Result of FASTA (omim) for
pFN21AA0300
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0300, 2839 aa
1>>>pF1KA0300 2839 - 2839 aa - 2839 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.4992+/-0.000511; mu= 3.2650+/- 0.032
mean_var=342.0511+/-74.059, 0's: 0 Z-trim(118.8): 261 B-trim: 1828 in 2/55
Lambda= 0.069347
statistics sampled from 31807 (32083) to 31807 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.692), E-opt: 0.2 (0.376), width: 16
Scan time: 25.650
The best scores are: opt bits E(85289)
NP_835260 (OMIM: 610697) PDZ domain-containing pro (2839) 18766 1894.0 0
XP_011512297 (OMIM: 610697) PREDICTED: PDZ domain- (2839) 18766 1894.0 0
XP_011512295 (OMIM: 610697) PREDICTED: PDZ domain- (2873) 18116 1829.0 0
XP_005248326 (OMIM: 610697) PREDICTED: PDZ domain- (2873) 18116 1829.0 0
XP_011512294 (OMIM: 610697) PREDICTED: PDZ domain- (2873) 18116 1829.0 0
XP_005248328 (OMIM: 610697) PREDICTED: PDZ domain- (2699) 16926 1709.9 0
XP_005248329 (OMIM: 610697) PREDICTED: PDZ domain- (2699) 16926 1709.9 0
XP_006714523 (OMIM: 610697) PREDICTED: PDZ domain- (2542) 15598 1577.0 0
XP_016864735 (OMIM: 610697) PREDICTED: PDZ domain- (2542) 15598 1577.0 0
XP_016864734 (OMIM: 610697) PREDICTED: PDZ domain- (2607) 15326 1549.8 0
XP_011512298 (OMIM: 610697) PREDICTED: PDZ domain- (2781) 15326 1549.8 0
XP_011512296 (OMIM: 610697) PREDICTED: PDZ domain- (2861) 9954 1012.4 0
XP_016877634 (OMIM: 603035) PREDICTED: pro-interle (1050) 807 96.9 1.8e-18
XP_011519821 (OMIM: 603035) PREDICTED: pro-interle (1271) 807 96.9 2e-18
XP_016877629 (OMIM: 603035) PREDICTED: pro-interle (1290) 807 96.9 2.1e-18
XP_016877631 (OMIM: 603035) PREDICTED: pro-interle (1331) 807 96.9 2.1e-18
NP_001165599 (OMIM: 603035) pro-interleukin-16 iso (1331) 807 96.9 2.1e-18
XP_011519822 (OMIM: 603035) PREDICTED: pro-interle (1332) 807 96.9 2.1e-18
XP_016877630 (OMIM: 603035) PREDICTED: pro-interle (1332) 807 96.9 2.1e-18
NP_757366 (OMIM: 603035) pro-interleukin-16 isofor (1332) 807 96.9 2.1e-18
XP_005254399 (OMIM: 603035) PREDICTED: pro-interle (1379) 807 97.0 2.2e-18
XP_016877633 (OMIM: 603035) PREDICTED: pro-interle (1162) 798 96.0 3.6e-18
XP_016877632 (OMIM: 603035) PREDICTED: pro-interle (1179) 798 96.0 3.6e-18
XP_005254403 (OMIM: 603035) PREDICTED: pro-interle ( 631) 688 84.7 4.7e-15
NP_004504 (OMIM: 603035) pro-interleukin-16 isofor ( 631) 688 84.7 4.7e-15
XP_016877635 (OMIM: 603035) PREDICTED: pro-interle ( 720) 688 84.8 5.2e-15
XP_011536691 (OMIM: 601234) PREDICTED: nascent pol (2078) 336 50.0 0.00045
XP_006719477 (OMIM: 601234) PREDICTED: nascent pol (2082) 336 50.0 0.00045
XP_006719475 (OMIM: 601234) PREDICTED: nascent pol (2082) 336 50.0 0.00045
XP_006719476 (OMIM: 601234) PREDICTED: nascent pol (2082) 336 50.0 0.00045
>>NP_835260 (OMIM: 610697) PDZ domain-containing protein (2839 aa)
initn: 18766 init1: 18766 opt: 18766 Z-score: 10157.5 bits: 1894.0 E(85289): 0
Smith-Waterman score: 18766; 100.0% identity (100.0% similar) in 2839 aa overlap (1-2839:1-2839)
10 20 30 40 50 60
pF1KA0 MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQKLQEYIQLNFAVDESTVPPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQKLQEYIQLNFAVDESTVPPD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HSPPEMEICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 HSPPEMEICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 VTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 HKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 HKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 EVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 EVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 LTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 LTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 SAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 SAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 GAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 GAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 PKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 PKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 SPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 SPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 GSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 GSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 KVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 KVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEER
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 PRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 PRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 SSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 SSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 QTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 QTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELAS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 ALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 ALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 RPENPSQPASPRVAKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRV
:::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::
NP_835 RPENPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRV
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 AALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 AALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLE
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 GADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 GADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAAR
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 SPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 SPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQ
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA0 PSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 PSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSS
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA0 DPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 DPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQ
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA0 AAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 AAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHA
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KA0 DISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 DISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLD
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KA0 DETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 DETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMA
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KA0 WFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 WFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLEN
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KA0 KDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 KDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISP
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KA0 QTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 QTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIR
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KA0 TFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 TFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAA
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KA0 SRNGMSVAGNRQSEPRLASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 SRNGMSVAGNRQSEPRLASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAV
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KA0 SETVCGNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 SETVCGNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSR
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KA0 SFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 SFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPAT
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KA0 RTYSMPAQFSSHFGREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 RTYSMPAQFSSHFGREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSV
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KA0 KPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 KPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIK
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KA0 SFENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 SFENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSC
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KA0 SENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 SENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLAS
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KA0 PVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 PVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRR
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KA0 SPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 SPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQL
2530 2540 2550 2560 2570 2580
2590 2600 2610 2620 2630 2640
pF1KA0 LVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 LVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGG
2590 2600 2610 2620 2630 2640
2650 2660 2670 2680 2690 2700
pF1KA0 TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDA
2650 2660 2670 2680 2690 2700
2710 2720 2730 2740 2750 2760
pF1KA0 LVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 LVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGL
2710 2720 2730 2740 2750 2760
2770 2780 2790 2800 2810 2820
pF1KA0 GLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 GLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIM
2770 2780 2790 2800 2810 2820
2830
pF1KA0 KSVPEGPVQLLIRKHRNSS
:::::::::::::::::::
NP_835 KSVPEGPVQLLIRKHRNSS
2830
>>XP_011512297 (OMIM: 610697) PREDICTED: PDZ domain-cont (2839 aa)
initn: 18766 init1: 18766 opt: 18766 Z-score: 10157.5 bits: 1894.0 E(85289): 0
Smith-Waterman score: 18766; 100.0% identity (100.0% similar) in 2839 aa overlap (1-2839:1-2839)
10 20 30 40 50 60
pF1KA0 MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQKLQEYIQLNFAVDESTVPPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQKLQEYIQLNFAVDESTVPPD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HSPPEMEICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSPPEMEICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 HKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 EVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 LTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 SAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 GAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 PKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 SPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 GSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 KVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEER
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 PRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 SSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 QTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELAS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 ALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 RPENPSQPASPRVAKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRV
:::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPENPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRV
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 AALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLE
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 GADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAAR
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 SPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQ
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA0 PSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSS
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA0 DPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQ
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA0 AAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHA
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KA0 DISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLD
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KA0 DETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMA
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KA0 WFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLEN
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KA0 KDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISP
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KA0 QTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIR
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KA0 TFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAA
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KA0 SRNGMSVAGNRQSEPRLASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRNGMSVAGNRQSEPRLASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAV
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KA0 SETVCGNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SETVCGNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSR
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KA0 SFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPAT
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KA0 RTYSMPAQFSSHFGREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTYSMPAQFSSHFGREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSV
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KA0 KPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIK
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KA0 SFENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSC
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KA0 SENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLAS
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KA0 PVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRR
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KA0 SPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQL
2530 2540 2550 2560 2570 2580
2590 2600 2610 2620 2630 2640
pF1KA0 LVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGG
2590 2600 2610 2620 2630 2640
2650 2660 2670 2680 2690 2700
pF1KA0 TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDA
2650 2660 2670 2680 2690 2700
2710 2720 2730 2740 2750 2760
pF1KA0 LVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGL
2710 2720 2730 2740 2750 2760
2770 2780 2790 2800 2810 2820
pF1KA0 GLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIM
2770 2780 2790 2800 2810 2820
2830
pF1KA0 KSVPEGPVQLLIRKHRNSS
:::::::::::::::::::
XP_011 KSVPEGPVQLLIRKHRNSS
2830
>>XP_011512295 (OMIM: 610697) PREDICTED: PDZ domain-cont (2873 aa)
initn: 18116 init1: 18116 opt: 18116 Z-score: 9805.9 bits: 1829.0 E(85289): 0
Smith-Waterman score: 18668; 98.8% identity (98.8% similar) in 2871 aa overlap (1-2837:1-2871)
10 20 30 40 50 60
pF1KA0 MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQKLQEYIQLNFAVDESTVPPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQKLQEYIQLNFAVDESTVPPD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HSPPEMEICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSPPEMEICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 HKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 EVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 LTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 SAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 GAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 PKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 SPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 GSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 KVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEER
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 PRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 SSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 QTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELAS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 ALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 RPENPSQPASPRVAKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRV
:::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPENPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRV
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 AALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLE
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 GADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAAR
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 SPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQ
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA0 PSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSS
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA0 DPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQ
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA0 AAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHA
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KA0 DISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLD
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KA0 DETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMA
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KA0 WFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLEN
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KA0 KDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISP
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KA0 QTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIR
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KA0 TFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAA
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KA0 SRNGMSVAGNRQSEPRLASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRNGMSVAGNRQSEPRLASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAV
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KA0 SETVCGNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SETVCGNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSR
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KA0 SFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPAT
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KA0 RTYSMPAQFSSHFGREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTYSMPAQFSSHFGREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSV
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KA0 KPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIK
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KA0 SFENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSC
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KA0 SENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLAS
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KA0 PVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRR
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KA0 SPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQL
2530 2540 2550 2560 2570 2580
2590 2600 2610 2620 2630 2640
pF1KA0 LVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGG
2590 2600 2610 2620 2630 2640
2650 2660 2670 2680 2690 2700
pF1KA0 TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDA
2650 2660 2670 2680 2690 2700
2710 2720 2730 2740
pF1KA0 LVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGI----------------G----
::::::::::::::::::::::::::::::::::::::: :
XP_011 LVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIENTEQRMQVQQQHSQEGSPRI
2710 2720 2730 2740 2750 2760
2750 2760 2770 2780
pF1KA0 --------------RSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGG
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRPTVLLGSSAVIRRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGG
2770 2780 2790 2800 2810 2820
2790 2800 2810 2820 2830
pF1KA0 AAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNSS
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNSS
2830 2840 2850 2860 2870
>>XP_005248326 (OMIM: 610697) PREDICTED: PDZ domain-cont (2873 aa)
initn: 18116 init1: 18116 opt: 18116 Z-score: 9805.9 bits: 1829.0 E(85289): 0
Smith-Waterman score: 18668; 98.8% identity (98.8% similar) in 2871 aa overlap (1-2837:1-2871)
10 20 30 40 50 60
pF1KA0 MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQKLQEYIQLNFAVDESTVPPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQKLQEYIQLNFAVDESTVPPD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HSPPEMEICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HSPPEMEICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 HKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 EVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 LTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 SAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 GAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 PKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 SPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 GSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 KVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEER
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 PRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 SSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 QTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELAS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 ALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 RPENPSQPASPRVAKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRV
:::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RPENPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRV
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 AALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLE
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 GADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAAR
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 SPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQ
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA0 PSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSS
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA0 DPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQ
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA0 AAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHA
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KA0 DISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLD
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KA0 DETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMA
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KA0 WFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLEN
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KA0 KDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISP
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KA0 QTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIR
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KA0 TFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAA
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KA0 SRNGMSVAGNRQSEPRLASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRNGMSVAGNRQSEPRLASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAV
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KA0 SETVCGNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SETVCGNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSR
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KA0 SFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPAT
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KA0 RTYSMPAQFSSHFGREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTYSMPAQFSSHFGREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSV
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KA0 KPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIK
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KA0 SFENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSC
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KA0 SENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLAS
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KA0 PVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRR
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KA0 SPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQL
2530 2540 2550 2560 2570 2580
2590 2600 2610 2620 2630 2640
pF1KA0 LVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGG
2590 2600 2610 2620 2630 2640
2650 2660 2670 2680 2690 2700
pF1KA0 TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDA
2650 2660 2670 2680 2690 2700
2710 2720 2730 2740
pF1KA0 LVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGI----------------G----
::::::::::::::::::::::::::::::::::::::: :
XP_005 LVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIENTEQRMQVQQQHSQEGSPRI
2710 2720 2730 2740 2750 2760
2750 2760 2770 2780
pF1KA0 --------------RSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGG
::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRPTVLLGSSAVIRRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGG
2770 2780 2790 2800 2810 2820
2790 2800 2810 2820 2830
pF1KA0 AAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNSS
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNSS
2830 2840 2850 2860 2870
>>XP_011512294 (OMIM: 610697) PREDICTED: PDZ domain-cont (2873 aa)
initn: 18116 init1: 18116 opt: 18116 Z-score: 9805.9 bits: 1829.0 E(85289): 0
Smith-Waterman score: 18668; 98.8% identity (98.8% similar) in 2871 aa overlap (1-2837:1-2871)
10 20 30 40 50 60
pF1KA0 MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQKLQEYIQLNFAVDESTVPPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQKLQEYIQLNFAVDESTVPPD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HSPPEMEICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSPPEMEICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 HKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 EVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 LTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 SAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 GAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 PKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 SPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 GSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 KVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEER
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 PRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 SSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 QTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELAS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 ALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 RPENPSQPASPRVAKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRV
:::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPENPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRV
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 AALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLE
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 GADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAAR
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 SPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQ
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA0 PSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSS
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA0 DPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQ
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA0 AAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHA
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KA0 DISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLD
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KA0 DETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMA
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KA0 WFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLEN
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KA0 KDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISP
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KA0 QTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIR
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KA0 TFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAA
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KA0 SRNGMSVAGNRQSEPRLASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRNGMSVAGNRQSEPRLASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAV
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KA0 SETVCGNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SETVCGNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSR
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KA0 SFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPAT
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KA0 RTYSMPAQFSSHFGREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTYSMPAQFSSHFGREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSV
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KA0 KPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIK
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KA0 SFENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSC
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KA0 SENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLAS
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KA0 PVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRR
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KA0 SPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQL
2530 2540 2550 2560 2570 2580
2590 2600 2610 2620 2630 2640
pF1KA0 LVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGG
2590 2600 2610 2620 2630 2640
2650 2660 2670 2680 2690 2700
pF1KA0 TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDA
2650 2660 2670 2680 2690 2700
2710 2720 2730 2740
pF1KA0 LVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGI----------------G----
::::::::::::::::::::::::::::::::::::::: :
XP_011 LVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIENTEQRMQVQQQHSQEGSPRI
2710 2720 2730 2740 2750 2760
2750 2760 2770 2780
pF1KA0 --------------RSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGG
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRPTVLLGSSAVIRRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGG
2770 2780 2790 2800 2810 2820
2790 2800 2810 2820 2830
pF1KA0 AAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNSS
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNSS
2830 2840 2850 2860 2870
>>XP_005248328 (OMIM: 610697) PREDICTED: PDZ domain-cont (2699 aa)
initn: 16926 init1: 16926 opt: 16926 Z-score: 9162.9 bits: 1709.9 E(85289): 0
Smith-Waterman score: 17478; 98.7% identity (98.7% similar) in 2697 aa overlap (175-2837:1-2697)
150 160 170 180 190 200
pF1KA0 LNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFKHKAHSTYNGNSSNSSEPGETPTLE
::::::::::::::::::::::::::::::
XP_005 MLRRFKHKAHSTYNGNSSNSSEPGETPTLE
10 20 30
210 220 230 240 250 260
pF1KA0 LGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGCEVSSDPSTELENGPDPELGNGHVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGCEVSSDPSTELENGPDPELGNGHVF
40 50 60 70 80 90
270 280 290 300 310 320
pF1KA0 QLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCL
100 110 120 130 140 150
330 340 350 360 370 380
pF1KA0 AREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDEL
160 170 180 190 200 210
390 400 410 420 430 440
pF1KA0 LVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVS
220 230 240 250 260 270
450 460 470 480 490 500
pF1KA0 SWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSR
280 290 300 310 320 330
510 520 530 540 550 560
pF1KA0 LSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKST
340 350 360 370 380 390
570 580 590 600 610 620
pF1KA0 RSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGS
400 410 420 430 440 450
630 640 650 660 670 680
pF1KA0 AAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTP
460 470 480 490 500 510
690 700 710 720 730 740
pF1KA0 THMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 THMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGAC
520 530 540 550 560 570
750 760 770 780 790 800
pF1KA0 CLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPG
580 590 600 610 620 630
810 820 830 840 850 860
pF1KA0 PVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKKDSLISESE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKKDSLISESE
640 650 660 670 680 690
870 880 890 900 910 920
pF1KA0 LSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHKEPGKPRANSLVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHKEPGKPRANSLVTL
700 710 720 730 740 750
930 940 950 960 970 980
pF1KA0 GSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQRKVGCYDANDASDEEEFDREGDCIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQRKVGCYDANDASDEEEFDREGDCIS
760 770 780 790 800 810
990 1000 1010 1020 1030 1040
pF1KA0 LPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAISAPLLGSSVDLEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAISAPLLGSSVDLEES
820 830 840 850 860 870
1050 1060 1070 1080 1090 1100
pF1KA0 IPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRTDTQSPTNTGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRTDTQSPTNTGSP
880 890 900 910 920 930
1110 1120 1130 1140 1150 1160
pF1KA0 SSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLDSRVQATSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLDSRVQATSV
940 950 960 970 980 990
1170 1180 1190 1200 1210 1220
pF1KA0 KVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELASALSHLDASHLTENLPKAASELGQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELASALSHLDASHLTENLPKAASELGQQ
1000 1010 1020 1030 1040 1050
1230 1240 1250 1260 1270 1280
pF1KA0 PMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVSRPENPSQPASPRVAKCKARSPVRL
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
XP_005 PMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVSRPENPSQPASPRVTKCKARSPVRL
1060 1070 1080 1090 1100 1110
1290 1300 1310 1320 1330 1340
pF1KA0 PHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRVAALRGAGPGAEGMTPAGAVLPGDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRVAALRGAGPGAEGMTPAGAVLPGDP
1120 1130 1140 1150 1160 1170
1350 1360 1370 1380 1390 1400
pF1KA0 LTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLEGADSVSSRAPQASLSMLPSTDNTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLEGADSVSSRAPQASLSMLPSTDNTK
1180 1190 1200 1210 1220 1230
1410 1420 1430 1440 1450 1460
pF1KA0 EACGHVSGHCCPGGSRESPVTDIDSFIKELDASAARSPSSQTGDSGSQEGSAQGHPPAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EACGHVSGHCCPGGSRESPVTDIDSFIKELDASAARSPSSQTGDSGSQEGSAQGHPPAGA
1240 1250 1260 1270 1280 1290
1470 1480 1490 1500 1510 1520
pF1KA0 GGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQPSVLDSINPDKHFTVNKNFLSNYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQPSVLDSINPDKHFTVNKNFLSNYS
1300 1310 1320 1330 1340 1350
1530 1540 1550 1560 1570 1580
pF1KA0 RNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPESLTEAPRASARDGWSPPRSRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPESLTEAPRASARDGWSPPRSRV
1360 1370 1380 1390 1400 1410
1590 1600 1610 1620 1630 1640
pF1KA0 SLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPASAKVLSLKYSTPRESVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPASAKVLSLKYSTPRESVAS
1420 1430 1440 1450 1460 1470
1650 1660 1670 1680 1690 1700
pF1KA0 PREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHRPSCAEETTEVTSASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHRPSCAEETTEVTSASS
1480 1490 1500 1510 1520 1530
1710 1720 1730 1740 1750 1760
pF1KA0 AMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAASLSSFSVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAASLSSFSVDV
1540 1550 1560 1570 1580 1590
1770 1780 1790 1800 1810 1820
pF1KA0 PKNGESVLENLHISESQDLDDLLQKPKMIARRPIMAWFKEINKHNQGTHLRSKTEKEQPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PKNGESVLENLHISESQDLDDLLQKPKMIARRPIMAWFKEINKHNQGTHLRSKTEKEQPL
1600 1610 1620 1630 1640 1650
1830 1840 1850 1860 1870 1880
pF1KA0 MPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLSKKSPAEMLLTNGQKAKCGPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLSKKSPAEMLLTNGQKAKCGPK
1660 1670 1680 1690 1700 1710
1890 1900 1910 1920 1930 1940
pF1KA0 LKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQTSHKTLSKAVSQRLHVADHEDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQTSHKTLSKAVSQRLHVADHEDPD
1720 1730 1740 1750 1760 1770
1950 1960 1970 1980 1990 2000
pF1KA0 RNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIRTFVSPLTSPKPVPEQGMWSRFHMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIRTFVSPLTSPKPVPEQGMWSRFHMA
1780 1790 1800 1810 1820 1830
2010 2020 2030 2040 2050 2060
pF1KA0 VLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAASRNGMSVAGNRQSEPRLASHVAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAASRNGMSVAGNRQSEPRLASHVAAD
1840 1850 1860 1870 1880 1890
2070 2080 2090 2100 2110 2120
pF1KA0 TAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAVSETVCGNKPAESDRRGGCLAQGNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAVSETVCGNKPAESDRRGGCLAQGNC
1900 1910 1920 1930 1940 1950
2130 2140 2150 2160 2170 2180
pF1KA0 QEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSRSFSMAKLASSSSSLQTAIRKAEYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSRSFSMAKLASSSSSLQTAIRKAEYS
1960 1970 1980 1990 2000 2010
2190 2200 2210 2220 2230 2240
pF1KA0 QGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSMPAQFSSHFGREGHPPHSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSMPAQFSSHFGREGHPPHSLG
2020 2030 2040 2050 2060 2070
2250 2260 2270 2280 2290 2300
pF1KA0 RSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSVKPLLDTSRNLPATDEGDIISVQET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSVKPLLDTSRNLPATDEGDIISVQET
2080 2090 2100 2110 2120 2130
2310 2320 2330 2340 2350 2360
pF1KA0 SCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSFENLANADRPVAKSGASPFLSVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSFENLANADRPVAKSGASPFLSVS
2140 2150 2160 2170 2180 2190
2370 2380 2390 2400 2410 2420
pF1KA0 SKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCSENQSEAGTLLPQMAKSPSIMTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCSENQSEAGTLLPQMAKSPSIMTLT
2200 2210 2220 2230 2240 2250
2430 2440 2450 2460 2470 2480
pF1KA0 ISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSPVSRSKLQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSPVSRSKLQE
2260 2270 2280 2290 2300 2310
2490 2500 2510 2520 2530 2540
pF1KA0 LRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSPGPPAGGVSCPEKGGNRACPGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSPGPPAGGVSCPEKGGNRACPGGS
2320 2330 2340 2350 2360 2370
2550 2560 2570 2580 2590 2600
pF1KA0 GPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQLLVSAGDQQRLQSVLSSVGSKSTIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQLLVSAGDQQRLQSVLSSVGSKSTIL
2380 2390 2400 2410 2420 2430
2610 2620 2630 2640 2650 2660
pF1KA0 TLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGT
2440 2450 2460 2470 2480 2490
2670 2680 2690 2700 2710 2720
pF1KA0 MNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANG
2500 2510 2520 2530 2540 2550
2730 2740 2750
pF1KA0 KGLLSRKTIPLEPGI----------------G------------------RSVAVHDALC
::::::::::::::: : ::::::::::
XP_005 KGLLSRKTIPLEPGIENTEQRMQVQQQHSQEGSPRIGRPTVLLGSSAVIRRSVAVHDALC
2560 2570 2580 2590 2600 2610
2760 2770 2780 2790 2800 2810
pF1KA0 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG
2620 2630 2640 2650 2660 2670
2820 2830
pF1KA0 LMHFDAWNIMKSVPEGPVQLLIRKHRNSS
:::::::::::::::::::::::::::
XP_005 LMHFDAWNIMKSVPEGPVQLLIRKHRNSS
2680 2690
>>XP_005248329 (OMIM: 610697) PREDICTED: PDZ domain-cont (2699 aa)
initn: 16926 init1: 16926 opt: 16926 Z-score: 9162.9 bits: 1709.9 E(85289): 0
Smith-Waterman score: 17478; 98.7% identity (98.7% similar) in 2697 aa overlap (175-2837:1-2697)
150 160 170 180 190 200
pF1KA0 LNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFKHKAHSTYNGNSSNSSEPGETPTLE
::::::::::::::::::::::::::::::
XP_005 MLRRFKHKAHSTYNGNSSNSSEPGETPTLE
10 20 30
210 220 230 240 250 260
pF1KA0 LGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGCEVSSDPSTELENGPDPELGNGHVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGCEVSSDPSTELENGPDPELGNGHVF
40 50 60 70 80 90
270 280 290 300 310 320
pF1KA0 QLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCL
100 110 120 130 140 150
330 340 350 360 370 380
pF1KA0 AREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDEL
160 170 180 190 200 210
390 400 410 420 430 440
pF1KA0 LVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVS
220 230 240 250 260 270
450 460 470 480 490 500
pF1KA0 SWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSR
280 290 300 310 320 330
510 520 530 540 550 560
pF1KA0 LSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKST
340 350 360 370 380 390
570 580 590 600 610 620
pF1KA0 RSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGS
400 410 420 430 440 450
630 640 650 660 670 680
pF1KA0 AAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTP
460 470 480 490 500 510
690 700 710 720 730 740
pF1KA0 THMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 THMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGAC
520 530 540 550 560 570
750 760 770 780 790 800
pF1KA0 CLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPG
580 590 600 610 620 630
810 820 830 840 850 860
pF1KA0 PVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKKDSLISESE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKKDSLISESE
640 650 660 670 680 690
870 880 890 900 910 920
pF1KA0 LSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHKEPGKPRANSLVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHKEPGKPRANSLVTL
700 710 720 730 740 750
930 940 950 960 970 980
pF1KA0 GSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQRKVGCYDANDASDEEEFDREGDCIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQRKVGCYDANDASDEEEFDREGDCIS
760 770 780 790 800 810
990 1000 1010 1020 1030 1040
pF1KA0 LPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAISAPLLGSSVDLEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAISAPLLGSSVDLEES
820 830 840 850 860 870
1050 1060 1070 1080 1090 1100
pF1KA0 IPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRTDTQSPTNTGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRTDTQSPTNTGSP
880 890 900 910 920 930
1110 1120 1130 1140 1150 1160
pF1KA0 SSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLDSRVQATSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLDSRVQATSV
940 950 960 970 980 990
1170 1180 1190 1200 1210 1220
pF1KA0 KVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELASALSHLDASHLTENLPKAASELGQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELASALSHLDASHLTENLPKAASELGQQ
1000 1010 1020 1030 1040 1050
1230 1240 1250 1260 1270 1280
pF1KA0 PMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVSRPENPSQPASPRVAKCKARSPVRL
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
XP_005 PMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVSRPENPSQPASPRVTKCKARSPVRL
1060 1070 1080 1090 1100 1110
1290 1300 1310 1320 1330 1340
pF1KA0 PHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRVAALRGAGPGAEGMTPAGAVLPGDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRVAALRGAGPGAEGMTPAGAVLPGDP
1120 1130 1140 1150 1160 1170
1350 1360 1370 1380 1390 1400
pF1KA0 LTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLEGADSVSSRAPQASLSMLPSTDNTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLEGADSVSSRAPQASLSMLPSTDNTK
1180 1190 1200 1210 1220 1230
1410 1420 1430 1440 1450 1460
pF1KA0 EACGHVSGHCCPGGSRESPVTDIDSFIKELDASAARSPSSQTGDSGSQEGSAQGHPPAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EACGHVSGHCCPGGSRESPVTDIDSFIKELDASAARSPSSQTGDSGSQEGSAQGHPPAGA
1240 1250 1260 1270 1280 1290
1470 1480 1490 1500 1510 1520
pF1KA0 GGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQPSVLDSINPDKHFTVNKNFLSNYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQPSVLDSINPDKHFTVNKNFLSNYS
1300 1310 1320 1330 1340 1350
1530 1540 1550 1560 1570 1580
pF1KA0 RNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPESLTEAPRASARDGWSPPRSRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPESLTEAPRASARDGWSPPRSRV
1360 1370 1380 1390 1400 1410
1590 1600 1610 1620 1630 1640
pF1KA0 SLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPASAKVLSLKYSTPRESVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPASAKVLSLKYSTPRESVAS
1420 1430 1440 1450 1460 1470
1650 1660 1670 1680 1690 1700
pF1KA0 PREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHRPSCAEETTEVTSASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHRPSCAEETTEVTSASS
1480 1490 1500 1510 1520 1530
1710 1720 1730 1740 1750 1760
pF1KA0 AMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAASLSSFSVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAASLSSFSVDV
1540 1550 1560 1570 1580 1590
1770 1780 1790 1800 1810 1820
pF1KA0 PKNGESVLENLHISESQDLDDLLQKPKMIARRPIMAWFKEINKHNQGTHLRSKTEKEQPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PKNGESVLENLHISESQDLDDLLQKPKMIARRPIMAWFKEINKHNQGTHLRSKTEKEQPL
1600 1610 1620 1630 1640 1650
1830 1840 1850 1860 1870 1880
pF1KA0 MPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLSKKSPAEMLLTNGQKAKCGPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLSKKSPAEMLLTNGQKAKCGPK
1660 1670 1680 1690 1700 1710
1890 1900 1910 1920 1930 1940
pF1KA0 LKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQTSHKTLSKAVSQRLHVADHEDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQTSHKTLSKAVSQRLHVADHEDPD
1720 1730 1740 1750 1760 1770
1950 1960 1970 1980 1990 2000
pF1KA0 RNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIRTFVSPLTSPKPVPEQGMWSRFHMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIRTFVSPLTSPKPVPEQGMWSRFHMA
1780 1790 1800 1810 1820 1830
2010 2020 2030 2040 2050 2060
pF1KA0 VLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAASRNGMSVAGNRQSEPRLASHVAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAASRNGMSVAGNRQSEPRLASHVAAD
1840 1850 1860 1870 1880 1890
2070 2080 2090 2100 2110 2120
pF1KA0 TAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAVSETVCGNKPAESDRRGGCLAQGNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAVSETVCGNKPAESDRRGGCLAQGNC
1900 1910 1920 1930 1940 1950
2130 2140 2150 2160 2170 2180
pF1KA0 QEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSRSFSMAKLASSSSSLQTAIRKAEYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSRSFSMAKLASSSSSLQTAIRKAEYS
1960 1970 1980 1990 2000 2010
2190 2200 2210 2220 2230 2240
pF1KA0 QGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSMPAQFSSHFGREGHPPHSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSMPAQFSSHFGREGHPPHSLG
2020 2030 2040 2050 2060 2070
2250 2260 2270 2280 2290 2300
pF1KA0 RSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSVKPLLDTSRNLPATDEGDIISVQET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSVKPLLDTSRNLPATDEGDIISVQET
2080 2090 2100 2110 2120 2130
2310 2320 2330 2340 2350 2360
pF1KA0 SCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSFENLANADRPVAKSGASPFLSVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSFENLANADRPVAKSGASPFLSVS
2140 2150 2160 2170 2180 2190
2370 2380 2390 2400 2410 2420
pF1KA0 SKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCSENQSEAGTLLPQMAKSPSIMTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCSENQSEAGTLLPQMAKSPSIMTLT
2200 2210 2220 2230 2240 2250
2430 2440 2450 2460 2470 2480
pF1KA0 ISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSPVSRSKLQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSPVSRSKLQE
2260 2270 2280 2290 2300 2310
2490 2500 2510 2520 2530 2540
pF1KA0 LRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSPGPPAGGVSCPEKGGNRACPGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSPGPPAGGVSCPEKGGNRACPGGS
2320 2330 2340 2350 2360 2370
2550 2560 2570 2580 2590 2600
pF1KA0 GPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQLLVSAGDQQRLQSVLSSVGSKSTIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQLLVSAGDQQRLQSVLSSVGSKSTIL
2380 2390 2400 2410 2420 2430
2610 2620 2630 2640 2650 2660
pF1KA0 TLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGT
2440 2450 2460 2470 2480 2490
2670 2680 2690 2700 2710 2720
pF1KA0 MNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANG
2500 2510 2520 2530 2540 2550
2730 2740 2750
pF1KA0 KGLLSRKTIPLEPGI----------------G------------------RSVAVHDALC
::::::::::::::: : ::::::::::
XP_005 KGLLSRKTIPLEPGIENTEQRMQVQQQHSQEGSPRIGRPTVLLGSSAVIRRSVAVHDALC
2560 2570 2580 2590 2600 2610
2760 2770 2780 2790 2800 2810
pF1KA0 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG
2620 2630 2640 2650 2660 2670
2820 2830
pF1KA0 LMHFDAWNIMKSVPEGPVQLLIRKHRNSS
:::::::::::::::::::::::::::
XP_005 LMHFDAWNIMKSVPEGPVQLLIRKHRNSS
2680 2690
>>XP_006714523 (OMIM: 610697) PREDICTED: PDZ domain-cont (2542 aa)
initn: 15594 init1: 15594 opt: 15598 Z-score: 8445.1 bits: 1577.0 E(85289): 0
Smith-Waterman score: 16150; 97.7% identity (98.1% similar) in 2525 aa overlap (347-2837:16-2540)
320 330 340 350 360 370
pF1KA0 DFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDG
.:.. .: : . .. . .. : :::
XP_006 MTNAASQKVGRRTSNRVTAWHGRKLAEYGRWSCSKNRMGWEFRDG
10 20 30 40
380 390 400 410 420 430
pF1KA0 RLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDL
50 60 70 80 90 100
440 450 460 470 480 490
pF1KA0 TSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGS
110 120 130 140 150 160
500 510 520 530 540 550
pF1KA0 NKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQE
170 180 190 200 210 220
560 570 580 590 600 610
pF1KA0 YHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFV
230 240 250 260 270 280
620 630 640 650 660 670
pF1KA0 KTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSP
290 300 310 320 330 340
680 690 700 710 720 730
pF1KA0 SLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPR
350 360 370 380 390 400
740 750 760 770 780 790
pF1KA0 VGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHA
410 420 430 440 450 460
800 810 820 830 840 850
pF1KA0 ILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKK
470 480 490 500 510 520
860 870 880 890 900 910
pF1KA0 DSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHKEPGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHKEPGKP
530 540 550 560 570 580
920 930 940 950 960 970
pF1KA0 RANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQRKVGCYDANDASDEEEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQRKVGCYDANDASDEEEF
590 600 610 620 630 640
980 990 1000 1010 1020 1030
pF1KA0 DREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAISAPLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAISAPLLG
650 660 670 680 690 700
1040 1050 1060 1070 1080 1090
pF1KA0 SSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRTDTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRTDTQ
710 720 730 740 750 760
1100 1110 1120 1130 1140 1150
pF1KA0 SPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLD
770 780 790 800 810 820
1160 1170 1180 1190 1200 1210
pF1KA0 SRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELASALSHLDASHLTENLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELASALSHLDASHLTENLPK
830 840 850 860 870 880
1220 1230 1240 1250 1260 1270
pF1KA0 AASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVSRPENPSQPASPRVAKC
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
XP_006 AASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVSRPENPSQPASPRVTKC
890 900 910 920 930 940
1280 1290 1300 1310 1320 1330
pF1KA0 KARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRVAALRGAGPGAEGMTPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRVAALRGAGPGAEGMTPA
950 960 970 980 990 1000
1340 1350 1360 1370 1380 1390
pF1KA0 GAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLEGADSVSSRAPQASLSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLEGADSVSSRAPQASLSM
1010 1020 1030 1040 1050 1060
1400 1410 1420 1430 1440 1450
pF1KA0 LPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAARSPSSQTGDSGSQEGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAARSPSSQTGDSGSQEGSA
1070 1080 1090 1100 1110 1120
1460 1470 1480 1490 1500 1510
pF1KA0 QGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQPSVLDSINPDKHFTVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQPSVLDSINPDKHFTVN
1130 1140 1150 1160 1170 1180
1520 1530 1540 1550 1560 1570
pF1KA0 KNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPESLTEAPRASARDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPESLTEAPRASARDG
1190 1200 1210 1220 1230 1240
1580 1590 1600 1610 1620 1630
pF1KA0 WSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPASAKVLSLKYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPASAKVLSLKYS
1250 1260 1270 1280 1290 1300
1640 1650 1660 1670 1680 1690
pF1KA0 TPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHRPSCAEET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHRPSCAEET
1310 1320 1330 1340 1350 1360
1700 1710 1720 1730 1740 1750
pF1KA0 TEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAAS
1370 1380 1390 1400 1410 1420
1760 1770 1780 1790 1800 1810
pF1KA0 LSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMAWFKEINKHNQGTHLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMAWFKEINKHNQGTHLRS
1430 1440 1450 1460 1470 1480
1820 1830 1840 1850 1860 1870
pF1KA0 KTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLSKKSPAEMLLTNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLSKKSPAEMLLTNG
1490 1500 1510 1520 1530 1540
1880 1890 1900 1910 1920 1930
pF1KA0 QKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQTSHKTLSKAVSQRLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQTSHKTLSKAVSQRLH
1550 1560 1570 1580 1590 1600
1940 1950 1960 1970 1980 1990
pF1KA0 VADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIRTFVSPLTSPKPVPEQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIRTFVSPLTSPKPVPEQG
1610 1620 1630 1640 1650 1660
2000 2010 2020 2030 2040 2050
pF1KA0 MWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAASRNGMSVAGNRQSEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAASRNGMSVAGNRQSEPR
1670 1680 1690 1700 1710 1720
2060 2070 2080 2090 2100 2110
pF1KA0 LASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAVSETVCGNKPAESDRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAVSETVCGNKPAESDRRG
1730 1740 1750 1760 1770 1780
2120 2130 2140 2150 2160 2170
pF1KA0 GCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSRSFSMAKLASSSSSLQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSRSFSMAKLASSSSSLQT
1790 1800 1810 1820 1830 1840
2180 2190 2200 2210 2220 2230
pF1KA0 AIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSMPAQFSSHFGRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSMPAQFSSHFGRE
1850 1860 1870 1880 1890 1900
2240 2250 2260 2270 2280 2290
pF1KA0 GHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSVKPLLDTSRNLPATDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSVKPLLDTSRNLPATDEG
1910 1920 1930 1940 1950 1960
2300 2310 2320 2330 2340 2350
pF1KA0 DIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSFENLANADRPVAKSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSFENLANADRPVAKSG
1970 1980 1990 2000 2010 2020
2360 2370 2380 2390 2400 2410
pF1KA0 ASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCSENQSEAGTLLPQMAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCSENQSEAGTLLPQMAK
2030 2040 2050 2060 2070 2080
2420 2430 2440 2450 2460 2470
pF1KA0 SPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSP
2090 2100 2110 2120 2130 2140
2480 2490 2500 2510 2520 2530
pF1KA0 VSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSPGPPAGGVSCPEKGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSPGPPAGGVSCPEKGG
2150 2160 2170 2180 2190 2200
2540 2550 2560 2570 2580 2590
pF1KA0 NRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQLLVSAGDQQRLQSVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQLLVSAGDQQRLQSVLSS
2210 2220 2230 2240 2250 2260
2600 2610 2620 2630 2640 2650
pF1KA0 VGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQ
2270 2280 2290 2300 2310 2320
2660 2670 2680 2690 2700 2710
pF1KA0 GAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSAR
2330 2340 2350 2360 2370 2380
2720 2730 2740
pF1KA0 QEPPTANGKGLLSRKTIPLEPGI---------------------GR-------------S
::::::::::::::::::::::: :: :
XP_006 QEPPTANGKGLLSRKTIPLEPGIENTEQRMQVQQQHSQEGSPRIGRPTVLLGSSAVIRRS
2390 2400 2410 2420 2430 2440
2750 2760 2770 2780 2790 2800
pF1KA0 VAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILA
2450 2460 2470 2480 2490 2500
2810 2820 2830
pF1KA0 INGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNSS
:::::::::::::::::::::::::::::::::::
XP_006 INGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNSS
2510 2520 2530 2540
>>XP_016864735 (OMIM: 610697) PREDICTED: PDZ domain-cont (2542 aa)
initn: 15594 init1: 15594 opt: 15598 Z-score: 8445.1 bits: 1577.0 E(85289): 0
Smith-Waterman score: 16150; 97.7% identity (98.1% similar) in 2525 aa overlap (347-2837:16-2540)
320 330 340 350 360 370
pF1KA0 DFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDG
.:.. .: : . .. . .. : :::
XP_016 MTNAASQKVGRRTSNRVTAWHGRKLAEYGRWSCSKNRMGWEFRDG
10 20 30 40
380 390 400 410 420 430
pF1KA0 RLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDL
50 60 70 80 90 100
440 450 460 470 480 490
pF1KA0 TSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGS
110 120 130 140 150 160
500 510 520 530 540 550
pF1KA0 NKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQE
170 180 190 200 210 220
560 570 580 590 600 610
pF1KA0 YHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFV
230 240 250 260 270 280
620 630 640 650 660 670
pF1KA0 KTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSP
290 300 310 320 330 340
680 690 700 710 720 730
pF1KA0 SLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPR
350 360 370 380 390 400
740 750 760 770 780 790
pF1KA0 VGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHA
410 420 430 440 450 460
800 810 820 830 840 850
pF1KA0 ILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKK
470 480 490 500 510 520
860 870 880 890 900 910
pF1KA0 DSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHKEPGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHKEPGKP
530 540 550 560 570 580
920 930 940 950 960 970
pF1KA0 RANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQRKVGCYDANDASDEEEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQRKVGCYDANDASDEEEF
590 600 610 620 630 640
980 990 1000 1010 1020 1030
pF1KA0 DREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAISAPLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAISAPLLG
650 660 670 680 690 700
1040 1050 1060 1070 1080 1090
pF1KA0 SSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRTDTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRTDTQ
710 720 730 740 750 760
1100 1110 1120 1130 1140 1150
pF1KA0 SPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLD
770 780 790 800 810 820
1160 1170 1180 1190 1200 1210
pF1KA0 SRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELASALSHLDASHLTENLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELASALSHLDASHLTENLPK
830 840 850 860 870 880
1220 1230 1240 1250 1260 1270
pF1KA0 AASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVSRPENPSQPASPRVAKC
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
XP_016 AASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVSRPENPSQPASPRVTKC
890 900 910 920 930 940
1280 1290 1300 1310 1320 1330
pF1KA0 KARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRVAALRGAGPGAEGMTPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRVAALRGAGPGAEGMTPA
950 960 970 980 990 1000
1340 1350 1360 1370 1380 1390
pF1KA0 GAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLEGADSVSSRAPQASLSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLEGADSVSSRAPQASLSM
1010 1020 1030 1040 1050 1060
1400 1410 1420 1430 1440 1450
pF1KA0 LPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAARSPSSQTGDSGSQEGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAARSPSSQTGDSGSQEGSA
1070 1080 1090 1100 1110 1120
1460 1470 1480 1490 1500 1510
pF1KA0 QGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQPSVLDSINPDKHFTVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQPSVLDSINPDKHFTVN
1130 1140 1150 1160 1170 1180
1520 1530 1540 1550 1560 1570
pF1KA0 KNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPESLTEAPRASARDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPESLTEAPRASARDG
1190 1200 1210 1220 1230 1240
1580 1590 1600 1610 1620 1630
pF1KA0 WSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPASAKVLSLKYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPASAKVLSLKYS
1250 1260 1270 1280 1290 1300
1640 1650 1660 1670 1680 1690
pF1KA0 TPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHRPSCAEET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHRPSCAEET
1310 1320 1330 1340 1350 1360
1700 1710 1720 1730 1740 1750
pF1KA0 TEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAAS
1370 1380 1390 1400 1410 1420
1760 1770 1780 1790 1800 1810
pF1KA0 LSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMAWFKEINKHNQGTHLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMAWFKEINKHNQGTHLRS
1430 1440 1450 1460 1470 1480
1820 1830 1840 1850 1860 1870
pF1KA0 KTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLSKKSPAEMLLTNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLSKKSPAEMLLTNG
1490 1500 1510 1520 1530 1540
1880 1890 1900 1910 1920 1930
pF1KA0 QKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQTSHKTLSKAVSQRLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQTSHKTLSKAVSQRLH
1550 1560 1570 1580 1590 1600
1940 1950 1960 1970 1980 1990
pF1KA0 VADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIRTFVSPLTSPKPVPEQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIRTFVSPLTSPKPVPEQG
1610 1620 1630 1640 1650 1660
2000 2010 2020 2030 2040 2050
pF1KA0 MWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAASRNGMSVAGNRQSEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAASRNGMSVAGNRQSEPR
1670 1680 1690 1700 1710 1720
2060 2070 2080 2090 2100 2110
pF1KA0 LASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAVSETVCGNKPAESDRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAVSETVCGNKPAESDRRG
1730 1740 1750 1760 1770 1780
2120 2130 2140 2150 2160 2170
pF1KA0 GCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSRSFSMAKLASSSSSLQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSRSFSMAKLASSSSSLQT
1790 1800 1810 1820 1830 1840
2180 2190 2200 2210 2220 2230
pF1KA0 AIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSMPAQFSSHFGRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSMPAQFSSHFGRE
1850 1860 1870 1880 1890 1900
2240 2250 2260 2270 2280 2290
pF1KA0 GHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSVKPLLDTSRNLPATDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSVKPLLDTSRNLPATDEG
1910 1920 1930 1940 1950 1960
2300 2310 2320 2330 2340 2350
pF1KA0 DIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSFENLANADRPVAKSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSFENLANADRPVAKSG
1970 1980 1990 2000 2010 2020
2360 2370 2380 2390 2400 2410
pF1KA0 ASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCSENQSEAGTLLPQMAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCSENQSEAGTLLPQMAK
2030 2040 2050 2060 2070 2080
2420 2430 2440 2450 2460 2470
pF1KA0 SPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSP
2090 2100 2110 2120 2130 2140
2480 2490 2500 2510 2520 2530
pF1KA0 VSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSPGPPAGGVSCPEKGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSPGPPAGGVSCPEKGG
2150 2160 2170 2180 2190 2200
2540 2550 2560 2570 2580 2590
pF1KA0 NRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQLLVSAGDQQRLQSVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQLLVSAGDQQRLQSVLSS
2210 2220 2230 2240 2250 2260
2600 2610 2620 2630 2640 2650
pF1KA0 VGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQ
2270 2280 2290 2300 2310 2320
2660 2670 2680 2690 2700 2710
pF1KA0 GAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSAR
2330 2340 2350 2360 2370 2380
2720 2730 2740
pF1KA0 QEPPTANGKGLLSRKTIPLEPGI---------------------GR-------------S
::::::::::::::::::::::: :: :
XP_016 QEPPTANGKGLLSRKTIPLEPGIENTEQRMQVQQQHSQEGSPRIGRPTVLLGSSAVIRRS
2390 2400 2410 2420 2430 2440
2750 2760 2770 2780 2790 2800
pF1KA0 VAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILA
2450 2460 2470 2480 2490 2500
2810 2820 2830
pF1KA0 INGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNSS
:::::::::::::::::::::::::::::::::::
XP_016 INGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNSS
2510 2520 2530 2540
>>XP_016864734 (OMIM: 610697) PREDICTED: PDZ domain-cont (2607 aa)
initn: 15326 init1: 15326 opt: 15326 Z-score: 8297.9 bits: 1549.8 E(85289): 0
Smith-Waterman score: 16704; 95.3% identity (95.3% similar) in 2697 aa overlap (175-2837:1-2605)
150 160 170 180 190 200
pF1KA0 LNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFKHKAHSTYNGNSSNSSEPGETPTLE
::::::::::::::::::::::::::::::
XP_016 MLRRFKHKAHSTYNGNSSNSSEPGETPTLE
10 20 30
210 220 230 240 250 260
pF1KA0 LGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGCEVSSDPSTELENGPDPELGNGHVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGCEVSSDPSTELENGPDPELGNGHVF
40 50 60 70 80 90
270 280 290 300 310 320
pF1KA0 QLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCL
100 110 120 130 140 150
330 340 350 360 370 380
pF1KA0 AREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDEL
:::
XP_016 ARE---------------------------------------------------------
390 400 410 420 430 440
pF1KA0 LVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVS
:::::::::::::::::::::::::
XP_016 -----------------------------------NSAEDLLRLTSKSLPDLTSSVEDVS
160 170
450 460 470 480 490 500
pF1KA0 SWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSR
180 190 200 210 220 230
510 520 530 540 550 560
pF1KA0 LSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKST
240 250 260 270 280 290
570 580 590 600 610 620
pF1KA0 RSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGS
300 310 320 330 340 350
630 640 650 660 670 680
pF1KA0 AAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTP
360 370 380 390 400 410
690 700 710 720 730 740
pF1KA0 THMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 THMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGAC
420 430 440 450 460 470
750 760 770 780 790 800
pF1KA0 CLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPG
480 490 500 510 520 530
810 820 830 840 850 860
pF1KA0 PVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKKDSLISESE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKKDSLISESE
540 550 560 570 580 590
870 880 890 900 910 920
pF1KA0 LSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHKEPGKPRANSLVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHKEPGKPRANSLVTL
600 610 620 630 640 650
930 940 950 960 970 980
pF1KA0 GSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQRKVGCYDANDASDEEEFDREGDCIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQRKVGCYDANDASDEEEFDREGDCIS
660 670 680 690 700 710
990 1000 1010 1020 1030 1040
pF1KA0 LPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAISAPLLGSSVDLEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAISAPLLGSSVDLEES
720 730 740 750 760 770
1050 1060 1070 1080 1090 1100
pF1KA0 IPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRTDTQSPTNTGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRTDTQSPTNTGSP
780 790 800 810 820 830
1110 1120 1130 1140 1150 1160
pF1KA0 SSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLDSRVQATSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLDSRVQATSV
840 850 860 870 880 890
1170 1180 1190 1200 1210 1220
pF1KA0 KVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELASALSHLDASHLTENLPKAASELGQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELASALSHLDASHLTENLPKAASELGQQ
900 910 920 930 940 950
1230 1240 1250 1260 1270 1280
pF1KA0 PMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVSRPENPSQPASPRVAKCKARSPVRL
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
XP_016 PMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVSRPENPSQPASPRVTKCKARSPVRL
960 970 980 990 1000 1010
1290 1300 1310 1320 1330 1340
pF1KA0 PHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRVAALRGAGPGAEGMTPAGAVLPGDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRVAALRGAGPGAEGMTPAGAVLPGDP
1020 1030 1040 1050 1060 1070
1350 1360 1370 1380 1390 1400
pF1KA0 LTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLEGADSVSSRAPQASLSMLPSTDNTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLEGADSVSSRAPQASLSMLPSTDNTK
1080 1090 1100 1110 1120 1130
1410 1420 1430 1440 1450 1460
pF1KA0 EACGHVSGHCCPGGSRESPVTDIDSFIKELDASAARSPSSQTGDSGSQEGSAQGHPPAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EACGHVSGHCCPGGSRESPVTDIDSFIKELDASAARSPSSQTGDSGSQEGSAQGHPPAGA
1140 1150 1160 1170 1180 1190
1470 1480 1490 1500 1510 1520
pF1KA0 GGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQPSVLDSINPDKHFTVNKNFLSNYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQPSVLDSINPDKHFTVNKNFLSNYS
1200 1210 1220 1230 1240 1250
1530 1540 1550 1560 1570 1580
pF1KA0 RNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPESLTEAPRASARDGWSPPRSRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPESLTEAPRASARDGWSPPRSRV
1260 1270 1280 1290 1300 1310
1590 1600 1610 1620 1630 1640
pF1KA0 SLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPASAKVLSLKYSTPRESVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPASAKVLSLKYSTPRESVAS
1320 1330 1340 1350 1360 1370
1650 1660 1670 1680 1690 1700
pF1KA0 PREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHRPSCAEETTEVTSASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHRPSCAEETTEVTSASS
1380 1390 1400 1410 1420 1430
1710 1720 1730 1740 1750 1760
pF1KA0 AMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAASLSSFSVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAASLSSFSVDV
1440 1450 1460 1470 1480 1490
1770 1780 1790 1800 1810 1820
pF1KA0 PKNGESVLENLHISESQDLDDLLQKPKMIARRPIMAWFKEINKHNQGTHLRSKTEKEQPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKNGESVLENLHISESQDLDDLLQKPKMIARRPIMAWFKEINKHNQGTHLRSKTEKEQPL
1500 1510 1520 1530 1540 1550
1830 1840 1850 1860 1870 1880
pF1KA0 MPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLSKKSPAEMLLTNGQKAKCGPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLSKKSPAEMLLTNGQKAKCGPK
1560 1570 1580 1590 1600 1610
1890 1900 1910 1920 1930 1940
pF1KA0 LKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQTSHKTLSKAVSQRLHVADHEDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQTSHKTLSKAVSQRLHVADHEDPD
1620 1630 1640 1650 1660 1670
1950 1960 1970 1980 1990 2000
pF1KA0 RNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIRTFVSPLTSPKPVPEQGMWSRFHMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIRTFVSPLTSPKPVPEQGMWSRFHMA
1680 1690 1700 1710 1720 1730
2010 2020 2030 2040 2050 2060
pF1KA0 VLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAASRNGMSVAGNRQSEPRLASHVAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAASRNGMSVAGNRQSEPRLASHVAAD
1740 1750 1760 1770 1780 1790
2070 2080 2090 2100 2110 2120
pF1KA0 TAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAVSETVCGNKPAESDRRGGCLAQGNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAVSETVCGNKPAESDRRGGCLAQGNC
1800 1810 1820 1830 1840 1850
2130 2140 2150 2160 2170 2180
pF1KA0 QEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSRSFSMAKLASSSSSLQTAIRKAEYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSRSFSMAKLASSSSSLQTAIRKAEYS
1860 1870 1880 1890 1900 1910
2190 2200 2210 2220 2230 2240
pF1KA0 QGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSMPAQFSSHFGREGHPPHSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSMPAQFSSHFGREGHPPHSLG
1920 1930 1940 1950 1960 1970
2250 2260 2270 2280 2290 2300
pF1KA0 RSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSVKPLLDTSRNLPATDEGDIISVQET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSVKPLLDTSRNLPATDEGDIISVQET
1980 1990 2000 2010 2020 2030
2310 2320 2330 2340 2350 2360
pF1KA0 SCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSFENLANADRPVAKSGASPFLSVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSFENLANADRPVAKSGASPFLSVS
2040 2050 2060 2070 2080 2090
2370 2380 2390 2400 2410 2420
pF1KA0 SKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCSENQSEAGTLLPQMAKSPSIMTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCSENQSEAGTLLPQMAKSPSIMTLT
2100 2110 2120 2130 2140 2150
2430 2440 2450 2460 2470 2480
pF1KA0 ISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSPVSRSKLQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSPVSRSKLQE
2160 2170 2180 2190 2200 2210
2490 2500 2510 2520 2530 2540
pF1KA0 LRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSPGPPAGGVSCPEKGGNRACPGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSPGPPAGGVSCPEKGGNRACPGGS
2220 2230 2240 2250 2260 2270
2550 2560 2570 2580 2590 2600
pF1KA0 GPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQLLVSAGDQQRLQSVLSSVGSKSTIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQLLVSAGDQQRLQSVLSSVGSKSTIL
2280 2290 2300 2310 2320 2330
2610 2620 2630 2640 2650 2660
pF1KA0 TLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGT
2340 2350 2360 2370 2380 2390
2670 2680 2690 2700 2710 2720
pF1KA0 MNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANG
2400 2410 2420 2430 2440 2450
2730 2740 2750
pF1KA0 KGLLSRKTIPLEPGI----------------G------------------RSVAVHDALC
::::::::::::::: : ::::::::::
XP_016 KGLLSRKTIPLEPGIENTEQRMQVQQQHSQEGSPRIGRPTVLLGSSAVIRRSVAVHDALC
2460 2470 2480 2490 2500 2510
2760 2770 2780 2790 2800 2810
pF1KA0 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG
2520 2530 2540 2550 2560 2570
2820 2830
pF1KA0 LMHFDAWNIMKSVPEGPVQLLIRKHRNSS
:::::::::::::::::::::::::::
XP_016 LMHFDAWNIMKSVPEGPVQLLIRKHRNSS
2580 2590 2600
2839 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 03:43:14 2016 done: Mon Nov 7 03:43:18 2016
Total Scan time: 25.650 Total Display time: 2.510
Function used was FASTA [36.3.4 Apr, 2011]