735 (OMIM: 176982) protein kinase C zeta type is (592 aa)
initn: 2917 init1: 1317 opt: 2960 Z-score: 1144.4 bits: 221.8 E(85289): 5.3e-57
Smith-Waterman score: 2960; 72.8% identity (88.5% similar) in 589 aa overlap (18-596:11-592)
10 20 30 40 50 60
pF1KB4 MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF
::: .::.::.: :::.:: . . .:: ::.:::::: .
NP_002 MPSRTGPKMEGSGG---RVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRL
10 20 30 40 50
70 80 90 100 110 120
pF1KB4 DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE
... .:.::.: ::::::::::.:::::::: . .: :.::::: .::.::.:::::
NP_002 HQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGE
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB4 DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK
:::::::::::::::: :::: ::::::::::.:. :..:::::.::::.::::::::::
NP_002 DKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHK
120 130 140 150 160 170
190 200 210 220 230
pF1KB4 KCHKLVTIECGRHS---LP-QEPVMPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVG
.:: :: . : .: .: ::: :.:... .: . : : :: :.:. . .
NP_002 RCHGLVPLTCRKHMDSVMPSQEP--PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDS
180 190 200 210 220
240 250 260 270 280 290
pF1KB4 EE-KEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELV
:. : ... .. : :..::::::::.::::::::::::::::::.:.::::::::::::
NP_002 EDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELV
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB4 NDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKL
.:::::::::::::::::::..:::::::::::: ::::.::::::::::::::::::::
NP_002 HDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKL
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB4 PEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTT
::::::::.::: .:::.:::::::::::::::::::..::::::::::::::: :::::
NP_002 PEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTT
350 360 370 380 390 400
420 430 440 450 460 470
pF1KB4 STFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYL
::::::::::::::::::.::::::::::::::::::::::::::. .::::.::::::
NP_002 STFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYL
410 420 430 440 450 460
480 490 500 510 520 530
pF1KB4 FQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMM
::::::: ::::: :::::. :::.::::::::::::.:::::.::..: :::..:::..
NP_002 FQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLL
470 480 490 500 510 520
540 550 560 570 580 590
pF1KB4 EQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLM
:.::..:::.:.:. ..::::::.:::.:::::::::.: ...::::::::::::::::.
NP_002 EKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL
530 540 550 560 570 580
pF1KB4 SAEECV
:.:: :
NP_002 STEESV
590
>>XP_011540075 (OMIM: 176982) PREDICTED: protein kinase (595 aa)
initn: 2579 init1: 1327 opt: 2612 Z-score: 1013.9 bits: 197.6 E(85289): 9.7e-50
Smith-Waterman score: 2612; 72.8% identity (87.6% similar) in 526 aa overlap (18-533:11-529)
10 20 30 40 50 60
pF1KB4 MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF
::: .::.::.: :::.:: . . .:: ::.:::::: .
XP_011 MPSRTGPKMEGSGG---RVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRL
10 20 30 40 50
70 80 90 100 110 120
pF1KB4 DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE
... .:.::.: ::::::::::.:::::::: . .: :.::::: .::.::.:::::
XP_011 HQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGE
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB4 DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK
:::::::::::::::: :::: ::::::::::.:. :..:::::.::::.::::::::::
XP_011 DKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHK
120 130 140 150 160 170
190 200 210 220 230
pF1KB4 KCHKLVTIECGRHS---LP-QEPVMPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVG
.:: :: . : .: .: ::: :.:... .: . : : :: :.:. . .
XP_011 RCHGLVPLTCRKHMDSVMPSQEP--PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDS
180 190 200 210 220
240 250 260 270 280 290
pF1KB4 EE-KEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELV
:. : ... .. : :..::::::::.::::::::::::::::::.:.::::::::::::
XP_011 EDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELV
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB4 NDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKL
.:::::::::::::::::::..:::::::::::: ::::.::::::::::::::::::::
XP_011 HDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKL
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB4 PEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTT
::::::::.::: .:::.:::::::::::::::::::..::::::::::::::: :::::
XP_011 PEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTT
350 360 370 380 390 400
420 430 440 450 460 470
pF1KB4 STFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYL
::::::::::::::::::.::::::::::::::::::::::::::. .::::.::::::
XP_011 STFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYL
410 420 430 440 450 460
480 490 500 510 520 530
pF1KB4 FQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMM
::::::: ::::: :::::. :::.::::::::::::.:::::.::..: :::..:::.:
XP_011 FQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLM
470 480 490 500 510 520
540 550 560 570 580 590
pF1KB4 EQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLM
...
XP_011 HRQLRCTDARTTWTPRRCGRTDDMDAQTMWMHGRRRHTDDSSTDDSDARTPRRRGRTDDA
530 540 550 560 570 580
>>NP_001229803 (OMIM: 176982) protein kinase C zeta type (488 aa)
initn: 2473 init1: 1317 opt: 2528 Z-score: 983.6 bits: 191.7 E(85289): 4.7e-48
Smith-Waterman score: 2528; 75.0% identity (89.4% similar) in 492 aa overlap (115-596:1-488)
90 100 110 120 130 140
pF1KB4 ELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQ
: : :.:::::::::::::: :::: ::
NP_001 MLTPRTDESIYRRGARRWRKLYRANGHLFQ
10 20 30
150 160 170 180 190 200
pF1KB4 AKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHS---LP-QEPV
::::::::.:. :..:::::.::::.::::::::::.:: :: . : .: .: :::
NP_001 AKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEP-
40 50 60 70 80
210 220 230 240 250
pF1KB4 MPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVGEE-KEAMNTRESGKASSSLGLQDF
:.:... .: . : : :: :.:. . .:. : ... .. : :..::::::
NP_001 -PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDF
90 100 110 120 130 140
260 270 280 290 300 310
pF1KB4 DLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPF
::.::::::::::::::::::.:.::::::::::::.:::::::::::::::::::..::
NP_001 DLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPF
150 160 170 180 190 200
320 330 340 350 360 370
pF1KB4 LVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGI
:::::::::: ::::.::::::::::::::::::::::::::::.::: .:::.::::::
NP_001 LVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGI
210 220 230 240 250 260
380 390 400 410 420 430
pF1KB4 IYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSV
:::::::::::::..::::::::::::::: :::::::::::::::::::::::.:::::
NP_001 IYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSV
270 280 290 300 310 320
440 450 460 470 480 490
pF1KB4 DWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLK
:::::::::::::::::::::. .::::.::::::::::::: ::::: :::::. :::
NP_001 DWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK
330 340 350 360 370 380
500 510 520 530 540 550
pF1KB4 SFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDS
.::::::::::::.:::::.::..: :::..:::..:.::..:::.:.:. ..::::::.
NP_001 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT
390 400 410 420 430 440
560 570 580 590
pF1KB4 QFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV
:::.:::::::::.: ...::::::::::::::::.:.:: :
NP_001 QFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
450 460 470 480
>>XP_016857280 (OMIM: 176982) PREDICTED: protein kinase (510 aa)
initn: 2475 init1: 1317 opt: 2513 Z-score: 977.8 bits: 190.7 E(85289): 1e-47
Smith-Waterman score: 2513; 74.3% identity (88.9% similar) in 495 aa overlap (112-596:20-510)
90 100 110 120 130 140
pF1KB4 SQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGH
:: . .:::::::::::::: ::::
XP_016 MCTAHSIGVLGWWRGAGLRRPVFYSEMVGESIYRRGARRWRKLYRANGH
10 20 30 40
150 160 170 180 190
pF1KB4 TFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHS---LP-Q
::::::::::.:. :..:::::.::::.::::::::::.:: :: . : .: .: :
XP_016 LFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQ
50 60 70 80 90 100
200 210 220 230 240 250
pF1KB4 EPVMPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVGEE-KEAMNTRESGKASSSLGL
:: :.:... .: . : : :: :.:. . .:. : ... .. : :..:::
XP_016 EP--PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGL
110 120 130 140 150 160
260 270 280 290 300 310
pF1KB4 QDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN
:::::.::::::::::::::::::.:.::::::::::::.:::::::::::::::::::.
XP_016 QDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS
170 180 190 200 210 220
320 330 340 350 360 370
pF1KB4 HPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHE
.:::::::::::: ::::.::::::::::::::::::::::::::::.::: .:::.:::
XP_016 NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHE
230 240 250 260 270 280
380 390 400 410 420 430
pF1KB4 RGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYG
::::::::::::::::..::::::::::::::: :::::::::::::::::::::::.::
XP_016 RGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYG
290 300 310 320 330 340
440 450 460 470 480 490
pF1KB4 FSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAAS
::::::::::::::::::::::::. .::::.::::::::::::: ::::: :::::.
XP_016 FSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH
350 360 370 380 390 400
500 510 520 530 540 550
pF1KB4 VLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDN
:::.::::::::::::.:::::.::..: :::..:::..:.::..:::.:.:. ..::::
XP_016 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN
410 420 430 440 450 460
560 570 580 590
pF1KB4 FDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV
::.:::.:::::::::.: ...::::::::::::::::.:.:: :
XP_016 FDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
470 480 490 500 510
>>XP_011540076 (OMIM: 176982) PREDICTED: protein kinase (491 aa)
initn: 2135 init1: 1327 opt: 2180 Z-score: 853.2 bits: 167.6 E(85289): 8.7e-41
Smith-Waterman score: 2180; 75.3% identity (88.6% similar) in 429 aa overlap (115-533:1-425)
90 100 110 120 130 140
pF1KB4 ELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQ
: : :.:::::::::::::: :::: ::
XP_011 MLTPRTDESIYRRGARRWRKLYRANGHLFQ
10 20 30
150 160 170 180 190 200
pF1KB4 AKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHS---LP-QEPV
::::::::.:. :..:::::.::::.::::::::::.:: :: . : .: .: :::
XP_011 AKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEP-
40 50 60 70 80
210 220 230 240 250
pF1KB4 MPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVGEE-KEAMNTRESGKASSSLGLQDF
:.:... .: . : : :: :.:. . .:. : ... .. : :..::::::
XP_011 -PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDF
90 100 110 120 130 140
260 270 280 290 300 310
pF1KB4 DLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPF
::.::::::::::::::::::.:.::::::::::::.:::::::::::::::::::..::
XP_011 DLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPF
150 160 170 180 190 200
320 330 340 350 360 370
pF1KB4 LVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGI
:::::::::: ::::.::::::::::::::::::::::::::::.::: .:::.::::::
XP_011 LVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGI
210 220 230 240 250 260
380 390 400 410 420 430
pF1KB4 IYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSV
:::::::::::::..::::::::::::::: :::::::::::::::::::::::.:::::
XP_011 IYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSV
270 280 290 300 310 320
440 450 460 470 480 490
pF1KB4 DWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLK
:::::::::::::::::::::. .::::.::::::::::::: ::::: :::::. :::
XP_011 DWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK
330 340 350 360 370 380
500 510 520 530 540 550
pF1KB4 SFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDS
.::::::::::::.:::::.::..: :::..:::.:...
XP_011 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLMHRQLRCTDARTTWTPRRCGRTDDM
390 400 410 420 430 440
560 570 580 590
pF1KB4 QFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV
XP_011 DAQTMWMHGRRRHTDDSSTDDSDARTPRRRGRTDDADAQMTWTHR
450 460 470 480 490
>>XP_016857290 (OMIM: 176982) PREDICTED: protein kinase (405 aa)
initn: 2061 init1: 1317 opt: 2103 Z-score: 825.5 bits: 162.2 E(85289): 3.1e-39
Smith-Waterman score: 2103; 76.0% identity (91.0% similar) in 409 aa overlap (195-596:1-405)
170 180 190 200 210 220
pF1KB4 GRQGYKCINCKLLVHKKCHKLVTIECGRHSLP-QEPVMPMDQSSMHSD---HAQTVIPYN
.: ::: :.:... .: . : :
XP_016 MPSQEP--PVDDKNEDADLPSEETDGIAYI
10 20
230 240 250 260 270
pF1KB4 PSS--HESLDQVGEE-KEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTD
:: :.:. . .:. : ... .. : :..::::::::.::::::::::::::::::.:
XP_016 SSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKND
30 40 50 60 70 80
280 290 300 310 320 330
pF1KB4 RIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNG
.::::::::::::.:::::::::::::::::::..:::::::::::: ::::.:::::::
XP_016 QIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNG
90 100 110 120 130 140
340 350 360 370 380 390
pF1KB4 GDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDY
:::::::::::::::::::::.::: .:::.:::::::::::::::::::..::::::::
XP_016 GDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDY
150 160 170 180 190 200
400 410 420 430 440 450
pF1KB4 GMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVG
::::::: :::::::::::::::::::::::.::::::::::::::::::::::::::.
XP_016 GMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDII-
210 220 230 240 250 260
460 470 480 490 500 510
pF1KB4 SSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQ
.::::.::::::::::::: ::::: :::::. :::.::::::::::::.:::::.::.
XP_016 -TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIK
270 280 290 300 310 320
520 530 540 550 560 570
pF1KB4 GHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQS
.: :::..:::..:.::..:::.:.:. ..::::::.:::.:::::::::.: ...::::
XP_016 SHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQS
330 340 350 360 370 380
580 590
pF1KB4 EFEGFEYINPLLMSAEECV
::::::::::::.:.:: :
XP_016 EFEGFEYINPLLLSTEESV
390 400
>>NP_001028754 (OMIM: 176982) protein kinase C zeta type (409 aa)
initn: 2061 init1: 1317 opt: 2103 Z-score: 825.4 bits: 162.2 E(85289): 3.1e-39
Smith-Waterman score: 2103; 76.0% identity (91.0% similar) in 409 aa overlap (195-596:5-409)
170 180 190 200 210 220
pF1KB4 GRQGYKCINCKLLVHKKCHKLVTIECGRHSLP-QEPVMPMDQSSMHSD---HAQTVIPYN
.: ::: :.:... .: . : :
NP_001 MDSVMPSQEP--PVDDKNEDADLPSEETDGIAYI
10 20 30
230 240 250 260 270
pF1KB4 PSS--HESLDQVGEE-KEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTD
:: :.:. . .:. : ... .. : :..::::::::.::::::::::::::::::.:
NP_001 SSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKND
40 50 60 70 80 90
280 290 300 310 320 330
pF1KB4 RIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNG
.::::::::::::.:::::::::::::::::::..:::::::::::: ::::.:::::::
NP_001 QIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNG
100 110 120 130 140 150
340 350 360 370 380 390
pF1KB4 GDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDY
:::::::::::::::::::::.::: .:::.:::::::::::::::::::..::::::::
NP_001 GDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDY
160 170 180 190 200 210
400 410 420 430 440 450
pF1KB4 GMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVG
::::::: :::::::::::::::::::::::.::::::::::::::::::::::::::.
NP_001 GMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDII-
220 230 240 250 260 270
460 470 480 490 500 510
pF1KB4 SSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQ
.::::.::::::::::::: ::::: :::::. :::.::::::::::::.:::::.::.
NP_001 -TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIK
280 290 300 310 320 330
520 530 540 550 560 570
pF1KB4 GHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQS
.: :::..:::..:.::..:::.:.:. ..::::::.:::.:::::::::.: ...::::
NP_001 SHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQS
340 350 360 370 380 390
580 590
pF1KB4 EFEGFEYINPLLMSAEECV
::::::::::::.:.:: :
NP_001 EFEGFEYINPLLLSTEESV
400
>>XP_016857288 (OMIM: 176982) PREDICTED: protein kinase (409 aa)
initn: 2061 init1: 1317 opt: 2103 Z-score: 825.4 bits: 162.2 E(85289): 3.1e-39
Smith-Waterman score: 2103; 76.0% identity (91.0% similar) in 409 aa overlap (195-596:5-409)
170 180 190 200 210 220
pF1KB4 GRQGYKCINCKLLVHKKCHKLVTIECGRHSLP-QEPVMPMDQSSMHSD---HAQTVIPYN
.: ::: :.:... .: . : :
XP_016 MDSVMPSQEP--PVDDKNEDADLPSEETDGIAYI
10 20 30
230 240 250 260 270
pF1KB4 PSS--HESLDQVGEE-KEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTD
:: :.:. . .:. : ... .. : :..::::::::.::::::::::::::::::.:
XP_016 SSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKND
40 50 60 70 80 90
280 290 300 310 320 330
pF1KB4 RIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNG
.::::::::::::.:::::::::::::::::::..:::::::::::: ::::.:::::::
XP_016 QIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNG
100 110 120 130 140 150
340 350 360 370 380 390
pF1KB4 GDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDY
:::::::::::::::::::::.::: .:::.:::::::::::::::::::..::::::::
XP_016 GDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDY
160 170 180 190 200 210
400 410 420 430 440 450
pF1KB4 GMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVG
::::::: :::::::::::::::::::::::.::::::::::::::::::::::::::.
XP_016 GMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDII-
220 230 240 250 260 270
460 470 480 490 500 510
pF1KB4 SSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQ
.::::.::::::::::::: ::::: :::::. :::.::::::::::::.:::::.::.
XP_016 -TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIK
280 290 300 310 320 330
520 530 540 550 560 570
pF1KB4 GHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQS
.: :::..:::..:.::..:::.:.:. ..::::::.:::.:::::::::.: ...::::
XP_016 SHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQS
340 350 360 370 380 390
580 590
pF1KB4 EFEGFEYINPLLMSAEECV
::::::::::::.:.:: :
XP_016 EFEGFEYINPLLLSTEESV
400
596 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 17:39:22 2016 done: Sun Nov 6 17:39:23 2016
Total Scan time: 6.490 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]