Result of FASTA (omim) for
pFN21AB3323
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3323, 502 aa
1>>>pF1KB3323 502 - 502 aa - 502 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9553+/-0.000377; mu= 20.7197+/- 0.023
mean_var=74.8168+/-14.721, 0's: 0 Z-trim(114.0): 169 B-trim: 133 in 1/54
Lambda= 0.148277
statistics sampled from 23424 (23593) to 23424 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.277), width: 16
Scan time: 8.270
The best scores are: opt bits E(85289)
NP_000739 (OMIM: 118507,605375) neuronal acetylcho ( 502) 3420 741.2 1.6e-213
XP_016855669 (OMIM: 118507,605375) PREDICTED: neur ( 332) 2250 490.8 2.6e-138
NP_000741 (OMIM: 118509) neuronal acetylcholine re ( 498) 2080 454.6 3.1e-127
XP_011519488 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 2074 453.3 7.6e-127
XP_011519489 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 2074 453.3 7.6e-127
XP_016877375 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 2052 448.5 1.9e-125
XP_016877374 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 2052 448.5 1.9e-125
XP_011519492 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 1873 410.2 5.9e-114
XP_011519493 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 1873 410.2 5.9e-114
XP_016877376 (OMIM: 118509) PREDICTED: neuronal ac ( 463) 1853 406.0 1.2e-112
XP_016877377 (OMIM: 118509) PREDICTED: neuronal ac ( 462) 1846 404.5 3.5e-112
XP_016877378 (OMIM: 118509) PREDICTED: neuronal ac ( 449) 1841 403.4 7.1e-112
NP_004189 (OMIM: 606888) neuronal acetylcholine re ( 494) 1491 328.6 2.6e-89
NP_000735 (OMIM: 118504,188890,600513) neuronal ac ( 627) 1358 300.2 1.2e-80
NP_001186208 (OMIM: 606888) neuronal acetylcholine ( 479) 1323 292.6 1.7e-78
XP_011542690 (OMIM: 118502,610353) PREDICTED: neur ( 529) 1314 290.7 6.9e-78
NP_000733 (OMIM: 118502,610353) neuronal acetylcho ( 529) 1314 290.7 6.9e-78
XP_006716345 (OMIM: 118502,610353) PREDICTED: neur ( 529) 1314 290.7 6.9e-78
NP_001160166 (OMIM: 118503,612052) neuronal acetyl ( 489) 1285 284.5 4.8e-76
NP_000734 (OMIM: 118503,612052) neuronal acetylcho ( 505) 1285 284.5 4.9e-76
XP_011519494 (OMIM: 118509) PREDICTED: neuronal ac ( 316) 1279 283.0 8.5e-76
NP_001269384 (OMIM: 118502,610353) neuronal acetyl ( 514) 1202 266.7 1.1e-70
XP_016883113 (OMIM: 118504,188890,600513) PREDICTE ( 546) 1194 265.1 3.8e-70
XP_006720445 (OMIM: 118503,612052) PREDICTED: neur ( 438) 1191 264.3 5e-70
NP_000740 (OMIM: 118508) neuronal acetylcholine re ( 458) 1157 257.1 8e-68
NP_000070 (OMIM: 100690,253290,601462,608930) acet ( 457) 1128 250.9 5.9e-66
NP_000736 (OMIM: 118505,612052) neuronal acetylcho ( 468) 1115 248.1 4.1e-65
XP_016858746 (OMIM: 100690,253290,601462,608930) P ( 464) 1109 246.8 1e-64
NP_000737 (OMIM: 118511,612001) neuronal acetylcho ( 502) 1019 227.6 6.6e-59
NP_001177384 (OMIM: 118511,612001) neuronal acetyl ( 531) 1000 223.5 1.2e-57
NP_001034612 (OMIM: 100690,253290,601462,608930) a ( 482) 976 218.4 3.8e-56
XP_016858745 (OMIM: 100690,253290,601462,608930) P ( 489) 976 218.4 3.8e-56
XP_011526826 (OMIM: 118504,188890,600513) PREDICTE ( 556) 962 215.4 3.3e-55
NP_060051 (OMIM: 605116) neuronal acetylcholine re ( 479) 949 212.6 2.1e-54
XP_011519478 (OMIM: 118511,612001) PREDICTED: neur ( 486) 925 207.5 7.3e-53
XP_016868492 (OMIM: 118502,610353) PREDICTED: neur ( 370) 915 205.2 2.6e-52
XP_005273454 (OMIM: 118502,610353) PREDICTED: neur ( 370) 915 205.2 2.6e-52
NP_065135 (OMIM: 606372) neuronal acetylcholine re ( 450) 907 203.6 1e-51
XP_011519480 (OMIM: 118511,612001) PREDICTED: neur ( 380) 877 197.1 7.5e-50
NP_001243586 (OMIM: 100720,253290,616321,616322,61 ( 502) 854 192.3 2.8e-48
XP_011542692 (OMIM: 118508) PREDICTED: neuronal ac ( 329) 816 184.0 5.7e-46
NP_001243502 (OMIM: 118504,188890,600513) neuronal ( 451) 759 171.9 3.4e-42
XP_016883114 (OMIM: 118504,188890,600513) PREDICTE ( 451) 759 171.9 3.4e-42
XP_011542691 (OMIM: 118502,610353) PREDICTED: neur ( 331) 746 169.0 1.9e-41
XP_016868493 (OMIM: 118502,610353) PREDICTED: neur ( 331) 746 169.0 1.9e-41
NP_647536 (OMIM: 609756) CHRNA7-FAM7A fusion prote ( 412) 735 166.8 1.1e-40
XP_011520455 (OMIM: 609756) PREDICTED: CHRNA7-FAM7 ( 412) 735 166.8 1.1e-40
XP_011519479 (OMIM: 118511,612001) PREDICTED: neur ( 401) 731 165.9 2e-40
NP_000738 (OMIM: 100710,616313,616314) acetylcholi ( 501) 732 166.2 2e-40
XP_016877372 (OMIM: 118511,612001) PREDICTED: neur ( 440) 727 165.1 3.8e-40
>>NP_000739 (OMIM: 118507,605375) neuronal acetylcholine (502 aa)
initn: 3420 init1: 3420 opt: 3420 Z-score: 3954.3 bits: 741.2 E(85289): 1.6e-213
Smith-Waterman score: 3420; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502)
10 20 30 40 50 60
pF1KB3 MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 MVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 NNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 TEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTIN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 LIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 LMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 LRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 GCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQ
430 440 450 460 470 480
490 500
pF1KB3 PLFQNYTTTTFLHSDHSAPSSK
::::::::::::::::::::::
NP_000 PLFQNYTTTTFLHSDHSAPSSK
490 500
>>XP_016855669 (OMIM: 118507,605375) PREDICTED: neuronal (332 aa)
initn: 2250 init1: 2250 opt: 2250 Z-score: 2604.1 bits: 490.8 E(85289): 2.6e-138
Smith-Waterman score: 2250; 100.0% identity (100.0% similar) in 332 aa overlap (171-502:1-332)
150 160 170 180 190 200
pF1KB3 GSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPS
::::::::::::::::::::::::::::::
XP_016 MKFRSWTYDRTEIDLVLKSEVASLDDFTPS
10 20 30
210 220 230 240 250 260
pF1KB3 GEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPS
40 50 60 70 80 90
270 280 290 300 310 320
pF1KB3 DCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLN
100 110 120 130 140 150
330 340 350 360 370 380
pF1KB3 VHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFRE
160 170 180 190 200 210
390 400 410 420 430 440
pF1KB3 APGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRS
220 230 240 250 260 270
450 460 470 480 490 500
pF1KB3 EDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPS
280 290 300 310 320 330
pF1KB3 SK
::
XP_016 SK
>>NP_000741 (OMIM: 118509) neuronal acetylcholine recept (498 aa)
initn: 2087 init1: 1763 opt: 2080 Z-score: 2405.2 bits: 454.6 E(85289): 3.1e-127
Smith-Waterman score: 2080; 64.8% identity (83.1% similar) in 486 aa overlap (11-489:7-489)
10 20 30 40 50
pF1KB3 MARRCGPVALLLGFGLLRLCS--GVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTV
:. : :. ::. . ...::.:.. ::. .:::.::::::..:.:...
NP_000 MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISI
10 20 30 40 50
60 70 80 90 100 110
pF1KB3 QLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVV
.:..::::::::.:::::::::::: ::: ::::::. ...... .:.:.:.:::::.:
NP_000 KLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB3 LYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTY
::::::: :::: :.: .: .::..::::::::::::::::.:::::::::.:::::::
NP_000 LYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTY
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB3 DRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYT
:.::::.:: . .::.::::::::::::::::::. ::.: .:::.::::::.:::::::
NP_000 DHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYT
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB3 INLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVG
::::::::: : ::::::::::::::::::::::::::: ::::::::::::::::::.:
NP_000 INLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIG
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB3 KYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCAR
::::::::::::::::::::::::::::.::::::::: ::.:::..:::..: .
NP_000 KYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSP
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB3 QR-LRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPG---
: . . . : : . . ::: ::. :. : .::: :
NP_000 ARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASA---ASKSPAGSTPVAIPRDFW
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB3 -RSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFG
::. ..::..:: :::.::...:.:::: :::::::::.::::::.:.::::.:
NP_000 LRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLG
420 430 440 450 460 470
480 490 500
pF1KB3 TIGMFLQPLFQNYTTTTFLHSDHSAPSSK
:.:.:: ::::.....
NP_000 TVGLFLPPLFQTHAASEGPYAAQRD
480 490
>>XP_011519488 (OMIM: 118509) PREDICTED: neuronal acetyl (495 aa)
initn: 2087 init1: 1763 opt: 2074 Z-score: 2398.3 bits: 453.3 E(85289): 7.6e-127
Smith-Waterman score: 2074; 66.2% identity (84.2% similar) in 468 aa overlap (27-489:22-486)
10 20 30 40 50 60
pF1KB3 MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQL
..::.:.. ::. .:::.::::::..:.:....:
XP_011 MGGSLLAPAPDHIVLWNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKL
10 20 30 40 50
70 80 90 100 110 120
pF1KB3 MVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLY
..::::::::.:::::::::::: ::: ::::::. ...... .:.:.:.:::::.:::
XP_011 QLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLY
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB3 NNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDR
::::: :::: :.: .: .::..::::::::::::::::.:::::::::.::::::::.
XP_011 NNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDH
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB3 TEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTIN
::::.:: . .::.::::::::::::::::::. ::.: .:::.::::::.:::::::::
XP_011 TEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTIN
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB3 LIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKY
::::::: : ::::::::::::::::::::::::::: ::::::::::::::::::.:::
XP_011 LIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKY
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB3 LMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQR
::::::::::::::::::::::::::.::::::::: ::.:::..:::..: . :
XP_011 LMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPAR
300 310 320 330 340 350
370 380 390 400 410
pF1KB3 -LRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPG----R
. . . : : . . ::: ::. :. : .::: : :
XP_011 AFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASA---ASKSPAGSTPVAIPRDFWLR
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB3 SGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTI
:. ..::..:: :::.::...:.:::: :::::::::.::::::.:.::::.::.
XP_011 SSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTV
420 430 440 450 460 470
480 490 500
pF1KB3 GMFLQPLFQNYTTTTFLHSDHSAPSSK
:.:: ::::.....
XP_011 GLFLPPLFQTHAASEGPYAAQRD
480 490
>>XP_011519489 (OMIM: 118509) PREDICTED: neuronal acetyl (495 aa)
initn: 2087 init1: 1763 opt: 2074 Z-score: 2398.3 bits: 453.3 E(85289): 7.6e-127
Smith-Waterman score: 2074; 66.2% identity (84.2% similar) in 468 aa overlap (27-489:22-486)
10 20 30 40 50 60
pF1KB3 MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQL
..::.:.. ::. .:::.::::::..:.:....:
XP_011 MGGSLLAPAPDHIVLWNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKL
10 20 30 40 50
70 80 90 100 110 120
pF1KB3 MVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLY
..::::::::.:::::::::::: ::: ::::::. ...... .:.:.:.:::::.:::
XP_011 QLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLY
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB3 NNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDR
::::: :::: :.: .: .::..::::::::::::::::.:::::::::.::::::::.
XP_011 NNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDH
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB3 TEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTIN
::::.:: . .::.::::::::::::::::::. ::.: .:::.::::::.:::::::::
XP_011 TEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTIN
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB3 LIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKY
::::::: : ::::::::::::::::::::::::::: ::::::::::::::::::.:::
XP_011 LIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKY
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB3 LMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQR
::::::::::::::::::::::::::.::::::::: ::.:::..:::..: . :
XP_011 LMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPAR
300 310 320 330 340 350
370 380 390 400 410
pF1KB3 -LRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPG----R
. . . : : . . ::: ::. :. : .::: : :
XP_011 AFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASA---ASKSPAGSTPVAIPRDFWLR
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB3 SGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTI
:. ..::..:: :::.::...:.:::: :::::::::.::::::.:.::::.::.
XP_011 SSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTV
420 430 440 450 460 470
480 490 500
pF1KB3 GMFLQPLFQNYTTTTFLHSDHSAPSSK
:.:: ::::.....
XP_011 GLFLPPLFQTHAASEGPYAAQRD
480 490
>>XP_016877375 (OMIM: 118509) PREDICTED: neuronal acetyl (468 aa)
initn: 2065 init1: 1741 opt: 2052 Z-score: 2373.2 bits: 448.5 E(85289): 1.9e-125
Smith-Waterman score: 2052; 66.5% identity (84.0% similar) in 462 aa overlap (33-489:1-459)
10 20 30 40 50 60
pF1KB3 RRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMV
.. ::. .:::.::::::..:.:....:..
XP_016 MDDLLNKTRYNNLIRPATSSSQLISIKLQL
10 20 30
70 80 90 100 110 120
pF1KB3 SLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNN
::::::::.:::::::::::: ::: ::::::. ...... .:.:.:.:::::.:::::
XP_016 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB3 ADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTE
::: :::: :.: .: .::..::::::::::::::::.:::::::::.::::::::.::
XP_016 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB3 IDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLI
::.:: . .::.::::::::::::::::::. ::.: .:::.::::::.:::::::::::
XP_016 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB3 IPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLM
::::: : ::::::::::::::::::::::::::: ::::::::::::::::::.:::::
XP_016 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB3 FTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQR-L
::::::::::::::::::::::::.::::::::: ::.:::..:::..: . : .
XP_016 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF
280 290 300 310 320 330
370 380 390 400 410
pF1KB3 RLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPG----RSG
. . : : . . ::: ::. :. : .::: : ::.
XP_016 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASA---ASKSPAGSTPVAIPRDFWLRSS
340 350 360 370 380
420 430 440 450 460 470
pF1KB3 EPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGM
..::..:: :::.::...:.:::: :::::::::.::::::.:.::::.::.:.
XP_016 GRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGL
390 400 410 420 430 440
480 490 500
pF1KB3 FLQPLFQNYTTTTFLHSDHSAPSSK
:: ::::.....
XP_016 FLPPLFQTHAASEGPYAAQRD
450 460
>>XP_016877374 (OMIM: 118509) PREDICTED: neuronal acetyl (468 aa)
initn: 2065 init1: 1741 opt: 2052 Z-score: 2373.2 bits: 448.5 E(85289): 1.9e-125
Smith-Waterman score: 2052; 66.5% identity (84.0% similar) in 462 aa overlap (33-489:1-459)
10 20 30 40 50 60
pF1KB3 RRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMV
.. ::. .:::.::::::..:.:....:..
XP_016 MDDLLNKTRYNNLIRPATSSSQLISIKLQL
10 20 30
70 80 90 100 110 120
pF1KB3 SLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNN
::::::::.:::::::::::: ::: ::::::. ...... .:.:.:.:::::.:::::
XP_016 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB3 ADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTE
::: :::: :.: .: .::..::::::::::::::::.:::::::::.::::::::.::
XP_016 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB3 IDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLI
::.:: . .::.::::::::::::::::::. ::.: .:::.::::::.:::::::::::
XP_016 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB3 IPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLM
::::: : ::::::::::::::::::::::::::: ::::::::::::::::::.:::::
XP_016 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB3 FTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQR-L
::::::::::::::::::::::::.::::::::: ::.:::..:::..: . : .
XP_016 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF
280 290 300 310 320 330
370 380 390 400 410
pF1KB3 RLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPG----RSG
. . : : . . ::: ::. :. : .::: : ::.
XP_016 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASA---ASKSPAGSTPVAIPRDFWLRSS
340 350 360 370 380
420 430 440 450 460 470
pF1KB3 EPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGM
..::..:: :::.::...:.:::: :::::::::.::::::.:.::::.::.:.
XP_016 GRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGL
390 400 410 420 430 440
480 490 500
pF1KB3 FLQPLFQNYTTTTFLHSDHSAPSSK
:: ::::.....
XP_016 FLPPLFQTHAASEGPYAAQRD
450 460
>>XP_011519492 (OMIM: 118509) PREDICTED: neuronal acetyl (424 aa)
initn: 1886 init1: 1562 opt: 1873 Z-score: 2166.8 bits: 410.2 E(85289): 5.9e-114
Smith-Waterman score: 1873; 67.0% identity (82.8% similar) in 418 aa overlap (77-489:1-415)
50 60 70 80 90 100
pF1KB3 RPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVR
::::::: ::: ::::::. ...... .:
XP_011 MTTNVWLKQEWTDYRLTWNSSRYEGVNILR
10 20 30
110 120 130 140 150 160
pF1KB3 LPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQ
.:.:.:::::.:::::::: :::: :.: .: .::..::::::::::::::::.:::::
XP_011 IPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQ
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB3 QNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITY
::::.::::::::.::::.:: . .::.::::::::::::::::::. ::.: .:::.::
XP_011 QNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTY
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB3 DFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKI
::::.:::::::::::::::: : ::::::::::::::::::::::::::: ::::::::
XP_011 DFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKI
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB3 VPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPAL
::::::::::.:::::::::::::::::::::::::::::.::::::::: ::.:::..
XP_011 VPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTF
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB3 LFMQQPRHHCARQR-LRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGA
:::..: . : . . . : : . . ::: ::. :. :
XP_011 LFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASA---ASKSPA
280 290 300 310 320
410 420 430 440 450 460
pF1KB3 EPAPVAGPG----RSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRL
.::: : ::. ..::..:: :::.::...:.:::: :::::::::.:::
XP_011 GSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRL
330 340 350 360 370 380
470 480 490 500
pF1KB3 FLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPSSK
:::.:.::::.::.:.:: ::::.....
XP_011 FLWVFMFVCVLGTVGLFLPPLFQTHAASEGPYAAQRD
390 400 410 420
>>XP_011519493 (OMIM: 118509) PREDICTED: neuronal acetyl (424 aa)
initn: 1886 init1: 1562 opt: 1873 Z-score: 2166.8 bits: 410.2 E(85289): 5.9e-114
Smith-Waterman score: 1873; 67.0% identity (82.8% similar) in 418 aa overlap (77-489:1-415)
50 60 70 80 90 100
pF1KB3 RPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVR
::::::: ::: ::::::. ...... .:
XP_011 MTTNVWLKQEWTDYRLTWNSSRYEGVNILR
10 20 30
110 120 130 140 150 160
pF1KB3 LPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQ
.:.:.:::::.:::::::: :::: :.: .: .::..::::::::::::::::.:::::
XP_011 IPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQ
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB3 QNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITY
::::.::::::::.::::.:: . .::.::::::::::::::::::. ::.: .:::.::
XP_011 QNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTY
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB3 DFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKI
::::.:::::::::::::::: : ::::::::::::::::::::::::::: ::::::::
XP_011 DFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKI
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB3 VPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPAL
::::::::::.:::::::::::::::::::::::::::::.::::::::: ::.:::..
XP_011 VPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTF
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB3 LFMQQPRHHCARQR-LRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGA
:::..: . : . . . : : . . ::: ::. :. :
XP_011 LFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASA---ASKSPA
280 290 300 310 320
410 420 430 440 450 460
pF1KB3 EPAPVAGPG----RSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRL
.::: : ::. ..::..:: :::.::...:.:::: :::::::::.:::
XP_011 GSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRL
330 340 350 360 370 380
470 480 490 500
pF1KB3 FLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPSSK
:::.:.::::.::.:.:: ::::.....
XP_011 FLWVFMFVCVLGTVGLFLPPLFQTHAASEGPYAAQRD
390 400 410 420
>>XP_016877376 (OMIM: 118509) PREDICTED: neuronal acetyl (463 aa)
initn: 1860 init1: 1763 opt: 1853 Z-score: 2143.2 bits: 406.0 E(85289): 1.2e-112
Smith-Waterman score: 1853; 64.3% identity (82.1% similar) in 446 aa overlap (11-449:7-449)
10 20 30 40 50
pF1KB3 MARRCGPVALLLGFGLLRLCS--GVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTV
:. : :. ::. . ...::.:.. ::. .:::.::::::..:.:...
XP_016 MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISI
10 20 30 40 50
60 70 80 90 100 110
pF1KB3 QLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVV
.:..::::::::.:::::::::::: ::: ::::::. ...... .:.:.:.:::::.:
XP_016 KLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB3 LYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTY
::::::: :::: :.: .: .::..::::::::::::::::.:::::::::.:::::::
XP_016 LYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTY
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB3 DRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYT
:.::::.:: . .::.::::::::::::::::::. ::.: .:::.::::::.:::::::
XP_016 DHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYT
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB3 INLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVG
::::::::: : ::::::::::::::::::::::::::: ::::::::::::::::::.:
XP_016 INLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIG
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB3 KYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCAR
::::::::::::::::::::::::::::.::::::::: ::.:::..:::..: .
XP_016 KYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSP
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB3 QR-LRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPG---
: . . . : : . . ::: ::. :. : .::: :
XP_016 ARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASA---ASKSPAGSTPVAIPRDFW
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB3 -RSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFG
::. ..::..:: :::.::...:.:::::.
XP_016 LRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVSQKQTPRWGLGCRWFT
420 430 440 450 460
480 490 500
pF1KB3 TIGMFLQPLFQNYTTTTFLHSDHSAPSSK
502 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 12:27:03 2016 done: Sat Nov 5 12:27:04 2016
Total Scan time: 8.270 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]