FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA0669, 780 aa
  1>>>pF1KSDA0669 780 - 780 aa - 780 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 17.1311+/-0.000517; mu= -34.1922+/- 0.032
 mean_var=814.9057+/-174.061, 0's: 0 Z-trim(124.6): 42  B-trim: 878 in 1/60
 Lambda= 0.044928
 statistics sampled from 46619 (46678) to 46619 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.799), E-opt: 0.2 (0.547), width:  16
 Scan time: 12.110

The best scores are:                                      opt bits E(85289)
NP_904358 (OMIM: 607715) TSC22 domain family prote (1073)  613 55.6 1.3e-06
NP_006013 (OMIM: 607715) TSC22 domain family prote ( 144)  402 41.2  0.0037


>>NP_904358 (OMIM: 607715) TSC22 domain family protein 1  (1073 aa)
 initn: 794 init1: 337 opt: 613  Z-score: 239.5  bits: 55.6 E(85289): 1.3e-06
Smith-Waterman score: 967; 32.5% identity (58.5% similar) in 805 aa overlap (71-775:312-1071)

               50        60        70        80          90        
pF1KSD TEDVSSEIFDVSRATDYGPEEVCERSSSEETLNNVGDAETPGTVSPNLL--LDGQLAAA-
                                     :.::: .  . :. .::.   . :..  . 
NP_904 SSGSPASVMTNMRAPSTTGGIGINSVTGTSTVNNV-NITAVGSFNPNVTSSMLGNVNIST
             290       300       310        320       330       340

            100       110          120       130       140         
pF1KSD -----AAAPANGGGVVSARSV---SGALASTLAAAATSAPAPGAPGGPQLAGSSAGPVTA
            ::. . : ::.:. .:   ::   .:....:. . .:.:      :: ..: :..
NP_904 SNIPSAAGVSVGPGVTSGVNVNILSGMGNGTISSSAAVSSVPNAA-----AGMTGGSVSS
              350       360       370       380            390     

     150       160       170       180            190       200    
pF1KSD APSQPPTTCSSRFRVIKLDHGSGEPYRRGRWTCMEYYERD-----SDSSVLTRSGDCIRH
         .: ::. .:::::.::: .:.::...::::: :.::..     ... ....  . ...
NP_904 Q-QQQPTVNTSRFRVVKLD-SSSEPFKKGRWTCTEFYEKENAVPATEGVLINKVVETVKQ
          400       410        420       430       440       450   

          210       220       230        240       250       260   
pF1KSD SSTFDQTAERDSGLGATGGSVVVVVASMQGAHGP-ESGTDSSLTAVSQLPPSEKMSQPT-
       .  .. :.::.:  :.. .: : ... .  . :  : :. . ..  .:   .....::. 
NP_904 NP-IEVTSERESTSGSSVSSSVSTLSHYTESVGSGEMGAPTVVVQQQQQQQQQQQQQPAL
            460       470       480       490       500       510  

               270        280               290       300          
pF1KSD ---PAQPQSFSVGQPQPPPP-PVGGAVAQS--------SAPLPPFPGAATGPQPM---MA
            : ..:.   ::  :   .  ...::        :  :      .  : :.   :.
NP_904 QGVTLQQMDFGSTGPQSIPAVSIPQSISQSQISQVQLQSQELSYQQKQGLQPVPLQATMS
            520       530       540       550       560       570  

       310       320           330           340       350         
pF1KSD AAQPSQPQGAGPGGQT----LPPTNVTLAQPAM----SLPPQPGPAVGAPAAQQPQQFAY
       ::   ::. ..  : :      :.  .:::: .    . ::   :  :::  ::  :.. 
NP_904 AATGIQPSPVNVVGVTSALGQQPSISSLAQPQLPYSQAAPPVQTPLPGAPPPQQ-LQYGQ
            580       590       600       610       620        630 

     360           370       380       390       400       410     
pF1KSD PQP----QIPPGHLLPVQPSGQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAATLPVGT
        ::    :. :::.  :  .  :::.::.       : .::::.:..:.   ....::. 
NP_904 QQPMVSTQMAPGHVKSVTQNPASEYVQQQPILQTAMSSGQPSSAGVGAG---TTVIPVAQ
             640       650       660       670       680           

               420       430        440       450                  
pF1KSD GQNA------SSVGAQLMGASSQP-SEAMAPRTGPAQGGQVA--------PC---QP-TG
        :.       ..: ::  ::: :: ..: :  ..   :.:.:        :    :: : 
NP_904 PQGIQLPVQPTAVPAQPAGASVQPVGQAPAAVSAVPTGSQIANIGQQANIPTAVQQPSTQ
      690       700       710       720       730       740        

        460               470       480           490       500    
pF1KSD VPPATV--GG-----VVQPC-LGPAGAGQPQSVP--PPQM--GGSGPLSAVPGGPHAVVP
       :::...  :.     :: :   :    :   :.:  : :.  .... : .::  :..: :
NP_904 VPPSVIQQGAPPSSQVVPPAQTGIIHQGVQTSAPSLPQQLVIASQSSLLTVPPQPQGVEP
      750       760       770       780       790       800        

               510       520              530       540       550  
pF1KSD ---GV--PNVPAAVPAPSVPSVSTTSVT-------MPNVPAPLAQSQQLSSHTPVSRSSS
          :.   ..::.   ::. :.:.:: .       ::..:. :.  :... .::......
NP_904 VAQGIVSQQLPAVSSLPSASSISVTSQVSSTGPSGMPSAPTNLVPPQNIA-QTPATQNGN
      810       820       830       840       850        860       

            560        570         580         590       600       
pF1KSD IIQHVGLPLAPGTHSA-PTS--LPQSDLSQFQTQT--QPLVGQVDDTRRKSEP----LPQ
       ..: :. :   .:..  : .  .: :. .::..:.  : . .:..:.:: .::    :::
NP_904 LVQSVSQPPLIATNTNLPLAQQIPLSS-TQFSAQSLAQAIGSQIEDARRAAEPSLVGLPQ
       870       880       890        900       910       920      

           610       620       630       640        650       660  
pF1KSD PPLSLIAENKPVVKPPVADSLANPLQLTPMNSLATSVFSIAIP-VDGDEDRNPSTAFYQA
         .:  . .  .:.   ..:::   .: :..     :. .. : :::...          
NP_904 T-ISGDSGGMSAVSDGSSSSLAASASLFPLK-----VLPLTTPLVDGEDE----------
         930       940       950            960       970          

            670       680       690       700       710       720  
pF1KSD FHLNTLKESKSLWDSASGGGVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELVER
                     :.::..:::::::::::::::::::::::::::::::::::::.:.
NP_904 --------------SSSGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEK
                            980       990      1000      1010      

            730       740         750       760       770       780
pF1KSD NSLLERENALLKSLSSNDQLSQLPTQ--QANPGSTSQQQAVIAQPPQPTQPPQQPNVSSA
       :: ::.:: :::.:.: .::.:. .:   ..: .:.: :..   : ::..  . :     
NP_904 NSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPPAQPASQGSGPTA   
       1020      1030      1040      1050      1060      1070      

>>NP_006013 (OMIM: 607715) TSC22 domain family protein 1  (144 aa)
 initn: 384 init1: 337 opt: 402  Z-score: 177.7  bits: 41.2 E(85289): 0.0037
Smith-Waterman score: 402; 53.3% identity (77.8% similar) in 135 aa overlap (643-775:9-142)

            620       630       640       650       660       670  
pF1KSD KPVVKPPVADSLANPLQLTPMNSLATSVFSIAIPVDGDEDRNPSTAFYQAFHLNTLKESK
                                     .:. .   . :. : .: ... :.: . : 
NP_006                       MKSQWCRPVAMDLGVYQLRHFSISFLSSL-LGTENASV
                                     10        20         30       

            680       690       700       710       720       730  
pF1KSD SLWDSASGGGVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENAL
        : .:.::..:::::::::::::::::::::::::::::::::::::.:.:: ::.:: :
NP_006 RLDNSSSGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNL
        40        50        60        70        80        90       

            740         750       760       770       780
pF1KSD LKSLSSNDQLSQLPTQ--QANPGSTSQQQAVIAQPPQPTQPPQQPNVSSA
       ::.:.: .::.:. .:   ..: .:.: :..   : ::..  . :     
NP_006 LKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPPAQPASQGSGPTA   
       100       110       120       130       140       




780 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 02:38:38 2016 done: Thu Nov  3 02:38:40 2016
 Total Scan time: 12.110 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]