Result of FASTA (omim) for
pFN21AA1417
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1417, 1353 aa
1>>>pF1KA1417 1353 - 1353 aa - 1353 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.7260+/-0.000537; mu= 11.5990+/- 0.033
mean_var=231.1872+/-48.548, 0's: 0 Z-trim(112.5): 208 B-trim: 313 in 1/55
Lambda= 0.084351
statistics sampled from 21267 (21485) to 21267 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.606), E-opt: 0.2 (0.252), width: 16
Scan time: 13.930
The best scores are: opt bits E(85289)
NP_056340 (OMIM: 606457) inhibitor of Bruton tyros (1353) 9010 1111.9 0
XP_006715516 (OMIM: 606457) PREDICTED: inhibitor o (1394) 8255 1020.0 0
NP_001287835 (OMIM: 606457) inhibitor of Bruton ty (1338) 6752 837.1 0
XP_006715517 (OMIM: 606457) PREDICTED: inhibitor o (1379) 6752 837.1 0
XP_016878186 (OMIM: 176270,227220,605837,615516) P (2556) 317 54.3 1.3e-05
XP_016878187 (OMIM: 176270,227220,605837,615516) P (2556) 317 54.3 1.3e-05
XP_011520435 (OMIM: 176270,227220,605837,615516) P (3749) 317 54.5 1.7e-05
XP_011520433 (OMIM: 176270,227220,605837,615516) P (4673) 317 54.6 1.9e-05
XP_006720790 (OMIM: 176270,227220,605837,615516) P (4748) 317 54.6 1.9e-05
XP_016878184 (OMIM: 176270,227220,605837,615516) P (4796) 317 54.6 2e-05
XP_016878185 (OMIM: 176270,227220,605837,615516) P (4796) 317 54.6 2e-05
XP_005268333 (OMIM: 176270,227220,605837,615516) P (4796) 317 54.6 2e-05
XP_006720789 (OMIM: 176270,227220,605837,615516) P (4829) 317 54.7 2e-05
NP_004658 (OMIM: 176270,227220,605837,615516) E3 u (4834) 317 54.7 2e-05
XP_011537899 (OMIM: 609248) PREDICTED: probable E3 ( 960) 302 52.0 2.4e-05
XP_011537897 (OMIM: 609248) PREDICTED: probable E3 (1011) 302 52.0 2.5e-05
XP_011537896 (OMIM: 609248) PREDICTED: probable E3 (1011) 302 52.0 2.5e-05
XP_011537895 (OMIM: 609248) PREDICTED: probable E3 (1073) 302 52.1 2.6e-05
XP_011537894 (OMIM: 609248) PREDICTED: probable E3 (1081) 302 52.1 2.6e-05
XP_016878195 (OMIM: 605109,617011) PREDICTED: prob (2792) 297 51.9 7.4e-05
NP_036271 (OMIM: 606051) secretion-regulating guan ( 458) 282 49.2 8.1e-05
XP_016871530 (OMIM: 609248) PREDICTED: probable E3 ( 936) 285 49.9 0.0001
NP_001265114 (OMIM: 609248) probable E3 ubiquitin- ( 979) 285 50.0 0.0001
XP_011537898 (OMIM: 609248) PREDICTED: probable E3 ( 987) 285 50.0 0.0001
NP_056416 (OMIM: 609248) probable E3 ubiquitin-pro (1049) 285 50.0 0.00011
NP_071362 (OMIM: 609248) probable E3 ubiquitin-pro (1057) 285 50.0 0.00011
NP_057407 (OMIM: 608242) E3 ISG15--protein ligase (1024) 283 49.7 0.00013
XP_011530324 (OMIM: 608242) PREDICTED: E3 ISG15--p (1100) 283 49.8 0.00013
NP_061185 (OMIM: 609587) protein RCC2 [Homo sapien ( 522) 276 48.5 0.00015
NP_001129676 (OMIM: 609587) protein RCC2 [Homo sap ( 522) 276 48.5 0.00015
NP_003913 (OMIM: 605109,617011) probable E3 ubiqui (4861) 275 49.5 0.00068
XP_016878194 (OMIM: 605109,617011) PREDICTED: prob (4883) 275 49.5 0.00069
XP_016878193 (OMIM: 605109,617011) PREDICTED: prob (4885) 275 49.5 0.00069
XP_016878192 (OMIM: 605109,617011) PREDICTED: prob (4891) 275 49.5 0.00069
XP_016878191 (OMIM: 605109,617011) PREDICTED: prob (4892) 275 49.5 0.00069
XP_016878190 (OMIM: 605109,617011) PREDICTED: prob (4892) 275 49.5 0.00069
XP_016878189 (OMIM: 605109,617011) PREDICTED: prob (4897) 275 49.5 0.00069
XP_016878188 (OMIM: 605109,617011) PREDICTED: prob (4909) 275 49.5 0.00069
NP_001305434 (OMIM: 605200) probable E3 ubiquitin- ( 368) 253 45.6 0.00081
XP_005263389 (OMIM: 605200) PREDICTED: probable E3 ( 896) 253 46.0 0.0015
XP_005263388 (OMIM: 605200) PREDICTED: probable E3 ( 903) 253 46.0 0.0015
XP_016864296 (OMIM: 605200) PREDICTED: probable E3 ( 924) 253 46.0 0.0015
NP_001258531 (OMIM: 605200) probable E3 ubiquitin- ( 932) 253 46.0 0.0015
XP_005263387 (OMIM: 605200) PREDICTED: probable E3 ( 993) 253 46.1 0.0016
XP_005263386 (OMIM: 605200) PREDICTED: probable E3 (1042) 253 46.1 0.0016
XP_016864295 (OMIM: 605200) PREDICTED: probable E3 (1042) 253 46.1 0.0016
XP_005263384 (OMIM: 605200) PREDICTED: probable E3 (1050) 253 46.1 0.0016
NP_055421 (OMIM: 605200) probable E3 ubiquitin-pro (1050) 253 46.1 0.0016
XP_016875866 (OMIM: 603524) PREDICTED: RCC1 and BT ( 285) 236 43.4 0.0029
NP_001316524 (OMIM: 608778,615081) kelch-like prot ( 608) 233 43.4 0.0061
>>NP_056340 (OMIM: 606457) inhibitor of Bruton tyrosine (1353 aa)
initn: 9010 init1: 9010 opt: 9010 Z-score: 5942.2 bits: 1111.9 E(85289): 0
Smith-Waterman score: 9010; 100.0% identity (100.0% similar) in 1353 aa overlap (1-1353:1-1353)
10 20 30 40 50 60
pF1KA1 MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA1 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA1 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLP
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA1 LLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLL
1270 1280 1290 1300 1310 1320
1330 1340 1350
pF1KA1 VFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC
:::::::::::::::::::::::::::::::::
NP_056 VFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC
1330 1340 1350
>>XP_006715516 (OMIM: 606457) PREDICTED: inhibitor of Br (1394 aa)
initn: 8255 init1: 8255 opt: 8255 Z-score: 5445.5 bits: 1020.0 E(85289): 0
Smith-Waterman score: 8837; 97.0% identity (97.0% similar) in 1385 aa overlap (1-1344:1-1385)
10 20 30 40 50 60
pF1KA1 MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA1 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240
pF1KA1 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVR------------------
::::::::::::::::::::::::::::::::::::::::::
XP_006 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRWSFVLVAQAGVQWLDLSS
1210 1220 1230 1240 1250 1260
1250 1260 1270
pF1KA1 -----------------------CSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMV
:::::::::::::::::::::::::::::::::::::
XP_006 PQPLPPGFKRFSCLRHPSSWDYRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMV
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KA1 APVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTP
1330 1340 1350 1360 1370 1380
1340 1350
pF1KA1 QGPLAVPMWNKHGC
:::::
XP_006 QGPLAVPMWNKHGC
1390
>>NP_001287835 (OMIM: 606457) inhibitor of Bruton tyrosi (1338 aa)
initn: 6752 init1: 6752 opt: 6752 Z-score: 4457.2 bits: 837.1 E(85289): 0
Smith-Waterman score: 8879; 98.9% identity (98.9% similar) in 1353 aa overlap (1-1353:1-1338)
10 20 30 40 50 60
pF1KA1 MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSST------------
970 980 990 1000
1030 1040 1050 1060 1070 1080
pF1KA1 SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ---ELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW
1010 1020 1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KA1 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KA1 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS
1130 1140 1150 1160 1170 1180
1210 1220 1230 1240 1250 1260
pF1KA1 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLP
1190 1200 1210 1220 1230 1240
1270 1280 1290 1300 1310 1320
pF1KA1 LLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLL
1250 1260 1270 1280 1290 1300
1330 1340 1350
pF1KA1 VFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC
:::::::::::::::::::::::::::::::::
NP_001 VFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC
1310 1320 1330
>>XP_006715517 (OMIM: 606457) PREDICTED: inhibitor of Br (1379 aa)
initn: 7500 init1: 6752 opt: 6752 Z-score: 4457.1 bits: 837.1 E(85289): 0
Smith-Waterman score: 8787; 96.0% identity (96.0% similar) in 1394 aa overlap (1-1353:1-1379)
10 20 30 40 50 60
pF1KA1 MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE
::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSST------------
970 980 990 1000
1030 1040 1050 1060 1070 1080
pF1KA1 SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ---ELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW
1010 1020 1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KA1 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KA1 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS
1130 1140 1150 1160 1170 1180
1210 1220 1230 1240
pF1KA1 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVR------------------
::::::::::::::::::::::::::::::::::::::::::
XP_006 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRWSFVLVAQAGVQWLDLSS
1190 1200 1210 1220 1230 1240
1250 1260 1270
pF1KA1 -----------------------CSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMV
:::::::::::::::::::::::::::::::::::::
XP_006 PQPLPPGFKRFSCLRHPSSWDYRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMV
1250 1260 1270 1280 1290 1300
1280 1290 1300 1310 1320 1330
pF1KA1 APVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTP
1310 1320 1330 1340 1350 1360
1340 1350
pF1KA1 QGPLAVPMWNKHGC
::::::::::::::
XP_006 QGPLAVPMWNKHGC
1370
>>XP_016878186 (OMIM: 176270,227220,605837,615516) PREDI (2556 aa)
initn: 212 init1: 212 opt: 317 Z-score: 221.7 bits: 54.3 E(85289): 1.3e-05
Smith-Waterman score: 353; 31.7% identity (60.4% similar) in 240 aa overlap (143-378:1781-2009)
120 130 140 150 160 170
pF1KA1 YIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLF
.::.::. . ::::... .:....
XP_016 TLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIE--
1760 1770 1780 1790 1800
180 190 200 210 220 230
pF1KA1 SRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCS
: :: . .:. ::. .. :..:: :.: :::::.: . : :.:::.:.::
XP_016 SLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVV
1810 1820 1830 1840 1850 1860
240 250 260 270 280 290
pF1KA1 QVAAAKD--HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVA
..: .. .:. ::.: :...: . . .:: ..:.:: .:.. : : .. :
XP_016 DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGR-GGSDGCKVPMKIDS--LTGLGVVKVE
1870 1880 1890 1900 1910 1920
300 310 320 330 340
pF1KA1 AG-RFHTVLWTREAVYTMGLNG-GQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAAS
: .: ..: :::: : . .:: : . : ::::..:. : . .:..
XP_016 CGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH----VRRPRQVQGLQGKKVIA--IATG
1930 1940 1950 1960 1970
350 360 370 380 390 400
pF1KA1 DGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICI
. :: : :..: .: . .... :
XP_016 SLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWS
1980 1990 2000 2010 2020 2030
>--
initn: 260 init1: 217 opt: 286 Z-score: 201.4 bits: 50.6 E(85289): 0.00018
Smith-Waterman score: 335; 30.6% identity (59.4% similar) in 288 aa overlap (144-424:790-1050)
120 130 140 150 160 170
pF1KA1 IQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFS
:..::.. . ::: :. . .:.:.. ..
XP_016 QITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALK
760 770 780 790 800 810
180 190 200 210 220 230
pF1KA1 RSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQ
. :.... . ::. :...:..:: : : :::::::. : : :..:. : :: :
XP_016 TK--RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQ
820 830 840 850 860 870
240 250 260 270 280 290
pF1KA1 VA-AAKD-HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAA
:: ...: .:..::..: :...: . : .:: .::.:..:. :.:. . .
XP_016 VACGSRDAQTLALTDEGLVFSWGDGDFGKLGR-GGSEGCNIPQNIE--RLNGQGVCQIEC
880 890 900 910 920 930
300 310 320 330 340 350
pF1KA1 G-RFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDG
: .: .: .:.: : .: . : ... : :. : .:. : : : .. :
XP_016 GAQFSLALTKSGVVWTWG-KGDYFR--LGHGSDVHVRKPQVVEGLRGKKI----VHVAVG
940 950 960 970 980
360 370 380 390 400
pF1KA1 ATVC--VTTRGDIYLLADYQCKKMA--SKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKI
: : :: :..: .: . ... . .: : .::.: .: ::::
XP_016 ALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQG--LE------------GQKI
990 1000 1010 1020 1030
410 420 430 440 450 460
pF1KA1 CILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFE
.: :... : .:.
XP_016 TRVAC-GSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDADSSAASNKISGA
1040 1050 1060 1070 1080 1090
>>XP_016878187 (OMIM: 176270,227220,605837,615516) PREDI (2556 aa)
initn: 212 init1: 212 opt: 317 Z-score: 221.7 bits: 54.3 E(85289): 1.3e-05
Smith-Waterman score: 353; 31.7% identity (60.4% similar) in 240 aa overlap (143-378:1781-2009)
120 130 140 150 160 170
pF1KA1 YIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLF
.::.::. . ::::... .:....
XP_016 TLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIE--
1760 1770 1780 1790 1800
180 190 200 210 220 230
pF1KA1 SRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCS
: :: . .:. ::. .. :..:: :.: :::::.: . : :.:::.:.::
XP_016 SLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVV
1810 1820 1830 1840 1850 1860
240 250 260 270 280 290
pF1KA1 QVAAAKD--HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVA
..: .. .:. ::.: :...: . . .:: ..:.:: .:.. : : .. :
XP_016 DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGR-GGSDGCKVPMKIDS--LTGLGVVKVE
1870 1880 1890 1900 1910 1920
300 310 320 330 340
pF1KA1 AG-RFHTVLWTREAVYTMGLNG-GQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAAS
: .: ..: :::: : . .:: : . : ::::..:. : . .:..
XP_016 CGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH----VRRPRQVQGLQGKKVIA--IATG
1930 1940 1950 1960 1970
350 360 370 380 390 400
pF1KA1 DGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICI
. :: : :..: .: . .... :
XP_016 SLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWS
1980 1990 2000 2010 2020 2030
>--
initn: 260 init1: 217 opt: 286 Z-score: 201.4 bits: 50.6 E(85289): 0.00018
Smith-Waterman score: 335; 30.6% identity (59.4% similar) in 288 aa overlap (144-424:790-1050)
120 130 140 150 160 170
pF1KA1 IQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFS
:..::.. . ::: :. . .:.:.. ..
XP_016 QITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALK
760 770 780 790 800 810
180 190 200 210 220 230
pF1KA1 RSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQ
. :.... . ::. :...:..:: : : :::::::. : : :..:. : :: :
XP_016 TK--RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQ
820 830 840 850 860 870
240 250 260 270 280 290
pF1KA1 VA-AAKD-HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAA
:: ...: .:..::..: :...: . : .:: .::.:..:. :.:. . .
XP_016 VACGSRDAQTLALTDEGLVFSWGDGDFGKLGR-GGSEGCNIPQNIE--RLNGQGVCQIEC
880 890 900 910 920 930
300 310 320 330 340 350
pF1KA1 G-RFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDG
: .: .: .:.: : .: . : ... : :. : .:. : : : .. :
XP_016 GAQFSLALTKSGVVWTWG-KGDYFR--LGHGSDVHVRKPQVVEGLRGKKI----VHVAVG
940 950 960 970 980
360 370 380 390 400
pF1KA1 ATVC--VTTRGDIYLLADYQCKKMA--SKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKI
: : :: :..: .: . ... . .: : .::.: .: ::::
XP_016 ALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQG--LE------------GQKI
990 1000 1010 1020 1030
410 420 430 440 450 460
pF1KA1 CILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFE
.: :... : .:.
XP_016 TRVAC-GSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDADSSAASNKISGA
1040 1050 1060 1070 1080 1090
>>XP_011520435 (OMIM: 176270,227220,605837,615516) PREDI (3749 aa)
initn: 212 init1: 212 opt: 317 Z-score: 219.8 bits: 54.5 E(85289): 1.7e-05
Smith-Waterman score: 353; 31.7% identity (60.4% similar) in 240 aa overlap (143-378:2974-3202)
120 130 140 150 160 170
pF1KA1 YIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLF
.::.::. . ::::... .:....
XP_011 TLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIE--
2950 2960 2970 2980 2990 3000
180 190 200 210 220 230
pF1KA1 SRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCS
: :: . .:. ::. .. :..:: :.: :::::.: . : :.:::.:.::
XP_011 SLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVV
3010 3020 3030 3040 3050 3060
240 250 260 270 280 290
pF1KA1 QVAAAKD--HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVA
..: .. .:. ::.: :...: . . .:: ..:.:: .:.. : : .. :
XP_011 DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGR-GGSDGCKVPMKIDS--LTGLGVVKVE
3070 3080 3090 3100 3110
300 310 320 330 340
pF1KA1 AG-RFHTVLWTREAVYTMGLNG-GQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAAS
: .: ..: :::: : . .:: : . : ::::..:. : . .:..
XP_011 CGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH----VRRPRQVQGLQGKKVIA--IATG
3120 3130 3140 3150 3160 3170
350 360 370 380 390 400
pF1KA1 DGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICI
. :: : :..: .: . .... :
XP_011 SLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWS
3180 3190 3200 3210 3220 3230
>--
initn: 260 init1: 217 opt: 286 Z-score: 199.4 bits: 50.8 E(85289): 0.00023
Smith-Waterman score: 335; 30.6% identity (59.4% similar) in 288 aa overlap (144-424:1983-2243)
120 130 140 150 160 170
pF1KA1 IQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFS
:..::.. . ::: :. . .:.:.. ..
XP_011 QITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALK
1960 1970 1980 1990 2000 2010
180 190 200 210 220 230
pF1KA1 RSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQ
. :.... . ::. :...:..:: : : :::::::. : : :..:. : :: :
XP_011 TK--RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQ
2020 2030 2040 2050 2060 2070
240 250 260 270 280 290
pF1KA1 VA-AAKD-HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAA
:: ...: .:..::..: :...: . : .:: .::.:..:. :.:. . .
XP_011 VACGSRDAQTLALTDEGLVFSWGDGDFGKLGR-GGSEGCNIPQNIE--RLNGQGVCQIEC
2080 2090 2100 2110 2120
300 310 320 330 340 350
pF1KA1 G-RFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDG
: .: .: .:.: : .: . : ... : :. : .:. : : : .. :
XP_011 GAQFSLALTKSGVVWTWG-KGDYFR--LGHGSDVHVRKPQVVEGLRGKKI----VHVAVG
2130 2140 2150 2160 2170 2180
360 370 380 390 400
pF1KA1 ATVC--VTTRGDIYLLADYQCKKMA--SKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKI
: : :: :..: .: . ... . .: : .::.: .: ::::
XP_011 ALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQG--LE------------GQKI
2190 2200 2210 2220
410 420 430 440 450 460
pF1KA1 CILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFE
.: :... : .:.
XP_011 TRVAC-GSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDADSSAASNKISGA
2230 2240 2250 2260 2270 2280
>>XP_011520433 (OMIM: 176270,227220,605837,615516) PREDI (4673 aa)
initn: 212 init1: 212 opt: 317 Z-score: 218.7 bits: 54.6 E(85289): 1.9e-05
Smith-Waterman score: 353; 31.7% identity (60.4% similar) in 240 aa overlap (143-378:3898-4126)
120 130 140 150 160 170
pF1KA1 YIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLF
.::.::. . ::::... .:....
XP_011 TLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIE--
3870 3880 3890 3900 3910 3920
180 190 200 210 220 230
pF1KA1 SRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCS
: :: . .:. ::. .. :..:: :.: :::::.: . : :.:::.:.::
XP_011 SLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVV
3930 3940 3950 3960 3970 3980
240 250 260 270 280 290
pF1KA1 QVAAAKD--HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVA
..: .. .:. ::.: :...: . . .:: ..:.:: .:.. : : .. :
XP_011 DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGR-GGSDGCKVPMKIDS--LTGLGVVKVE
3990 4000 4010 4020 4030 4040
300 310 320 330 340
pF1KA1 AG-RFHTVLWTREAVYTMGLNG-GQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAAS
: .: ..: :::: : . .:: : . : ::::..:. : . .:..
XP_011 CGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH----VRRPRQVQGLQGKKVIA--IATG
4050 4060 4070 4080 4090
350 360 370 380 390 400
pF1KA1 DGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICI
. :: : :..: .: . .... :
XP_011 SLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWS
4100 4110 4120 4130 4140 4150
>>XP_006720790 (OMIM: 176270,227220,605837,615516) PREDI (4748 aa)
initn: 212 init1: 212 opt: 317 Z-score: 218.6 bits: 54.6 E(85289): 1.9e-05
Smith-Waterman score: 353; 31.7% identity (60.4% similar) in 240 aa overlap (143-378:3973-4201)
120 130 140 150 160 170
pF1KA1 YIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLF
.::.::. . ::::... .:....
XP_006 TLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIE--
3950 3960 3970 3980 3990 4000
180 190 200 210 220 230
pF1KA1 SRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCS
: :: . .:. ::. .. :..:: :.: :::::.: . : :.:::.:.::
XP_006 SLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVV
4010 4020 4030 4040 4050 4060
240 250 260 270 280 290
pF1KA1 QVAAAKD--HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVA
..: .. .:. ::.: :...: . . .:: ..:.:: .:.. : : .. :
XP_006 DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGR-GGSDGCKVPMKIDS--LTGLGVVKVE
4070 4080 4090 4100 4110
300 310 320 330 340
pF1KA1 AG-RFHTVLWTREAVYTMGLNG-GQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAAS
: .: ..: :::: : . .:: : . : ::::..:. : . .:..
XP_006 CGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH----VRRPRQVQGLQGKKVIA--IATG
4120 4130 4140 4150 4160 4170
350 360 370 380 390 400
pF1KA1 DGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICI
. :: : :..: .: . .... :
XP_006 SLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWS
4180 4190 4200 4210 4220 4230
>>XP_016878184 (OMIM: 176270,227220,605837,615516) PREDI (4796 aa)
initn: 212 init1: 212 opt: 317 Z-score: 218.5 bits: 54.6 E(85289): 2e-05
Smith-Waterman score: 353; 31.7% identity (60.4% similar) in 240 aa overlap (143-378:4021-4249)
120 130 140 150 160 170
pF1KA1 YIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLF
.::.::. . ::::... .:....
XP_016 TLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIE--
4000 4010 4020 4030 4040
180 190 200 210 220 230
pF1KA1 SRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCS
: :: . .:. ::. .. :..:: :.: :::::.: . : :.:::.:.::
XP_016 SLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVV
4050 4060 4070 4080 4090 4100
240 250 260 270 280 290
pF1KA1 QVAAAKD--HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVA
..: .. .:. ::.: :...: . . .:: ..:.:: .:.. : : .. :
XP_016 DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGR-GGSDGCKVPMKIDS--LTGLGVVKVE
4110 4120 4130 4140 4150 4160
300 310 320 330 340
pF1KA1 AG-RFHTVLWTREAVYTMGLNG-GQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAAS
: .: ..: :::: : . .:: : . : ::::..:. : . .:..
XP_016 CGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH----VRRPRQVQGLQGKKVIA--IATG
4170 4180 4190 4200 4210
350 360 370 380 390 400
pF1KA1 DGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICI
. :: : :..: .: . .... :
XP_016 SLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWS
4220 4230 4240 4250 4260 4270
1353 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 14:37:23 2016 done: Mon Nov 7 14:37:25 2016
Total Scan time: 13.930 Total Display time: 0.540
Function used was FASTA [36.3.4 Apr, 2011]