Result of FASTA (omim) for
pF1KE3822
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3822, 2527 aa
1>>>pF1KE3822 2527 - 2527 aa - 2527 aa
Library: /omim/omim.rfq.tfa
64369986 residues in 92320 sequences
Statistics: Expectation_n fit: rho(ln(x))= 15.3622+/-0.00129; mu= -18.4549+/- 0.078
mean_var=1396.0850+/-300.669, 0's: 0 Z-trim(109.6): 418 B-trim: 0 in 0/51
Lambda= 0.034326
statistics sampled from 18391 (18555) to 18391 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.501), E-opt: 0.2 (0.201), width: 16
Scan time: 12.380
The best scores are: opt bits E(92320)
NP_940980 (OMIM: 607060,609007) leucine-rich repea (2527) 16617 843.6 0
XP_005268686 (OMIM: 607060,609007) leucine-rich re (2521) 16556 840.6 0
XP_011536179 (OMIM: 607060,609007) leucine-rich re (2503) 16210 823.4 0
XP_024304601 (OMIM: 607060,609007) leucine-rich re (2126) 13985 713.1 1e-203
XP_011536183 (OMIM: 607060,609007) leucine-rich re (1611) 10520 541.4 4.1e-152
XP_016874276 (OMIM: 607060,609007) leucine-rich re (1499) 9900 510.6 6.8e-143
XP_016874275 (OMIM: 607060,609007) leucine-rich re (1524) 9871 509.2 1.9e-142
XP_016874277 (OMIM: 607060,609007) leucine-rich re (1281) 8418 437.1 7.8e-121
XP_011536184 (OMIM: 607060,609007) leucine-rich re (1271) 8204 426.5 1.2e-117
XP_016874278 (OMIM: 607060,609007) leucine-rich re (1268) 8202 426.4 1.3e-117
>>NP_940980 (OMIM: 607060,609007) leucine-rich repeat se (2527 aa)
initn: 16617 init1: 16617 opt: 16617 Z-score: 4482.5 bits: 843.6 E(92320): 0
Smith-Waterman score: 16617; 100.0% identity (100.0% similar) in 2527 aa overlap (1-2527:1-2527)
10 20 30 40 50 60
pF1KE3 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
NP_940 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE3 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE3 PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE3 FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE3 RDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 RDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE3 RASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 RASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE3 RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREN
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE3 QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE3 HPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 HPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE3 ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE3 NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE3 CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE3 LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE3 LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE3 GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE3 PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYG
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE3 CAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 CAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHH
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE3 NSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 NSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQ
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE3 SGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 SGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTV
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE3 KLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 KLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRT
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE3 SQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 SQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKE
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE3 NKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 NKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMT
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KE3 AQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 AQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEK
2470 2480 2490 2500 2510 2520
pF1KE3 MRRTSVE
:::::::
NP_940 MRRTSVE
>>XP_005268686 (OMIM: 607060,609007) leucine-rich repeat (2521 aa)
initn: 16418 init1: 16319 opt: 16556 Z-score: 4466.2 bits: 840.6 E(92320): 0
Smith-Waterman score: 16556; 99.7% identity (99.8% similar) in 2527 aa overlap (1-2527:1-2521)
10 20 30 40 50 60
pF1KE3 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
XP_005 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE3 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE3 PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE3 FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE3 RDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE3 RASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE3 RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREN
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE3 QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE3 HPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE3 ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE3 NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE3 CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE3 LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE3 LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE3 GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE3 PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYG
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE3 CAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHH
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE3 NSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQ
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE3 SGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTV
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE3 KLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRT
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE3 SQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKE
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE3 NKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMT
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KE3 AQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEK
::::::::::::::::::::: :::::::::::::::::::::::::::::::::
XP_005 AQLGSLKNVMLVLGYNRKNTE------EIQSCLTVWDINLPHEVQNLEKHIEVRKELAEK
2470 2480 2490 2500 2510
pF1KE3 MRRTSVE
:::::::
XP_005 MRRTSVE
2520
>>XP_011536179 (OMIM: 607060,609007) leucine-rich repeat (2503 aa)
initn: 16204 init1: 16204 opt: 16210 Z-score: 4373.7 bits: 823.4 E(92320): 0
Smith-Waterman score: 16408; 99.0% identity (99.1% similar) in 2527 aa overlap (1-2527:1-2503)
10 20 30 40 50 60
pF1KE3 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
XP_011 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE3 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE3 PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE3 FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE3 RDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE3 RASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE3 RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREN
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE3 QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE3 HPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE3 ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE3 NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE3 CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE3 LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE3 LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE3 GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE3 PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYG
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE3 CAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHH
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE3 NSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQ
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE3 SGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTV
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE3 KLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRT
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE3 SQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKE
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE3 NKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMT
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KE3 AQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEK
::: :::::::::::::::::::::::::::::::::
XP_011 AQL------------------------EIQSCLTVWDINLPHEVQNLEKHIEVRKELAEK
2470 2480 2490
pF1KE3 MRRTSVE
:::::::
XP_011 MRRTSVE
2500
>>XP_024304601 (OMIM: 607060,609007) leucine-rich repeat (2126 aa)
initn: 13985 init1: 13985 opt: 13985 Z-score: 3778.8 bits: 713.1 E(92320): 1e-203
Smith-Waterman score: 13985; 100.0% identity (100.0% similar) in 2126 aa overlap (402-2527:1-2126)
380 390 400 410 420 430
pF1KE3 WALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASANALSTLLEQNVN
::::::::::::::::::::::::::::::
XP_024 MLSMLMHSSSKEVFQASANALSTLLEQNVN
10 20 30
440 450 460 470 480 490
pF1KE3 FRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 FRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVM
40 50 60 70 80 90
500 510 520 530 540 550
pF1KE3 KRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 KRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALN
100 110 120 130 140 150
560 570 580 590 600 610
pF1KE3 RFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 RFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIG
160 170 180 190 200 210
620 630 640 650 660 670
pF1KE3 YLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 YLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSF
220 230 240 250 260 270
680 690 700 710 720 730
pF1KE3 DLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 DLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLL
280 290 300 310 320 330
740 750 760 770 780 790
pF1KE3 GADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 GADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLL
340 350 360 370 380 390
800 810 820 830 840 850
pF1KE3 RRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 RRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSA
400 410 420 430 440 450
860 870 880 890 900 910
pF1KE3 VEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 VEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSI
460 470 480 490 500 510
920 930 940 950 960 970
pF1KE3 SVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 SVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHS
520 530 540 550 560 570
980 990 1000 1010 1020 1030
pF1KE3 DSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 DSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLC
580 590 600 610 620 630
1040 1050 1060 1070 1080 1090
pF1KE3 ETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 ETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLS
640 650 660 670 680 690
1100 1110 1120 1130 1140 1150
pF1KE3 YNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 YNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEA
700 710 720 730 740 750
1160 1170 1180 1190 1200 1210
pF1KE3 CPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 CPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL
760 770 780 790 800 810
1220 1230 1240 1250 1260 1270
pF1KE3 PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLT
820 830 840 850 860 870
1280 1290 1300 1310 1320 1330
pF1KE3 SLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 SLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVP
880 890 900 910 920 930
1340 1350 1360 1370 1380 1390
pF1KE3 YNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 YNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLN
940 950 960 970 980 990
1400 1410 1420 1430 1440 1450
pF1KE3 VWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 VWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVG
1000 1010 1020 1030 1040 1050
1460 1470 1480 1490 1500 1510
pF1KE3 THLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 THLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNF
1060 1070 1080 1090 1100 1110
1520 1530 1540 1550 1560 1570
pF1KE3 KIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 KIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPH
1120 1130 1140 1150 1160 1170
1580 1590 1600 1610 1620 1630
pF1KE3 AVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 AVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDV
1180 1190 1200 1210 1220 1230
1640 1650 1660 1670 1680 1690
pF1KE3 EKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 EKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEII
1240 1250 1260 1270 1280 1290
1700 1710 1720 1730 1740 1750
pF1KE3 IRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 IRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVG
1300 1310 1320 1330 1340 1350
1760 1770 1780 1790 1800 1810
pF1KE3 SEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 SEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKW
1360 1370 1380 1390 1400 1410
1820 1830 1840 1850 1860 1870
pF1KE3 ALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 ALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLN
1420 1430 1440 1450 1460 1470
1880 1890 1900 1910 1920 1930
pF1KE3 NDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 NDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPS
1480 1490 1500 1510 1520 1530
1940 1950 1960 1970 1980 1990
pF1KE3 LISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 LISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMII
1540 1550 1560 1570 1580 1590
2000 2010 2020 2030 2040 2050
pF1KE3 YRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 YRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYN
1600 1610 1620 1630 1640 1650
2060 2070 2080 2090 2100 2110
pF1KE3 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI
1660 1670 1680 1690 1700 1710
2120 2130 2140 2150 2160 2170
pF1KE3 KQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 KQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGC
1720 1730 1740 1750 1760 1770
2180 2190 2200 2210 2220 2230
pF1KE3 GHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 GHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTED
1780 1790 1800 1810 1820 1830
2240 2250 2260 2270 2280 2290
pF1KE3 GKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 GKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKIL
1840 1850 1860 1870 1880 1890
2300 2310 2320 2330 2340 2350
pF1KE3 NIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 NIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSD
1900 1910 1920 1930 1940 1950
2360 2370 2380 2390 2400 2410
pF1KE3 SNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKENKESKHKMSYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 SNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKENKESKHKMSYS
1960 1970 1980 1990 2000 2010
2420 2430 2440 2450 2460 2470
pF1KE3 GRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 GRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVML
2020 2030 2040 2050 2060 2070
2480 2490 2500 2510 2520
pF1KE3 VLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 VLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE
2080 2090 2100 2110 2120
>>XP_011536183 (OMIM: 607060,609007) leucine-rich repeat (1611 aa)
initn: 10696 init1: 10520 opt: 10520 Z-score: 2852.6 bits: 541.4 E(92320): 4.1e-152
Smith-Waterman score: 10520; 99.8% identity (100.0% similar) in 1611 aa overlap (1-1611:1-1611)
10 20 30 40 50 60
pF1KE3 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
XP_011 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE3 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE3 PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE3 FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE3 RDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE3 RASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE3 RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREN
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE3 QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK
:::::::::::::::::::::::::::::::::::::::::::::::::..
XP_011 QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQFV
1570 1580 1590 1600 1610
1630 1640 1650 1660 1670 1680
pF1KE3 HPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
>>XP_016874276 (OMIM: 607060,609007) leucine-rich repeat (1499 aa)
initn: 9900 init1: 9900 opt: 9900 Z-score: 2687.0 bits: 510.6 E(92320): 6.8e-143
Smith-Waterman score: 9900; 100.0% identity (100.0% similar) in 1495 aa overlap (1033-2527:5-1499)
1010 1020 1030 1040 1050 1060
pF1KE3 KCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIAN
::::::::::::::::::::::::::::::
XP_016 MIHSTLKSLTHLDLHSNKFTSFPSYLLKMSCIAN
10 20 30
1070 1080 1090 1100 1110 1120
pF1KE3 LDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGI
40 50 60 70 80 90
1130 1140 1150 1160 1170 1180
pF1KE3 CSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ
100 110 120 130 140 150
1190 1200 1210 1220 1230 1240
pF1KE3 NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY
160 170 180 190 200 210
1250 1260 1270 1280 1290 1300
pF1KE3 LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDEL
220 230 240 250 260 270
1310 1320 1330 1340 1350 1360
pF1KE3 HLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDL
280 290 300 310 320 330
1370 1380 1390 1400 1410 1420
pF1KE3 GMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLS
340 350 360 370 380 390
1430 1440 1450 1460 1470 1480
pF1KE3 KGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAI
400 410 420 430 440 450
1490 1500 1510 1520 1530 1540
pF1KE3 RDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVP
460 470 480 490 500 510
1550 1560 1570 1580 1590 1600
pF1KE3 IEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKW
520 530 540 550 560 570
1610 1620 1630 1640 1650 1660
pF1KE3 LCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPI
580 590 600 610 620 630
1670 1680 1690 1700 1710 1720
pF1KE3 GEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSG
640 650 660 670 680 690
1730 1740 1750 1760 1770 1780
pF1KE3 RERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVD
700 710 720 730 740 750
1790 1800 1810 1820 1830 1840
pF1KE3 HIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVN
760 770 780 790 800 810
1850 1860 1870 1880 1890 1900
pF1KE3 PDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEE
820 830 840 850 860 870
1910 1920 1930 1940 1950 1960
pF1KE3 VAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQD
880 890 900 910 920 930
1970 1980 1990 2000 2010 2020
pF1KE3 KASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQ
940 950 960 970 980 990
2030 2040 2050 2060 2070 2080
pF1KE3 YCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNE
1000 1010 1020 1030 1040 1050
2090 2100 2110 2120 2130 2140
pF1KE3 FDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTR
1060 1070 1080 1090 1100 1110
2150 2160 2170 2180 2190 2200
pF1KE3 RILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCL
1120 1130 1140 1150 1160 1170
2210 2220 2230 2240 2250 2260
pF1KE3 ALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNF
1180 1190 1200 1210 1220 1230
2270 2280 2290 2300 2310 2320
pF1KE3 LLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTK
1240 1250 1260 1270 1280 1290
2330 2340 2350 2360 2370 2380
pF1KE3 IFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEK
1300 1310 1320 1330 1340 1350
2390 2400 2410 2420 2430 2440
pF1KE3 LCGLIDCVHFLREVMVKENKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCGLIDCVHFLREVMVKENKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTR
1360 1370 1380 1390 1400 1410
2450 2460 2470 2480 2490 2500
pF1KE3 RLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPH
1420 1430 1440 1450 1460 1470
2510 2520
pF1KE3 EVQNLEKHIEVRKELAEKMRRTSVE
:::::::::::::::::::::::::
XP_016 EVQNLEKHIEVRKELAEKMRRTSVE
1480 1490
>>XP_016874275 (OMIM: 607060,609007) leucine-rich repeat (1524 aa)
initn: 9871 init1: 9871 opt: 9871 Z-score: 2679.1 bits: 509.2 E(92320): 1.9e-142
Smith-Waterman score: 9871; 99.9% identity (100.0% similar) in 1512 aa overlap (1-1512:1-1512)
10 20 30 40 50 60
pF1KE3 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
XP_016 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE3 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE3 PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE3 FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE3 RDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE3 RASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE3 RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREN
::::::::::::
XP_016 RKTIINESLNFKESFFIFKTQHCS
1510 1520
>>XP_016874277 (OMIM: 607060,609007) leucine-rich repeat (1281 aa)
initn: 8418 init1: 8418 opt: 8418 Z-score: 2291.0 bits: 437.1 E(92320): 7.8e-121
Smith-Waterman score: 8418; 100.0% identity (100.0% similar) in 1268 aa overlap (1260-2527:14-1281)
1230 1240 1250 1260 1270 1280
pF1KE3 NQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMG
::::::::::::::::::::::::::::::
XP_016 MKSQIMDNQIHFVIPPEIGCLENLTSLDVSYNLELRSFPNEMG
10 20 30 40
1290 1300 1310 1320 1330 1340
pF1KE3 KLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTT
50 60 70 80 90 100
1350 1360 1370 1380 1390 1400
pF1KE3 LLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFM
110 120 130 140 150 160
1410 1420 1430 1440 1450 1460
pF1KE3 TQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKI
170 180 190 200 210 220
1470 1480 1490 1500 1510 1520
pF1KE3 TKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVE
230 240 250 260 270 280
1530 1540 1550 1560 1570 1580
pF1KE3 LEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQDPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQDPA
290 300 310 320 330 340
1590 1600 1610 1620 1630 1640
pF1KE3 LQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPKNYMSQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPKNYMSQY
350 360 370 380 390 400
1650 1660 1670 1680 1690 1700
pF1KE3 FKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLI
410 420 430 440 450 460
1710 1720 1730 1740 1750 1760
pF1KE3 NRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPS
470 480 490 500 510 520
1770 1780 1790 1800 1810 1820
pF1KE3 CRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDD
530 540 550 560 570 580
1830 1840 1850 1860 1870 1880
pF1KE3 LMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGS
590 600 610 620 630 640
1890 1900 1910 1920 1930 1940
pF1KE3 FGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMEL
650 660 670 680 690 700
1950 1960 1970 1980 1990 2000
pF1KE3 ASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNA
710 720 730 740 750 760
2010 2020 2030 2040 2050 2060
pF1KE3 AIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTT
770 780 790 800 810 820
2070 2080 2090 2100 2110 2120
pF1KE3 GGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVF
830 840 850 860 870 880
2130 2140 2150 2160 2170 2180
pF1KE3 DILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTEGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTEGY
890 900 910 920 930 940
2190 2200 2210 2220 2230 2240
pF1KE3 TSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLY
950 960 970 980 990 1000
2250 2260 2270 2280 2290 2300
pF1KE3 CNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESTNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESTNS
1010 1020 1030 1040 1050 1060
2310 2320 2330 2340 2350 2360
pF1KE3 TERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQN
1070 1080 1090 1100 1110 1120
2370 2380 2390 2400 2410 2420
pF1KE3 SPVVEVWDKKTEKLCGLIDCVHFLREVMVKENKESKHKMSYSGRVKTLCLQKNTALWIGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPVVEVWDKKTEKLCGLIDCVHFLREVMVKENKESKHKMSYSGRVKTLCLQKNTALWIGT
1130 1140 1150 1160 1170 1180
2430 2440 2450 2460 2470 2480
pF1KE3 GGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEGTQKQKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEGTQKQKEI
1190 1200 1210 1220 1230 1240
2490 2500 2510 2520
pF1KE3 QSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE
::::::::::::::::::::::::::::::::::::::
XP_016 QSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE
1250 1260 1270 1280
>>XP_011536184 (OMIM: 607060,609007) leucine-rich repeat (1271 aa)
initn: 8321 init1: 8203 opt: 8204 Z-score: 2233.7 bits: 426.5 E(92320): 1.2e-117
Smith-Waterman score: 8204; 99.3% identity (99.4% similar) in 1269 aa overlap (1-1266:1-1269)
10 20 30 40 50 60
pF1KE3 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
XP_011 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE3 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_011 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEV
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310
pF1KE3 PPEI---GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKD
::
XP_011 SSTAIKKGCAL
1270
>>XP_016874278 (OMIM: 607060,609007) leucine-rich repeat (1268 aa)
initn: 8199 init1: 8199 opt: 8202 Z-score: 2233.2 bits: 426.4 E(92320): 1.3e-117
Smith-Waterman score: 8202; 99.6% identity (99.8% similar) in 1264 aa overlap (1-1264:1-1264)
10 20 30 40 50 60
pF1KE3 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
XP_016 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE3 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEE
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE3 PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR
:.
XP_016 QNEVTDNG
2527 residues in 1 query sequences
64369986 residues in 92320 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Oct 24 21:51:19 2019 done: Thu Oct 24 21:51:21 2019
Total Scan time: 12.380 Total Display time: 0.990
Function used was FASTA [36.3.4 Apr, 2011]