Result of FASTA (omim) for
pFN21AA0213
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0213, 1558 aa
1>>>pF1KA0213 1558 - 1558 aa - 1558 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.4735+/-0.000601; mu= -6.1843+/- 0.038
mean_var=719.8189+/-152.080, 0's: 0 Z-trim(119.9): 1440 B-trim: 0 in 0/61
Lambda= 0.047804
statistics sampled from 32609 (34555) to 32609 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.686), E-opt: 0.2 (0.405), width: 16
Scan time: 18.060
The best scores are: opt bits E(85289)
NP_006715 (OMIM: 602425) mitogen-activated protein (1558) 10475 739.9 3.9e-212
XP_005267046 (OMIM: 602425) PREDICTED: mitogen-act (1554) 10421 736.1 5.2e-211
NP_005913 (OMIM: 602425) mitogen-activated protein (1608) 7919 563.6 4.6e-159
NP_001288001 (OMIM: 602425) mitogen-activated prot (1604) 7875 560.6 3.8e-158
XP_016866358 (OMIM: 602425) PREDICTED: mitogen-act (1517) 7258 518.0 2.4e-145
NP_001278887 (OMIM: 602425) mitogen-activated prot (1061) 4080 298.6 1.8e-79
NP_001317360 (OMIM: 602539) mitogen-activated prot ( 622) 671 63.2 7.8e-09
NP_002392 (OMIM: 602539) mitogen-activated protein ( 626) 671 63.2 7.9e-09
XP_005257433 (OMIM: 602539) PREDICTED: mitogen-act ( 653) 671 63.2 8.1e-09
NP_976226 (OMIM: 602539) mitogen-activated protein ( 657) 671 63.2 8.1e-09
NP_006600 (OMIM: 609487) mitogen-activated protein ( 619) 642 61.2 3.1e-08
XP_011543813 (OMIM: 300820) PREDICTED: mitogen-act ( 748) 565 56.0 1.4e-06
XP_011543812 (OMIM: 300820) PREDICTED: mitogen-act ( 871) 565 56.1 1.5e-06
XP_016864974 (OMIM: 600982,613762) PREDICTED: mito (1349) 570 56.7 1.6e-06
XP_016864973 (OMIM: 600982,613762) PREDICTED: mito (1375) 570 56.7 1.6e-06
XP_016866366 (OMIM: 602448) PREDICTED: mitogen-act (1181) 568 56.5 1.6e-06
XP_016866365 (OMIM: 602448) PREDICTED: mitogen-act (1191) 568 56.5 1.6e-06
XP_011534141 (OMIM: 602448) PREDICTED: mitogen-act (1286) 568 56.5 1.7e-06
NP_005912 (OMIM: 600982,613762) mitogen-activated (1512) 570 56.7 1.7e-06
NP_005914 (OMIM: 602448) mitogen-activated protein (1374) 568 56.5 1.7e-06
XP_016866364 (OMIM: 602448) PREDICTED: mitogen-act (1447) 568 56.6 1.8e-06
XP_016866363 (OMIM: 602448) PREDICTED: mitogen-act (1458) 568 56.6 1.8e-06
XP_016866362 (OMIM: 602448) PREDICTED: mitogen-act (1483) 568 56.6 1.8e-06
XP_016866361 (OMIM: 602448) PREDICTED: mitogen-act (1484) 568 56.6 1.8e-06
XP_016866360 (OMIM: 602448) PREDICTED: mitogen-act (1493) 568 56.6 1.8e-06
XP_016866359 (OMIM: 602448) PREDICTED: mitogen-act (1494) 568 56.6 1.8e-06
XP_011543810 (OMIM: 300820) PREDICTED: mitogen-act (1295) 565 56.3 1.9e-06
XP_016858260 (OMIM: 604468) PREDICTED: mitogen-act ( 869) 560 55.7 1.9e-06
NP_001001671 (OMIM: 300820) mitogen-activated prot (1313) 565 56.3 1.9e-06
XP_011543809 (OMIM: 300820) PREDICTED: mitogen-act (1324) 565 56.3 2e-06
NP_001284538 (OMIM: 604468) mitogen-activated prot (1280) 560 56.0 2.4e-06
NP_004663 (OMIM: 604468) mitogen-activated protein (1288) 560 56.0 2.4e-06
XP_011538703 (OMIM: 616563) PREDICTED: STE20-like ( 783) 531 53.7 7.3e-06
XP_016873338 (OMIM: 602590) PREDICTED: serine/thre ( 545) 525 53.0 7.8e-06
XP_016873339 (OMIM: 602590) PREDICTED: serine/thre ( 545) 525 53.0 7.8e-06
XP_016873337 (OMIM: 602590) PREDICTED: serine/thre ( 545) 525 53.0 7.8e-06
XP_016873336 (OMIM: 602590) PREDICTED: serine/thre ( 545) 525 53.0 7.8e-06
XP_016873335 (OMIM: 602590) PREDICTED: serine/thre ( 545) 525 53.0 7.8e-06
NP_002567 (OMIM: 602590) serine/threonine-protein ( 545) 525 53.0 7.8e-06
NP_002568 (OMIM: 605022) serine/threonine-protein ( 524) 524 53.0 8e-06
XP_016861990 (OMIM: 605022) PREDICTED: serine/thre ( 524) 524 53.0 8e-06
XP_011511172 (OMIM: 605022) PREDICTED: serine/thre ( 524) 524 53.0 8e-06
NP_001311255 (OMIM: 300142,300558) serine/threonin ( 544) 524 53.0 8.2e-06
NP_001311261 (OMIM: 300142,300558) serine/threonin ( 544) 524 53.0 8.2e-06
XP_016885050 (OMIM: 300142,300558) PREDICTED: seri ( 544) 524 53.0 8.2e-06
NP_001311263 (OMIM: 300142,300558) serine/threonin ( 544) 524 53.0 8.2e-06
NP_001121639 (OMIM: 300142,300558) serine/threonin ( 544) 524 53.0 8.2e-06
NP_001311260 (OMIM: 300142,300558) serine/threonin ( 544) 524 53.0 8.2e-06
NP_002569 (OMIM: 300142,300558) serine/threonine-p ( 544) 524 53.0 8.2e-06
NP_001311254 (OMIM: 300142,300558) serine/threonin ( 544) 524 53.0 8.2e-06
>>NP_006715 (OMIM: 602425) mitogen-activated protein kin (1558 aa)
initn: 10475 init1: 10475 opt: 10475 Z-score: 3929.5 bits: 739.9 E(85289): 3.9e-212
Smith-Waterman score: 10475; 100.0% identity (100.0% similar) in 1558 aa overlap (1-1558:1-1558)
10 20 30 40 50 60
pF1KA0 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFRGSSVPENDRLASIAAELQFRSLSRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFRGSSVPENDRLASIAAELQFRSLSRH
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 SSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYR
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 EMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMA
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 MKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 SRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKN
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 NAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEH
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550
pF1KA0 NFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
1510 1520 1530 1540 1550
>>XP_005267046 (OMIM: 602425) PREDICTED: mitogen-activat (1554 aa)
initn: 7992 init1: 7614 opt: 10421 Z-score: 3909.4 bits: 736.1 E(85289): 5.2e-211
Smith-Waterman score: 10421; 99.7% identity (99.7% similar) in 1558 aa overlap (1-1558:1-1554)
10 20 30 40 50 60
pF1KA0 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::
XP_005 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVT--
1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KA0 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFRGSSVPENDRLASIAAELQFRSLSRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 --AIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFRGSSVPENDRLASIAAELQFRSLSRH
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KA0 SSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYR
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KA0 EMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMA
1260 1270 1280 1290 1300 1310
1330 1340 1350 1360 1370 1380
pF1KA0 MKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV
1320 1330 1340 1350 1360 1370
1390 1400 1410 1420 1430 1440
pF1KA0 SRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKN
1380 1390 1400 1410 1420 1430
1450 1460 1470 1480 1490 1500
pF1KA0 NAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEH
1440 1450 1460 1470 1480 1490
1510 1520 1530 1540 1550
pF1KA0 NFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
1500 1510 1520 1530 1540 1550
>>NP_005913 (OMIM: 602425) mitogen-activated protein kin (1608 aa)
initn: 7910 init1: 7910 opt: 7919 Z-score: 2976.6 bits: 563.6 E(85289): 4.6e-159
Smith-Waterman score: 10248; 96.9% identity (96.9% similar) in 1590 aa overlap (1-1540:1-1590)
10 20 30 40 50 60
pF1KA0 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
1090 1100 1110 1120 1130 1140
1150 1160 1170
pF1KA0 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGF--------------------------
::::::::::::::::::::::::::::::::::
NP_005 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210
pF1KA0 ------------------------RGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP
::::::::::::::::::::::::::::::::::::
NP_005 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP
1210 1220 1230 1240 1250 1260
1220 1230 1240 1250 1260 1270
pF1KA0 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KA0 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KA0 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KA0 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KA0 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550
pF1KA0 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
::::::::::::::::::::::::::::::
NP_005 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
1570 1580 1590 1600
>>NP_001288001 (OMIM: 602425) mitogen-activated protein (1604 aa)
initn: 10195 init1: 7624 opt: 7875 Z-score: 2960.2 bits: 560.6 E(85289): 3.8e-158
Smith-Waterman score: 10226; 96.6% identity (96.6% similar) in 1594 aa overlap (1-1544:1-1590)
10 20 30 40 50 60
pF1KA0 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVT--
1090 1100 1110 1120 1130
1150 1160 1170
pF1KA0 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGF--------------------------
::::::::::::::::::::::::::::::::
NP_001 --AIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV
1140 1150 1160 1170 1180 1190
1180 1190 1200 1210
pF1KA0 ------------------------RGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP
::::::::::::::::::::::::::::::::::::
NP_001 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP
1200 1210 1220 1230 1240 1250
1220 1230 1240 1250 1260 1270
pF1KA0 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
1260 1270 1280 1290 1300 1310
1280 1290 1300 1310 1320 1330
pF1KA0 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
1320 1330 1340 1350 1360 1370
1340 1350 1360 1370 1380 1390
pF1KA0 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
1380 1390 1400 1410 1420 1430
1400 1410 1420 1430 1440 1450
pF1KA0 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
1440 1450 1460 1470 1480 1490
1460 1470 1480 1490 1500 1510
pF1KA0 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
1500 1510 1520 1530 1540 1550
1520 1530 1540 1550
pF1KA0 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
::::::::::::::::::::::::::::::::::
NP_001 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
1560 1570 1580 1590 1600
>>XP_016866358 (OMIM: 602425) PREDICTED: mitogen-activat (1517 aa)
initn: 7249 init1: 7249 opt: 7258 Z-score: 2730.5 bits: 518.0 E(85289): 2.4e-145
Smith-Waterman score: 9587; 96.6% identity (96.7% similar) in 1499 aa overlap (92-1540:1-1499)
70 80 90 100 110 120
pF1KA0 KSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAPN
::::::::::::::::::::::::::::::
XP_016 MKRMSTKHQRNNVGRPASRSNLKEKMNAPN
10 20 30
130 140 150 160 170 180
pF1KA0 QPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIPD
:::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::
XP_016 QPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIPD
40 50 60 70 80 90
190 200 210 220 230 240
pF1KA0 VDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKK
100 110 120 130 140 150
250 260 270 280 290 300
pF1KA0 KDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILTF
160 170 180 190 200 210
310 320 330 340 350 360
pF1KA0 KVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMELL
220 230 240 250 260 270
370 380 390 400 410 420
pF1KA0 EYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSD
280 290 300 310 320 330
430 440 450 460 470 480
pF1KA0 IGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDNS
340 350 360 370 380 390
490 500 510 520 530 540
pF1KA0 FDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRK
400 410 420 430 440 450
550 560 570 580 590 600
pF1KA0 LILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSW
460 470 480 490 500 510
610 620 630 640 650 660
pF1KA0 EELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKG
520 530 540 550 560 570
670 680 690 700 710 720
pF1KA0 GLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHS
580 590 600 610 620 630
730 740 750 760 770 780
pF1KA0 LKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSA
640 650 660 670 680 690
790 800 810 820 830 840
pF1KA0 DDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDL
700 710 720 730 740 750
850 860 870 880 890 900
pF1KA0 LDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYL
760 770 780 790 800 810
910 920 930 940 950 960
pF1KA0 LLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKA
820 830 840 850 860 870
970 980 990 1000 1010 1020
pF1KA0 FQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVD
880 890 900 910 920 930
1030 1040 1050 1060 1070 1080
pF1KA0 ESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKC
940 950 960 970 980 990
1090 1100 1110 1120 1130 1140
pF1KA0 ESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLY
1000 1010 1020 1030 1040 1050
1150 1160 1170
pF1KA0 LAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGF---------------------------
:::::::::::::::::::::::::::::::::
XP_016 LAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVA
1060 1070 1080 1090 1100 1110
1180 1190 1200 1210
pF1KA0 -----------------------RGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA
:::::::::::::::::::::::::::::::::::::
XP_016 ASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA
1120 1130 1140 1150 1160 1170
1220 1230 1240 1250 1260 1270
pF1KA0 YPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQV
1180 1190 1200 1210 1220 1230
1280 1290 1300 1310 1320 1330
pF1KA0 CDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDH
1240 1250 1260 1270 1280 1290
1340 1350 1360 1370 1380 1390
pF1KA0 KTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIR
1300 1310 1320 1330 1340 1350
1400 1410 1420 1430 1440 1450
pF1KA0 LYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNS
1360 1370 1380 1390 1400 1410
1460 1470 1480 1490 1500 1510
pF1KA0 TLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMG
1420 1430 1440 1450 1460 1470
1520 1530 1540 1550
pF1KA0 HKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
:::::::::::::::::::::::::::::
XP_016 HKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
1480 1490 1500 1510
>>NP_001278887 (OMIM: 602425) mitogen-activated protein (1061 aa)
initn: 4062 init1: 4062 opt: 4080 Z-score: 1547.7 bits: 298.6 E(85289): 1.8e-79
Smith-Waterman score: 6409; 93.8% identity (94.3% similar) in 1040 aa overlap (552-1540:4-1043)
530 540 550 560 570 580
pF1KA0 LTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKNDR-PVEFSEFPDPMWGS
::.:. : . .. .:::::::::::
NP_001 MYIGSIQKDRTTRSRDGACRSQFSEFPDPMWGS
10 20 30
590 600 610 620 630 640
pF1KA0 DYVQLSRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYVQLSRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPA
40 50 60 70 80 90
650 660 670 680 690 700
pF1KA0 GEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMV
100 110 120 130 140 150
710 720 730 740 750 760
pF1KA0 YFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLK
160 170 180 190 200 210
770 780 790 800 810 820
pF1KA0 STGSFLEFGLQESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STGSFLEFGLQESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAK
220 230 240 250 260 270
830 840 850 860 870 880
pF1KA0 MLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLL
280 290 300 310 320 330
890 900 910 920 930 940
pF1KA0 NAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSM
340 350 360 370 380 390
950 960 970 980 990 1000
pF1KA0 QVDNLLLVVMQSAHLTIQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVDNLLLVVMQSAHLTIQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNR
400 410 420 430 440 450
1010 1020 1030 1040 1050 1060
pF1KA0 ISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQ
460 470 480 490 500 510
1070 1080 1090 1100 1110 1120
pF1KA0 KIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQA
520 530 540 550 560 570
1130 1140 1150 1160 1170
pF1KA0 LMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGF------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMP
580 590 600 610 620 630
1180 1190
pF1KA0 --------------------------------------------RGSSVPENDRLASIAA
::::::::::::::::
NP_001 SDARSHGSPAAAAAAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAA
640 650 660 670 680 690
1200 1210 1220 1230 1240 1250
pF1KA0 ELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKS
700 710 720 730 740 750
1260 1270 1280 1290 1300 1310
pF1KA0 VRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTC
760 770 780 790 800 810
1320 1330 1340 1350 1360 1370
pF1KA0 ISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFME
820 830 840 850 860 870
1380 1390 1400 1410 1420 1430
pF1KA0 YCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLG
880 890 900 910 920 930
1440 1450 1460 1470 1480 1490
pF1KA0 DFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVT
940 950 960 970 980 990
1500 1510 1520 1530 1540 1550
pF1KA0 GKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSF
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSF
1000 1010 1020 1030 1040 1050
pF1KA0 VKVCTDEE
NP_001 VKVCTDEE
1060
>>NP_001317360 (OMIM: 602539) mitogen-activated protein (622 aa)
initn: 527 init1: 216 opt: 671 Z-score: 279.5 bits: 63.2 E(85289): 7.8e-09
Smith-Waterman score: 676; 30.2% identity (60.6% similar) in 467 aa overlap (1101-1553:190-620)
1080 1090 1100 1110 1120 1130
pF1KA0 RKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVI
: . .. : : .:. . ..:. .
NP_001 PRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETS--EQCMLDPL
160 170 180 190 200 210
1140 1150 1160 1170 1180
pF1KA0 GKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTP-----EGFRGSSVPENDRL
.. .. ..: .. : : .. : .: : : . .: .:.. :.
NP_001 SSAENSLSGSCQSLDSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPR----
220 230 240 250 260 270
1190 1200 1210 1220 1230 1240
pF1KA0 ASIAAELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIE
... .:.. .. : ..:: :.. .: ::. .:.. ... : :
NP_001 -------RYHVSVHHKDYSDGRR--TFPR-----IRRHQGNLFTLVPSSRSLSTN-G--E
280 290 300 310
1250 1260 1270 1280 1290 1300
pF1KA0 AIQKSVRLFEEK-RYREMRRKNIIG-QVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQ
. .:. .. . : : .: .. : ..: . .. ..:.::. .:.:
NP_001 NMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSA--------PINWRRGKLLGQGA
320 330 340 350 360
1310 1320 1330 1340 1350 1360
pF1KA0 YGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETAD---ELKIFEGIKHPNLVRYFGVEL
.:.:: : .::::. .: :...:.:.. .: ::.. :........: .:.:.:
NP_001 FGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLR
370 380 390 400 410 420
1370 1380 1390 1400 1410
pF1KA0 HREE--MYIFMEYCDEGTL-EEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKG
: : . ::::: :.. .... : : : : : :..:: ... :: . ::::::::
NP_001 DRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKG
430 440 450 460 470 480
1420 1430 1440 1450 1460 1470
pF1KA0 ANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAA
:::. :.: .:::::: : .:.. .. : . :. :: .:.::::. :::.:: :
NP_001 ANILRDSAGNVKLGDFGASKRLQTICMSGTG-MRSVTGTPYWMSPEVIS---GEGYGRKA
490 500 510 520 530 540
1480 1490 1500 1510 1520 1530
pF1KA0 DIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDP
:.:::::.:.::.: : :: ::: :. . . .: .: ..: .:.::: . . .
NP_001 DVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRR-IFVEA
550 560 570 580 590 600
1540 1550
pF1KA0 KMRWTASQLLDHSFVKVCTDEE
..: .: .:: : :...
NP_001 RQRPSAEELLTHHFAQLMY
610 620
>>NP_002392 (OMIM: 602539) mitogen-activated protein kin (626 aa)
initn: 561 init1: 216 opt: 671 Z-score: 279.5 bits: 63.2 E(85289): 7.9e-09
Smith-Waterman score: 682; 32.3% identity (59.5% similar) in 452 aa overlap (1132-1553:186-624)
1110 1120 1130 1140 1150 1160
pF1KA0 IEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPR-PMKVPRCHSD
. : : : .:. .. : .: :
NP_002 QPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLD
160 170 180 190 200 210
1170 1180 1190 1200 1210
pF1KA0 PPNPHLIIPTPEGFRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA------YPR
: . . :. ..: :: :. . . : .:: .: ..:.: . : .
NP_002 P------LSSAENSLSGSCQSLDRSADSPSFRKSR-MSRAQSFPDNRQEYSDRETQLYDK
220 230 240 250 260
1220 1230 1240 1250 1260 1270
pF1KA0 GDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSV-RLFEEKRYREMRRKNI--IGQV
: ..:. : ... . .. .: . :. : .. : .: .:. :
NP_002 GVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQY
270 280 290 300 310 320
1280 1290 1300 1310
pF1KA0 CDTPKSY------DNVMHVGLRKVTFK-------WQRGNKIGEGQYGKVYTCISVDTGEL
: :.. .:.. : :.: : :.::. .:.: .:.:: : .::::.
NP_002 LD-PRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRE
330 340 350 360 370 380
1320 1330 1340 1350 1360 1370
pF1KA0 MAMKEIRFQPNDHKTIKETAD---ELKIFEGIKHPNLVRYFGVELHREE--MYIFMEYCD
.: :...:.:.. .: ::.. :........: .:.:.: : : . :::::
NP_002 LASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMP
390 400 410 420 430 440
1380 1390 1400 1410 1420 1430
pF1KA0 EGTL-EEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGD
:.. .... : : : : : :..:: ... :: . :::::::::::. :.: .::::
NP_002 GGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGD
450 460 470 480 490 500
1440 1450 1460 1470 1480 1490
pF1KA0 FGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTG
:: : .:.. .. : . :. :: .:.::::. :::.:: ::.:::::.:.::.:
NP_002 FGASKRLQTICMSGTG-MRSVTGTPYWMSPEVIS---GEGYGRKADVWSLGCTVVEMLTE
510 520 530 540 550 560
1500 1510 1520 1530 1540 1550
pF1KA0 KRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV
: :: ::: :. . . .: .: ..: .:.::: . . . ..: .: .:: : :.
NP_002 KPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELLTHHFA
570 580 590 600 610 620
pF1KA0 KVCTDEE
..
NP_002 QLMY
>>XP_005257433 (OMIM: 602539) PREDICTED: mitogen-activat (653 aa)
initn: 561 init1: 216 opt: 671 Z-score: 279.3 bits: 63.2 E(85289): 8.1e-09
Smith-Waterman score: 676; 30.2% identity (60.6% similar) in 467 aa overlap (1101-1553:221-651)
1080 1090 1100 1110 1120 1130
pF1KA0 RKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVI
: . .. : : .:. . ..:. .
XP_005 PRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETS--EQCMLDPL
200 210 220 230 240
1140 1150 1160 1170 1180
pF1KA0 GKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTP-----EGFRGSSVPENDRL
.. .. ..: .. : : .. : .: : : . .: .:.. :.
XP_005 SSAENSLSGSCQSLDSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPR----
250 260 270 280 290 300
1190 1200 1210 1220 1230 1240
pF1KA0 ASIAAELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIE
... .:.. .. : ..:: :.. .: ::. .:.. ... : :
XP_005 -------RYHVSVHHKDYSDGRR--TFPR-----IRRHQGNLFTLVPSSRSLSTN-G--E
310 320 330 340
1250 1260 1270 1280 1290 1300
pF1KA0 AIQKSVRLFEEK-RYREMRRKNIIG-QVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQ
. .:. .. . : : .: .. : ..: . .. ..:.::. .:.:
XP_005 NMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSA--------PINWRRGKLLGQGA
350 360 370 380 390
1310 1320 1330 1340 1350 1360
pF1KA0 YGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETAD---ELKIFEGIKHPNLVRYFGVEL
.:.:: : .::::. .: :...:.:.. .: ::.. :........: .:.:.:
XP_005 FGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLR
400 410 420 430 440 450
1370 1380 1390 1400 1410
pF1KA0 HREE--MYIFMEYCDEGTL-EEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKG
: : . ::::: :.. .... : : : : : :..:: ... :: . ::::::::
XP_005 DRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKG
460 470 480 490 500 510
1420 1430 1440 1450 1460 1470
pF1KA0 ANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAA
:::. :.: .:::::: : .:.. .. : . :. :: .:.::::. :::.:: :
XP_005 ANILRDSAGNVKLGDFGASKRLQTICMSGTG-MRSVTGTPYWMSPEVIS---GEGYGRKA
520 530 540 550 560 570
1480 1490 1500 1510 1520 1530
pF1KA0 DIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDP
:.:::::.:.::.: : :: ::: :. . . .: .: ..: .:.::: . . .
XP_005 DVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRR-IFVEA
580 590 600 610 620 630
1540 1550
pF1KA0 KMRWTASQLLDHSFVKVCTDEE
..: .: .:: : :...
XP_005 RQRPSAEELLTHHFAQLMY
640 650
>>NP_976226 (OMIM: 602539) mitogen-activated protein kin (657 aa)
initn: 527 init1: 216 opt: 671 Z-score: 279.3 bits: 63.2 E(85289): 8.1e-09
Smith-Waterman score: 682; 32.3% identity (59.5% similar) in 452 aa overlap (1132-1553:217-655)
1110 1120 1130 1140 1150 1160
pF1KA0 IEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPR-PMKVPRCHSD
. : : : .:. .. : .: :
NP_976 QPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLD
190 200 210 220 230 240
1170 1180 1190 1200 1210
pF1KA0 PPNPHLIIPTPEGFRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA------YPR
: . . :. ..: :: :. . . : .:: .: ..:.: . : .
NP_976 P------LSSAENSLSGSCQSLDRSADSPSFRKSR-MSRAQSFPDNRQEYSDRETQLYDK
250 260 270 280 290
1220 1230 1240 1250 1260 1270
pF1KA0 GDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSV-RLFEEKRYREMRRKNI--IGQV
: ..:. : ... . .. .: . :. : .. : .: .:. :
NP_976 GVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQY
300 310 320 330 340 350
1280 1290 1300 1310
pF1KA0 CDTPKSY------DNVMHVGLRKVTFK-------WQRGNKIGEGQYGKVYTCISVDTGEL
: :.. .:.. : :.: : :.::. .:.: .:.:: : .::::.
NP_976 LD-PRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRE
360 370 380 390 400 410
1320 1330 1340 1350 1360 1370
pF1KA0 MAMKEIRFQPNDHKTIKETAD---ELKIFEGIKHPNLVRYFGVELHREE--MYIFMEYCD
.: :...:.:.. .: ::.. :........: .:.:.: : : . :::::
NP_976 LASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMP
420 430 440 450 460 470
1380 1390 1400 1410 1420 1430
pF1KA0 EGTL-EEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGD
:.. .... : : : : : :..:: ... :: . :::::::::::. :.: .::::
NP_976 GGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGD
480 490 500 510 520 530
1440 1450 1460 1470 1480 1490
pF1KA0 FGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTG
:: : .:.. .. : . :. :: .:.::::. :::.:: ::.:::::.:.::.:
NP_976 FGASKRLQTICMSGTG-MRSVTGTPYWMSPEVIS---GEGYGRKADVWSLGCTVVEMLTE
540 550 560 570 580 590
1500 1510 1520 1530 1540 1550
pF1KA0 KRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV
: :: ::: :. . . .: .: ..: .:.::: . . . ..: .: .:: : :.
NP_976 KPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELLTHHFA
600 610 620 630 640 650
pF1KA0 KVCTDEE
..
NP_976 QLMY
1558 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 06:55:02 2016 done: Sun Nov 6 06:55:05 2016
Total Scan time: 18.060 Total Display time: 0.740
Function used was FASTA [36.3.4 Apr, 2011]