Result of FASTA (omim) for
pF1KE2630
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2630, 819 aa
1>>>pF1KE2630 819 - 819 aa - 819 aa
Library: /omim/omim.rfq.tfa
64536644 residues in 91102 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2736+/-0.000426; mu= 20.6698+/- 0.026
mean_var=69.3285+/-13.682, 0's: 0 Z-trim(108.4): 243 B-trim: 15 in 2/57
Lambda= 0.154035
statistics sampled from 16754 (17005) to 16754 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.535), E-opt: 0.2 (0.187), width: 16
Scan time: 5.230
The best scores are: opt bits E(91102)
NP_006567 (OMIM: 613397) advillin [Homo sapiens] ( 819) 5472 1226.2 0
XP_016874199 (OMIM: 613397) advillin isoform X1 [H ( 819) 5472 1226.2 0
XP_016874202 (OMIM: 613397) advillin isoform X2 [H ( 796) 5315 1191.3 0
XP_016874200 (OMIM: 613397) advillin isoform X2 [H ( 796) 5315 1191.3 0
XP_024304568 (OMIM: 613397) advillin isoform X2 [H ( 796) 5315 1191.3 0
XP_016874201 (OMIM: 613397) advillin isoform X2 [H ( 796) 5315 1191.3 0
NP_009058 (OMIM: 193040) villin-1 [Homo sapiens] ( 827) 3489 785.5 0
XP_016874203 (OMIM: 613397) advillin isoform X3 [H ( 520) 3412 768.3 0
XP_016874204 (OMIM: 613397) advillin isoform X4 [H ( 502) 3379 760.9 0
NP_001106177 (OMIM: 613416) adseverin isoform 1 [H ( 715) 2325 526.8 1.4e-148
NP_001121134 (OMIM: 105120,137350) gelsolin isofor ( 731) 2209 501.0 8.2e-141
NP_001339983 (OMIM: 105120,137350) gelsolin isofor ( 731) 2209 501.0 8.2e-141
NP_001339988 (OMIM: 105120,137350) gelsolin isofor ( 731) 2209 501.0 8.2e-141
NP_001121136 (OMIM: 105120,137350) gelsolin isofor ( 731) 2209 501.0 8.2e-141
NP_001339989 (OMIM: 105120,137350) gelsolin isofor ( 731) 2209 501.0 8.2e-141
XP_024303292 (OMIM: 105120,137350) gelsolin isofor ( 731) 2209 501.0 8.2e-141
NP_001339985 (OMIM: 105120,137350) gelsolin isofor ( 731) 2209 501.0 8.2e-141
XP_024303291 (OMIM: 105120,137350) gelsolin isofor ( 731) 2209 501.0 8.2e-141
NP_001339991 (OMIM: 105120,137350) gelsolin isofor ( 731) 2209 501.0 8.2e-141
NP_001339990 (OMIM: 105120,137350) gelsolin isofor ( 731) 2209 501.0 8.2e-141
NP_001121137 (OMIM: 105120,137350) gelsolin isofor ( 731) 2209 501.0 8.2e-141
NP_001339986 (OMIM: 105120,137350) gelsolin isofor ( 731) 2209 501.0 8.2e-141
XP_011516895 (OMIM: 105120,137350) gelsolin isofor ( 731) 2209 501.0 8.2e-141
NP_937895 (OMIM: 105120,137350) gelsolin isoform b ( 731) 2209 501.0 8.2e-141
NP_001339982 (OMIM: 105120,137350) gelsolin isofor ( 731) 2209 501.0 8.2e-141
NP_001339984 (OMIM: 105120,137350) gelsolin isofor ( 731) 2209 501.0 8.2e-141
NP_001339987 (OMIM: 105120,137350) gelsolin isofor ( 731) 2209 501.0 8.2e-141
NP_001244959 (OMIM: 105120,137350) gelsolin isofor ( 739) 2209 501.0 8.3e-141
NP_001340004 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
NP_001339999 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
NP_001339998 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
XP_005252001 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
NP_001339993 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
NP_001339995 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
NP_001121138 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
NP_001340001 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
XP_016870137 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
NP_001340006 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
NP_001121139 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
NP_001339992 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
NP_001340002 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
NP_001339994 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
NP_001340000 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
NP_001339996 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
NP_001339997 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
NP_001340003 (OMIM: 105120,137350) gelsolin isofor ( 742) 2209 501.0 8.3e-141
NP_001244958 (OMIM: 105120,137350) gelsolin isofor ( 748) 2209 501.0 8.4e-141
XP_016870134 (OMIM: 105120,137350) gelsolin isofor ( 752) 2209 501.0 8.4e-141
NP_001340005 (OMIM: 105120,137350) gelsolin isofor ( 755) 2209 501.0 8.4e-141
XP_011516887 (OMIM: 105120,137350) gelsolin isofor ( 761) 2209 501.0 8.5e-141
>>NP_006567 (OMIM: 613397) advillin [Homo sapiens] (819 aa)
initn: 5472 init1: 5472 opt: 5472 Z-score: 6567.7 bits: 1226.2 E(91102): 0
Smith-Waterman score: 5472; 100.0% identity (100.0% similar) in 819 aa overlap (1-819:1-819)
10 20 30 40 50 60
pF1KE2 MPLTSAFRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MPLTSAFRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 FWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 SGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 SGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 IIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 TKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 IGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 GDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 EPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 DVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 YANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFLWIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 YANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFLWIG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 AEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 TYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAK
730 740 750 760 770 780
790 800 810
pF1KE2 KENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLF
:::::::::::::::::::::::::::::::::::::::
NP_006 KENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLF
790 800 810
>>XP_016874199 (OMIM: 613397) advillin isoform X1 [Homo (819 aa)
initn: 5472 init1: 5472 opt: 5472 Z-score: 6567.7 bits: 1226.2 E(91102): 0
Smith-Waterman score: 5472; 100.0% identity (100.0% similar) in 819 aa overlap (1-819:1-819)
10 20 30 40 50 60
pF1KE2 MPLTSAFRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPLTSAFRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 FWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 SGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 SGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 IIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 TKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 IGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 GDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 EPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 DVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 YANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFLWIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFLWIG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 AEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 TYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAK
730 740 750 760 770 780
790 800 810
pF1KE2 KENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLF
:::::::::::::::::::::::::::::::::::::::
XP_016 KENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLF
790 800 810
>>XP_016874202 (OMIM: 613397) advillin isoform X2 [Homo (796 aa)
initn: 5315 init1: 5315 opt: 5315 Z-score: 6379.3 bits: 1191.3 E(91102): 0
Smith-Waterman score: 5315; 100.0% identity (100.0% similar) in 796 aa overlap (24-819:1-796)
10 20 30 40 50 60
pF1KE2 MPLTSAFRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIH
:::::::::::::::::::::::::::::::::::::
XP_016 MELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIH
10 20 30
70 80 90 100 110 120
pF1KE2 FWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 SGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESN
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 SGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDE
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 IIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGA
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 TKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFS
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 IGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYG
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 GDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGT
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 EPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSN
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE2 DVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTP
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE2 YANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFLWIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFLWIG
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE2 AEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGK
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE2 TYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAK
700 710 720 730 740 750
790 800 810
pF1KE2 KENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLF
:::::::::::::::::::::::::::::::::::::::
XP_016 KENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLF
760 770 780 790
>>XP_016874200 (OMIM: 613397) advillin isoform X2 [Homo (796 aa)
initn: 5315 init1: 5315 opt: 5315 Z-score: 6379.3 bits: 1191.3 E(91102): 0
Smith-Waterman score: 5315; 100.0% identity (100.0% similar) in 796 aa overlap (24-819:1-796)
10 20 30 40 50 60
pF1KE2 MPLTSAFRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIH
:::::::::::::::::::::::::::::::::::::
XP_016 MELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIH
10 20 30
70 80 90 100 110 120
pF1KE2 FWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 SGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESN
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 SGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDE
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 IIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGA
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 TKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFS
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 IGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYG
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 GDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGT
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 EPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSN
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE2 DVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTP
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE2 YANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFLWIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFLWIG
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE2 AEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGK
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE2 TYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAK
700 710 720 730 740 750
790 800 810
pF1KE2 KENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLF
:::::::::::::::::::::::::::::::::::::::
XP_016 KENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLF
760 770 780 790
>>XP_024304568 (OMIM: 613397) advillin isoform X2 [Homo (796 aa)
initn: 5315 init1: 5315 opt: 5315 Z-score: 6379.3 bits: 1191.3 E(91102): 0
Smith-Waterman score: 5315; 100.0% identity (100.0% similar) in 796 aa overlap (24-819:1-796)
10 20 30 40 50 60
pF1KE2 MPLTSAFRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIH
:::::::::::::::::::::::::::::::::::::
XP_024 MELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIH
10 20 30
70 80 90 100 110 120
pF1KE2 FWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 FWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 SGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 SGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESN
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 SGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 SGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDE
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 IIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 IIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGA
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 TKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 TKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFS
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 IGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 IGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYG
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 GDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 GDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGT
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 EPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 EPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSN
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE2 DVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 DVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTP
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE2 YANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFLWIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 YANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFLWIG
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE2 AEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 AEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGK
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE2 TYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 TYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAK
700 710 720 730 740 750
790 800 810
pF1KE2 KENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLF
:::::::::::::::::::::::::::::::::::::::
XP_024 KENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLF
760 770 780 790
>>XP_016874201 (OMIM: 613397) advillin isoform X2 [Homo (796 aa)
initn: 5315 init1: 5315 opt: 5315 Z-score: 6379.3 bits: 1191.3 E(91102): 0
Smith-Waterman score: 5315; 100.0% identity (100.0% similar) in 796 aa overlap (24-819:1-796)
10 20 30 40 50 60
pF1KE2 MPLTSAFRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIH
:::::::::::::::::::::::::::::::::::::
XP_016 MELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIH
10 20 30
70 80 90 100 110 120
pF1KE2 FWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 SGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESN
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 SGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDE
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 IIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGA
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 TKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFS
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 IGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYG
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 GDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGT
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 EPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSN
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE2 DVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTP
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE2 YANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFLWIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFLWIG
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE2 AEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGK
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE2 TYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAK
700 710 720 730 740 750
790 800 810
pF1KE2 KENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLF
:::::::::::::::::::::::::::::::::::::::
XP_016 KENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLF
760 770 780 790
>>NP_009058 (OMIM: 193040) villin-1 [Homo sapiens] (827 aa)
initn: 3828 init1: 3282 opt: 3489 Z-score: 4186.0 bits: 785.5 E(91102): 0
Smith-Waterman score: 3489; 61.8% identity (84.6% similar) in 811 aa overlap (14-819:17-827)
10 20 30 40 50
pF1KE2 MPLTSAFRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQ
::. .:::: :... :: :. :.:..::::.::. ...:: ::
NP_009 MTKLSAQVKGSLNITTPGLQIWRIEAMQMVPVPSSTFGSFFDGDCYIILAIHKTASSLSY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 DIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQG
:::.:::.::: :::. :::::::.::.: : ::::::: .::..::::::::.. ..:
NP_009 DIHYWIGQDSSLDEQGAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 GVASGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGP
::::::::::::.:::.::::::::::. : :::::: ::::::::::::::.:::::::
NP_009 GVASGMKHVETNSYDVQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 ESNSGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTV
::. :::..: :::.:::.:::::. .::..:..: :::.::.:.. .::.: .: .:
NP_009 ESTRMERLRGMTLAKEIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 PDEIIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKG
:: ... :... :::.::: :.:.: :::::::.::::.:.:::::::.: :::::::
NP_009 PDTVVEPALKAALKLYHVSDSEGNLVVREVATRPLTQDLLSHEDCYILDQGGLKIYVWKG
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE2 KGATKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGK
: :.. ::..:::.::.::: :.:: ::.::. :::::::.:.::::::.....: ::::
NP_009 KKANEQEKKGAMSHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGK
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE2 TFSIGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGF
: ..:..::: : :::.: .:.::.::::..:::::.:.:.::::::::::::. .: :
NP_009 THTVGSVAKVEQVKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGH
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE2 FYGGDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVR
::::::::.:::: .. : :..::.::: .:::::..::::::: .:....: ::.::
NP_009 FYGGDCYLLLYTYLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVP
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE2 MGTEPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSL
:: :: :.:.::::..:...::::: .: : : .::::..:. .:::: :::: :. :
NP_009 MGKEPPHLMSIFKGRMVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFL
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE2 NSNDVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGG
::::::.:.::. ::: ::: ::::: ::: .:. . ...:.::::::.:: :::
NP_009 NSNDVFVLKTQSCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGG
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE2 KTPYANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFL
:.:::: ::::.: : . ::::::::::.:..::: ::.::::. ::.:::.:::::.
NP_009 KAPYANTKRLQEENLVITPRLFECSNKTGRFLATEIPDFNQDDLEEDDVFLLDVWDQVFF
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE2 WIGAEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWS
::: .:: ::..: .:::.::.::::::::.:::...::: ::: :::::::::: ::
NP_009 WIGKHANEEEKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWS
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE2 AGKTYEQLKEELGDAAAIMRITADM---KNATLSLNSN-DSEP-KYYPIAVLLKNQNQEL
:.::.:: :::.. .:::.. : ... ::: .: : .:. :... .::
NP_009 NTKSYEDLKAELGNSRDWSQITAEVTSPKVDVFNANSNLSSGPLPIFPLEQLVNKPVEEL
730 740 750 760 770 780
780 790 800 810
pF1KE2 PEDVNPAKKENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLF
:: :.:..::..:: .::...::.: . :.::: ::: ..:::::::
NP_009 PEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKEKGLF
790 800 810 820
>>XP_016874203 (OMIM: 613397) advillin isoform X3 [Homo (520 aa)
initn: 3406 init1: 3406 opt: 3412 Z-score: 4096.5 bits: 768.3 E(91102): 0
Smith-Waterman score: 3412; 98.8% identity (99.2% similar) in 515 aa overlap (306-819:6-520)
280 290 300 310 320 330
pF1KE2 LLNHDDCYILDQSGTKIYVWKGKGATKAEKQAAMSKAL-GFIKMKSYPSSTNVETVNDGA
: . .:: :::::::::::::::::::::
XP_016 MCNTVQIILLRALQGFIKMKSYPSSTNVETVNDGA
10 20 30
340 350 360 370 380 390
pF1KE2 ESAMFKQLFQKWSVKDQTMGLGKTFSIGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESAMFKQLFQKWSVKDQTMGLGKTFSIGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGN
40 50 60 70 80 90
400 410 420 430 440 450
pF1KE2 GKVEVWRIENLELVPVEYQWYGFFYGGDCYLVLYTYEVNGKPHHILYIWQGRHASQDELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKVEVWRIENLELVPVEYQWYGFFYGGDCYLVLYTYEVNGKPHHILYIWQGRHASQDELA
100 110 120 130 140 150
460 470 480 490 500 510
pF1KE2 ASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRL
160 170 180 190 200 210
520 530 540 550 560 570
pF1KE2 FQIHGNDKSNTKAVEVPAFASSLNSNDVFLLRTQAEHYLWYGKGSSGDERAMAKELASLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQIHGNDKSNTKAVEVPAFASSLNSNDVFLLRTQAEHYLWYGKGSSGDERAMAKELASLL
220 230 240 250 260 270
580 590 600 610 620 630
pF1KE2 CDGSENTVAEGQEPAEFWDLLGGKTPYANDKRLQQEILDVQSRLFECSNKTGQFVVTEIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CDGSENTVAEGQEPAEFWDLLGGKTPYANDKRLQQEILDVQSRLFECSNKTGQFVVTEIT
280 290 300 310 320 330
640 650 660 670 680 690
pF1KE2 DFTQDDLNPTDVMLLDTWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTPILI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFTQDDLNPTDVMLLDTWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTPILI
340 350 360 370 380 390
700 710 720 730 740 750
pF1KE2 IKQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELGDAAAIMRITADMKNATLSLNSNDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELGDAAAIMRITADMKNATLSLNSNDS
400 410 420 430 440 450
760 770 780 790 800 810
pF1KE2 EPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRGQFAALPGWKQLQMKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRGQFAALPGWKQLQMKK
460 470 480 490 500 510
pF1KE2 EKGLF
:::::
XP_016 EKGLF
520
>>XP_016874204 (OMIM: 613397) advillin isoform X4 [Homo (502 aa)
initn: 3379 init1: 3379 opt: 3379 Z-score: 4057.1 bits: 760.9 E(91102): 0
Smith-Waterman score: 3379; 100.0% identity (100.0% similar) in 502 aa overlap (318-819:1-502)
290 300 310 320 330 340
pF1KE2 SGTKIYVWKGKGATKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWS
::::::::::::::::::::::::::::::
XP_016 MKSYPSSTNVETVNDGAESAMFKQLFQKWS
10 20 30
350 360 370 380 390 400
pF1KE2 VKDQTMGLGKTFSIGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKDQTMGLGKTFSIGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLEL
40 50 60 70 80 90
410 420 430 440 450 460
pF1KE2 VPVEYQWYGFFYGGDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPVEYQWYGFFYGGDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQF
100 110 120 130 140 150
470 480 490 500 510 520
pF1KE2 DGAAVQVRVRMGTEPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGAAVQVRVRMGTEPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKA
160 170 180 190 200 210
530 540 550 560 570 580
pF1KE2 VEVPAFASSLNSNDVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEVPAFASSLNSNDVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQE
220 230 240 250 260 270
590 600 610 620 630 640
pF1KE2 PAEFWDLLGGKTPYANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAEFWDLLGGKTPYANDKRLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVM
280 290 300 310 320 330
650 660 670 680 690 700
pF1KE2 LLDTWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLDTWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGW
340 350 360 370 380 390
710 720 730 740 750 760
pF1KE2 FLAWDPNIWSAGKTYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLAWDPNIWSAGKTYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKN
400 410 420 430 440 450
770 780 790 800 810
pF1KE2 QNQELPEDVNPAKKENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLF
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNQELPEDVNPAKKENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLF
460 470 480 490 500
>>NP_001106177 (OMIM: 613416) adseverin isoform 1 [Homo (715 aa)
initn: 1971 init1: 773 opt: 2325 Z-score: 2789.0 bits: 526.8 E(91102): 1.4e-148
Smith-Waterman score: 2332; 49.4% identity (74.5% similar) in 722 aa overlap (7-716:10-715)
10 20 30 40 50
pF1KE2 MPLTSAFRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQ
: . .. :. ::::::.::. :: ::::.:: :: :..: : ... ..
NP_001 MARELYHEEFARAGKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRGFTY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 DIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQG
.:::.::. ::::.. :::.:.:.::::::.:::.::.: .::. : .::: :. :: :
NP_001 HLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGGLKYKAG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 GVASGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGP
:::::..:: :: .::::::::.: .::::: .::::::.:: :..::: : :: :
NP_001 GVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGS
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 ESNSGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTV
:. ::::: .: :: :: ::... :.: .: . ::.::: . :: .
NP_001 SCNKYERLKANQVATGIRYNERKGRSELIVVEEGSEPS--ELIKVLGE--------KPEL
190 200 210 220 230
240 250 260 270 280 290
pF1KE2 PD-----EII-DQKQKSTIMLYHISDSAGQLAVTEVATR-PLVQDLLNHDDCYILDQSGT
:: .:: : .... :: .::..:.. :: :: . :. . .: ..:.:::....
NP_001 PDGGDDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAA
240 250 260 270 280 290
300 310 320 330 340
pF1KE2 K-IYVWKGKGATKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVK
: :.::::: :. :..:::. : :... .: ..:..... .:.:. .:::.:. : :
NP_001 KQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDK
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE2 DQTMGLGKTFSIGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVP
::. :.::.. :.:.. : ::.. ::..:..:::. :::::.::::.::.:: .
NP_001 DQSDGFGKVYVTEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQ
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE2 VEYQWYGFFYGGDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDG
:. . :: :::::::..:::: :. :.: ::: .:..:::..::. .:..::.. :
NP_001 VDQNSYGEFYGGDCYIILYTYP-RGQ---IIYTWQGANATRDELTTSAFLTVQLDRSLGG
420 430 440 450 460
470 480 490 500 510 520
pF1KE2 AAVQVRVRMGTEPRHFMAIFKGK-LVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAV
:::.:: .: :: :....:: : :.:...:::.::. : ::.::::.. : : :. :
NP_001 QAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIV
470 480 490 500 510 520
530 540 550 560 570 580
pF1KE2 EVPAFASSLNSNDVFLLRT-QAEHYLWYGKGSSGDERAMAKELASLL-CDGSENTVAEGQ
:: . :.::::::::.:. : :.: :::.: .:. :. .::.: : . . ::.
NP_001 EVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLR--IQEGE
530 540 550 560 570 580
590 600 610 620 630 640
pF1KE2 EPAEFWDLLGGKTPYANDKRLQQEILDVQSRLFECSNKTGQFVVTEIT-DFTQDDLNPTD
:: :::. :::: : .. :. . : ::. ::::::.::. :: .:::::: :
NP_001 EPEEFWNSLGGKKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDD
590 600 610 620 630 640
650 660 670 680 690 700
pF1KE2 VMLLDTWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFT
:::::.:.:.:.::: .:: .::. .: .:..::.: ::::: :::.::::: ::: ::
NP_001 VMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFT
650 660 670 680 690 700
710 720 730 740 750 760
pF1KE2 GWFLAWDPNIWSAGKTYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLL
::::.:: . :
NP_001 GWFLGWDSSKW
710
819 residues in 1 query sequences
64536644 residues in 91102 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Jun 3 14:39:17 2018 done: Sun Jun 3 14:39:18 2018
Total Scan time: 5.230 Total Display time: 0.180
Function used was FASTA [36.3.4 Apr, 2011]