Result of FASTA (omim) for
pF1KE2506
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2506, 456 aa
1>>>pF1KE2506 456 - 456 aa - 456 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6973+/-0.000372; mu= 16.2644+/- 0.023
mean_var=84.9717+/-16.804, 0's: 0 Z-trim(113.1): 24 B-trim: 32 in 1/53
Lambda= 0.139135
statistics sampled from 22236 (22256) to 22236 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.628), E-opt: 0.2 (0.261), width: 16
Scan time: 7.770
The best scores are: opt bits E(85289)
NP_001029366 (OMIM: 606180) exosome complex compon ( 456) 2991 610.6 2.8e-174
NP_005024 (OMIM: 606180) exosome complex component ( 439) 2540 520.0 4.9e-147
XP_011530337 (OMIM: 606180) PREDICTED: exosome com ( 392) 2538 519.6 6e-147
NP_852480 (OMIM: 606019,616081) exosome complex co ( 276) 412 92.7 1.3e-18
XP_006719826 (OMIM: 606019,616081) PREDICTED: exos ( 313) 403 91.0 5.1e-18
NP_055819 (OMIM: 606488) exosome complex component ( 291) 371 84.5 4.1e-16
XP_016861419 (OMIM: 606488) PREDICTED: exosome com ( 210) 222 54.5 3.2e-07
>>NP_001029366 (OMIM: 606180) exosome complex component (456 aa)
initn: 2991 init1: 2991 opt: 2991 Z-score: 3249.7 bits: 610.6 E(85289): 2.8e-174
Smith-Waterman score: 2991; 100.0% identity (100.0% similar) in 456 aa overlap (1-456:1-456)
10 20 30 40 50 60
pF1KE2 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 CELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCIDTES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCIDTES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVTLYTPEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVTLYTPEER
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 MLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRITAFKMEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRITAFKMEK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 APIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDSEKEDDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDSEKEDDEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 GGDQAIILDGIKMDTGVEVSDIGSQELGFHHVGQTGLEFLTSDAPIILSDSEEEEMIILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGDQAIILDGIKMDTGVEVSDIGSQELGFHHVGQTGLEFLTSDAPIILSDSEEEEMIILE
370 380 390 400 410 420
430 440 450
pF1KE2 PDKNPKKIRTQTTSAKQEKAPSKKPVKRRKKKRAAN
::::::::::::::::::::::::::::::::::::
NP_001 PDKNPKKIRTQTTSAKQEKAPSKKPVKRRKKKRAAN
430 440 450
>>NP_005024 (OMIM: 606180) exosome complex component RRP (439 aa)
initn: 2540 init1: 2540 opt: 2540 Z-score: 2760.7 bits: 520.0 E(85289): 4.9e-147
Smith-Waterman score: 2833; 96.3% identity (96.3% similar) in 456 aa overlap (1-456:1-439)
10 20 30 40 50 60
pF1KE2 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 CELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCIDTES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCIDTES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVTLYTPEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVTLYTPEER
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 MLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRITAFKMEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRITAFKMEK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 APIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDSEKEDDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 APIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDSEKEDDEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 GGDQAIILDGIKMDTGVEVSDIGSQELGFHHVGQTGLEFLTSDAPIILSDSEEEEMIILE
::::::::::::::::::::::::: ::::::::::::::::::
NP_005 GGDQAIILDGIKMDTGVEVSDIGSQ-----------------DAPIILSDSEEEEMIILE
370 380 390 400
430 440 450
pF1KE2 PDKNPKKIRTQTTSAKQEKAPSKKPVKRRKKKRAAN
::::::::::::::::::::::::::::::::::::
NP_005 PDKNPKKIRTQTTSAKQEKAPSKKPVKRRKKKRAAN
410 420 430
>>XP_011530337 (OMIM: 606180) PREDICTED: exosome complex (392 aa)
initn: 2538 init1: 2538 opt: 2538 Z-score: 2759.2 bits: 519.6 E(85289): 6e-147
Smith-Waterman score: 2538; 100.0% identity (100.0% similar) in 385 aa overlap (1-385:1-385)
10 20 30 40 50 60
pF1KE2 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 CELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCIDTES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCIDTES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVTLYTPEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVTLYTPEER
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 MLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRITAFKMEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRITAFKMEK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 APIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDSEKEDDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDSEKEDDEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 GGDQAIILDGIKMDTGVEVSDIGSQELGFHHVGQTGLEFLTSDAPIILSDSEEEEMIILE
:::::::::::::::::::::::::
XP_011 GGDQAIILDGIKMDTGVEVSDIGSQVYSSNSE
370 380 390
>>NP_852480 (OMIM: 606019,616081) exosome complex compon (276 aa)
initn: 227 init1: 142 opt: 412 Z-score: 455.0 bits: 92.7 E(85289): 1.3e-18
Smith-Waterman score: 412; 29.2% identity (64.0% similar) in 264 aa overlap (11-271:15-272)
10 20 30 40 50
pF1KE2 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFG---TDYGCCIVELGKT
:::: .:. : :::. ..:. ...: : : .:.::.:
NP_852 MAAGFKTVEPLEYYRRFL----KENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNT
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 RVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNS
:. :. :...:. . .: . :..: . . :. : .. .... ..::
NP_852 TVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 KCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVT
. :. :.::. :. :: . :: :..::::.:: ..: ..:: . . :.:... .:..
NP_852 QIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTIN-EETA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 LYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICT
: . . :.:. :. .::: :.. : :.:::. .::.. : :.:.:... ..:
NP_852 LAEVNLKKKSYLNIRTHPVATSFAVFDD-TLLIVDPTGEEEHLATGTLTIVMDEEGKLCC
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 IQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRI
... :: : .. : . : .. :. .:. .....
NP_852 LHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK
240 250 260 270
300 310 320 330 340 350
pF1KE2 TAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDS
>>XP_006719826 (OMIM: 606019,616081) PREDICTED: exosome (313 aa)
initn: 227 init1: 142 opt: 403 Z-score: 444.5 bits: 91.0 E(85289): 5.1e-18
Smith-Waterman score: 403; 28.5% identity (64.5% similar) in 256 aa overlap (19-271:56-309)
10 20 30 40
pF1KE2 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFG---TDYGC
.:. : :::. ..:. ...: : :
XP_006 RVESAAAEQARRRGAAQAQTRGREDGGWVQKENCRPDGRELGEFRTTTVNIGSISTADGS
30 40 50 60 70 80
50 60 70 80 90 100
pF1KE2 CIVELGKTRVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRL
.:.::.: :. :. :...:. . .: . :..: . . :. : .. ...
XP_006 ALVKLGNTTVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQF
90 100 110 120 130 140
110 120 130 140 150 160
pF1KE2 MERCLRNSKCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDV
. ..::. :. :.::. :. :: . :: :..::::.:: ..: ..:: . . :.:
XP_006 IADVIENSQIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEV
150 160 170 180 190 200
170 180 190 200 210 220
pF1KE2 SVQGDEVTLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAM
... .:..: . . :.:. :. .::: :.. : :.:::. .::.. : :.:.:
XP_006 TIN-EETALAEVNLKKKSYLNIRTHPVATSFAVFDD-TLLIVDPTGEEEHLATGTLTIVM
210 220 230 240 250 260
230 240 250 260 270 280
pF1KE2 NKHREICTIQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFA
... ..: ... :: : .. : . : .. :. .:. .....
XP_006 DEEGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK
270 280 290 300 310
290 300 310 320 330 340
pF1KE2 ESIANQRITAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVEN
>>NP_055819 (OMIM: 606488) exosome complex component RRP (291 aa)
initn: 355 init1: 262 opt: 371 Z-score: 410.2 bits: 84.5 E(85289): 4.1e-16
Smith-Waterman score: 371; 27.3% identity (60.8% similar) in 293 aa overlap (1-284:1-289)
10 20 30 40 50
pF1KE2 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRIS---FGTDYGCCIVELGKTRVLG
: . ::. :. .......: :.::: ::: ... .. : :.::.: .:
NP_055 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 QVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCID
:. :. .:::.. .:: : : .. : :.: :: .:: ... . : . :.. .:
NP_055 GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVD
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 TESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDE-----V
..::. :. : . ::. ::. ::..:: :::. .:: . : : : : :: .
NP_055 LKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDI
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 TLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREIC
: . . : . ::....: :. .. . : .:: . .:: . :....... .
NP_055 EL-SDDPYDCIRLSVENVP-CI-VTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVT
190 200 210 220 230
240 250 260 270 280 290
pF1KE2 TIQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKAL-ENDQKVRKEGGKFGFAESIANQ
... : : ..... . .: .:... . :... ...... . : ::
NP_055 CMRKVGKGSLDPESIFEMME-TGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE2 RITAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLE
>>XP_016861419 (OMIM: 606488) PREDICTED: exosome complex (210 aa)
initn: 205 init1: 183 opt: 222 Z-score: 250.6 bits: 54.5 E(85289): 3.2e-07
Smith-Waterman score: 222; 25.5% identity (59.6% similar) in 208 aa overlap (83-284:5-208)
60 70 80 90 100 110
pF1KE2 TRVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRN
: :.: :: .:: ... . : . :
XP_016 MASSSASATPEFEGRGGDDLGTEIANTLYRIFNN
10 20 30
120 130 140 150 160 170
pF1KE2 SKCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDE-
.. .: ..::. :. : . ::. ::. ::..:: :::. .:: . : : : : ::
XP_016 KSSVDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEE
40 50 60 70 80 90
180 190 200 210 220
pF1KE2 ----VTLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNK
. : . . : . ::....: :. .. . : .:: . .:: . :......
XP_016 GSKDIEL-SDDPYDCIRLSVENVP-CI-VTLCKIGYRHVVDATLQEEACSLASLLVSVTS
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE2 HREICTIQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKAL-ENDQKVRKEGGKFGFAE
. . ... : : ..... . .: .:... . :... ...... . : ::
XP_016 KGVVTCMRKVGKGSLDPESIFEMME-TGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG
160 170 180 190 200 210
290 300 310 320 330 340
pF1KE2 SIANQRITAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENS
456 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 03:04:43 2016 done: Tue Nov 8 03:04:44 2016
Total Scan time: 7.770 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]