FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA0448, 356 aa
  1>>>pF1KSDA0448 356 - 356 aa - 356 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.4607+/-0.000375; mu= 15.4569+/- 0.023
 mean_var=64.5201+/-13.364, 0's: 0 Z-trim(111.8): 29  B-trim: 1022 in 1/52
 Lambda= 0.159671
 statistics sampled from 20438 (20448) to 20438 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.61), E-opt: 0.2 (0.24), width:  16
 Scan time:  5.970

The best scores are:                                      opt bits E(85289)
NP_036394 (OMIM: 604844) heparan sulfate 2-O-sulfo ( 356) 2393 560.1 2.6e-159
NP_001127964 (OMIM: 604844) heparan sulfate 2-O-su ( 229) 1561 368.4 8.8e-102
NP_005706 (OMIM: 610752) uronyl 2-sulfotransferase ( 406)  531 131.2 3.8e-30
XP_011533680 (OMIM: 610752) PREDICTED: uronyl 2-su ( 230)  242 64.6 2.6e-10


>>NP_036394 (OMIM: 604844) heparan sulfate 2-O-sulfotran  (356 aa)
 initn: 2393 init1: 2393 opt: 2393  Z-score: 2981.1  bits: 560.1 E(85289): 2.6e-159
Smith-Waterman score: 2393; 100.0% identity (100.0% similar) in 356 aa overlap (1-356:1-356)

               10        20        30        40        50        60
pF1KSD MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRSKLERAIARHEVREIEQRHTMD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRSKLERAIARHEVREIEQRHTMD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD GPRQDATLDEEEDMVIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 GPRQDATLDEEEDMVIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD QVRFVKNITSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 QVRFVKNITSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD DDYRPGLRRRKQGDKKTFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 DDYRPGLRRRKQGDKKTFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD KYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATELYRTGKKSHLRKTTEKKLPTKQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 KYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATELYRTGKKSHLRKTTEKKLPTKQT
              250       260       270       280       290       300

              310       320       330       340       350      
pF1KSD IAKLQQSDIWKMENEFYEFALEQFQFIRAHAVREKDGDLYILAQNFFYEKIYPKSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 IAKLQQSDIWKMENEFYEFALEQFQFIRAHAVREKDGDLYILAQNFFYEKIYPKSN
              310       320       330       340       350      

>>NP_001127964 (OMIM: 604844) heparan sulfate 2-O-sulfot  (229 aa)
 initn: 1561 init1: 1561 opt: 1561  Z-score: 1948.3  bits: 368.4 E(85289): 8.8e-102
Smith-Waterman score: 1561; 100.0% identity (100.0% similar) in 229 aa overlap (1-229:1-229)

               10        20        30        40        50        60
pF1KSD MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRSKLERAIARHEVREIEQRHTMD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRSKLERAIARHEVREIEQRHTMD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD GPRQDATLDEEEDMVIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPRQDATLDEEEDMVIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD QVRFVKNITSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVRFVKNITSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD DDYRPGLRRRKQGDKKTFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQA
       :::::::::::::::::::::::::::::::::::::::::::::::::           
NP_001 DDYRPGLRRRKQGDKKTFDECVAEGGSDCAPEKLWLQIPFFCGHSSECW           
              190       200       210       220                    

              250       260       270       280       290       300
pF1KSD KYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATELYRTGKKSHLRKTTEKKLPTKQT

>>NP_005706 (OMIM: 610752) uronyl 2-sulfotransferase [Ho  (406 aa)
 initn: 437 init1: 165 opt: 531  Z-score: 662.1  bits: 131.2 E(85289): 3.8e-30
Smith-Waterman score: 531; 32.1% identity (68.3% similar) in 265 aa overlap (76-328:105-359)

          50        60        70        80        90       100     
pF1KSD ARHEVREIEQRHTMDGPRQDATLDEEEDMVIIYNRVPKTASTSFTNIAYDLCAKNKYHVL
                                     ..:::: : .: . . .   :  :. ....
NP_005 LLDLRQYLGNSTYLDDHGPPPSKVLPFPSQVVYNRVGKCGSRTVVLLLRILSEKHGFNLV
           80        90       100       110       120       130    

         110       120       130       140       150       160     
pF1KSD HINTTKNNPVMSLQDQVRFVKNITSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRD
         .  .:.  .. ..:....:::.. .  .: ..  :: .:.:..::   .:.:::.:::
NP_005 -TSDIHNKTRLTKNEQMELIKNISTAE--QPYLFTRHVHFLNFSRFG-GDQPVYINIIRD
           140       150       160         170        180       190

         170       180                190       200       210      
pF1KSD PIERLVSYYYFLRFGDDYR---------PGLRRRKQGDKKTFDECVAEGGSDCAPEKLWL
       :..:..: :.: :::: .:         :..:....     ..::. :.  .:.  .:. 
NP_005 PVNRFLSNYFFRRFGD-WRGEQNHMIRTPSMRQEER--YLDINECILENYPECSNPRLFY
              200        210       220         230       240       

        220       230       240       250       260       270      
pF1KSD QIPFFCGHSSECWNVGSRWAMDQAKYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGAT
        ::.:::.  .: . : .::...:: :. ....:::. ::::: ..:::  ::..:.:. 
NP_005 IIPYFCGQHPRCREPG-EWALERAKLNVNENFLLVGILEELEDVLLLLERFLPHYFKGVL
       250       260        270       280       290       300      

        280          290       300       310       320       330   
pF1KSD ELYRTG---KKSHLRKTTEKKLPTKQTIAKLQQSDIWKMENEFYEFALEQFQFIRAHAVR
        .:.     : ...  :..: .:. ...  : :    ..: :::... :::....     
NP_005 SIYKDPEHRKLGNMTVTVKKTVPSPEAVQILYQR--MRYEYEFYHYVKEQFHLLKRKFGL
        310       320       330       340         350       360    

           340       350                         
pF1KSD EKDGDLYILAQNFFYEKIYPKSN                   
                                                 
NP_005 KSHVSKPPLRPHFFIPTPLETEEPIDDEEQDDEKWLEDIYKR
          370       380       390       400      

>>XP_011533680 (OMIM: 610752) PREDICTED: uronyl 2-sulfot  (230 aa)
 initn: 215 init1: 134 opt: 242  Z-score: 306.2  bits: 64.6 E(85289): 2.6e-10
Smith-Waterman score: 242; 34.0% identity (71.7% similar) in 106 aa overlap (76-181:105-206)

          50        60        70        80        90       100     
pF1KSD ARHEVREIEQRHTMDGPRQDATLDEEEDMVIIYNRVPKTASTSFTNIAYDLCAKNKYHVL
                                     ..:::: : .: . . .   :  :. ....
XP_011 LLDLRQYLGNSTYLDDHGPPPSKVLPFPSQVVYNRVGKCGSRTVVLLLRILSEKHGFNLV
           80        90       100       110       120       130    

         110       120       130       140       150       160     
pF1KSD HINTTKNNPVMSLQDQVRFVKNITSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRD
         .  .:.  .. ..:....:::.. .  .: ..  :: .:.:..::   .:.:::.:::
XP_011 -TSDIHNKTRLTKNEQMELIKNISTAE--QPYLFTRHVHFLNFSRFG-GDQPVYINIIRD
           140       150       160         170        180       190

         170       180       190       200       210       220     
pF1KSD PIERLVSYYYFLRFGDDYRPGLRRRKQGDKKTFDECVAEGGSDCAPEKLWLQIPFFCGHS
       :..:..: :.: ::::                                            
XP_011 PVNRFLSNYFFRRFGDWRGEQNHMIRTPSMRQEERYLDQP                    
              200       210       220       230                    




356 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 01:46:08 2016 done: Thu Nov  3 01:46:09 2016
 Total Scan time:  5.970 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]