Result of FASTA (omim) for
pFN21AB0445
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB0445, 491 aa
1>>>pF1KB0445 491 - 491 aa - 491 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7914+/-0.000307; mu= 16.4778+/- 0.019
mean_var=83.2515+/-16.754, 0's: 0 Z-trim(116.9): 118 B-trim: 83 in 1/56
Lambda= 0.140565
statistics sampled from 28361 (28487) to 28361 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.697), E-opt: 0.2 (0.334), width: 16
Scan time: 9.640
The best scores are: opt bits E(85289)
NP_000925 (OMIM: 262850,613168) alpha-2-antiplasmi ( 491) 3311 681.1 1.9e-195
NP_001159392 (OMIM: 262850,613168) alpha-2-antipla ( 491) 3311 681.1 1.9e-195
XP_016880254 (OMIM: 262850,613168) PREDICTED: alph ( 495) 3311 681.1 1.9e-195
XP_005256758 (OMIM: 262850,613168) PREDICTED: alph ( 507) 3311 681.1 1.9e-195
NP_001159393 (OMIM: 262850,613168) alpha-2-antipla ( 427) 2514 519.5 7.6e-147
NP_001316832 (OMIM: 172860,613982) pigment epithel ( 418) 613 133.9 8.4e-31
NP_002606 (OMIM: 172860,613982) pigment epithelium ( 418) 613 133.9 8.4e-31
NP_000053 (OMIM: 106100,120790,606860) plasma prot ( 500) 612 133.8 1.1e-30
NP_001027466 (OMIM: 106100,120790,606860) plasma p ( 500) 612 133.8 1.1e-30
NP_001248760 (OMIM: 603357,615598) serpin B7 isofo ( 363) 466 104.1 7e-22
XP_005249241 (OMIM: 601799) PREDICTED: serpin B9 i ( 376) 450 100.9 6.8e-21
NP_004146 (OMIM: 601799) serpin B9 [Homo sapiens] ( 376) 450 100.9 6.8e-21
NP_001121175 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19
NP_001121179 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19
NP_001002235 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19
NP_001121178 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19
NP_001002236 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19
NP_001121173 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19
NP_000286 (OMIM: 107400,606963,613490) alpha-1-ant ( 418) 431 97.0 1.1e-19
XP_016876859 (OMIM: 107400,606963,613490) PREDICTE ( 418) 431 97.0 1.1e-19
NP_001121174 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19
NP_001121177 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19
NP_001121176 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19
NP_001121172 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19
XP_011524553 (OMIM: 615682) PREDICTED: serpin B11 ( 392) 430 96.8 1.2e-19
NP_536723 (OMIM: 615682) serpin B11 isoform a [Hom ( 392) 430 96.8 1.2e-19
NP_000176 (OMIM: 142360,612356) heparin cofactor 2 ( 499) 430 96.9 1.4e-19
NP_006208 (OMIM: 605587) serpin I2 isoform 2 precu ( 405) 427 96.2 1.8e-19
NP_001012303 (OMIM: 605587) serpin I2 isoform 1 pr ( 415) 427 96.2 1.9e-19
XP_016866430 (OMIM: 173321,613453) PREDICTED: serp ( 332) 400 90.7 7e-18
XP_011512978 (OMIM: 173321,613453) PREDICTED: serp ( 332) 400 90.7 7e-18
NP_001193943 (OMIM: 600943,610504,613848) serpin H ( 418) 401 91.0 7.3e-18
NP_001226 (OMIM: 600943,610504,613848) serpin H1 p ( 418) 401 91.0 7.3e-18
XP_011543629 (OMIM: 600943,610504,613848) PREDICTE ( 418) 401 91.0 7.3e-18
NP_004559 (OMIM: 173321,613453) serpin B6 isoform ( 376) 400 90.7 7.7e-18
XP_011512975 (OMIM: 173321,613453) PREDICTED: serp ( 376) 400 90.7 7.7e-18
NP_001258753 (OMIM: 173321,613453) serpin B6 isofo ( 376) 400 90.7 7.7e-18
XP_011512976 (OMIM: 173321,613453) PREDICTED: serp ( 376) 400 90.7 7.7e-18
NP_001258754 (OMIM: 173321,613453) serpin B6 isofo ( 376) 400 90.7 7.7e-18
NP_001284629 (OMIM: 173321,613453) serpin B6 isofo ( 376) 400 90.7 7.7e-18
NP_001284628 (OMIM: 173321,613453) serpin B6 isofo ( 376) 400 90.7 7.7e-18
NP_001182220 (OMIM: 173321,613453) serpin B6 isofo ( 380) 400 90.7 7.8e-18
XP_016866429 (OMIM: 173321,613453) PREDICTED: serp ( 380) 400 90.7 7.8e-18
NP_001258751 (OMIM: 173321,613453) serpin B6 isofo ( 390) 400 90.7 8e-18
NP_001258752 (OMIM: 173321,613453) serpin B6 isofo ( 395) 400 90.7 8e-18
XP_011512974 (OMIM: 173321,613453) PREDICTED: serp ( 454) 400 90.8 9e-18
NP_001076 (OMIM: 107280) alpha-1-antichymotrypsin ( 423) 398 90.3 1.1e-17
NP_001094077 (OMIM: 605271) protein Z-dependent pr ( 444) 398 90.4 1.2e-17
NP_057270 (OMIM: 605271) protein Z-dependent prote ( 444) 398 90.4 1.2e-17
XP_005267790 (OMIM: 605271) PREDICTED: protein Z-d ( 444) 398 90.4 1.2e-17
>>NP_000925 (OMIM: 262850,613168) alpha-2-antiplasmin is (491 aa)
initn: 3311 init1: 3311 opt: 3311 Z-score: 3630.0 bits: 681.1 E(85289): 1.9e-195
Smith-Waterman score: 3311; 100.0% identity (100.0% similar) in 491 aa overlap (1-491:1-491)
10 20 30 40 50 60
pF1KB0 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 TALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 ALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM
430 440 450 460 470 480
490
pF1KB0 EEDYPQFGSPK
:::::::::::
NP_000 EEDYPQFGSPK
490
>>NP_001159392 (OMIM: 262850,613168) alpha-2-antiplasmin (491 aa)
initn: 3311 init1: 3311 opt: 3311 Z-score: 3630.0 bits: 681.1 E(85289): 1.9e-195
Smith-Waterman score: 3311; 100.0% identity (100.0% similar) in 491 aa overlap (1-491:1-491)
10 20 30 40 50 60
pF1KB0 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 TALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 ALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM
430 440 450 460 470 480
490
pF1KB0 EEDYPQFGSPK
:::::::::::
NP_001 EEDYPQFGSPK
490
>>XP_016880254 (OMIM: 262850,613168) PREDICTED: alpha-2- (495 aa)
initn: 3311 init1: 3311 opt: 3311 Z-score: 3629.9 bits: 681.1 E(85289): 1.9e-195
Smith-Waterman score: 3311; 100.0% identity (100.0% similar) in 491 aa overlap (1-491:5-495)
10 20 30 40 50
pF1KB0 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPRNMALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB0 PGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB0 LSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB0 DFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIH
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB0 FQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNM
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB0 SFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB0 QELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFL
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB0 FFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKL
430 440 450 460 470 480
480 490
pF1KB0 VPPMEEDYPQFGSPK
:::::::::::::::
XP_016 VPPMEEDYPQFGSPK
490
>>XP_005256758 (OMIM: 262850,613168) PREDICTED: alpha-2- (507 aa)
initn: 3311 init1: 3311 opt: 3311 Z-score: 3629.8 bits: 681.1 E(85289): 1.9e-195
Smith-Waterman score: 3311; 100.0% identity (100.0% similar) in 491 aa overlap (1-491:17-507)
10 20 30 40
pF1KB0 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQV
::::::::::::::::::::::::::::::::::::::::::::
XP_005 MHVRRVRDLCHRFTRNMALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB0 SPLTLLKLGNQEPGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPLTLLKLGNQEPGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCP
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB0 NLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAA
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB0 RMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLP
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB0 EDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPE
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB0 IQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQ
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB0 MDLVATLSQLGLQELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDLVATLSQLGLQELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRM
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB0 SLSSFSVNRPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLSSFSVNRPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFP
430 440 450 460 470 480
470 480 490
pF1KB0 RGDKLFGPDLKLVPPMEEDYPQFGSPK
:::::::::::::::::::::::::::
XP_005 RGDKLFGPDLKLVPPMEEDYPQFGSPK
490 500
>>NP_001159393 (OMIM: 262850,613168) alpha-2-antiplasmin (427 aa)
initn: 2507 init1: 2507 opt: 2514 Z-score: 2757.3 bits: 519.5 E(85289): 7.6e-147
Smith-Waterman score: 2736; 86.6% identity (87.0% similar) in 491 aa overlap (1-491:1-427)
10 20 30 40 50 60
pF1KB0 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQ-----
10 20 30 40 50
70 80 90 100 110 120
pF1KB0 TALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHL
..:
NP_001 -----------------------------------------------VQP----------
130 140 150 160 170 180
pF1KB0 ALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 --GAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE
60 70 80 90 100 110
190 200 210 220 230 240
pF1KB0 QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF
120 130 140 150 160 170
250 260 270 280 290 300
pF1KB0 WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV
180 190 200 210 220 230
310 320 330 340 350 360
pF1KB0 LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF
240 250 260 270 280 290
370 380 390 400 410 420
pF1KB0 QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF
300 310 320 330 340 350
430 440 450 460 470 480
pF1KB0 EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM
360 370 380 390 400 410
490
pF1KB0 EEDYPQFGSPK
:::::::::::
NP_001 EEDYPQFGSPK
420
>>NP_001316832 (OMIM: 172860,613982) pigment epithelium- (418 aa)
initn: 605 init1: 326 opt: 613 Z-score: 674.0 bits: 133.9 E(85289): 8.4e-31
Smith-Waterman score: 613; 29.2% identity (63.8% similar) in 414 aa overlap (31-436:10-415)
10 20 30 40 50 60
pF1KB0 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ
.: : . :. .:: . :. .: .
NP_001 MQALVLLLCIGALLGHSSCQNPASPP---EEGSPDPDST
10 20 30
70 80 90 100 110
pF1KB0 TALKSPPGVCSRDPTPE-QTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSH
:: : .:: . ...:: :. : ::. . ..:: :..::::::: :::
NP_001 GAL-----VEEEDPFFKVPVNKLAAAVSNFGYDLYRVRSSTSPTTNVLLSPLSVATALSA
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB0 LALGAQNHTLQRLQQVLHAG--SGPCLPHLLSRLCQDL-GPGA-FRLAARMYLQKGFPIK
:.:::...: . ....:. :.: . ..: . . .: .. :.:. ..: . ::
NP_001 LSLGAEQRTESIIHRALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIK
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB0 EDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAI
.:. :. .:..: :::. . :: .::.::. .::. . . .:.. .:::..
NP_001 SSFVAPLEKSYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGVA
160 170 180 190 200 210
240 250 260 270 280 290
pF1KB0 HFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNN
::.: : .::: :. ..:.:::. :: : ::. ::. : . ..:..:. ..
NP_001 HFKGQWVTKFDSRKTSLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGS
220 230 240 250 260 270
300 310 320 330 340 350
pF1KB0 MSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRL--PKLYLKHQMDLVATLSQ
::.. ..: . :.. . .:. . .: . ... : ::: :... ... .:..
NP_001 MSIIFFLPLKVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQE
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB0 LGLQELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLS-SFSVN
. :: ::..::. :. . . .. :.:.. .: .: :. .. . .. ..... .. .:
NP_001 MKLQSLFDSPDFSKITGKPIKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLN
340 350 360 370 380 390
420 430 440 450 460 470
pF1KB0 RPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGP
.::.: . . :: ::.:.. .:
NP_001 QPFIFVLRDTDTGALLFIGKILDPRGP
400 410
>>NP_002606 (OMIM: 172860,613982) pigment epithelium-der (418 aa)
initn: 605 init1: 326 opt: 613 Z-score: 674.0 bits: 133.9 E(85289): 8.4e-31
Smith-Waterman score: 613; 29.2% identity (63.8% similar) in 414 aa overlap (31-436:10-415)
10 20 30 40 50 60
pF1KB0 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ
.: : . :. .:: . :. .: .
NP_002 MQALVLLLCIGALLGHSSCQNPASPP---EEGSPDPDST
10 20 30
70 80 90 100 110
pF1KB0 TALKSPPGVCSRDPTPE-QTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSH
:: : .:: . ...:: :. : ::. . ..:: :..::::::: :::
NP_002 GAL-----VEEEDPFFKVPVNKLAAAVSNFGYDLYRVRSSTSPTTNVLLSPLSVATALSA
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB0 LALGAQNHTLQRLQQVLHAG--SGPCLPHLLSRLCQDL-GPGA-FRLAARMYLQKGFPIK
:.:::...: . ....:. :.: . ..: . . .: .. :.:. ..: . ::
NP_002 LSLGAEQRTESIIHRALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIK
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB0 EDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAI
.:. :. .:..: :::. . :: .::.::. .::. . . .:.. .:::..
NP_002 SSFVAPLEKSYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGVA
160 170 180 190 200 210
240 250 260 270 280 290
pF1KB0 HFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNN
::.: : .::: :. ..:.:::. :: : ::. ::. : . ..:..:. ..
NP_002 HFKGQWVTKFDSRKTSLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGS
220 230 240 250 260 270
300 310 320 330 340 350
pF1KB0 MSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRL--PKLYLKHQMDLVATLSQ
::.. ..: . :.. . .:. . .: . ... : ::: :... ... .:..
NP_002 MSIIFFLPLKVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQE
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB0 LGLQELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLS-SFSVN
. :: ::..::. :. . . .. :.:.. .: .: :. .. . .. ..... .. .:
NP_002 MKLQSLFDSPDFSKITGKPIKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLN
340 350 360 370 380 390
420 430 440 450 460 470
pF1KB0 RPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGP
.::.: . . :: ::.:.. .:
NP_002 QPFIFVLRDTDTGALLFIGKILDPRGP
400 410
>>NP_000053 (OMIM: 106100,120790,606860) plasma protease (500 aa)
initn: 482 init1: 172 opt: 612 Z-score: 671.8 bits: 133.8 E(85289): 1.1e-30
Smith-Waterman score: 612; 28.5% identity (65.4% similar) in 410 aa overlap (36-436:95-498)
10 20 30 40 50 60
pF1KB0 GLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQ-EPGGQTALK
:. :. . ..: : : . .: .
NP_000 LPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCP
70 80 90 100 110 120
70 80 90 100 110 120
pF1KB0 SPPGVCSRDPTPEQTHRLARAMMAFTADLF-SLVAQTSTCPNLILSPLSVALALSHLALG
.: .:: . :. :.. :. :. .. :. .. :. .::.:.: :... ::
NP_000 GPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLG
130 140 150 160 170 180
130 140 150 160 170 180
pF1KB0 AQNHTLQRLQQVL-HAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQS
: ..: :...: . . :. . : . . . ..... . . :.. :.. :
NP_000 AGENTKTNLESILSYPKDFTCVHQAL----KGFTTKGVTSVSQIFHSPDLAIRDTFVNAS
190 200 210 220 230 240
190 200 210 220 230 240
pF1KB0 EQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWR
. :....: :..... .: :: :: . :..::...:..:: :: :.:::::.... :.
NP_000 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK
250 260 270 280 290 300
250 260 270 280 290 300
pF1KB0 NKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLV
. :::. :. . ::. .. .. : ::... ::. :. . . .:... ...:.:.:.::
NP_000 TTFDPKKTRMEPFHFKNS-VIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILV
310 320 330 340 350
310 320 330 340 350
pF1KB0 PT---HFEWNVSQVLANLSWDTLHPPLVWER--PTKVRLPKLYLKHQMDLVATLSQLGLQ
: : .. :.:. . .. : . :: . ::.. . ..:... . .: .
NP_000 PQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFF
360 370 380 390 400 410
360 370 380 390 400 410
pF1KB0 ELFQAPDLRGISEQ-SLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFL
.. .: :..:. .: ::..:::..:::.:.:::::::..:...: .: : :..:::
NP_000 DFSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVAR-TLLVFEVQQPFL
420 430 440 450 460 470
420 430 440 450 460 470
pF1KB0 FFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKL
: .... .:.:.: : .:
NP_000 FVLWDQQHKFPVFMGRVYDPRA
480 490 500
>>NP_001027466 (OMIM: 106100,120790,606860) plasma prote (500 aa)
initn: 482 init1: 172 opt: 612 Z-score: 671.8 bits: 133.8 E(85289): 1.1e-30
Smith-Waterman score: 612; 28.5% identity (65.4% similar) in 410 aa overlap (36-436:95-498)
10 20 30 40 50 60
pF1KB0 GLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQ-EPGGQTALK
:. :. . ..: : : . .: .
NP_001 LPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCP
70 80 90 100 110 120
70 80 90 100 110 120
pF1KB0 SPPGVCSRDPTPEQTHRLARAMMAFTADLF-SLVAQTSTCPNLILSPLSVALALSHLALG
.: .:: . :. :.. :. :. .. :. .. :. .::.:.: :... ::
NP_001 GPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLG
130 140 150 160 170 180
130 140 150 160 170 180
pF1KB0 AQNHTLQRLQQVL-HAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQS
: ..: :...: . . :. . : . . . ..... . . :.. :.. :
NP_001 AGENTKTNLESILSYPKDFTCVHQAL----KGFTTKGVTSVSQIFHSPDLAIRDTFVNAS
190 200 210 220 230 240
190 200 210 220 230 240
pF1KB0 EQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWR
. :....: :..... .: :: :: . :..::...:..:: :: :.:::::.... :.
NP_001 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK
250 260 270 280 290 300
250 260 270 280 290 300
pF1KB0 NKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLV
. :::. :. . ::. .. .. : ::... ::. :. . . .:... ...:.:.:.::
NP_001 TTFDPKKTRMEPFHFKNS-VIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILV
310 320 330 340 350
310 320 330 340 350
pF1KB0 PT---HFEWNVSQVLANLSWDTLHPPLVWER--PTKVRLPKLYLKHQMDLVATLSQLGLQ
: : .. :.:. . .. : . :: . ::.. . ..:... . .: .
NP_001 PQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFF
360 370 380 390 400 410
360 370 380 390 400 410
pF1KB0 ELFQAPDLRGISEQ-SLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFL
.. .: :..:. .: ::..:::..:::.:.:::::::..:...: .: : :..:::
NP_001 DFSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVAR-TLLVFEVQQPFL
420 430 440 450 460 470
420 430 440 450 460 470
pF1KB0 FFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKL
: .... .:.:.: : .:
NP_001 FVLWDQQHKFPVFMGRVYDPRA
480 490 500
>>NP_001248760 (OMIM: 603357,615598) serpin B7 isoform 2 (363 aa)
initn: 263 init1: 85 opt: 466 Z-score: 513.8 bits: 104.1 E(85289): 7e-22
Smith-Waterman score: 466; 28.9% identity (63.5% similar) in 370 aa overlap (82-436:4-363)
60 70 80 90 100 110
pF1KB0 LGNQEPGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPL
:: : : .:: . ... :...: :
NP_001 MASLAAANAEFCFNLFREMDDNQGNGNVFFSSL
10 20 30
120 130 140 150 160 170
pF1KB0 SVALALSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKG
:. ::. . ::::. .:. :. ..: : ...: . . . .. .. .:
NP_001 SLFAALALVRLGAQDDSLS---QIDKSGLQSQLKRVFSDINASHKDYDLSIVNGLFAEKV
40 50 60 70 80 90
180 190 200 210 220
pF1KB0 FPIKEDFLEQSEQLFGAKP--VSLTGKQEDDLANINQWVKEATEGKIQEFLS--GLPEDT
. ...:..: .:.:. :: :..:.. :: :::.::.. :.:::.. .. :. ..
NP_001 YGFHKDYIECAEKLYDAKVERVDFTNHLEDTRRNINKWVENETHGKIKNVIGEGGISSSA
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB0 VLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMM-QARTYPLRWFLLEQPEIQ
:..:.::..:.: :.. : : : :. . : :: : : . : ..:.: ..
NP_001 VMVLVNAVYFKGKWQSAFTKSETINCHFKSPKCSGKAVAMMHQERKFNLS--VIEDPSMK
160 170 180 190 200
290 300 310 320 330 340
pF1KB0 VAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTL----HPPLVWERPTKVRLPKLYLK
. .. ....... ::.: : ..:.. .:....: .: . . ..: .:.. ..
NP_001 ILELRYNGGINMYVLLP---ENDLSEIENKLTFQNLMEWTNPRRMTSKYVEVFFPQFKIE
210 220 230 240 250 260
350 360 370 380 390
pF1KB0 HQMDLVATLSQLGLQELFQAP--DLRGI-SEQSLVVSGVQHQSTLELSEVGVEAAAAT--
..... : :::...:. :: :: : : .: ..:.: .:..: :.::.:::
NP_001 KNYEMKQYLRALGLKDIFDESKADLSGIASGGRLYISRMMHKSYIEVTEEGTEATAATGS
270 280 290 300 310 320
400 410 420 430 440 450
pF1KB0 SIAMSRMSLSS-FSVNRPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDF
.:. ... :. : ...:::: : .: . :: :.: :
NP_001 NIVEKQLPQSTLFRADHPFLFVIRKD--DIILFSGKVSCP
330 340 350 360
460 470 480 490
pF1KB0 LQSLKGFPRGDKLFGPDLKLVPPMEEDYPQFGSPK
491 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 22:30:51 2016 done: Sat Nov 5 22:30:53 2016
Total Scan time: 9.640 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]