Result of FASTA (omim) for
pF1KE3190
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3190, 442 aa
1>>>pF1KE3190 442 - 442 aa - 442 aa
Library: /omim/omim.rfq.tfa
64704883 residues in 91410 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1277+/-0.000328; mu= 19.2595+/- 0.021
mean_var=71.8895+/-14.532, 0's: 0 Z-trim(114.6): 15 B-trim: 1440 in 1/55
Lambda= 0.151266
statistics sampled from 25336 (25347) to 25336 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.277), width: 16
Scan time: 3.940
The best scores are: opt bits E(91410)
NP_057386 (OMIM: 607417,609262) protein cereblon i ( 442) 3032 670.9 1.9e-192
NP_001166953 (OMIM: 607417,609262) protein cereblo ( 441) 3015 667.2 2.5e-191
XP_005265259 (OMIM: 607417,609262) protein cereblo ( 379) 2611 579.0 7.8e-165
XP_011532093 (OMIM: 607417,609262) protein cereblo ( 398) 2294 509.8 5.4e-144
XP_024309319 (OMIM: 607417,609262) protein cereblo ( 284) 1885 420.5 3.1e-117
XP_011532095 (OMIM: 607417,609262) protein cereblo ( 278) 1871 417.4 2.5e-116
XP_011532096 (OMIM: 607417,609262) protein cereblo ( 278) 1871 417.4 2.5e-116
>>NP_057386 (OMIM: 607417,609262) protein cereblon isofo (442 aa)
initn: 3032 init1: 3032 opt: 3032 Z-score: 3576.4 bits: 670.9 E(91410): 1.9e-192
Smith-Waterman score: 3032; 100.0% identity (100.0% similar) in 442 aa overlap (1-442:1-442)
10 20 30 40 50 60
pF1KE3 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 TVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
370 380 390 400 410 420
430 440
pF1KE3 ALLPTIPDTEDEISPDKVILCL
::::::::::::::::::::::
NP_057 ALLPTIPDTEDEISPDKVILCL
430 440
>>NP_001166953 (OMIM: 607417,609262) protein cereblon is (441 aa)
initn: 2869 init1: 2869 opt: 3015 Z-score: 3556.4 bits: 667.2 E(91410): 2.5e-191
Smith-Waterman score: 3015; 99.8% identity (99.8% similar) in 442 aa overlap (1-442:1-441)
10 20 30 40 50 60
pF1KE3 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
NP_001 MAGEGDQQDAAHNMGNHLPLLP-ESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE3 AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE3 KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE3 PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE3 IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE3 TVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
360 370 380 390 400 410
430 440
pF1KE3 ALLPTIPDTEDEISPDKVILCL
::::::::::::::::::::::
NP_001 ALLPTIPDTEDEISPDKVILCL
420 430 440
>>XP_005265259 (OMIM: 607417,609262) protein cereblon is (379 aa)
initn: 2611 init1: 2611 opt: 2611 Z-score: 3080.8 bits: 579.0 E(91410): 7.8e-165
Smith-Waterman score: 2611; 100.0% identity (100.0% similar) in 379 aa overlap (64-442:1-379)
40 50 60 70 80 90
pF1KE3 EDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIP
::::::::::::::::::::::::::::::
XP_005 MEEFHGRTLHDDDSCQVIPVLPQVMMILIP
10 20 30
100 110 120 130 140 150
pF1KE3 GQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIE
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE3 IVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPV
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE3 SREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSL
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE3 PSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITT
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE3 KNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKI
280 290 300 310 320 330
400 410 420 430 440
pF1KE3 CASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
340 350 360 370
>>XP_011532093 (OMIM: 607417,609262) protein cereblon is (398 aa)
initn: 2695 init1: 2292 opt: 2294 Z-score: 2706.7 bits: 509.8 E(91410): 5.4e-144
Smith-Waterman score: 2610; 89.8% identity (89.8% similar) in 442 aa overlap (1-442:1-398)
10 20 30 40 50 60
pF1KE3 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL
::::::::::::::::::::::::::::::::::::::
XP_011 IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFR---------------------
310 320 330
370 380 390 400 410 420
pF1KE3 TVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
:::::::::::::::::::::::::::::::::::::
XP_011 -----------------------YAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
340 350 360 370
430 440
pF1KE3 ALLPTIPDTEDEISPDKVILCL
::::::::::::::::::::::
XP_011 ALLPTIPDTEDEISPDKVILCL
380 390
>>XP_024309319 (OMIM: 607417,609262) protein cereblon is (284 aa)
initn: 1885 init1: 1885 opt: 1885 Z-score: 2226.3 bits: 420.5 E(91410): 3.1e-117
Smith-Waterman score: 1885; 100.0% identity (100.0% similar) in 278 aa overlap (1-278:1-278)
10 20 30 40 50 60
pF1KE3 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
::::::::::::::::::::::::::::::::::::::
XP_024 PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIVYFPLL
250 260 270 280
310 320 330 340 350 360
pF1KE3 IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL
>>XP_011532095 (OMIM: 607417,609262) protein cereblon is (278 aa)
initn: 1871 init1: 1871 opt: 1871 Z-score: 2209.9 bits: 417.4 E(91410): 2.5e-116
Smith-Waterman score: 1871; 100.0% identity (100.0% similar) in 266 aa overlap (177-442:13-278)
150 160 170 180 190 200
pF1KE3 EQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQ
::::::::::::::::::::::::::::::
XP_011 MRLQHLLKMIFRIQQAKVQILPECVLPSTMSAVQLESLNKCQ
10 20 30 40
210 220 230 240 250 260
pF1KE3 IFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDE
50 60 70 80 90 100
270 280 290 300 310 320
pF1KE3 NLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQC
110 120 130 140 150 160
330 340 350 360 370 380
pF1KE3 QETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAW
170 180 190 200 210 220
390 400 410 420 430 440
pF1KE3 TVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
230 240 250 260 270
>>XP_011532096 (OMIM: 607417,609262) protein cereblon is (278 aa)
initn: 1871 init1: 1871 opt: 1871 Z-score: 2209.9 bits: 417.4 E(91410): 2.5e-116
Smith-Waterman score: 1871; 100.0% identity (100.0% similar) in 266 aa overlap (177-442:13-278)
150 160 170 180 190 200
pF1KE3 EQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQ
::::::::::::::::::::::::::::::
XP_011 MRLQHLLKMIFRIQQAKVQILPECVLPSTMSAVQLESLNKCQ
10 20 30 40
210 220 230 240 250 260
pF1KE3 IFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDE
50 60 70 80 90 100
270 280 290 300 310 320
pF1KE3 NLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQC
110 120 130 140 150 160
330 340 350 360 370 380
pF1KE3 QETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAW
170 180 190 200 210 220
390 400 410 420 430 440
pF1KE3 TVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
230 240 250 260 270
442 residues in 1 query sequences
64704883 residues in 91410 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Jul 14 21:18:08 2018 done: Sat Jul 14 21:18:09 2018
Total Scan time: 3.940 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]