Result of FASTA (omim) for
pF1KE2587
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2587, 656 aa
1>>>pF1KE2587 656 - 656 aa - 656 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1483+/-0.000504; mu= 20.1018+/- 0.031
mean_var=65.0233+/-12.964, 0's: 0 Z-trim(107.6): 70 B-trim: 905 in 1/53
Lambda= 0.159052
statistics sampled from 15598 (15667) to 15598 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.519), E-opt: 0.2 (0.184), width: 16
Scan time: 8.160
The best scores are: opt bits E(85289)
NP_439897 (OMIM: 608479) anion exchange transporte ( 656) 4274 990.4 0
NP_001269285 (OMIM: 608479) anion exchange transpo ( 656) 4274 990.4 0
NP_599028 (OMIM: 608479) anion exchange transporte ( 663) 4212 976.2 0
NP_001269286 (OMIM: 608479) anion exchange transpo ( 355) 2329 544.0 3.5e-154
XP_011514169 (OMIM: 126650,214700) PREDICTED: chlo ( 764) 1073 256.0 3.8e-67
NP_000102 (OMIM: 126650,214700) chloride anion exc ( 764) 1073 256.0 3.8e-67
XP_005250482 (OMIM: 274600,600791,605646) PREDICTE ( 780) 1062 253.5 2.2e-66
NP_000432 (OMIM: 274600,600791,605646) pendrin [Ho ( 780) 1062 253.5 2.2e-66
NP_001035544 (OMIM: 610068) solute carrier family ( 738) 1047 250.0 2.3e-65
NP_602298 (OMIM: 610068) solute carrier family 26 ( 740) 1047 250.0 2.3e-65
NP_599025 (OMIM: 610068) solute carrier family 26 ( 758) 1047 250.0 2.3e-65
NP_075062 (OMIM: 610068) solute carrier family 26 ( 759) 1047 250.0 2.3e-65
NP_996766 (OMIM: 604943,613865) prestin isoform b ( 685) 1022 244.2 1.1e-63
NP_945350 (OMIM: 604943,613865) prestin isoform a ( 744) 1022 244.3 1.2e-63
XP_011514472 (OMIM: 604943,613865) PREDICTED: pres ( 744) 1022 244.3 1.2e-63
NP_996767 (OMIM: 604943,613865) prestin isoform c ( 516) 990 236.8 1.5e-61
XP_016864680 (OMIM: 222600,226900,256050,600972,60 ( 739) 960 230.0 2.3e-59
NP_000103 (OMIM: 222600,226900,256050,600972,60671 ( 739) 960 230.0 2.3e-59
NP_443166 (OMIM: 608481) solute carrier family 26 ( 791) 945 226.6 2.7e-58
NP_599152 (OMIM: 608481) solute carrier family 26 ( 887) 945 226.6 3e-58
XP_011507426 (OMIM: 608481) PREDICTED: solute carr ( 466) 850 204.7 6.4e-52
XP_011507423 (OMIM: 608481) PREDICTED: solute carr ( 702) 835 201.3 9.7e-51
NP_001308716 (OMIM: 604943,613865) prestin isoform ( 653) 822 198.3 7.2e-50
NP_001161434 (OMIM: 604943,613865) prestin isoform ( 712) 822 198.4 7.7e-50
XP_006716088 (OMIM: 274600,600791,605646) PREDICTE ( 423) 807 194.8 5.5e-49
XP_016867807 (OMIM: 274600,600791,605646) PREDICTE ( 754) 807 194.9 8.8e-49
NP_071325 (OMIM: 167030,610130) sulfate anion tran ( 701) 741 179.8 3e-44
NP_998778 (OMIM: 167030,610130) sulfate anion tran ( 701) 741 179.8 3e-44
XP_011507424 (OMIM: 608481) PREDICTED: solute carr ( 627) 692 168.5 6.7e-41
XP_016865724 (OMIM: 606766,608480) PREDICTED: test ( 970) 692 168.6 9.5e-41
NP_001180405 (OMIM: 606766,608480) testis anion tr ( 970) 692 168.6 9.5e-41
NP_443193 (OMIM: 606766,608480) testis anion trans ( 970) 692 168.6 9.5e-41
NP_996768 (OMIM: 604943,613865) prestin isoform d ( 335) 594 145.8 2.3e-34
NP_001268662 (OMIM: 610068) solute carrier family ( 651) 591 145.3 6.5e-34
NP_001268661 (OMIM: 610068) solute carrier family ( 723) 591 145.4 7.1e-34
XP_011512596 (OMIM: 606766,608480) PREDICTED: test ( 944) 532 131.9 1e-29
NP_619732 (OMIM: 606766,608480) testis anion trans ( 865) 342 88.3 1.3e-16
NP_001159821 (OMIM: 610117) sodium-independent sul ( 606) 340 87.7 1.3e-16
NP_001159819 (OMIM: 610117) sodium-independent sul ( 606) 340 87.7 1.3e-16
NP_001159820 (OMIM: 610117) sodium-independent sul ( 606) 340 87.7 1.3e-16
NP_775897 (OMIM: 610117) sodium-independent sulfat ( 606) 340 87.7 1.3e-16
XP_011522955 (OMIM: 610117) PREDICTED: sodium-inde ( 441) 259 69.0 4.1e-11
XP_011522956 (OMIM: 610117) PREDICTED: sodium-inde ( 441) 259 69.0 4.1e-11
XP_011522954 (OMIM: 610117) PREDICTED: sodium-inde ( 465) 259 69.1 4.2e-11
XP_006721896 (OMIM: 610117) PREDICTED: sodium-inde ( 630) 252 67.5 1.7e-10
XP_016879996 (OMIM: 610117) PREDICTED: sodium-inde ( 630) 252 67.5 1.7e-10
XP_016879995 (OMIM: 610117) PREDICTED: sodium-inde ( 677) 252 67.6 1.8e-10
XP_016879994 (OMIM: 610117) PREDICTED: sodium-inde ( 696) 252 67.6 1.8e-10
NP_602297 (OMIM: 167030,610130) sulfate anion tran ( 224) 209 57.4 6.6e-08
>>NP_439897 (OMIM: 608479) anion exchange transporter is (656 aa)
initn: 4274 init1: 4274 opt: 4274 Z-score: 5297.2 bits: 990.4 E(85289): 0
Smith-Waterman score: 4274; 100.0% identity (100.0% similar) in 656 aa overlap (1-656:1-656)
10 20 30 40 50 60
pF1KE2 MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_439 MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 QVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_439 QVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_439 QNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVIS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_439 AMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_439 LVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 PMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_439 PMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 PSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_439 PSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 LIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_439 LIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 KNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_439 KNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 SKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_439 SKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGR
550 560 570 580 590 600
610 620 630 640 650
pF1KE2 SVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKNLSKLSDHSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_439 SVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKNLSKLSDHSEV
610 620 630 640 650
>>NP_001269285 (OMIM: 608479) anion exchange transporter (656 aa)
initn: 4274 init1: 4274 opt: 4274 Z-score: 5297.2 bits: 990.4 E(85289): 0
Smith-Waterman score: 4274; 100.0% identity (100.0% similar) in 656 aa overlap (1-656:1-656)
10 20 30 40 50 60
pF1KE2 MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 QVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVIS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 PMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 PSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 LIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 KNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 SKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGR
550 560 570 580 590 600
610 620 630 640 650
pF1KE2 SVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKNLSKLSDHSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKNLSKLSDHSEV
610 620 630 640 650
>>NP_599028 (OMIM: 608479) anion exchange transporter is (663 aa)
initn: 4212 init1: 4212 opt: 4212 Z-score: 5220.2 bits: 976.2 E(85289): 0
Smith-Waterman score: 4212; 99.5% identity (99.5% similar) in 650 aa overlap (1-650:1-650)
10 20 30 40 50 60
pF1KE2 MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 QVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 QVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 QNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVIS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 AMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 LVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 PMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 PMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 PSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 PSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 LIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 LIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 KNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 KNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 SKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 SKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGR
550 560 570 580 590 600
610 620 630 640 650
pF1KE2 SVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKNLSKLSDHSEV
::::::::::::::::::::::::::::::::::::::::::::: ::
NP_599 SVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKASYKLLFDNLDLPTM
610 620 630 640 650 660
NP_599 PPL
>>NP_001269286 (OMIM: 608479) anion exchange transporter (355 aa)
initn: 2329 init1: 2329 opt: 2329 Z-score: 2889.0 bits: 544.0 E(85289): 3.5e-154
Smith-Waterman score: 2329; 100.0% identity (100.0% similar) in 355 aa overlap (302-656:1-355)
280 290 300 310 320 330
pF1KE2 ACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGSA
::::::::::::::::::::::::::::::
NP_001 MNILSAVITEAFGVALVGYVASLALAQGSA
10 20 30
340 350 360 370 380 390
pF1KE2 KKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVL
40 50 60 70 80 90
400 410 420 430 440 450
pF1KE2 IVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICF
100 110 120 130 140 150
460 470 480 490 500 510
pF1KE2 AANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISINNPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISINNPL
160 170 180 190 200 210
520 530 540 550 560 570
pF1KE2 VFLNAKKFYTDLMNMIQKENACNQPLDDISKCEQNTLLNSLSNGNCNEEASQSCPNEKCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFLNAKKFYTDLMNMIQKENACNQPLDDISKCEQNTLLNSLSNGNCNEEASQSCPNEKCY
220 230 240 250 260 270
580 590 600 610 620 630
pF1KE2 LILDCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCTASLIKAMTYYGNLDSEKPIFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LILDCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCTASLIKAMTYYGNLDSEKPIFF
280 290 300 310 320 330
640 650
pF1KE2 ESVSAAISHIHSNKNLSKLSDHSEV
:::::::::::::::::::::::::
NP_001 ESVSAAISHIHSNKNLSKLSDHSEV
340 350
>>XP_011514169 (OMIM: 126650,214700) PREDICTED: chloride (764 aa)
initn: 1027 init1: 728 opt: 1073 Z-score: 1326.6 bits: 256.0 E(85289): 3.8e-67
Smith-Waterman score: 1086; 31.9% identity (62.5% similar) in 662 aa overlap (32-640:58-719)
10 20 30 40 50 60
pF1KE2 TGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQQ
.:: .: : : ::: :: : :::: ..
XP_011 TGRHHKTFLDHLKVCCSCSPQKAKRIVLSLFPIASWLPAYRLKEWLLSDIVSGISTGIVA
30 40 50 60 70 80
70 80 90 100 110
pF1KE2 VTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLIS----ANAVER
: ::::::.: .. ::.:::.:.:::::: .:: ..:...: : . :.. ..:: .
XP_011 VLQGLAFALLVDIPPVYGLYASFFPAIIYLFFGTSRHISVGPFPILSMMVGLAVSGAVSK
90 100 110 120 130 140
120 130 140 150 160 170
pF1KE2 IVP-QNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTE
:: .: .: .:.. .: : : :. .::.:. :.:.::.:. .:..: ... ..:
XP_011 AVPDRNATTLGLPNNSNNSSLLDDERVRVAAAASVTVLSGIIQLAFGILRIGFVVIYLSE
150 160 170 180 190 200
180 190 200 210 220 230
pF1KE2 PVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLL
.::..::.::.::..::.:... . .: . :...: . :: .:... . :. .:.
XP_011 SLISGFTTAAAVHVLVSQLKFIFQLTVPSHTDPVSIFKVLYSVFSQIEKTNIADLVTALI
210 220 230 240 250 260
240 250 260 270 280 290
pF1KE2 SIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPS
..:. .:::.:..:: :. : .:..... . :. . : ...: . . ::: . :.
XP_011 VLLVVSIVKEINQRFKDKLPVPIPIEFIMTVIAAGVSYGCDFKNRFKVAVVGDMNPGFQP
270 280 290 300 310 320
300 310 320 330 340 350
pF1KE2 PRAPPMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSF
: .: .. .. .. . ::.:.:........:. . :. : .: :::..: ::.::: .
XP_011 PITPDVETFQNTVGDCFGIAMVAFAVAFSVASVYSLKYDYPLDGNQELIALGLGNIVCGV
330 340 350 360 370 380
360 370 380 390 400 410
pF1KE2 FFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVG
: . ...:..:.: :::.:::.: ::. :.::::. ::: :: : :::.. . .
XP_011 FRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIVVLAIGFLLAPLQKSVLAALALGN
390 400 410 420 430 440
420 430 440 450 460 470
pF1KE2 LKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGR--FPR
:::::.:: .. . : :: : ::. :..::: .. ..:: .:. . .. : ::.
XP_011 LKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGLGLGLAASVAFQLLTIVFRTQFPK
450 460 470 480 490 500
480 490 500 510 520
pF1KE2 AMTVSIKNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMI-----QK
:.. . .. . : .: . :::. .:. : : : :.. . .
XP_011 CSTLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPIYFANIGFFRRKLIDAVGFSPLRI
510 520 530 540 550 560
530 540 550 560
pF1KE2 ENACNQPLDDISKCEQNTLLNSLSNG---------NCNEEASQS----------------
:. : : : ... ::. .: . .:: ...
XP_011 LRKRNKALRKIRKLQKQGLLQVTPKGFICTVDTIKDSDEELDNNQIEVLDQPINTTDLPF
570 580 590 600 610 620
570 580 590 600 610
pF1KE2 -------------CPNEKCY-LILDCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCT
:. . . :::: :. .:.: :.: : . .. .::: ..
XP_011 HIDWNDDLPLNIEVPKISLHSLILDFSAVSFLDVSSVRGLKSILQEFIRIKVDVYIVGTD
630 640 650 660 670 680
620 630 640 650
pF1KE2 ASLIKAMTYYGNLDSE--KPIFFESVSAAISHIHSNKNLSKLSDHSEV
..:. .. : .:.: . ::: .. :. :
XP_011 DDFIEKLNRYEFFDGEVKSSIFFLTIHDAVLHILMKKDYSTSKFNPSQEKDGKIDFTINT
690 700 710 720 730 740
XP_011 NGGLRNRVYEVPVETKF
750 760
>>NP_000102 (OMIM: 126650,214700) chloride anion exchang (764 aa)
initn: 1027 init1: 728 opt: 1073 Z-score: 1326.6 bits: 256.0 E(85289): 3.8e-67
Smith-Waterman score: 1086; 31.9% identity (62.5% similar) in 662 aa overlap (32-640:58-719)
10 20 30 40 50 60
pF1KE2 TGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQQ
.:: .: : : ::: :: : :::: ..
NP_000 TGRHHKTFLDHLKVCCSCSPQKAKRIVLSLFPIASWLPAYRLKEWLLSDIVSGISTGIVA
30 40 50 60 70 80
70 80 90 100 110
pF1KE2 VTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLIS----ANAVER
: ::::::.: .. ::.:::.:.:::::: .:: ..:...: : . :.. ..:: .
NP_000 VLQGLAFALLVDIPPVYGLYASFFPAIIYLFFGTSRHISVGPFPILSMMVGLAVSGAVSK
90 100 110 120 130 140
120 130 140 150 160 170
pF1KE2 IVP-QNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTE
:: .: .: .:.. .: : : :. .::.:. :.:.::.:. .:..: ... ..:
NP_000 AVPDRNATTLGLPNNSNNSSLLDDERVRVAAAASVTVLSGIIQLAFGILRIGFVVIYLSE
150 160 170 180 190 200
180 190 200 210 220 230
pF1KE2 PVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLL
.::..::.::.::..::.:... . .: . :...: . :: .:... . :. .:.
NP_000 SLISGFTTAAAVHVLVSQLKFIFQLTVPSHTDPVSIFKVLYSVFSQIEKTNIADLVTALI
210 220 230 240 250 260
240 250 260 270 280 290
pF1KE2 SIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPS
..:. .:::.:..:: :. : .:..... . :. . : ...: . . ::: . :.
NP_000 VLLVVSIVKEINQRFKDKLPVPIPIEFIMTVIAAGVSYGCDFKNRFKVAVVGDMNPGFQP
270 280 290 300 310 320
300 310 320 330 340 350
pF1KE2 PRAPPMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSF
: .: .. .. .. . ::.:.:........:. . :. : .: :::..: ::.::: .
NP_000 PITPDVETFQNTVGDCFGIAMVAFAVAFSVASVYSLKYDYPLDGNQELIALGLGNIVCGV
330 340 350 360 370 380
360 370 380 390 400 410
pF1KE2 FFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVG
: . ...:..:.: :::.:::.: ::. :.::::. ::: :: : :::.. . .
NP_000 FRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIVVLAIGFLLAPLQKSVLAALALGN
390 400 410 420 430 440
420 430 440 450 460 470
pF1KE2 LKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGR--FPR
:::::.:: .. . : :: : ::. :..::: .. ..:: .:. . .. : ::.
NP_000 LKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGLGLGLAASVAFQLLTIVFRTQFPK
450 460 470 480 490 500
480 490 500 510 520
pF1KE2 AMTVSIKNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMI-----QK
:.. . .. . : .: . :::. .:. : : : :.. . .
NP_000 CSTLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPIYFANIGFFRRKLIDAVGFSPLRI
510 520 530 540 550 560
530 540 550 560
pF1KE2 ENACNQPLDDISKCEQNTLLNSLSNG---------NCNEEASQS----------------
:. : : : ... ::. .: . .:: ...
NP_000 LRKRNKALRKIRKLQKQGLLQVTPKGFICTVDTIKDSDEELDNNQIEVLDQPINTTDLPF
570 580 590 600 610 620
570 580 590 600 610
pF1KE2 -------------CPNEKCY-LILDCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCT
:. . . :::: :. .:.: :.: : . .. .::: ..
NP_000 HIDWNDDLPLNIEVPKISLHSLILDFSAVSFLDVSSVRGLKSILQEFIRIKVDVYIVGTD
630 640 650 660 670 680
620 630 640 650
pF1KE2 ASLIKAMTYYGNLDSE--KPIFFESVSAAISHIHSNKNLSKLSDHSEV
..:. .. : .:.: . ::: .. :. :
NP_000 DDFIEKLNRYEFFDGEVKSSIFFLTIHDAVLHILMKKDYSTSKFNPSQEKDGKIDFTINT
690 700 710 720 730 740
NP_000 NGGLRNRVYEVPVETKF
750 760
>>XP_005250482 (OMIM: 274600,600791,605646) PREDICTED: p (780 aa)
initn: 1019 init1: 735 opt: 1062 Z-score: 1312.8 bits: 253.5 E(85289): 2.2e-66
Smith-Waterman score: 1077; 31.5% identity (63.7% similar) in 663 aa overlap (32-641:69-729)
10 20 30 40 50 60
pF1KE2 TGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQQ
.:::.: :.: .:: :: :..::. ..
XP_005 RLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVA
40 50 60 70 80 90
70 80 90 100 110 120
pF1KE2 VTQGLAFAVLSSVHPV-FGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVP
. ::.:.:.:..: :: .:::...:: . : ::: ..:...: : ..::. ...: ..:
XP_005 TLQGMAYALLAAV-PVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAP
100 110 120 130 140 150
130 140 150 160 170
pF1KE2 QNMQNLTTQSNTSVLGLSDFEMQ-----RIHVAAAVSFLGGVIQVAMFVLQLGSATFVVT
. . :...:: .::. . .. :. .:.:...: :.::. . ::.: . ..
XP_005 -DEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLA
160 170 180 190 200 210
180 190 200 210 220 230
pF1KE2 EPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSL
.:.....::.:: .:..::.: .:... .: :...: . .:.:: .. : . .:
XP_005 DPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGL
220 230 240 250 260 270
240 250 260 270 280 290
pF1KE2 LSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIP
:.::: . :::::..:..:: : .:..... : :. : .:.:..:. .: ::.:.
XP_005 LTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFL
280 290 300 310 320 330
300 310 320 330 340 350
pF1KE2 SPRAPPMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSS
:. ::....: ... .:..:.:.:. ...... : :. :.:: ::::.: :.::: :.
XP_005 PPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSG
340 350 360 370 380 390
360 370 380 390 400 410
pF1KE2 FFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVV
:: :. ...:..::: :::.::::: .:: .:.:.: :.: :: : :::.....
XP_005 FFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIA
400 410 420 430 440 450
420 430 440 450 460 470
pF1KE2 GLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGR--FP
.::::..:. :. . : .::: ::: : . .: .. ..::: :.. . :. : ::
XP_005 NLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFP
460 470 480 490 500 510
480 490 500 510 520
pF1KE2 RAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDL-----MNMIQ
.. .. ..:. . : : :::. ...:. . :. : . .. :.
XP_005 SWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIR
520 530 540 550 560 570
530 540 550 560 570
pF1KE2 KENACNQPLDDISKCEQNTLLNSLSNGNCNEEASQSC---PNEKCY--------------
: . : :.: .. : . .:: .. .: . :.:
XP_005 VYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEI
580 590 600 610 620 630
580 590 600 610
pF1KE2 ---------------------LILDCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCT
:.:::....:.: :: : . . . .:.: .:
XP_005 QVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQ
640 650 660 670 680 690
620 630 640 650
pF1KE2 ASLIKAMTYYGNLDSE--KPIFFESVSAAISHIHSNKNLSKLSDHSEV
.:. . : .:.. : :: .: :: ..
XP_005 DYVIEKLEQCGFFDDNIRKDTFFLTVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTL
700 710 720 730 740 750
XP_005 ELIETELTEEELDVQDEAMRTLAS
760 770 780
>>NP_000432 (OMIM: 274600,600791,605646) pendrin [Homo s (780 aa)
initn: 1019 init1: 735 opt: 1062 Z-score: 1312.8 bits: 253.5 E(85289): 2.2e-66
Smith-Waterman score: 1077; 31.5% identity (63.7% similar) in 663 aa overlap (32-641:69-729)
10 20 30 40 50 60
pF1KE2 TGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQQ
.:::.: :.: .:: :: :..::. ..
NP_000 RLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVA
40 50 60 70 80 90
70 80 90 100 110 120
pF1KE2 VTQGLAFAVLSSVHPV-FGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVP
. ::.:.:.:..: :: .:::...:: . : ::: ..:...: : ..::. ...: ..:
NP_000 TLQGMAYALLAAV-PVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAP
100 110 120 130 140 150
130 140 150 160 170
pF1KE2 QNMQNLTTQSNTSVLGLSDFEMQ-----RIHVAAAVSFLGGVIQVAMFVLQLGSATFVVT
. . :...:: .::. . .. :. .:.:...: :.::. . ::.: . ..
NP_000 -DEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLA
160 170 180 190 200 210
180 190 200 210 220 230
pF1KE2 EPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSL
.:.....::.:: .:..::.: .:... .: :...: . .:.:: .. : . .:
NP_000 DPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGL
220 230 240 250 260 270
240 250 260 270 280 290
pF1KE2 LSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIP
:.::: . :::::..:..:: : .:..... : :. : .:.:..:. .: ::.:.
NP_000 LTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFL
280 290 300 310 320 330
300 310 320 330 340 350
pF1KE2 SPRAPPMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSS
:. ::....: ... .:..:.:.:. ...... : :. :.:: ::::.: :.::: :.
NP_000 PPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSG
340 350 360 370 380 390
360 370 380 390 400 410
pF1KE2 FFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVV
:: :. ...:..::: :::.::::: .:: .:.:.: :.: :: : :::.....
NP_000 FFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIA
400 410 420 430 440 450
420 430 440 450 460 470
pF1KE2 GLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGR--FP
.::::..:. :. . : .::: ::: : . .: .. ..::: :.. . :. : ::
NP_000 NLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFP
460 470 480 490 500 510
480 490 500 510 520
pF1KE2 RAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDL-----MNMIQ
.. .. ..:. . : : :::. ...:. . :. : . .. :.
NP_000 SWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIR
520 530 540 550 560 570
530 540 550 560 570
pF1KE2 KENACNQPLDDISKCEQNTLLNSLSNGNCNEEASQSC---PNEKCY--------------
: . : :.: .. : . .:: .. .: . :.:
NP_000 VYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEI
580 590 600 610 620 630
580 590 600 610
pF1KE2 ---------------------LILDCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCT
:.:::....:.: :: : . . . .:.: .:
NP_000 QVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQ
640 650 660 670 680 690
620 630 640 650
pF1KE2 ASLIKAMTYYGNLDSE--KPIFFESVSAAISHIHSNKNLSKLSDHSEV
.:. . : .:.. : :: .: :: ..
NP_000 DYVIEKLEQCGFFDDNIRKDTFFLTVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTL
700 710 720 730 740 750
NP_000 ELIETELTEEELDVQDEAMRTLAS
760 770 780
>>NP_001035544 (OMIM: 610068) solute carrier family 26 m (738 aa)
initn: 1027 init1: 736 opt: 1047 Z-score: 1294.5 bits: 250.0 E(85289): 2.3e-65
Smith-Waterman score: 1047; 33.0% identity (72.2% similar) in 497 aa overlap (30-524:52-540)
10 20 30 40 50
pF1KE2 MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAV
..::.: : :.: ... :: : .::. .:.
NP_001 ELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAI
30 40 50 60 70 80
60 70 80 90 100 110
pF1KE2 QQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIV
.:. ::::.:.:... ::::::.:..:..:: .:: ..:...::::. :.. ....: ..
NP_001 MQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLA
90 100 110 120 130 140
120 130 140 150 160 170
pF1KE2 PQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVI
:: . : :... . . :..::...: : :..::.. ....: .. ..::..
NP_001 PQAL-------NDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLV
150 160 170 180 190
180 190 200 210 220 230
pF1KE2 SAMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIV
..::.::..: .::.::..:... ::::...: : .. . .. ... . .. :
NP_001 RGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGV
200 210 220 230 240 250
240 250 260 270 280 290
pF1KE2 VLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRA
:::.:: ::....... . .: .:. .:.:. : .... . ..:::.:: :. : :
NP_001 VLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVA
260 270 280 290 300 310
300 310 320 330 340 350
pF1KE2 PPMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFC
: ...: .. :: .:.::.. ...:.. : . : .:.:::..: ::::.....: :
NP_001 PNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQC
320 330 340 350 360 370
360 370 380 390 400 410
pF1KE2 IPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKG
.: . .:.:. :::...::: :: .:.:..: .: :.. :: :::.::.:.:::
NP_001 FPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKG
380 390 400 410 420 430
420 430 440 450 460 470
pF1KE2 MLIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGR--FPRAMT
:: :. :... :.... : ::. :.. :: . ..::. .:. .. .:. : .:. .
NP_001 MLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSV
440 450 460 470 480 490
480 490 500 510 520 530
pF1KE2 VSIKNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPL
.. .. : ... .. ::.. . . : ::. ::.: .
NP_001 LGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAE-FYSDALKQRCGVDVDFLIS
500 510 520 530 540 550
540 550 560 570 580 590
pF1KE2 DDISKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDC
NP_001 QKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVS
560 570 580 590 600 610
>>NP_602298 (OMIM: 610068) solute carrier family 26 memb (740 aa)
initn: 1027 init1: 736 opt: 1047 Z-score: 1294.5 bits: 250.0 E(85289): 2.3e-65
Smith-Waterman score: 1060; 29.4% identity (65.3% similar) in 659 aa overlap (30-639:73-721)
10 20 30 40 50
pF1KE2 MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAV
..::.: : :.: ... :: : .::. .:.
NP_602 ELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAI
50 60 70 80 90 100
60 70 80 90 100 110
pF1KE2 QQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIV
.:. ::::.:.:... ::::::.:..:..:: .:: ..:...::::. :.. ....: ..
NP_602 MQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLA
110 120 130 140 150 160
120 130 140 150 160 170
pF1KE2 PQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVI
:: . : :... . . :..::...: : :..::.. ....: .. ..::..
NP_602 PQAL-------NDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLV
170 180 190 200 210
180 190 200 210 220 230
pF1KE2 SAMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIV
..::.::..: .::.::..:... ::::...: : .. . .. ... . .. :
NP_602 RGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGV
220 230 240 250 260 270
240 250 260 270 280 290
pF1KE2 VLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRA
:::.:: ::....... . .: .:. .:.:. : .... . ..:::.:: :. : :
NP_602 VLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVA
280 290 300 310 320 330
300 310 320 330 340 350
pF1KE2 PPMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFC
: ...: .. :: .:.::.. ...:.. : . : .:.:::..: ::::.....: :
NP_602 PNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQC
340 350 360 370 380 390
360 370 380 390 400 410
pF1KE2 IPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKG
.: . .:.:. :::...::: :: .:.:..: .: :.. :: :::.::.:.:::
NP_602 FPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKG
400 410 420 430 440 450
420 430 440 450 460 470
pF1KE2 MLIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGR--FPRAMT
:: :. :... :.... : ::. :.. :: . ..::. .:. .. .:. : .:. .
NP_602 MLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSV
460 470 480 490 500 510
480 490 500 510 520
pF1KE2 VSIKNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNM-----------
.. .. : ... .. ::.. . . : ::. ::.: ...
NP_602 LGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAE-FYSDALKQRCGVDVDFLIS
520 530 540 550 560 570
530 540 550 560
pF1KE2 ----------------IQKENACNQ---PLDDISKC---EQ----NTLLNSLSNGNCNEE
.:::. . :: .: : .: . . .. .::. . .
NP_602 QKKKLLKKQEQLKLKQLQKEEKLRKQAGPL--LSACLAPQQVSSGDKMEDATANGQEDSK
580 590 600 610 620 630
570 580 590 600 610
pF1KE2 ASQSC-------PNEKCY-LILDCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCTAS
: .. :. . :::: ....: : .. : ... : . :.: .: : .
NP_602 APDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSP
640 650 660 670 680 690
620 630 640 650
pF1KE2 LIKAMTYYGNLDSE--KPIFFESVSAAISHIHSNKNLSKLSDHSEV
... . .:. : .: :: :..
NP_602 VVSQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
700 710 720 730 740
656 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 16:36:02 2016 done: Tue Nov 8 16:36:03 2016
Total Scan time: 8.160 Total Display time: 0.130
Function used was FASTA [36.3.4 Apr, 2011]