Result of FASTA (omim) for
pFN21AB3035
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3035, 621 aa
1>>>pF1KB3035 621 - 621 aa - 621 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.0824+/-0.000388; mu= -1.7103+/- 0.024
mean_var=272.3768+/-58.276, 0's: 0 Z-trim(121.5): 25 B-trim: 1391 in 2/58
Lambda= 0.077712
statistics sampled from 38181 (38219) to 38181 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.763), E-opt: 0.2 (0.448), width: 16
Scan time: 12.740
The best scores are: opt bits E(85289)
NP_006523 (OMIM: 600284) RNA polymerase II elongat ( 621) 4178 481.9 2.9e-135
XP_016882824 (OMIM: 600284) PREDICTED: RNA polymer ( 488) 3280 381.1 4.8e-105
XP_016882825 (OMIM: 600284) PREDICTED: RNA polymer ( 370) 2536 297.6 5e-80
XP_016882826 (OMIM: 600284) PREDICTED: RNA polymer ( 337) 2266 267.3 6e-71
XP_011526632 (OMIM: 600284) PREDICTED: RNA polymer ( 357) 1920 228.6 3e-59
XP_016864728 (OMIM: 601874) PREDICTED: RNA polymer ( 589) 1298 159.0 4.3e-38
NP_036213 (OMIM: 601874) RNA polymerase II elongat ( 640) 1298 159.0 4.6e-38
XP_006714638 (OMIM: 601874) PREDICTED: RNA polymer ( 585) 1102 137.0 1.8e-31
XP_016864732 (OMIM: 601874) PREDICTED: RNA polymer ( 455) 635 84.6 8.4e-16
XP_016864729 (OMIM: 601874) PREDICTED: RNA polymer ( 508) 635 84.6 9.2e-16
XP_016864730 (OMIM: 601874) PREDICTED: RNA polymer ( 508) 635 84.6 9.2e-16
XP_016864731 (OMIM: 601874) PREDICTED: RNA polymer ( 508) 635 84.6 9.2e-16
NP_079441 (OMIM: 609885) RNA polymerase II elongat ( 397) 394 57.5 1e-07
NP_001231663 (OMIM: 610153,610572) MARVEL domain-c ( 546) 286 45.5 0.00058
XP_005248504 (OMIM: 610153,610572) PREDICTED: MARV ( 546) 286 45.5 0.00058
XP_005248503 (OMIM: 610153,610572) PREDICTED: MARV ( 558) 286 45.5 0.00059
NP_001033692 (OMIM: 610153,610572) MARVEL domain-c ( 558) 286 45.5 0.00059
XP_005248502 (OMIM: 610153,610572) PREDICTED: MARV ( 558) 286 45.5 0.00059
NP_001192184 (OMIM: 251290,602876) occludin isofor ( 271) 247 40.9 0.007
>>NP_006523 (OMIM: 600284) RNA polymerase II elongation (621 aa)
initn: 4178 init1: 4178 opt: 4178 Z-score: 2549.5 bits: 481.9 E(85289): 2.9e-135
Smith-Waterman score: 4178; 100.0% identity (100.0% similar) in 621 aa overlap (1-621:1-621)
10 20 30 40 50 60
pF1KB3 MAALKEDRSYGLSCGRVSDGSKVSVFHVKLTDSALRAFESYRARQDSVSLRPSIRFQGSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MAALKEDRSYGLSCGRVSDGSKVSVFHVKLTDSALRAFESYRARQDSVSLRPSIRFQGSQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 GHISIPQPDCPAEARTFSFYLSNIGRDNPQGSFDCIQQYVSSHGEVHLDCLGSIQDKITV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GHISIPQPDCPAEARTFSFYLSNIGRDNPQGSFDCIQQYVSSHGEVHLDCLGSIQDKITV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 CATDDSYQKARQSMAQAEEETRSRSAIVIKAGGRYLGKKVQFRKPAPGATDAVPSRKRAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 CATDDSYQKARQSMAQAEEETRSRSAIVIKAGGRYLGKKVQFRKPAPGATDAVPSRKRAT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 PINLASAIRKSGASAVSGGSGVSQRPFRDRVLHLLALRPYRKAELLLRLQKDGLTQADKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PINLASAIRKSGASAVSGGSGVSQRPFRDRVLHLLALRPYRKAELLLRLQKDGLTQADKD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 ALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQLLKRVLVRKLCQPQSTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQLLKRVLVRKLCQPQSTGS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 LLGDPAASSPPGERGRSASPPQKRLQPPDFIDPLANKKPRISHFTQRAQPAVNGKLGVPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LLGDPAASSPPGERGRSASPPQKRLQPPDFIDPLANKKPRISHFTQRAQPAVNGKLGVPN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 GREALLPTPGPPASTDTLSSSTHLPPRLEPPRAHDPLADVSNDLGHSGRDCEHGEAAAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GREALLPTPGPPASTDTLSSSTHLPPRLEPPRAHDPLADVSNDLGHSGRDCEHGEAAAPA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 PTVRLGLPLLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERAAEDKPRAQLPDCAPATHAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PTVRLGLPLLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERAAEDKPRAQLPDCAPATHAT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 PGAPADTPGLNGTCSVSSVPTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEYSEYRDLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PGAPADTPGLNGTCSVSSVPTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEYSEYRDLH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 ARIERITRRFTQLDAQLRQLSQGSEEYETTRGQILQEYRKIKKTNTNYSQEKHRCEYLHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ARIERITRRFTQLDAQLRQLSQGSEEYETTRGQILQEYRKIKKTNTNYSQEKHRCEYLHS
550 560 570 580 590 600
610 620
pF1KB3 KLAHIKRLIAEYDQRQLQAWP
:::::::::::::::::::::
NP_006 KLAHIKRLIAEYDQRQLQAWP
610 620
>>XP_016882824 (OMIM: 600284) PREDICTED: RNA polymerase (488 aa)
initn: 3280 init1: 3280 opt: 3280 Z-score: 2006.9 bits: 381.1 E(85289): 4.8e-105
Smith-Waterman score: 3280; 100.0% identity (100.0% similar) in 488 aa overlap (134-621:1-488)
110 120 130 140 150 160
pF1KB3 GEVHLDCLGSIQDKITVCATDDSYQKARQSMAQAEEETRSRSAIVIKAGGRYLGKKVQFR
::::::::::::::::::::::::::::::
XP_016 MAQAEEETRSRSAIVIKAGGRYLGKKVQFR
10 20 30
170 180 190 200 210 220
pF1KB3 KPAPGATDAVPSRKRATPINLASAIRKSGASAVSGGSGVSQRPFRDRVLHLLALRPYRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPAPGATDAVPSRKRATPINLASAIRKSGASAVSGGSGVSQRPFRDRVLHLLALRPYRKA
40 50 60 70 80 90
230 240 250 260 270 280
pF1KB3 ELLLRLQKDGLTQADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELLLRLQKDGLTQADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQL
100 110 120 130 140 150
290 300 310 320 330 340
pF1KB3 LKRVLVRKLCQPQSTGSLLGDPAASSPPGERGRSASPPQKRLQPPDFIDPLANKKPRISH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKRVLVRKLCQPQSTGSLLGDPAASSPPGERGRSASPPQKRLQPPDFIDPLANKKPRISH
160 170 180 190 200 210
350 360 370 380 390 400
pF1KB3 FTQRAQPAVNGKLGVPNGREALLPTPGPPASTDTLSSSTHLPPRLEPPRAHDPLADVSND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FTQRAQPAVNGKLGVPNGREALLPTPGPPASTDTLSSSTHLPPRLEPPRAHDPLADVSND
220 230 240 250 260 270
410 420 430 440 450 460
pF1KB3 LGHSGRDCEHGEAAAPAPTVRLGLPLLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGHSGRDCEHGEAAAPAPTVRLGLPLLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERAAE
280 290 300 310 320 330
470 480 490 500 510 520
pF1KB3 DKPRAQLPDCAPATHATPGAPADTPGLNGTCSVSSVPTSTSETPDYLLKYAAISSSEQRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKPRAQLPDCAPATHATPGAPADTPGLNGTCSVSSVPTSTSETPDYLLKYAAISSSEQRQ
340 350 360 370 380 390
530 540 550 560 570 580
pF1KB3 SYKNDFNAEYSEYRDLHARIERITRRFTQLDAQLRQLSQGSEEYETTRGQILQEYRKIKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYKNDFNAEYSEYRDLHARIERITRRFTQLDAQLRQLSQGSEEYETTRGQILQEYRKIKK
400 410 420 430 440 450
590 600 610 620
pF1KB3 TNTNYSQEKHRCEYLHSKLAHIKRLIAEYDQRQLQAWP
::::::::::::::::::::::::::::::::::::::
XP_016 TNTNYSQEKHRCEYLHSKLAHIKRLIAEYDQRQLQAWP
460 470 480
>>XP_016882825 (OMIM: 600284) PREDICTED: RNA polymerase (370 aa)
initn: 2536 init1: 2536 opt: 2536 Z-score: 1557.8 bits: 297.6 E(85289): 5e-80
Smith-Waterman score: 2536; 100.0% identity (100.0% similar) in 370 aa overlap (252-621:1-370)
230 240 250 260 270 280
pF1KB3 KAELLLRLQKDGLTQADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQ
::::::::::::::::::::::::::::::
XP_016 MSAKDGTCTLQDCMYKDVQKDWPGYSEGDQ
10 20 30
290 300 310 320 330 340
pF1KB3 QLLKRVLVRKLCQPQSTGSLLGDPAASSPPGERGRSASPPQKRLQPPDFIDPLANKKPRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLLKRVLVRKLCQPQSTGSLLGDPAASSPPGERGRSASPPQKRLQPPDFIDPLANKKPRI
40 50 60 70 80 90
350 360 370 380 390 400
pF1KB3 SHFTQRAQPAVNGKLGVPNGREALLPTPGPPASTDTLSSSTHLPPRLEPPRAHDPLADVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHFTQRAQPAVNGKLGVPNGREALLPTPGPPASTDTLSSSTHLPPRLEPPRAHDPLADVS
100 110 120 130 140 150
410 420 430 440 450 460
pF1KB3 NDLGHSGRDCEHGEAAAPAPTVRLGLPLLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDLGHSGRDCEHGEAAAPAPTVRLGLPLLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERA
160 170 180 190 200 210
470 480 490 500 510 520
pF1KB3 AEDKPRAQLPDCAPATHATPGAPADTPGLNGTCSVSSVPTSTSETPDYLLKYAAISSSEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEDKPRAQLPDCAPATHATPGAPADTPGLNGTCSVSSVPTSTSETPDYLLKYAAISSSEQ
220 230 240 250 260 270
530 540 550 560 570 580
pF1KB3 RQSYKNDFNAEYSEYRDLHARIERITRRFTQLDAQLRQLSQGSEEYETTRGQILQEYRKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQSYKNDFNAEYSEYRDLHARIERITRRFTQLDAQLRQLSQGSEEYETTRGQILQEYRKI
280 290 300 310 320 330
590 600 610 620
pF1KB3 KKTNTNYSQEKHRCEYLHSKLAHIKRLIAEYDQRQLQAWP
::::::::::::::::::::::::::::::::::::::::
XP_016 KKTNTNYSQEKHRCEYLHSKLAHIKRLIAEYDQRQLQAWP
340 350 360 370
>>XP_016882826 (OMIM: 600284) PREDICTED: RNA polymerase (337 aa)
initn: 2266 init1: 2266 opt: 2266 Z-score: 1394.8 bits: 267.3 E(85289): 6e-71
Smith-Waterman score: 2266; 100.0% identity (100.0% similar) in 332 aa overlap (290-621:6-337)
260 270 280 290 300 310
pF1KB3 TLQDCMYKDVQKDWPGYSEGDQQLLKRVLVRKLCQPQSTGSLLGDPAASSPPGERGRSAS
::::::::::::::::::::::::::::::
XP_016 MASSSRKLCQPQSTGSLLGDPAASSPPGERGRSAS
10 20 30
320 330 340 350 360 370
pF1KB3 PPQKRLQPPDFIDPLANKKPRISHFTQRAQPAVNGKLGVPNGREALLPTPGPPASTDTLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPQKRLQPPDFIDPLANKKPRISHFTQRAQPAVNGKLGVPNGREALLPTPGPPASTDTLS
40 50 60 70 80 90
380 390 400 410 420 430
pF1KB3 SSTHLPPRLEPPRAHDPLADVSNDLGHSGRDCEHGEAAAPAPTVRLGLPLLTDCAQPSRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSTHLPPRLEPPRAHDPLADVSNDLGHSGRDCEHGEAAAPAPTVRLGLPLLTDCAQPSRP
100 110 120 130 140 150
440 450 460 470 480 490
pF1KB3 HGSPSRSKPKKKSKKHKDKERAAEDKPRAQLPDCAPATHATPGAPADTPGLNGTCSVSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HGSPSRSKPKKKSKKHKDKERAAEDKPRAQLPDCAPATHATPGAPADTPGLNGTCSVSSV
160 170 180 190 200 210
500 510 520 530 540 550
pF1KB3 PTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEYSEYRDLHARIERITRRFTQLDAQLRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEYSEYRDLHARIERITRRFTQLDAQLRQ
220 230 240 250 260 270
560 570 580 590 600 610
pF1KB3 LSQGSEEYETTRGQILQEYRKIKKTNTNYSQEKHRCEYLHSKLAHIKRLIAEYDQRQLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSQGSEEYETTRGQILQEYRKIKKTNTNYSQEKHRCEYLHSKLAHIKRLIAEYDQRQLQA
280 290 300 310 320 330
620
pF1KB3 WP
::
XP_016 WP
>>XP_011526632 (OMIM: 600284) PREDICTED: RNA polymerase (357 aa)
initn: 1946 init1: 1920 opt: 1920 Z-score: 1184.8 bits: 228.6 E(85289): 3e-59
Smith-Waterman score: 1920; 99.7% identity (100.0% similar) in 291 aa overlap (1-291:1-291)
10 20 30 40 50 60
pF1KB3 MAALKEDRSYGLSCGRVSDGSKVSVFHVKLTDSALRAFESYRARQDSVSLRPSIRFQGSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAALKEDRSYGLSCGRVSDGSKVSVFHVKLTDSALRAFESYRARQDSVSLRPSIRFQGSQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 GHISIPQPDCPAEARTFSFYLSNIGRDNPQGSFDCIQQYVSSHGEVHLDCLGSIQDKITV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GHISIPQPDCPAEARTFSFYLSNIGRDNPQGSFDCIQQYVSSHGEVHLDCLGSIQDKITV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 CATDDSYQKARQSMAQAEEETRSRSAIVIKAGGRYLGKKVQFRKPAPGATDAVPSRKRAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CATDDSYQKARQSMAQAEEETRSRSAIVIKAGGRYLGKKVQFRKPAPGATDAVPSRKRAT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 PINLASAIRKSGASAVSGGSGVSQRPFRDRVLHLLALRPYRKAELLLRLQKDGLTQADKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PINLASAIRKSGASAVSGGSGVSQRPFRDRVLHLLALRPYRKAELLLRLQKDGLTQADKD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 ALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQLLKRVLVRKLCQPQSTGS
::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_011 ALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQLLKRVLVREHSSWSTSLR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 LLGDPAASSPPGERGRSASPPQKRLQPPDFIDPLANKKPRISHFTQRAQPAVNGKLGVPN
XP_011 TGLQEDCWPHLHAQTMVLLSRRLITSRLVESKMLSLHVEAASPSQAGGHSAALQILL
310 320 330 340 350
>>XP_016864728 (OMIM: 601874) PREDICTED: RNA polymerase (589 aa)
initn: 1253 init1: 688 opt: 1298 Z-score: 804.8 bits: 159.0 E(85289): 4.3e-38
Smith-Waterman score: 1649; 47.0% identity (72.1% similar) in 591 aa overlap (4-568:9-587)
10 20 30 40 50
pF1KB3 MAALKEDRSYGLSCGRVSDGSKVSVFHVKLTDSALRAFESYRARQDSVSLRPSIR
:.:.. :::::::... ....:.:::::..:.::.:.:..... . .::::.
XP_016 MAAGGTGGLREEQRYGLSCGRLGQ-DNITVLHVKLTETAIRALETYQSHKNLIPFRPSIQ
10 20 30 40 50
60 70 80 90 100 110
pF1KB3 FQGSQGHISIPQPDCPAEARTFSFYLSNIGRDNPQGSFDCIQQYVSSHGEVHLDCLGSIQ
::: .: ..::. : :...:.:::::.:.:::::::::::: :: : .:.::: ::
XP_016 FQGLHGLVKIPKNDPLNEVHNFNFYLSNVGKDNPQGSFDCIQQTFSSSGASQLNCLGFIQ
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB3 DKITVCATDDSYQKARQSMAQAEEETRSRSAIVIKAGGRYLGKKVQFRKPAPGATDAVPS
::::::::.:::: .:. :.:::::.:.::. ::: :: :.::.::.:: ...:.::
XP_016 DKITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYVGKRVQIRKAPQAVSDTVPE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB3 RKRATPINLASAIRKSGASAVSGGSGVSQRPFRDRVLHLLALRPYRKAELLLRLQKDGLT
:::.::.: :..:::. .: : .::::.::::.:::::. :.: ::: ::::::..
XP_016 RKRSTPMNPANTIRKTHSS-----STISQRPYRDRVIHLLALKAYKKPELLARLQKDGVN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB3 QADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQLLKRVLVRKLCQP
: ::..: ..::::::...:: . ::.: ..:..:.::::::: :.. :. :: :::
XP_016 QKDKNSLGAILQQVANLNSKDLSYTLKDYVFKELQRDWPGYSEIDRRSLESVLSRKLNPS
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB3 QSTGSLLGDPAASSPPGERGRSASPPQKRLQPPDFIDPLANKKPRISHFTQRAQPAVNGK
:... : . :: ..: ::::: .::::: ::: ::::.:.:. :..::.
XP_016 QNAA---GTSRSESPVCSSRDAVSSPQKRLLDSEFIDPLMNKKARISHLTNRVPPTLNGH
300 310 320 330 340 350
360 370 380 390 400
pF1KB3 LGVPNGREALLPTPGPPAS----TDTLSSSTHLPPRLEPPRAHD--------PLADVSND
:. :..... : :::. : ::.:: .::. . : . ..:
XP_016 LN-PTSEKSAAGLPLPPAAAAIPTPPPLPSTYLPIS-HPPQIVNSNSNSPSTPEGRGTQD
360 370 380 390 400
410 420 430 440 450
pF1KB3 L---GHSGRDC--EHGEAAAPAPTVRLGLP---LLTDCAQPSRPHGSPSRSKPKKKSKKH
: . : : : . . : :: .: : .: . . : :..: :::::::
XP_016 LPVDSFSQNDSIYEDQQDKYTSRTSLETLPPGSVLLKCPKPMEENHSMSHKKSKKKSKKH
410 420 430 440 450 460
460 470 480 490 500
pF1KB3 KDKERAAE------DKPRAQLPDCAPATHATPGAPADTPGLNGTCSVSSVPTSTSETPDY
:.:.. . .. . .: .. . ..: .. :.. :..: : :. : :::
XP_016 KEKDQIKKHDIETIEEKEEDLKREEEIAKLNNSSPNSSGGVKEDCTASMEP-SAIELPDY
470 480 490 500 510 520
510 520 530 540 550 560
pF1KB3 LLKYAAISSSEQRQSYKNDFNAEYSEYRDLHARIERITRRFTQLDAQLRQLSQGSEEYET
:.:: :: : ::::.::.::::::.::: ::::.: ..::: .:::: ..:: ::.::.
XP_016 LIKYIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQRKRLSPGSKEYQV
530 540 550 560 570 580
570 580 590 600 610 620
pF1KB3 TRGQILQEYRKIKKTNTNYSQEKHRCEYLHSKLAHIKRLIAEYDQRQLQAWP
XP_016 V
>>NP_036213 (OMIM: 601874) RNA polymerase II elongation (640 aa)
initn: 1487 init1: 688 opt: 1298 Z-score: 804.3 bits: 159.0 E(85289): 4.6e-38
Smith-Waterman score: 1883; 47.9% identity (73.7% similar) in 643 aa overlap (4-620:9-639)
10 20 30 40 50
pF1KB3 MAALKEDRSYGLSCGRVSDGSKVSVFHVKLTDSALRAFESYRARQDSVSLRPSIR
:.:.. :::::::... ....:.:::::..:.::.:.:..... . .::::.
NP_036 MAAGGTGGLREEQRYGLSCGRLGQ-DNITVLHVKLTETAIRALETYQSHKNLIPFRPSIQ
10 20 30 40 50
60 70 80 90 100 110
pF1KB3 FQGSQGHISIPQPDCPAEARTFSFYLSNIGRDNPQGSFDCIQQYVSSHGEVHLDCLGSIQ
::: .: ..::. : :...:.:::::.:.:::::::::::: :: : .:.::: ::
NP_036 FQGLHGLVKIPKNDPLNEVHNFNFYLSNVGKDNPQGSFDCIQQTFSSSGASQLNCLGFIQ
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB3 DKITVCATDDSYQKARQSMAQAEEETRSRSAIVIKAGGRYLGKKVQFRKPAPGATDAVPS
::::::::.:::: .:. :.:::::.:.::. ::: :: :.::.::.:: ...:.::
NP_036 DKITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYVGKRVQIRKAPQAVSDTVPE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB3 RKRATPINLASAIRKSGASAVSGGSGVSQRPFRDRVLHLLALRPYRKAELLLRLQKDGLT
:::.::.: :..:::. .: : .::::.::::.:::::. :.: ::: ::::::..
NP_036 RKRSTPMNPANTIRKTHSS-----STISQRPYRDRVIHLLALKAYKKPELLARLQKDGVN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB3 QADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQLLKRVLVRKLCQP
: ::..: ..::::::...:: . ::.: ..:..:.::::::: :.. :. :: :::
NP_036 QKDKNSLGAILQQVANLNSKDLSYTLKDYVFKELQRDWPGYSEIDRRSLESVLSRKLNPS
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB3 QSTGSLLGDPAASSPPGERGRSASPPQKRLQPPDFIDPLANKKPRISHFTQRAQPAVNGK
:... : . :: ..: ::::: .::::: ::: ::::.:.:. :..::.
NP_036 QNAA---GTSRSESPVCSSRDAVSSPQKRLLDSEFIDPLMNKKARISHLTNRVPPTLNGH
300 310 320 330 340 350
360 370 380 390 400
pF1KB3 LGVPNGREALLPTPGPPAS----TDTLSSSTHLPPRLEPPRAHD--------PLADVSND
:. :..... : :::. : ::.:: .::. . : . ..:
NP_036 LN-PTSEKSAAGLPLPPAAAAIPTPPPLPSTYLPIS-HPPQIVNSNSNSPSTPEGRGTQD
360 370 380 390 400
410 420 430 440 450
pF1KB3 L---GHSGRDC--EHGEAAAPAPTVRLGLP---LLTDCAQPSRPHGSPSRSKPKKKSKKH
: . : : : . . : :: .: : .: . . : :..: :::::::
NP_036 LPVDSFSQNDSIYEDQQDKYTSRTSLETLPPGSVLLKCPKPMEENHSMSHKKSKKKSKKH
410 420 430 440 450 460
460 470 480 490 500
pF1KB3 KDKERAAE------DKPRAQLPDCAPATHATPGAPADTPGLNGTCSVSSVPTSTSETPDY
:.:.. . .. . .: .. . ..: .. :.. :..: :.. : :::
NP_036 KEKDQIKKHDIETIEEKEEDLKREEEIAKLNNSSPNSSGGVKEDCTASMEPSAI-ELPDY
470 480 490 500 510 520
510 520 530 540 550 560
pF1KB3 LLKYAAISSSEQRQSYKNDFNAEYSEYRDLHARIERITRRFTQLDAQLRQLSQGSEEYET
:.:: :: : ::::.::.::::::.::: ::::.: ..::: .:::: ..:: ::.::..
NP_036 LIKYIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQRKRLSPGSKEYQN
530 540 550 560 570 580
570 580 590 600 610 620
pF1KB3 TRGQILQEYRKIKKTNTNYSQEKHRCEYLHSKLAHIKRLIAEYDQRQLQAWP
.. ..::::.:::... :: .::.::::::.:::::::::.:.::.: ..:
NP_036 VHEEVLQEYQKIKQSSPNYHEEKYRCEYLHNKLAHIKRLIGEFDQQQAESWS
590 600 610 620 630 640
>>XP_006714638 (OMIM: 601874) PREDICTED: RNA polymerase (585 aa)
initn: 1293 init1: 551 opt: 1102 Z-score: 686.1 bits: 137.0 E(85289): 1.8e-31
Smith-Waterman score: 1687; 47.9% identity (72.1% similar) in 591 aa overlap (56-620:5-584)
30 40 50 60 70 80
pF1KB3 FHVKLTDSALRAFESYRARQDSVSLRPSIRFQGSQGHISIPQPDCPAEARTFSFYLSNIG
:. :.. ..::. : :...:.:::::.:
XP_006 MDLFFSWSNALVKIPKNDPLNEVHNFNFYLSNVG
10 20 30
90 100 110 120 130 140
pF1KB3 RDNPQGSFDCIQQYVSSHGEVHLDCLGSIQDKITVCATDDSYQKARQSMAQAEEETRSRS
.:::::::::::: :: : .:.::: ::::::::::.:::: .:. :.:::::.:.::
XP_006 KDNPQGSFDCIQQTFSSSGASQLNCLGFIQDKITVCATNDSYQMTRERMTQAEEESRNRS
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB3 AIVIKAGGRYLGKKVQFRKPAPGATDAVPSRKRATPINLASAIRKSGASAVSGGSGVSQR
. ::: :: :.::.::.:: ...:.:: :::.::.: :..:::. .: : .:::
XP_006 TKVIKPGGPYVGKRVQIRKAPQAVSDTVPERKRSTPMNPANTIRKTHSS-----STISQR
100 110 120 130 140
210 220 230 240 250 260
pF1KB3 PFRDRVLHLLALRPYRKAELLLRLQKDGLTQADKDALDGLLQQVANMSAKDGTCTLQDCM
:.::::.:::::. :.: ::: ::::::..: ::..: ..::::::...:: . ::.: .
XP_006 PYRDRVIHLLALKAYKKPELLARLQKDGVNQKDKNSLGAILQQVANLNSKDLSYTLKDYV
150 160 170 180 190 200
270 280 290 300 310 320
pF1KB3 YKDVQKDWPGYSEGDQQLLKRVLVRKLCQPQSTGSLLGDPAASSPPGERGRSASPPQKRL
.:..:.::::::: :.. :. :: ::: :... : . :: ..: :::::
XP_006 FKELQRDWPGYSEIDRRSLESVLSRKLNPSQNAA---GTSRSESPVCSSRDAVSSPQKRL
210 220 230 240 250 260
330 340 350 360 370 380
pF1KB3 QPPDFIDPLANKKPRISHFTQRAQPAVNGKLGVPNGREALLPTPGPPAS----TDTLSSS
.::::: ::: ::::.:.:. :..::.:. :..... : :::. : :
XP_006 LDSEFIDPLMNKKARISHLTNRVPPTLNGHLN-PTSEKSAAGLPLPPAAAAIPTPPPLPS
270 280 290 300 310 320
390 400 410 420
pF1KB3 THLPPRLEPPRAHD--------PLADVSNDL---GHSGRDC--EHGEAAAPAPTVRLGLP
:.:: .::. . : . ..:: . : : : . . : ::
XP_006 TYLPIS-HPPQIVNSNSNSPSTPEGRGTQDLPVDSFSQNDSIYEDQQDKYTSRTSLETLP
330 340 350 360 370 380
430 440 450 460 470
pF1KB3 ---LLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERAAE------DKPRAQLPDCAPATHA
.: : .: . . : :..: ::::::::.:.. . .. . .: ..
XP_006 PGSVLLKCPKPMEENHSMSHKKSKKKSKKHKEKDQIKKHDIETIEEKEEDLKREEEIAKL
390 400 410 420 430 440
480 490 500 510 520 530
pF1KB3 TPGAPADTPGLNGTCSVSSVPTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEYSEYRDL
. ..: .. :.. :..: : :. : ::::.:: :: : ::::.::.::::::.::: :
XP_006 NNSSPNSSGGVKEDCTASMEP-SAIELPDYLIKYIAIVSYEQRQNYKDDFNAEYDEYRAL
450 460 470 480 490 500
540 550 560 570 580 590
pF1KB3 HARIERITRRFTQLDAQLRQLSQGSEEYETTRGQILQEYRKIKKTNTNYSQEKHRCEYLH
:::.: ..::: .:::: ..:: ::.::.... ..::::.:::... :: .::.::::::
XP_006 HARMETVARRFIKLDAQRKRLSPGSKEYQNVHEEVLQEYQKIKQSSPNYHEEKYRCEYLH
510 520 530 540 550 560
600 610 620
pF1KB3 SKLAHIKRLIAEYDQRQLQAWP
.:::::::::.:.::.: ..:
XP_006 NKLAHIKRLIGEFDQQQAESWS
570 580
>>XP_016864732 (OMIM: 601874) PREDICTED: RNA polymerase (455 aa)
initn: 1133 init1: 522 opt: 635 Z-score: 404.7 bits: 84.6 E(85289): 8.4e-16
Smith-Waterman score: 1172; 44.2% identity (69.4% similar) in 464 aa overlap (182-620:1-454)
160 170 180 190 200 210
pF1KB3 GGRYLGKKVQFRKPAPGATDAVPSRKRATPINLASAIRKSGASAVSGGSGVSQRPFRDRV
.: :..:::. .: : .::::.::::
XP_016 MNPANTIRKTHSS-----STISQRPYRDRV
10 20
220 230 240 250 260 270
pF1KB3 LHLLALRPYRKAELLLRLQKDGLTQADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQK
.:::::. :.: ::: ::::::..: ::..: ..::::::...:: . ::.: ..:..:.
XP_016 IHLLALKAYKKPELLARLQKDGVNQKDKNSLGAILQQVANLNSKDLSYTLKDYVFKELQR
30 40 50 60 70 80
280 290 300 310 320 330
pF1KB3 DWPGYSEGDQQLLKRVLVRKLCQPQSTGSLLGDPAASSPPGERGRSASPPQKRLQPPDFI
::::::: :.. :. :: ::: :... : . :: ..: ::::: .::
XP_016 DWPGYSEIDRRSLESVLSRKLNPSQNAA---GTSRSESPVCSSRDAVSSPQKRLLDSEFI
90 100 110 120 130 140
340 350 360 370 380
pF1KB3 DPLANKKPRISHFTQRAQPAVNGKLGVPNGREALLPTPGPPAS----TDTLSSSTHLP--
::: ::: ::::.:.:. :..::.:. :..... : :::. : ::.::
XP_016 DPLMNKKARISHLTNRVPPTLNGHLN-PTSEKSAAGLPLPPAAAAIPTPPPLPSTYLPIS
150 160 170 180 190 200
390 400 410 420 430
pF1KB3 --PRLEPPRAHDPLADV---SNDL---GHSGRDC--EHGEAAAPAPTVRLGLP---LLTD
:.. ...: . ..:: . : : : . . : :: .:
XP_016 HPPQIVNSNSNSPSTPEGRGTQDLPVDSFSQNDSIYEDQQDKYTSRTSLETLPPGSVLLK
210 220 230 240 250 260
440 450 460 470 480
pF1KB3 CAQPSRPHGSPSRSKPKKKSKKHKDKERAAE------DKPRAQLPDCAPATHATPGAPAD
: .: . . : :..: ::::::::.:.. . .. . .: .. . ..: .
XP_016 CPKPMEENHSMSHKKSKKKSKKHKEKDQIKKHDIETIEEKEEDLKREEEIAKLNNSSPNS
270 280 290 300 310 320
490 500 510 520 530 540
pF1KB3 TPGLNGTCSVSSVPTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEYSEYRDLHARIERI
. :.. :..: :.. : ::::.:: :: : ::::.::.::::::.::: ::::.: .
XP_016 SGGVKEDCTASMEPSAI-ELPDYLIKYIAIVSYEQRQNYKDDFNAEYDEYRALHARMETV
330 340 350 360 370 380
550 560 570 580 590 600
pF1KB3 TRRFTQLDAQLRQLSQGSEEYETTRGQILQEYRKIKKTNTNYSQEKHRCEYLHSKLAHIK
.::: .:::: ..:: ::.::.... ..::::.:::... :: .::.::::::.::::::
XP_016 ARRFIKLDAQRKRLSPGSKEYQNVHEEVLQEYQKIKQSSPNYHEEKYRCEYLHNKLAHIK
390 400 410 420 430 440
610 620
pF1KB3 RLIAEYDQRQLQAWP
:::.:.::.: ..:
XP_016 RLIGEFDQQQAESWS
450
>>XP_016864729 (OMIM: 601874) PREDICTED: RNA polymerase (508 aa)
initn: 1133 init1: 522 opt: 635 Z-score: 404.0 bits: 84.6 E(85289): 9.2e-16
Smith-Waterman score: 1372; 45.9% identity (70.5% similar) in 516 aa overlap (131-620:3-507)
110 120 130 140 150 160
pF1KB3 SSHGEVHLDCLGSIQDKITVCATDDSYQKARQSMAQAEEETRSRSAIVIKAGGRYLGKKV
:. :.:::::.:.::. ::: :: :.::.:
XP_016 MTRERMTQAEEESRNRSTKVIKPGGPYVGKRV
10 20 30
170 180 190 200 210 220
pF1KB3 QFRKPAPGATDAVPSRKRATPINLASAIRKSGASAVSGGSGVSQRPFRDRVLHLLALRPY
:.:: ...:.:: :::.::.: :..:::. .: : .::::.::::.:::::. :
XP_016 QIRKAPQAVSDTVPERKRSTPMNPANTIRKTHSS-----STISQRPYRDRVIHLLALKAY
40 50 60 70 80
230 240 250 260 270 280
pF1KB3 RKAELLLRLQKDGLTQADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGD
.: ::: ::::::..: ::..: ..::::::...:: . ::.: ..:..:.::::::: :
XP_016 KKPELLARLQKDGVNQKDKNSLGAILQQVANLNSKDLSYTLKDYVFKELQRDWPGYSEID
90 100 110 120 130 140
290 300 310 320 330 340
pF1KB3 QQLLKRVLVRKLCQPQSTGSLLGDPAASSPPGERGRSASPPQKRLQPPDFIDPLANKKPR
.. :. :: ::: :... : . :: ..: ::::: .::::: ::: :
XP_016 RRSLESVLSRKLNPSQNAA---GTSRSESPVCSSRDAVSSPQKRLLDSEFIDPLMNKKAR
150 160 170 180 190 200
350 360 370 380 390
pF1KB3 ISHFTQRAQPAVNGKLGVPNGREALLPTPGPPAS----TDTLSSSTHLPPRLEPPRAHD-
:::.:.:. :..::.:. :..... : :::. : ::.:: .::. .
XP_016 ISHLTNRVPPTLNGHLN-PTSEKSAAGLPLPPAAAAIPTPPPLPSTYLPIS-HPPQIVNS
210 220 230 240 250 260
400 410 420 430 440
pF1KB3 -------PLADVSNDL---GHSGRDC--EHGEAAAPAPTVRLGLP---LLTDCAQPSRPH
: . ..:: . : : : . . : :: .: : .: . .
XP_016 NSNSPSTPEGRGTQDLPVDSFSQNDSIYEDQQDKYTSRTSLETLPPGSVLLKCPKPMEEN
270 280 290 300 310 320
450 460 470 480 490
pF1KB3 GSPSRSKPKKKSKKHKDKERAAE------DKPRAQLPDCAPATHATPGAPADTPGLNGTC
: :..: ::::::::.:.. . .. . .: .. . ..: .. :.. :
XP_016 HSMSHKKSKKKSKKHKEKDQIKKHDIETIEEKEEDLKREEEIAKLNNSSPNSSGGVKEDC
330 340 350 360 370 380
500 510 520 530 540 550
pF1KB3 SVSSVPTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEYSEYRDLHARIERITRRFTQLD
..: : :. : ::::.:: :: : ::::.::.::::::.::: ::::.: ..::: .::
XP_016 TASMEP-SAIELPDYLIKYIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLD
390 400 410 420 430 440
560 570 580 590 600 610
pF1KB3 AQLRQLSQGSEEYETTRGQILQEYRKIKKTNTNYSQEKHRCEYLHSKLAHIKRLIAEYDQ
:: ..:: ::.::.... ..::::.:::... :: .::.::::::.:::::::::.:.::
XP_016 AQRKRLSPGSKEYQNVHEEVLQEYQKIKQSSPNYHEEKYRCEYLHNKLAHIKRLIGEFDQ
450 460 470 480 490 500
620
pF1KB3 RQLQAWP
.: ..:
XP_016 QQAESWS
621 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 03:16:35 2016 done: Tue Nov 8 03:16:36 2016
Total Scan time: 12.740 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]