FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4538, 620 aa 1>>>pF1KE4538 620 - 620 aa - 620 aa Library: /omim/omim.rfq.tfa 64369986 residues in 92320 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.4754+/-0.000421; mu= 0.0544+/- 0.026 mean_var=255.9640+/-54.118, 0's: 0 Z-trim(117.6): 75 B-trim: 587 in 2/53 Lambda= 0.080165 statistics sampled from 30814 (30889) to 30814 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.682), E-opt: 0.2 (0.335), width: 16 Scan time: 6.620 The best scores are: opt bits E(92320) NP_003972 (OMIM: 603484) protein regulator of cyto ( 620) 4020 478.8 2.5e-134 XP_011520489 (OMIM: 603484) protein regulator of c ( 621) 3890 463.8 8.5e-130 NP_955445 (OMIM: 603484) protein regulator of cyto ( 606) 3810 454.5 5.1e-127 XP_011520490 (OMIM: 603484) protein regulator of c ( 607) 3801 453.5 1.1e-126 XP_016878204 (OMIM: 603484) protein regulator of c ( 568) 3686 440.2 1e-122 XP_011520493 (OMIM: 603484) protein regulator of c ( 563) 3642 435.1 3.4e-121 XP_006720822 (OMIM: 603484) protein regulator of c ( 563) 3642 435.1 3.4e-121 XP_006720823 (OMIM: 603484) protein regulator of c ( 562) 3641 435.0 3.7e-121 XP_005255044 (OMIM: 603484) protein regulator of c ( 566) 3631 433.8 8.3e-121 XP_016878203 (OMIM: 603484) protein regulator of c ( 569) 3556 425.1 3.4e-118 XP_016878206 (OMIM: 603484) protein regulator of c ( 514) 3297 395.2 3.3e-109 XP_016878202 (OMIM: 603484) protein regulator of c ( 569) 3178 381.4 4.9e-105 XP_016878201 (OMIM: 603484) protein regulator of c ( 583) 3178 381.4 5e-105 XP_011520491 (OMIM: 603484) protein regulator of c ( 584) 3178 381.4 5e-105 NP_001254509 (OMIM: 603484) protein regulator of c ( 525) 3064 368.2 4.3e-101 XP_011520492 (OMIM: 603484) protein regulator of c ( 564) 2519 305.2 4.3e-82 XP_016878205 (OMIM: 603484) protein regulator of c ( 549) 2439 295.9 2.6e-79 XP_011520494 (OMIM: 603484) protein regulator of c ( 514) 2177 265.6 3.2e-70 >>NP_003972 (OMIM: 603484) protein regulator of cytokine (620 aa) initn: 4020 init1: 4020 opt: 4020 Z-score: 2533.1 bits: 478.8 E(92320): 2.5e-134 Smith-Waterman score: 4020; 99.8% identity (99.8% similar) in 620 aa overlap (1-620:1-620) 10 20 30 40 50 60 pF1KE4 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR :::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IILCMEALDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQREL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQREL 550 560 570 580 590 600 610 620 pF1KE4 SKASKSDATSGILNSTNIQS :::::::::::::::::::: NP_003 SKASKSDATSGILNSTNIQS 610 620 >>XP_011520489 (OMIM: 603484) protein regulator of cytok (621 aa) initn: 3976 init1: 3890 opt: 3890 Z-score: 2451.8 bits: 463.8 E(92320): 8.5e-130 Smith-Waterman score: 3890; 99.5% identity (99.5% similar) in 600 aa overlap (1-600:1-600) 10 20 30 40 50 60 pF1KE4 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR :::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IILCMEALDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQREL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: : XP_011 RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQDSL 550 560 570 580 590 600 610 620 pF1KE4 SKASKSDATSGILNSTNIQS XP_011 PPEENVFVCPKLRWPALLPKR 610 620 >>NP_955445 (OMIM: 603484) protein regulator of cytokine (606 aa) initn: 3849 init1: 3810 opt: 3810 Z-score: 2402.0 bits: 454.5 E(92320): 5.1e-127 Smith-Waterman score: 3895; 97.6% identity (97.6% similar) in 620 aa overlap (1-620:1-606) 10 20 30 40 50 60 pF1KE4 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR :::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 IILCMEALDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQREL ::::::::::::::::::::::::::::::::::::::::::: ::: NP_955 RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFA--------------REL 550 560 570 580 610 620 pF1KE4 SKASKSDATSGILNSTNIQS :::::::::::::::::::: NP_955 SKASKSDATSGILNSTNIQS 590 600 >>XP_011520490 (OMIM: 603484) protein regulator of cytok (607 aa) initn: 3801 init1: 3801 opt: 3801 Z-score: 2396.3 bits: 453.5 E(92320): 1.1e-126 Smith-Waterman score: 3801; 99.8% identity (99.8% similar) in 583 aa overlap (1-583:1-583) 10 20 30 40 50 60 pF1KE4 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR :::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IILCMEALDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQREL ::::::::::::::::::::::::::::::::::::::::::: XP_011 RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFADSLPPEENVFVCPKLRW 550 560 570 580 590 600 610 620 pF1KE4 SKASKSDATSGILNSTNIQS XP_011 PALLPKR >>XP_016878204 (OMIM: 603484) protein regulator of cytok (568 aa) initn: 3686 init1: 3686 opt: 3686 Z-score: 2324.9 bits: 440.2 E(92320): 1e-122 Smith-Waterman score: 3686; 99.8% identity (99.8% similar) in 568 aa overlap (53-620:1-568) 30 40 50 60 70 80 pF1KE4 REIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSE :::::::::::::::::::::::::::::: XP_016 MMIAEEESLKERLIKSISVCQKELNTLCSE 10 20 30 90 100 110 120 130 140 pF1KE4 LHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDI 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE4 DSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVC :::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::: XP_016 DSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEALDHTPDTSFERDVVC 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE4 EDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVAT 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE4 IMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFC 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE4 AEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRG 280 290 300 310 320 330 390 400 410 420 430 440 pF1KE4 GNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLE 340 350 360 370 380 390 450 460 470 480 490 500 pF1KE4 KERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSI 400 410 420 430 440 450 510 520 530 540 550 560 pF1KE4 RPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTGRHGANKENLELNGSILSGGYPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTGRHGANKENLELNGSILSGGYPG 460 470 480 490 500 510 570 580 590 600 610 620 pF1KE4 SAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQRELSKASKSDATSGILNSTNIQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQRELSKASKSDATSGILNSTNIQS 520 530 540 550 560 >>XP_011520493 (OMIM: 603484) protein regulator of cytok (563 aa) initn: 3722 init1: 3636 opt: 3642 Z-score: 2297.4 bits: 435.1 E(92320): 3.4e-121 Smith-Waterman score: 3642; 98.9% identity (99.1% similar) in 566 aa overlap (1-566:1-563) 10 20 30 40 50 60 pF1KE4 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR :::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IILCMEALDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQREL ::::::::::::::::: ::.:: XP_011 RHGANKENLELNGSILS---EGSVPL 550 560 >>XP_006720822 (OMIM: 603484) protein regulator of cytok (563 aa) initn: 3722 init1: 3636 opt: 3642 Z-score: 2297.4 bits: 435.1 E(92320): 3.4e-121 Smith-Waterman score: 3642; 98.9% identity (99.1% similar) in 566 aa overlap (1-566:1-563) 10 20 30 40 50 60 pF1KE4 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR :::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IILCMEALDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQREL ::::::::::::::::: ::.:: XP_006 RHGANKENLELNGSILS---EGSVPL 550 560 >>XP_006720823 (OMIM: 603484) protein regulator of cytok (562 aa) initn: 3639 init1: 3639 opt: 3641 Z-score: 2296.8 bits: 435.0 E(92320): 3.7e-121 Smith-Waterman score: 3641; 99.3% identity (99.5% similar) in 563 aa overlap (1-563:1-562) 10 20 30 40 50 60 pF1KE4 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR :::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IILCMEALDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQREL :::::::::::::::::: :.: XP_006 RHGANKENLELNGSILSG-QPSS 550 560 >>XP_005255044 (OMIM: 603484) protein regulator of cytok (566 aa) initn: 3631 init1: 3631 opt: 3631 Z-score: 2290.5 bits: 433.8 E(92320): 8.3e-121 Smith-Waterman score: 3631; 99.8% identity (99.8% similar) in 557 aa overlap (1-557:1-557) 10 20 30 40 50 60 pF1KE4 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR :::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IILCMEALDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQREL ::::::::::::::::: XP_005 RHGANKENLELNGSILSARTFKGFQI 550 560 >>XP_016878203 (OMIM: 603484) protein regulator of cytok (569 aa) initn: 3642 init1: 3556 opt: 3556 Z-score: 2243.6 bits: 425.1 E(92320): 3.4e-118 Smith-Waterman score: 3556; 99.5% identity (99.5% similar) in 548 aa overlap (53-600:1-548) 30 40 50 60 70 80 pF1KE4 REIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSE :::::::::::::::::::::::::::::: XP_016 MMIAEEESLKERLIKSISVCQKELNTLCSE 10 20 30 90 100 110 120 130 140 pF1KE4 LHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDI 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE4 DSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVC :::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::: XP_016 DSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEALDHTPDTSFERDVVC 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE4 EDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVAT 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE4 IMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFC 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE4 AEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRG 280 290 300 310 320 330 390 400 410 420 430 440 pF1KE4 GNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLE 340 350 360 370 380 390 450 460 470 480 490 500 pF1KE4 KERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSI 400 410 420 430 440 450 510 520 530 540 550 560 pF1KE4 RPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTGRHGANKENLELNGSILSGGYPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTGRHGANKENLELNGSILSGGYPG 460 470 480 490 500 510 570 580 590 600 610 620 pF1KE4 SAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQRELSKASKSDATSGILNSTNIQS ::::::::::::::::::::::::::::::::::: : XP_016 SAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQDSLPPEENVFVCPKLRWPALLPKR 520 530 540 550 560 620 residues in 1 query sequences 64369986 residues in 92320 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Oct 24 21:26:44 2019 done: Thu Oct 24 21:26:44 2019 Total Scan time: 6.620 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]