Result of FASTA (omim) for
pF1KE2387
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2387, 1756 aa
1>>>pF1KE2387 1756 - 1756 aa - 1756 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 17.6090+/-0.000762; mu= -35.6260+/- 0.046
mean_var=813.7874+/-173.161, 0's: 0 Z-trim(115.6): 492 B-trim: 0 in 0/55
Lambda= 0.044959
statistics sampled from 25617 (26087) to 25617 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.61), E-opt: 0.2 (0.306), width: 16
Scan time: 22.500
The best scores are: opt bits E(85289)
NP_002696 (OMIM: 602871) periplakin [Homo sapiens] (1756) 11190 743.7 3.5e-213
XP_006720965 (OMIM: 602871) PREDICTED: periplakin (1769) 11053 734.8 1.7e-210
XP_016878864 (OMIM: 602871) PREDICTED: periplakin (1772) 8467 567.1 5.2e-160
XP_016878863 (OMIM: 602871) PREDICTED: periplakin (1785) 8467 567.1 5.3e-160
NP_001979 (OMIM: 601590) envoplakin isoform 2 [Hom (2033) 2212 161.4 7.9e-38
NP_001307676 (OMIM: 601590) envoplakin isoform 1 [ (2055) 1879 139.8 2.5e-31
NP_001714 (OMIM: 113810,614653,615425) dystonin is (2649) 948 79.5 4.7e-13
XP_016866714 (OMIM: 113810,614653,615425) PREDICTE (3195) 948 79.5 5.4e-13
NP_004406 (OMIM: 125647,605676,607450,607655,60963 (2871) 940 79.0 7.1e-13
NP_958783 (OMIM: 131950,226670,226730,601282,61213 (4515) 918 77.7 2.7e-12
XP_005251041 (OMIM: 131950,226670,226730,601282,61 (4520) 918 77.7 2.8e-12
XP_005251040 (OMIM: 131950,226670,226730,601282,61 (4524) 918 77.7 2.8e-12
XP_011515433 (OMIM: 131950,226670,226730,601282,61 (4524) 918 77.7 2.8e-12
NP_958781 (OMIM: 131950,226670,226730,601282,61213 (4525) 918 77.7 2.8e-12
XP_006716652 (OMIM: 131950,226670,226730,601282,61 (4529) 918 77.7 2.8e-12
XP_006716653 (OMIM: 131950,226670,226730,601282,61 (4529) 918 77.7 2.8e-12
XP_005251039 (OMIM: 131950,226670,226730,601282,61 (4530) 918 77.7 2.8e-12
NP_958780 (OMIM: 131950,226670,226730,601282,61213 (4533) 918 77.7 2.8e-12
XP_005251038 (OMIM: 131950,226670,226730,601282,61 (4538) 918 77.7 2.8e-12
NP_958786 (OMIM: 131950,226670,226730,601282,61213 (4547) 918 77.7 2.8e-12
NP_958784 (OMIM: 131950,226670,226730,601282,61213 (4547) 918 77.7 2.8e-12
NP_958785 (OMIM: 131950,226670,226730,601282,61213 (4551) 918 77.7 2.8e-12
XP_005251036 (OMIM: 131950,226670,226730,601282,61 (4552) 918 77.7 2.8e-12
XP_005251037 (OMIM: 131950,226670,226730,601282,61 (4552) 918 77.7 2.8e-12
XP_011515432 (OMIM: 131950,226670,226730,601282,61 (4552) 918 77.7 2.8e-12
XP_005251035 (OMIM: 131950,226670,226730,601282,61 (4556) 918 77.7 2.8e-12
NP_000436 (OMIM: 131950,226670,226730,601282,61213 (4574) 918 77.7 2.8e-12
XP_006716651 (OMIM: 131950,226670,226730,601282,61 (4579) 918 77.7 2.8e-12
NP_958782 (OMIM: 131950,226670,226730,601282,61213 (4684) 918 77.7 2.8e-12
XP_005251033 (OMIM: 131950,226670,226730,601282,61 (4689) 918 77.7 2.8e-12
NP_001305963 (OMIM: 125647,605676,607450,607655,60 (2428) 863 73.9 2e-11
NP_001008844 (OMIM: 125647,605676,607450,607655,60 (2272) 804 70.1 2.7e-10
NP_056363 (OMIM: 113810,614653,615425) dystonin is (5171) 741 66.3 8.7e-09
XP_016866713 (OMIM: 113810,614653,615425) PREDICTE (5375) 741 66.3 9e-09
NP_899236 (OMIM: 113810,614653,615425) dystonin is (5497) 741 66.3 9.2e-09
NP_001138242 (OMIM: 113810,614653,615425) dystonin (5537) 741 66.3 9.2e-09
XP_016866712 (OMIM: 113810,614653,615425) PREDICTE (5632) 741 66.3 9.4e-09
XP_016866711 (OMIM: 113810,614653,615425) PREDICTE (5637) 741 66.3 9.4e-09
NP_001138241 (OMIM: 113810,614653,615425) dystonin (5675) 741 66.3 9.4e-09
XP_011513127 (OMIM: 113810,614653,615425) PREDICTE (5684) 741 66.3 9.4e-09
XP_016866709 (OMIM: 113810,614653,615425) PREDICTE (5699) 741 66.3 9.4e-09
XP_016866708 (OMIM: 113810,614653,615425) PREDICTE (5741) 741 66.3 9.5e-09
XP_016866710 (OMIM: 113810,614653,615425) PREDICTE (5663) 713 64.5 3.3e-08
XP_011515434 (OMIM: 131950,226670,226730,601282,61 (3429) 678 62.1 1.1e-07
XP_005249381 (OMIM: 113810,614653,615425) PREDICTE (7281) 666 61.5 3.3e-07
XP_011513128 (OMIM: 113810,614653,615425) PREDICTE (7461) 666 61.5 3.4e-07
XP_005249380 (OMIM: 113810,614653,615425) PREDICTE (7607) 666 61.5 3.5e-07
XP_016866706 (OMIM: 113810,614653,615425) PREDICTE (7619) 666 61.5 3.5e-07
XP_005249379 (OMIM: 113810,614653,615425) PREDICTE (7633) 666 61.5 3.5e-07
XP_005249377 (OMIM: 113810,614653,615425) PREDICTE (7640) 666 61.5 3.5e-07
>>NP_002696 (OMIM: 602871) periplakin [Homo sapiens] (1756 aa)
initn: 11190 init1: 11190 opt: 11190 Z-score: 3948.2 bits: 743.7 E(85289): 3.5e-213
Smith-Waterman score: 11190; 99.9% identity (100.0% similar) in 1756 aa overlap (1-1756:1-1756)
10 20 30 40 50 60
pF1KE2 MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 EGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 HKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 HKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 HLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 HLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 WSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 DWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 YSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 KRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 DSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTQVEDTNRKYEHL
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
NP_002 DSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMAC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 ELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVER
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 RAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 EQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 ALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELD
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 EETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 QHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEAL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 RRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQ
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 DQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 AAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQER
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 KYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTR
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 LIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQK
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 KQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELR
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 QIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREK
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 VTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVV
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 LSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDF
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 LREENHKLQLERENLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELD
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELD
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 DLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLI
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 DWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVN
1690 1700 1710 1720 1730 1740
1750
pF1KE2 KDMSIQELAVLVSGQK
::::::::::::::::
NP_002 KDMSIQELAVLVSGQK
1750
>>XP_006720965 (OMIM: 602871) PREDICTED: periplakin isof (1769 aa)
initn: 11053 init1: 11053 opt: 11053 Z-score: 3900.1 bits: 734.8 E(85289): 1.7e-210
Smith-Waterman score: 11053; 99.8% identity (99.9% similar) in 1736 aa overlap (21-1756:34-1769)
10 20 30 40 50
pF1KE2 MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEA
::::::::::::::::::::::::::::::
XP_006 TGVQEPGTEPGVRDSRERGTEATLKLGSAASISNKELSELIEQLQKNADQVEKNIVDTEA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 KMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 KERVTNLRGKHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KERVTNLRGKHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNI
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 FHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE2 IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE2 FKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDF
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE2 EGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQY
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE2 RSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILR
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE2 PPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
XP_006 PPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRV
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE2 EDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDS
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE2 KGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQR
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE2 FNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQ
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE2 KNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQS
:::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::
XP_006 KNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRRSHVSKRARLQS
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE2 PATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVE
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE2 EAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESF
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE2 QQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEV
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE2 LQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEY
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE2 QQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREV
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE2 SDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVAN
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KE2 LRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQR
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KE2 LREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVAS
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KE2 LRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASA
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KE2 FAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAAL
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KE2 EQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAAL
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE2 EKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFH
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE2 NSKSSKELDFLREENHKLQLERENLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDS
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_006 NSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDS
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE2 RLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELS
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KE2 PEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQSGRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQSGRL
1690 1700 1710 1720 1730 1740
1740 1750
pF1KE2 TPAQYDRYVNKDMSIQELAVLVSGQK
::::::::::::::::::::::::::
XP_006 TPAQYDRYVNKDMSIQELAVLVSGQK
1750 1760
>>XP_016878864 (OMIM: 602871) PREDICTED: periplakin isof (1772 aa)
initn: 8440 init1: 8440 opt: 8467 Z-score: 2993.6 bits: 567.1 E(85289): 5.2e-160
Smith-Waterman score: 11142; 98.9% identity (99.0% similar) in 1772 aa overlap (1-1756:1-1772)
10 20 30 40 50 60
pF1KE2 MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 EGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 HKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 HLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 WSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 DWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELL
310 320 330 340 350 360
370 380 390 400 410
pF1KE2 LRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQ------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQALRPCR
370 380 390 400 410 420
420 430 440 450 460
pF1KE2 ----------GLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALAD
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPDCPACPRQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALAD
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE2 SLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKA
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE2 ITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTP
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE2 LLRTQVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPES
::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPES
610 620 630 640 650 660
650 660 670 680 690 700
pF1KE2 SRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEV
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE2 HKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQME
730 740 750 760 770 780
770 780 790 800 810 820
pF1KE2 TKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSK
:::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
XP_016 TKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRRSHVSK
790 800 810 820 830 840
830 840 850 860 870 880
pF1KE2 RARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNR
850 860 870 880 890 900
890 900 910 920 930 940
pF1KE2 PDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDP
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KE2 VLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDR
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KE2 AQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDP
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KE2 QLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDA
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KE2 ATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKA
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KE2 ESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEM
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KE2 EKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQT
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KE2 KEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGL
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KE2 RAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQ
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KE2 QRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLR
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KE2 RKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARL
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KE2 SELEFHNSKSSKELDFLREENHKLQLERENLQLETRRLQSEINMAATETRDLRNMTVADS
::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
XP_016 SELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADS
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KE2 GTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPD
1630 1640 1650 1660 1670 1680
1670 1680 1690 1700 1710 1720
pF1KE2 TGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEA
1690 1700 1710 1720 1730 1740
1730 1740 1750
pF1KE2 LQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK
::::::::::::::::::::::::::::::::
XP_016 LQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK
1750 1760 1770
>>XP_016878863 (OMIM: 602871) PREDICTED: periplakin isof (1785 aa)
initn: 8440 init1: 8440 opt: 8467 Z-score: 2993.6 bits: 567.1 E(85289): 5.3e-160
Smith-Waterman score: 11011; 98.9% identity (99.0% similar) in 1752 aa overlap (21-1756:34-1785)
10 20 30 40 50
pF1KE2 MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEA
::::::::::::::::::::::::::::::
XP_016 TGVQEPGTEPGVRDSRERGTEATLKLGSAASISNKELSELIEQLQKNADQVEKNIVDTEA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 KMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 KERVTNLRGKHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KERVTNLRGKHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNI
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 FHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE2 IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE2 FKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDF
370 380 390 400 410 420
420 430 440 450
pF1KE2 EGEQ----------------GLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPP
:::: ::::::::::::::::::::::::::::::::::::::::
XP_016 EGEQALRPCRDPDCPACPRQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPP
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE2 TDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKV
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE2 ASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFI
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE2 QALPGSGTTPLLRTQVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENH
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
XP_016 QALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENH
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE2 LNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHC
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE2 PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEP
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE2 QETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDL
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE2 ENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVE
:::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENGRRSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVE
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE2 VTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVR
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE2 KEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVV
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE2 KEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTE
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE2 KEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITV
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KE2 KEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKV
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KE2 REIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKE
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KE2 VIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQE
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330 1340 1350
pF1KE2 ILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQE
1330 1340 1350 1360 1370 1380
1360 1370 1380 1390 1400 1410
pF1KE2 VVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARR
1390 1400 1410 1420 1430 1440
1420 1430 1440 1450 1460 1470
pF1KE2 EAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQ
1450 1460 1470 1480 1490 1500
1480 1490 1500 1510 1520 1530
pF1KE2 LLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELD
1510 1520 1530 1540 1550 1560
1540 1550 1560 1570 1580 1590
pF1KE2 VEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERENLQLETRRLQSEINMAATETR
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_016 VEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETR
1570 1580 1590 1600 1610 1620
1600 1610 1620 1630 1640 1650
pF1KE2 DLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHL
1630 1640 1650 1660 1670 1680
1660 1670 1680 1690 1700 1710
pF1KE2 RRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRK
1690 1700 1710 1720 1730 1740
1720 1730 1740 1750
pF1KE2 SGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK
::::::::::::::::::::::::::::::::::::::::::
XP_016 SGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK
1750 1760 1770 1780
>>NP_001979 (OMIM: 601590) envoplakin isoform 2 [Homo sa (2033 aa)
initn: 2190 init1: 702 opt: 2212 Z-score: 800.1 bits: 161.4 E(85289): 7.9e-38
Smith-Waterman score: 2867; 30.9% identity (65.6% similar) in 1778 aa overlap (8-1755:21-1783)
10 20 30 40
pF1KE2 MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVD
... : ::. ..:. . .::. :: ..: ::::::..:..
NP_001 MFKGLSKGSQGKGSPKGSPAKGSPKGSPSRHSRAAT-QELALLISRMQANADQVERDILE
10 20 30 40 50
50 60 70 80 90 100
pF1KE2 TEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDI
:. ..:.: .... .:.. : ... ..: :: : :. :...::::.. : .::
NP_001 TQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDI
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE2 RQLKERVTNLRGKHKQIYRLAV--KEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV
.::.::::. .... .:. : .: :.:.:: ..:.: .. ..: . ...:.
NP_001 KQLHERVTQECAEYRALYEKMVLPPDVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQI
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 EEHNIFHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNE
::::...:. : : .: .. . . .:..:. :: :.. : : :.:: ..: :: .
NP_001 AEHNILQKEIDAYGQQL-RSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQ
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE2 LYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEH
: : .: . .: :::: : . ::.::.: ...: ..:. .:.:...:.... .:
NP_001 LSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRH
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE2 PGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQ
:. . :.::.::.. .:...::: ::.:..:...:::..:.:.. .... : :..:.:.
NP_001 PAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDA
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE2 KYGPDFKDRYQIEL-LLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPV
::.: ::..:. .:: : : .. ::.:...:.:: ::. : .:. :
NP_001 KYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHV
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE2 EALCDFEGEQGLISRGYSYTLQKN-NGESWELMDSAGNKLIAPAVCFVIPPTDPEALALA
...::... . . .: : : : . ..: .. .:. :::.:: :: ::.:.: :
NP_001 DSICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARA
420 430 440 450 460 470
470 480 490 500 510
pF1KE2 DSLGSQYRSVRQKAAGSKRTLQQR-YEVLK-TENPGDASDL---QGRQLLAGLDKVASDL
. :.:. ....:: : . :. : :. ... ..::: :...::. . .. .::
NP_001 SRLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDL
480 490 500 510 520 530
520 530 540 550 560 570
pF1KE2 DRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALP
. :. . . : :: . ..: : .. .. ...: . :: . : :::... :
NP_001 GQIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRP
540 550 560 570 580 590
580 590 600 610 620 630
pF1KE2 GSGTTPLLRTQVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQD
. .. : . ..... :. . : .: ::. .: ::...:.. ... : : :.
NP_001 VGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQE
600 610 620 630 640 650
640 650 660 670 680 690
pF1KE2 DTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLE
.: .:. . .:: . :: :.. . .... :.:... ..: . ::: : ::
NP_001 APIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLP
660 670 680 690 700 710
700 710 720 730 740 750
pF1KE2 RQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETD
::. .:. : .:.. . .:.. : . .:.: .:..:. .:.. ..: .: . . .:
NP_001 RQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSD
720 730 740 750 760 770
760 770 780 790 800 810
pF1KE2 SLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGR
. ::. ::. :: : .:: :::.. :: : :..::::.:. : .::
NP_001 GPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRC--SLEPTL
780 790 800 810 820 830
820 830 840 850 860 870
pF1KE2 SSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQP---EVEV
. . :: :. ... .: :: .::: : ..: ::.:::: ..:... ...
NP_001 AVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRR
840 850 860 870 880 890
880 890 900 910 920 930
pF1KE2 THETLQRNR-PDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVR
::.. : .. : .. .:. .. .:.:: .: ....:... . .. ::.: : : . .
NP_001 THDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEE
900 910 920 930 940 950
940 950 960 970 980 990
pF1KE2 KEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVV
:::.. :: :: :..... . :: .. :: .::. .. ::.. . . ..
NP_001 KEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLT
960 970 980 990 1000 1010
1000 1010 1020 1030 1040 1050
pF1KE2 KEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTE
::: ..: : . ... ::: ... :: . .. :.. :.... :: ... ..:::.
NP_001 KEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV
1020 1030 1040 1050 1060 1070
1060 1070 1080 1090 1100 1110
pF1KE2 KEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEE-LSFLQDKLKRLEKERAMAEGKIT
:::::.... .. : :. . . .: :.:: :: .. :: ... ::. . .: :.
NP_001 KEVVKVEKNLEMVKAAQALRLQME-EDAARRKQAEEAVAKLQARIEDLERAISSVEPKVI
1080 1090 1100 1110 1120 1130
1120 1130 1140 1150 1160 1170
pF1KE2 VKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEK
:::: :::.: . .: : : :.: .: . :: ..: : ..:.. :: .::.
NP_001 VKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQER
1140 1150 1160 1170 1180 1190
1180 1190 1200 1210 1220 1230
pF1KE2 VREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTK
:.:: . ::..:.:.. :. .: :. : :.:..... .::.:: . : :: ::::.
NP_001 VHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQ
1200 1210 1220 1230 1240 1250
1240 1250 1260 1270 1280 1290
pF1KE2 EVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQ
::.... .::. .:..::. .. . . : . .. .:. : . . . .:.:: : .
NP_001 EVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSK
1260 1270 1280 1290 1300 1310
1300 1310 1320 1330 1340 1350
pF1KE2 EILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQ
:... ..:: ..:. :: .. : .:. : : : : : : . .:.:: :
NP_001 EVVRHEKDPVLEKEAERLRQEVREAAQKR--RAAEDAVYELQSKRLLLERRKPEEKVVVQ
1320 1330 1340 1350 1360 1370
1360 1370 1380 1390 1400 1410
pF1KE2 EVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQAR
::: ...: :: : : .. :.: :. . .:. :...: : .: .. : ....:. .
NP_001 EVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQL-RAGVEEQEGLLSFQEDRSKK
1380 1390 1400 1410 1420 1430
1420 1430 1440 1450 1460 1470
pF1KE2 REAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRR
.:::...: :. ::.. ..::. . : :..::. . :: .:..:. .
NP_001 LAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQV
1440 1450 1460 1470 1480 1490
1480 1490 1500 1510 1520 1530
pF1KE2 QLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDT-EQEIQRLKSSLEEESRSKRE
:. : ..:. .. .:.::. .::.. .: ..:.: . :.: :. :..: ...
NP_001 TELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQA
1500 1510 1520 1530 1540 1550
1540 1550 1560 1570 1580
pF1KE2 LDVEVSRLEARLSELEFHN---SKSSKELDFLRE----ENHKLQ-----LERENLQLETR
. :. ::. :... : . :. .::. :. : .:: :::.. : .:
NP_001 REEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQ-QTL
1560 1570 1580 1590 1600 1610
1590 1600 1610 1620 1630
pF1KE2 RLQSEINMAATETRDLRNMTVADSGTNHDSRLWS-LERELDDLKRLSKDKDLEIDELQKR
.:: : .. . .:.. :. .:. : .. ::: . . :: :.. .:. . .:. .
NP_001 QLQEESKLLSQKTESERQ-KAAQRG-QELSRLEAAILREKDQIY----EKERTLRDLHAK
1620 1630 1640 1650 1660
1640 1650 1660 1670 1680 1690
pF1KE2 LGSVAVKREQ--RENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEE
.. ...: ::..: .: ...:.::...:: ::.. :.:: .....:. ::::::
NP_001 VSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEE
1670 1680 1690 1700 1710 1720
1700 1710 1720 1730 1740 1750
pF1KE2 ISVKGPNGESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK
....:: :: ::. ::::::..::: ::. :.. .: : . . :.:.:.::.:.
NP_001 VTTSGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETK
1730 1740 1750 1760 1770 1780
NP_001 PSSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAV
1790 1800 1810 1820 1830 1840
>>NP_001307676 (OMIM: 601590) envoplakin isoform 1 [Homo (2055 aa)
initn: 2170 init1: 702 opt: 1879 Z-score: 683.3 bits: 139.8 E(85289): 2.5e-31
Smith-Waterman score: 2830; 30.5% identity (64.8% similar) in 1800 aa overlap (8-1755:21-1805)
10 20 30 40
pF1KE2 MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVD
... : ::. ..:. . .::. :: ..: ::::::..:..
NP_001 MFKGLSKGSQGKGSPKGSPAKGSPKGSPSRHSRAAT-QELALLISRMQANADQVERDILE
10 20 30 40 50
50 60 70 80 90 100
pF1KE2 TEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDI
:. ..:.: .... .:.. : ... ..: :: : :. :...::::.. : .::
NP_001 TQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDI
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE2 RQLKERVTNLRGKHKQIYRLAV--KEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV
.::.::::. .... .:. : .: :.:.:: ..:.: .. ..: . ...:.
NP_001 KQLHERVTQECAEYRALYEKMVLPPDVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQI
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 EEHNIFHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNE
::::...:. : : .: .. . . .:..:. :: :.. : : :.:: ..: :: .
NP_001 AEHNILQKEIDAYGQQL-RSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQ
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE2 LYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEH
: : .: . .: :::: : . ::.::.: ...: ..:. .:.:...:.... .:
NP_001 LSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRH
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE2 PGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQ
:. . :.::.::.. .:...::: ::.:..:...:::..:.:.. .... : :..:.:.
NP_001 PAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDA
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE2 KYGPDFKDRYQIEL-LLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPV
::.: ::..:. .:: : : .. ::.:...:.:: ::. : .:. :
NP_001 KYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHV
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE2 EALCDFEGEQGLISRGYSYTLQKN-NGESWELMDSAGNKLIAPAVCFVIPPTDPEALALA
...::... . . .: : : : . ..: .. .:. :::.:: :: ::.:.: :
NP_001 DSICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARA
420 430 440 450 460 470
470 480 490
pF1KE2 DSLGSQYRSVRQK-----------AAGSKRTLQQ----------------RYEVLKTENP
. :.:. ....:: :. : : :: :... . .
NP_001 SRLASELQALKQKLATVQSRLKASAVESLRPSQQGTQGGPGRGGCGARRSRFRLPTAPSG
480 490 500 510 520 530
500 510 520 530 540 550
pF1KE2 GDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNEL
.: .. :...::. . .. .:: . :. . . : :: . ..: : .. .. ...:
NP_001 SDLANPQAQKLLTQMTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRL
540 550 560 570 580 590
560 570 580 590 600 610
pF1KE2 LRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTQVEDTNRKYEHLLQLLDLAQEKVDVANR
. :: . : :::... : . .. : . ..... :. . : .: ::. .:
NP_001 QSLGTEKETAQKECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALD
600 610 620 630 640 650
620 630 640 650 660 670
pF1KE2 LEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNL
::...:.. ... : : :. .: .:. . .:: . :: :.. . .... :
NP_001 LERQIQDADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRAL
660 670 680 690 700 710
680 690 700 710 720 730
pF1KE2 QAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFH
.:... ..: . ::: : :: ::. .:. : .:.. . .:.. : . .:.: .:..:.
NP_001 KASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFK
720 730 740 750 760 770
740 750 760 770 780 790
pF1KE2 RGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQ
.:.. ..: .: . . .:. ::. ::. :: : .:: :::.. :: :
NP_001 NCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQA
780 790 800 810 820 830
800 810 820 830 840 850
pF1KE2 AVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQR
:..::::.:. : .:: . . :: :. ... .: :: .::: : ..:
NP_001 ALQDYELQADTYRC--SLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQL
840 850 860 870 880 890
860 870 880 890 900 910
pF1KE2 LQNLEFALNLLRQQP---EVEVTHETLQRNR-PDSGVEEAWKIRKELDEETERRRQLENE
::.:::: ..:... ... ::.. : .. : .. .:. .. .:.:: .: ....:
NP_001 LQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHE
900 910 920 930 940 950
920 930 940 950 960 970
pF1KE2 VKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELE
... . .. ::.: : : . .:::.. :: :: :..... . :: .. :: .::
NP_001 LEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLE
960 970 980 990 1000 1010
980 990 1000 1010 1020 1030
pF1KE2 ALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVL
. .. ::.. . . ..::: ..: : . ... ::: ... :: . .. :..
NP_001 VAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLE
1020 1030 1040 1050 1060 1070
1040 1050 1060 1070 1080 1090
pF1KE2 LLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEE-L
:.... :: ... ..:::. :::::.... .. : :. . . .: :.:: :: .
NP_001 GLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQME-EDAARRKQAEEAV
1080 1090 1100 1110 1120 1130
1100 1110 1120 1130 1140 1150
pF1KE2 SFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREK
. :: ... ::. . .: :. :::: :::.: . .: : : :.: .: . ::
NP_001 AKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLAREL
1140 1150 1160 1170 1180 1190
1160 1170 1180 1190 1200 1210
pF1KE2 TELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRS
..: : ..:.. :: .::.:.:: . ::..:.:.. :. .: :. : :.:.....
NP_001 SDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEK
1200 1210 1220 1230 1240 1250
1220 1230 1240 1250 1260 1270
pF1KE2 YQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQ
.::.:: . : :: ::::.::.... .::. .:..::. .. . . : . .. .
NP_001 LLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIR
1260 1270 1280 1290 1300 1310
1280 1290 1300 1310 1320 1330
pF1KE2 LKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERAS
:. : . . . .:.:: : .:... ..:: ..:. :: .. : .:. : :
NP_001 LQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKR--RAAEDAV
1320 1330 1340 1350 1360 1370
1340 1350 1360 1370 1380 1390
pF1KE2 QEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRR
: : : : . .:.:: :::: ...: :: : : .. :.: :. . .:. :...
NP_001 YELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQ
1380 1390 1400 1410 1420 1430
1400 1410 1420 1430 1440 1450
pF1KE2 LQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQ
: : .: .. : ....:. . .:::...: :. ::.. ..::. . : :..
NP_001 L-RAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEK
1440 1450 1460 1470 1480 1490
1460 1470 1480 1490 1500 1510
pF1KE2 DPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGD
::. . :: .:..:. . :. : ..:. .. .:.::. .::.. .: ..:.:
NP_001 DPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDR
1500 1510 1520 1530 1540 1550
1520 1530 1540 1550 1560
pF1KE2 T-EQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHN---SKSSKELDFLRE----
. :.: :. :..: ... . :. ::. :... : . :. .::. :.
NP_001 VLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQ
1560 1570 1580 1590 1600 1610
1570 1580 1590 1600 1610
pF1KE2 ENHKLQ-----LERENLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWS-LER
: .:: :::.. : .: .:: : .. . .:.. :. .:. : .. ::: . . :
NP_001 ECGRLQQELRALERQKQQ-QTLQLQEESKLLSQKTESERQ-KAAQRG-QELSRLEAAILR
1620 1630 1640 1650 1660
1620 1630 1640 1650 1660 1670
pF1KE2 ELDDLKRLSKDKDLEIDELQKRLGSVAVKREQ--RENHLRRSIVVIHPDTGRELSPEEAH
: :.. .:. . .:. ... ...: ::..: .: ...:.::...:: ::.
NP_001 EKDQIY----EKERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGKDMSPYEAY
1670 1680 1690 1700 1710 1720
1680 1690 1700 1710 1720 1730
pF1KE2 RAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQSGRLTPAQY
. :.:: .....:. ::::::....:: :: ::. ::::::..::: ::. :.. .:
NP_001 KRGIIDRGQYLQLQELECDWEEVTTSGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEY
1730 1740 1750 1760 1770 1780
1740 1750
pF1KE2 DRYVNKDMSIQELAVLVSGQK
: . . :.:.:.::.:.
NP_001 HLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDD
1790 1800 1810 1820 1830 1840
>>NP_001714 (OMIM: 113810,614653,615425) dystonin isofor (2649 aa)
initn: 500 init1: 224 opt: 948 Z-score: 355.4 bits: 79.5 E(85289): 4.7e-13
Smith-Waterman score: 1317; 23.4% identity (59.1% similar) in 1690 aa overlap (127-1678:277-1893)
100 110 120 130 140 150
pF1KE2 HPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGT
. .: :. .::. .. .::. . .:.
NP_001 PNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---WGS
250 260 270 280 290 300
160 170 180 190 200
pF1KE2 DLPLVDHQVEEHNIFHNEVKAIGPHL--AKDGDKEQNSELR-----------AKYQKLLA
::: :. ..:.:. : .. . : :: .. .... :. ..: :::
NP_001 DLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLN
310 320 330 340 350 360
210 220 230 240 250 260
pF1KE2 ASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNL
.:. ...::..:.....: :::: ::... . .. ::::.:: . .:...:. . :.:
NP_001 TSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI-ARKKDYHAELMREL
370 380 390 400 410 420
270 280 290 300 310 320
pF1KE2 EAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYH
. ::: :.... ..::: .::.: .:::. :....:. :.: : :.:.: :
NP_001 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF
430 440 450 460 470 480
330 340 350 360 370 380
pF1KE2 QFHEDVKDAQELLRKVDSDLNQKYGPDFKDR-YQIELLLRE-LDDQEKVLDKYEDVVQGL
.: .:.:.: . ::.. . ...::. : .. ...: :..: ....:..: .:.... .:
NP_001 EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELL-QYKSTIANL
490 500 510 520 530 540
390 400 410 420 430
pF1KE2 QKRGQQVVPLKYRR-ETPLKP-IPVEALCDFEGEQGLISRGYSYTLQKNNGES-WELMDS
. ... .. :: : . ::: ::..:.::.. . : . .: .:. .. :....
NP_001 MGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP
550 560 570 580 590 600
440 450 460 470 480 490
pF1KE2 AGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSV----RQKAAGSKRTLQQRYEV----
.::. ..:.:::..:: . ::. ::. . .::..: ... . : ... .: .
NP_001 TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID
610 620 630 640 650 660
500 510
pF1KE2 ---------LKTENPGDA----SDLQGR-----------QLLAGLDKV------------
.:: ::. :.::.: :...: : .
NP_001 RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY
670 680 690 700 710 720
520 530 540
pF1KE2 ------ASDLDRQEKAITGI----------------------LRPPLEQGRAVQDSAERA
... ..::... .. .: :::. ...:. :
NP_001 YQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD-LHESVFRI
730 740 750 760 770 780
550 560 570 580 590 600
pF1KE2 KDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTQVEDTNRKYEHLLQLLDL
. ... .:: :.. . : . : :.. .:...: ::.... . ...... .. .
NP_001 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST
790 800 810 820 830 840
610 620 630 640 650 660
pF1KE2 AQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQK
.:. ..: . :. : . :. .:..: ....: .. ... . : :.. ..
NP_001 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR
850 860 870 880 890 900
670 680 690 700 710 720
pF1KE2 SLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQ
... .:..:: :: :. . . ..:. :.. .. .. .: .:..:.. :.. : ..:.
NP_001 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE
910 920 930 940 950 960
730 740 750 760 770 780
pF1KE2 ----SAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQ
: : . .: : . : .. . . .. .. . . :.:..:: :..:: ...
NP_001 GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS
970 980 990 1000 1010 1020
790 800 810 820 830 840
pF1KE2 EVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAAL
.... ..::. .::::::.. :...: . ..: : :: :.:: : . .: :
NP_001 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQ--QKSPV-KRRRMQSSADLIIQEFMDL
1030 1040 1050 1060 1070
850 860 870 880 890
pF1KE2 AAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTH--ETLQRN-------RPDSGVEEAW
...: . .. : .. :: . :.. : :. . :: ... : . : :
NP_001 RTRYTALVTLMTQYIK---FAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENS
1080 1090 1100 1110 1120 1130
900 910 920 930 940 950
pF1KE2 KIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQL
:. ...: . .:... . ..::. .:. . .: .::. ..: : .:
NP_001 KLTGKISELERMVAELKKQKSRVEEELPKVREAAENE--LRKQ-QRNVED-------ISL
1140 1150 1160 1170 1180
960 970 980 990 1000 1010
pF1KE2 QRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADE-VLQ
:. :: . :. ..:::.. . .: :.: : : . ... : :: ..: .:.
NP_001 QKIRAESEAKQY--RRELETIVREKEAAEREL-----ERVRQLTIEAEAKRAAVEENLLN
1190 1200 1210 1220 1230
1020 1030 1040 1050 1060 1070
pF1KE2 LREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQ
.:..:: . . : .. . . : ..:.. .:.. .:. .:. .: .:
NP_001 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR----DNEEELLKLIKQ
1240 1250 1260 1270 1280 1290
1080 1090 1100 1110 1120
pF1KE2 LQEDHQRQDQLREKQEEELSFLQDKLK-RLEKERAMAEGKITVKE-VLKVEK--DAATER
...: : :. ::: :..: : .:: .: ..: . : .: .: : .:.. :
NP_001 MEKDLAFQKQVAEKQ------LKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCR
1300 1310 1320 1330 1340
1130 1140 1150 1160 1170
pF1KE2 EVSDLTRQYE-----------DE-AAKARASQREKTELLRKIWALEEENAKVVVQEKVRE
:. : .... :: .: : .... :: .. ::. : :. .::.:
NP_001 AVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLE--KTSSEEKARL
1350 1360 1370 1380 1390 1400
1180 1190 1200 1210 1220 1230
pF1KE2 IVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVI
. .... . :.::: .... .: .::: .:. . : :. . ....
NP_001 LKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN--QTTGKAEEAMQEASDLK
1410 1420 1430 1440 1450 1460
1240 1250 1260 1270 1280 1290
pF1KE2 KYKTDPEME-----KELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEV
: : . ..: .: .:..:. :: . .: .:...:....: : :
NP_001 KIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKEL----ER
1470 1480 1490 1500 1510
1300 1310 1320 1330 1340 1350
pF1KE2 VQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVV
.: : : . : . ::. . . .: .. : . . . . .:.. ...: .:..:
NP_001 LQ-ICQRKSD-HLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKV-
1520 1530 1540 1550 1560 1570
1360 1370 1380 1390 1400
pF1KE2 QQEVVRYEEEPGLRAE-ASAFAESIDVELRQIDKLRAELRRLQRR--RTELERQLEELER
.:..: ..: : . .: .:.: .: .: . : : ..: . .:. :.:..
NP_001 -EELTRQNNETKLMMQRIQAESENIVLE-KQTIQQRCEALKIQADGFKDQLRSTNEHLHK
1580 1590 1600 1610 1620 1630
1410 1420 1430 1440 1450 1460
pF1KE2 ERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQARE-HALLRLQLE
. ..... .:... :.. :: .. .: ..: . :....:. ...:. .: : . :
NP_001 QTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQ-QNIIIQNTKKEVRNLNAELNASKE
1640 1650 1660 1670 1680 1690
1470 1480 1490 1500 1510
pF1KE2 EE---QHRRQLLEGELETLRRKLAALEKA----EVKEKVVLSESV--QVEKGDTEQEIQR
:. ... :: ..... : .: .. ..:... . : : :.: .: ..
NP_001 EKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEE
1700 1710 1720 1730 1740 1750
1520 1530 1540 1550 1560 1570
pF1KE2 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERENLQLE
.....:. .:: . ..: .. . :. .::.. .: : : : : .:::. ::
NP_001 FRKKMEKLMESKVITENDISGIRLDFVSLQQENSRA-QENAKLCETNIK-ELERQ-LQQY
1760 1770 1780 1790 1800 1810
1580 1590 1600 1610 1620 1630
pF1KE2 TRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQK
...:. .: :.. . ... ...: . .::...:: . : .: : ..
NP_001 REQMQQGQHMEANHYQKCQKL---------EDELIAQKREVENLK---QKMDQQIKEHEH
1820 1830 1840 1850
1640 1650 1660 1670 1680 1690
pF1KE2 RLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEI
.: : .. : ... .. ...:: :.. .: ...:
NP_001 QL--VLLQCEIQKKSTAKD-CTFKPDF--EMTVKECQHSGELSSRNTGHLHPTPRSPLLR
1860 1870 1880 1890 1900 1910
1700 1710 1720 1730 1740 1750
pF1KE2 SVKGPNGESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK
NP_001 WTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDET
1920 1930 1940 1950 1960 1970
>>XP_016866714 (OMIM: 113810,614653,615425) PREDICTED: d (3195 aa)
initn: 500 init1: 224 opt: 948 Z-score: 354.2 bits: 79.5 E(85289): 5.4e-13
Smith-Waterman score: 1317; 23.4% identity (59.1% similar) in 1690 aa overlap (127-1678:823-2439)
100 110 120 130 140 150
pF1KE2 HPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGT
. .: :. .::. .. .::. . .:.
XP_016 PNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---WGS
800 810 820 830 840
160 170 180 190 200
pF1KE2 DLPLVDHQVEEHNIFHNEVKAIGPHL--AKDGDKEQNSELR-----------AKYQKLLA
::: :. ..:.:. : .. . : :: .. .... :. ..: :::
XP_016 DLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLN
850 860 870 880 890 900
210 220 230 240 250 260
pF1KE2 ASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNL
.:. ...::..:.....: :::: ::... . .. ::::.:: . .:...:. . :.:
XP_016 TSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI-ARKKDYHAELMREL
910 920 930 940 950 960
270 280 290 300 310 320
pF1KE2 EAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYH
. ::: :.... ..::: .::.: .:::. :....:. :.: : :.:.: :
XP_016 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF
970 980 990 1000 1010 1020
330 340 350 360 370 380
pF1KE2 QFHEDVKDAQELLRKVDSDLNQKYGPDFKDR-YQIELLLRE-LDDQEKVLDKYEDVVQGL
.: .:.:.: . ::.. . ...::. : .. ...: :..: ....:..: .:.... .:
XP_016 EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELL-QYKSTIANL
1030 1040 1050 1060 1070 1080
390 400 410 420 430
pF1KE2 QKRGQQVVPLKYRR-ETPLKP-IPVEALCDFEGEQGLISRGYSYTLQKNNGES-WELMDS
. ... .. :: : . ::: ::..:.::.. . : . .: .:. .. :....
XP_016 MGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP
1090 1100 1110 1120 1130 1140
440 450 460 470 480 490
pF1KE2 AGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSV----RQKAAGSKRTLQQRYEV----
.::. ..:.:::..:: . ::. ::. . .::..: ... . : ... .: .
XP_016 TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID
1150 1160 1170 1180 1190 1200
500 510
pF1KE2 ---------LKTENPGDA----SDLQGR-----------QLLAGLDKV------------
.:: ::. :.::.: :...: : .
XP_016 RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY
1210 1220 1230 1240 1250 1260
520 530 540
pF1KE2 ------ASDLDRQEKAITGI----------------------LRPPLEQGRAVQDSAERA
... ..::... .. .: :::. ...:. :
XP_016 YQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD-LHESVFRI
1270 1280 1290 1300 1310 1320
550 560 570 580 590 600
pF1KE2 KDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTQVEDTNRKYEHLLQLLDL
. ... .:: :.. . : . : :.. .:...: ::.... . ...... .. .
XP_016 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST
1330 1340 1350 1360 1370 1380
610 620 630 640 650 660
pF1KE2 AQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQK
.:. ..: . :. : . :. .:..: ....: .. ... . : :.. ..
XP_016 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR
1390 1400 1410 1420 1430 1440
670 680 690 700 710 720
pF1KE2 SLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQ
... .:..:: :: :. . . ..:. :.. .. .. .: .:..:.. :.. : ..:.
XP_016 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE
1450 1460 1470 1480 1490 1500
730 740 750 760 770 780
pF1KE2 ----SAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQ
: : . .: : . : .. . . .. .. . . :.:..:: :..:: ...
XP_016 GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS
1510 1520 1530 1540 1550 1560
790 800 810 820 830 840
pF1KE2 EVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAAL
.... ..::. .::::::.. :...: . ..: : :: :.:: : . .: :
XP_016 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQ--QKSPV-KRRRMQSSADLIIQEFMDL
1570 1580 1590 1600 1610 1620
850 860 870 880 890
pF1KE2 AAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTH--ETLQRN-------RPDSGVEEAW
...: . .. : .. :: . :.. : :. . :: ... : . : :
XP_016 RTRYTALVTLMTQYIK---FAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENS
1630 1640 1650 1660 1670 1680
900 910 920 930 940 950
pF1KE2 KIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQL
:. ...: . .:... . ..::. .:. . .: .::. ..: : .:
XP_016 KLTGKISELERMVAELKKQKSRVEEELPKVREAAENE--LRKQ-QRNVED-------ISL
1690 1700 1710 1720 1730
960 970 980 990 1000 1010
pF1KE2 QRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADE-VLQ
:. :: . :. ..:::.. . .: :.: : : . ... : :: ..: .:.
XP_016 QKIRAESEAKQY--RRELETIVREKEAAEREL-----ERVRQLTIEAEAKRAAVEENLLN
1740 1750 1760 1770 1780
1020 1030 1040 1050 1060 1070
pF1KE2 LREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQ
.:..:: . . : .. . . : ..:.. .:.. .:. .:. .: .:
XP_016 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR----DNEEELLKLIKQ
1790 1800 1810 1820 1830
1080 1090 1100 1110 1120
pF1KE2 LQEDHQRQDQLREKQEEELSFLQDKLK-RLEKERAMAEGKITVKE-VLKVEK--DAATER
...: : :. ::: :..: : .:: .: ..: . : .: .: : .:.. :
XP_016 MEKDLAFQKQVAEKQ------LKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCR
1840 1850 1860 1870 1880 1890
1130 1140 1150 1160 1170
pF1KE2 EVSDLTRQYE-----------DE-AAKARASQREKTELLRKIWALEEENAKVVVQEKVRE
:. : .... :: .: : .... :: .. ::. : :. .::.:
XP_016 AVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLE--KTSSEEKARL
1900 1910 1920 1930 1940 1950
1180 1190 1200 1210 1220 1230
pF1KE2 IVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVI
. .... . :.::: .... .: .::: .:. . : :. . ....
XP_016 LKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN--QTTGKAEEAMQEASDLK
1960 1970 1980 1990 2000
1240 1250 1260 1270 1280 1290
pF1KE2 KYKTDPEME-----KELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEV
: : . ..: .: .:..:. :: . .: .:...:....: : :
XP_016 KIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKEL----ER
2010 2020 2030 2040 2050 2060
1300 1310 1320 1330 1340 1350
pF1KE2 VQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVV
.: : : . : . ::. . . .: .. : . . . . .:.. ...: .:..:
XP_016 LQ-ICQRKSD-HLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKV-
2070 2080 2090 2100 2110 2120
1360 1370 1380 1390 1400
pF1KE2 QQEVVRYEEEPGLRAE-ASAFAESIDVELRQIDKLRAELRRLQRR--RTELERQLEELER
.:..: ..: : . .: .:.: .: .: . : : ..: . .:. :.:..
XP_016 -EELTRQNNETKLMMQRIQAESENIVLE-KQTIQQRCEALKIQADGFKDQLRSTNEHLHK
2130 2140 2150 2160 2170 2180
1410 1420 1430 1440 1450 1460
pF1KE2 ERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQARE-HALLRLQLE
. ..... .:... :.. :: .. .: ..: . :....:. ...:. .: : . :
XP_016 QTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQ-QNIIIQNTKKEVRNLNAELNASKE
2190 2200 2210 2220 2230
1470 1480 1490 1500 1510
pF1KE2 EE---QHRRQLLEGELETLRRKLAALEKA----EVKEKVVLSESV--QVEKGDTEQEIQR
:. ... :: ..... : .: .. ..:... . : : :.: .: ..
XP_016 EKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEE
2240 2250 2260 2270 2280 2290
1520 1530 1540 1550 1560 1570
pF1KE2 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERENLQLE
.....:. .:: . ..: .. . :. .::.. .: : : : : .:::. ::
XP_016 FRKKMEKLMESKVITENDISGIRLDFVSLQQENSRA-QENAKLCETNIK-ELERQ-LQQY
2300 2310 2320 2330 2340 2350
1580 1590 1600 1610 1620 1630
pF1KE2 TRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQK
...:. .: :.. . ... ...: . .::...:: . : .: : ..
XP_016 REQMQQGQHMEANHYQKCQKL---------EDELIAQKREVENLK---QKMDQQIKEHEH
2360 2370 2380 2390 2400
1640 1650 1660 1670 1680 1690
pF1KE2 RLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEI
.: : .. : ... .. ...:: :.. .: ...:
XP_016 QL--VLLQCEIQKKSTAKD-CTFKPDF--EMTVKECQHSGELSSRNTGHLHPTPRSPLLR
2410 2420 2430 2440 2450
1700 1710 1720 1730 1740 1750
pF1KE2 SVKGPNGESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK
XP_016 WTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDET
2460 2470 2480 2490 2500 2510
>>NP_004406 (OMIM: 125647,605676,607450,607655,609638,61 (2871 aa)
initn: 739 init1: 214 opt: 940 Z-score: 352.1 bits: 79.0 E(85289): 7.1e-13
Smith-Waterman score: 1106; 22.7% identity (57.5% similar) in 1649 aa overlap (136-1691:192-1755)
110 120 130 140 150 160
pF1KE2 DIRQLKERVTNLRGKHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV
..: . ..: . ..:.:: :....
NP_004 RRASSKGGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMV---AWGVDLASVEQHI
170 180 190 200 210
170 180 190 200 210 220
pF1KE2 EEHNIFHNEVKAIGPHLAK-DGDKEQNS---ELRAKYQKLLAASQARQQHLSSLQDYMQR
. : .:: . .: : .: ...: .:. .:..:: :: :..:: .::. .:
NP_004 NSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQA
220 230 240 250 260 270
230 240 250 260 270 280
pF1KE2 CTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLL
. :..:... . .. :::::.: . .... . ... ::.::...:::..:.:::.
NP_004 TSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQ-LEVKEKELNKLKQESDQLV
280 290 300 310 320 330
290 300 310 320 330 340
pF1KE2 AAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDS
.::. ..:::.:......:. :.. : . ::: : :: :...... :. ...
NP_004 LNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQD
340 350 360 370 380 390
350 360 370 380 390
pF1KE2 DLNQKYGPDFKDRYQIELL--LRELD-DQEKVLDKYEDVVQGLQKRGQQVVPLKYRRET-
.. .:: : :. .:: ..::. ..::.:. :. ::.: ......: :: :
NP_004 SIRKKYPCD-KNMPLQHLLEQIKELEKEREKILE-YKRQVQNLVNKSKKIVQLKPRNPDY
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE2 -PLKPIPVEALCDFEGEQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPPT
::: ..::::.. .: .. .: :. :: .: : . .: ...:.: ..:::
NP_004 RSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPP
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE2 DPEALALADSLGSQYRSV----RQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGL
.: :. :. .. . :... : . : .. .: .. : . : . .
NP_004 NPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIE--------KIRAMTIAK
520 530 540 550 560
520 530 540 550 560 570
pF1KE2 DKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGE
:. . : . :.:. . : : : : . : : .:. . : . . .
NP_004 LKTMRQEDYM-KTIADLELHYQEFIRNSQGSEMFGDDDKR------KIQSQFTDAQKHYQ
570 580 590 600 610 620
580 590 600 610 620 630
pF1KE2 AFIQALPGSGTTPLLRTQVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATH
... ::: : .: :. . : :. ..:: .:: :.. :..: :. .
NP_004 TLVIQLPGY---PQHQTV---TTTEITHHGTCQDVNHNKVIETNR-ENDKQETWMLMELQ
630 640 650 660 670
640 650 660 670 680
pF1KE2 E-----NHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTL
. .: . :. . . ......... :: ::. .. . .. .: .. :
NP_004 KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINEL---KSVQNDSQAIAEVLNQLKDML
680 690 700 710 720 730
690 700 710 720 730 740
pF1KE2 AS-RFQE-HCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQ
:. : .: .: . :: : :...:. .. .:: ...: . . . .: .
NP_004 ANFRGSEKYC----YLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKV
740 750 760 770 780
750 760 770 780 790
pF1KE2 FLVSIPSYEPQETDSLSQMET------KLKN----QKNLLDEIASREQEVQKICAN-SQQ
. . . : : :...:. :.:: .:.:: . .. :..:.: .. :::
NP_004 YEARLTEEETVCLD-LDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQ
790 800 810 820 830 840
800 810 820 830 840 850
pF1KE2 YQQAVKDYELEAEKLRSLLDLENGRSSHVSKRA-RLQSPATKVKEEEAALAAKFTEVYAI
: : .::. .: : . ..... : :.. .... . : .:
NP_004 YPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDA
850 860 870 880 890 900
860 870 880 890 900
pF1KE2 NRQR--LQNLEFALN--LLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQ
.:.. :....:. . ..: : . : .. .: : ::. :: :: .. . .
NP_004 KRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKS--EEVQKI-AELCANSIKDYE
910 920 930 940 950 960
910 920 930 940 950 960
pF1KE2 LENEVKSTQEEIWTLRNQGPQESVVRKE---VLKKVPDPVLEESFQQLQRTLAEEQHKNQ
:. . : . :: : ....... .:... : : . .. : :. . ..
NP_004 LQ--LASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD-VHARYIELLTRSGDYYRFLSE
970 980 990 1000 1010
970 980 990 1000 1010
pF1KE2 LLQ--EELEALQLQLRALEQE---TRDGGQEYVVK-EVLRIEPDRAQADEVLQLREELEA
.:. :.:. . ....::.: .::...: : . : . .. :: : :.. .: .
NP_004 MLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQA-ECSQFKAKLAS
1020 1030 1040 1050 1060 1070
1020 1030 1040 1050 1060 1070
pF1KE2 LRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQ--------LEAEYQ
:.. : :.:: :. . : .: .: : ......: . . .: ...
NP_004 LEELK--RQAE---LDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD
1080 1090 1100 1110 1120 1130
1080 1090 1100 1110 1120 1130
pF1KE2 QLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVS
: ..:... .. :. ..:.:.. ..::.:.:. : . .... . .. .:..
NP_004 QQKNDYDQLQKARQCEKENLGW-----QKLESEKAIKEKEYEIERLRVLLQEEGTRK---
1140 1150 1160 1170 1180
1140 1150 1160 1170
pF1KE2 DLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQE--------------KVREI
:.::.: ::.: :. ::. . : . .:....: .. ..
NP_004 ---REYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRL
1190 1200 1210 1220 1230 1240
1180 1190 1200 1210 1220 1230
pF1KE2 VRPDPKAESEVANLRLELVEQERKYRGAEE---QLRSYQSELEALRRRGPQVEVKEVTKE
: . ..:.. : ... .. : ::: : .. ::. ... ..:.:.: ..
NP_004 SRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEI-MQKKQHLEIELKQVMQQ
1250 1260 1270 1280 1290 1300
1240 1250 1260 1270 1280 1290
pF1KE2 VIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQT---KEV
. . . . .. :.. . : ::.. ::: :. . :. .. .:.. .:.
NP_004 --RSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEI
1310 1320 1330 1340 1350
1300 1310 1320 1330 1340
pF1KE2 VQEILQFQEDPQ-TKEEVASLRAKLSEEQ---KKQVD-LERERASQEEQIARKEEELSRV
.. ::. . . :: . .: . :. . :.: : :: : :.: : .. :...
NP_004 ISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQT
1360 1370 1380 1390 1400 1410
1350 1360 1370 1380 1390 1400
pF1KE2 KE--RVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE
: : :.... ... . .:.: ....:::::. ..:.: : : .
NP_004 TENLRRVEEDI---QQQKATGSEVSQRKQQLEVELRQVTQMRTE---------ESVRYKQ
1420 1430 1440 1450 1460
1410 1420 1430 1440 1450 1460
pF1KE2 ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHA---L
:. .. .. ..:..::.: . ... ... .. :.: : : :.: : .
NP_004 SLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRV--QYDLQKANSSATETI
1470 1480 1490 1500 1510 1520
1470 1480 1490 1500 1510 1520
pF1KE2 LRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKS
.:...:.. : :. . : . .. .. .. .. . :.: .:..: .:.:..:::
NP_004 NKLKVQEQELTR--LRIDYERVSQERTVKDQDITRFQNSLKE-LQLQKQKVEEELNRLKR
1530 1540 1550 1560 1570 1580
1530 1540 1550 1560 1570
pF1KE2 SLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELD----FLREENHKLQLERENLQ-
. :.: ....:. :. .. :.: .. .. ...:. .. . :. .:. :.
NP_004 TASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDG
1590 1600 1610 1620 1630 1640
1580 1590 1600 1610 1620 1630
pF1KE2 --LETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWS--LERELDDLKRLSKDKDLE
: .: : :. ..:.. :: . . .. . ....: . ... ..: .: ... .:
NP_004 HLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIE
1650 1660 1670 1680 1690 1700
1640 1650 1660 1670 1680 1690
pF1KE2 IDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQE
:..::. ... .. . :..:: .. . . : : : .. . . : ..::::
NP_004 IERLQSLTENLTKEHLMLEEELR-NLRLEYDDLRRGRSEADSDKNATI-----LELRSQL
1710 1720 1730 1740 1750
1700 1710 1720 1730 1740 1750
pF1KE2 CDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLV
NP_004 QISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLL
1760 1770 1780 1790 1800 1810
>>NP_958783 (OMIM: 131950,226670,226730,601282,612138,61 (4515 aa)
initn: 697 init1: 234 opt: 918 Z-score: 341.6 bits: 77.7 E(85289): 2.7e-12
Smith-Waterman score: 1475; 25.8% identity (57.0% similar) in 1816 aa overlap (27-1657:362-2118)
10 20 30 40 50
pF1KE2 MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDL
:.... .:: .: :... ...: .:::.
NP_958 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV
340 350 360 370 380 390
60 70 80 90 100 110
pF1KE2 ARLQEGRQPEHRDVTLQKVLD-SEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVT
: :. :. : ... :: ..... .: :. : .::::... . . .:.::..
NP_958 RLLAAGKVPQ-RAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLV
400 410 420 430 440 450
120 130 140 150
pF1KE2 NLRGKHK------------QIYRLAVKEVD--PQVNWAAL---------VEEKLDKLNNQ
.: ... :. ..... :. :... ..: :::. ....
NP_958 AIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGA
460 470 480 490 500 510
160 170 180 190
pF1KE2 SFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKD-GDKEQNS------------ELRAKYQ
.:.::: :. :. : .:. .. . .. . .:. : : .: .:
NP_958 EWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA
520 530 540 550 560 570
200 210 220 230 240 250
pF1KE2 KLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFI
::: .:.:: . : ::.... :.::.::... . .. .:::::: .. .....: ..
NP_958 KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM
580 590 600 610 620 630
260 270 280 290 300 310
pF1KE2 NRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYM
:.:: ::..:..:.. ::.:: .::.: ..:. . :....:. .:.: : :.:::
NP_958 -RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKEN
640 650 660 670 680
320 330 340 350 360 370
pF1KE2 EDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRY-QIELLLRELDDQEKVLDKYEDVV
: :: ::..:. :.:.. : .::. : . ..: ::.. .:... :..:. .
NP_958 AAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHL
690 700 710 720 730 740
380 390 400 410 420 430
pF1KE2 QGLQKRGQQVVPLKYRRET-PLKP-IPVEALCDFEGEQGLISRGYSYTLQKNNGES-WEL
.:: ::.. :: :: :. . :.. .:. :.::.. . . .: : : :..
NP_958 SGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKV
750 760 770 780 790 800
440 450 460 470
pF1KE2 MDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRS-----------------------
..:.:.. .:.:::..:: . :: . : .:...
NP_958 LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRR
810 820 830 840 850 860
480 490 500
pF1KE2 ----VRQKAAGSKRTLQ---QRYEVLKTENPG-----DASDLQG----------------
.:. . .. :::. :: . . : :..: :
NP_958 DVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSC
870 880 890 900 910 920
510 520 530 540
pF1KE2 ----RQLLAGLDKVASDLDRQEKAITGI-----------------LRPPLEQGRAVQDSA
.::: .:.. :.. .: .. :. . :: ::.. : .. :
NP_958 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA-RECA
930 940 950 960 970 980
550 560 570 580 590 600
pF1KE2 ERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALP-GSGTTPLLRTQVEDTNRKYEHLLQ
.: . .. :. . .: .::.: . ::: : ..: ::...: : : :.. .
NP_958 QRIAEQQKAQAEVEGLGKGVARLSAEAEK-VLALPEPSPAAPTLRSELELTLGKLEQVRS
990 1000 1010 1020 1030 1040
610 620 630 640 650 660
pF1KE2 LLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACEL
: . ::. . . . .. : . :.: .::..:.. ..:: . :.. : . .
NP_958 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA
1050 1060 1070 1080 1090 1100
670 680 690 700 710 720
pF1KE2 QAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRA
.::. . ....:..:.. . : .: :. ..:: . .: .: .:.. . :.. :
NP_958 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ
1110 1120 1130 1140 1150 1160
730 740 750 760 770
pF1KE2 QSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQ-----ETDSLSQMETKLKNQKNLLDEI
. :.. ...... : . .: . . : .:: . : .:.... ::.::
NP_958 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE-QLRQEQALLEEI
1170 1180 1190 1200 1210 1220
780 790 800 810 820 830
pF1KE2 ASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKE
. ..:.. ..:: .:.:::::. .. .:: : .:. ..:: . .: .
NP_958 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKA--QLEPVASP--AKKPKVQSGSESVIQ
1230 1240 1250 1260 1270 1280
840 850 860 870 880 890
pF1KE2 EEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRK
: . : ....:. ... : .. . .: .... .. ... .:.: . :: : . ..
NP_958 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL-AEVEAALEKQR
1290 1300 1310 1320 1330 1340
900 910 920 930 940 950
pF1KE2 ELDE-ETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKE---VLKKVPDPVLEESFQQL
.: : ... . : : :.: :... :: :::.: : . ..: .:::
NP_958 QLAEAHAQAKAQAEREAKELQQRM--------QEEVVRREEAAVDAQQQKRSIQEELQQL
1350 1360 1370 1380 1390
960 970 980 990 1000
pF1KE2 QRT----------LAEEQHKNQL-LQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEP
... :: ....: ..::.....:::.: :.. :: : .. .:: .
NP_958 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR--GGAEGELQ-ALRARA
1400 1410 1420 1430 1440 1450
1010 1020 1030 1040 1050
pF1KE2 DRAQADEVLQLREELEALRRQ-----KGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEV
..:.:.. : .:: : :::: . :.::: : .:: : :: . :. . :
NP_958 EEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVEL-ASRVKAEAEAAREKQRALQALEE
1460 1470 1480 1490 1500
1060 1070 1080 1090 1100 1110
pF1KE2 VKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEV
..:: . ::: . : . .: :.. : . .:. :. ..:: ...
NP_958 LRLQAE---EAERRLRQAEVERARQVQVALETAQRSAEAELQS--KRASFAEKTAQLERS
1510 1520 1530 1540 1550 1560
1120 1130 1140 1150 1160 1170
pF1KE2 LKVEKDAATE-REVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVRE
:. :. :... :: .. : . :: .:: .. . :: : : :. : . .. ...:
NP_958 LQEEHVAVAQLREEAERRAQQQAEAERAR--EEAERELER--WQLKA-NEALRLRLQAEE
1570 1580 1590 1600 1610
1180 1190 1200 1210 1220
pF1KE2 IVRPDPKAESEVANLRLELVEQERKYRG-AEEQ-LRSYQ---SELEALRR--RGPQVEVK
... :..: :. . : .:.: . :: :::: .:. . .::: :. .: .
NP_958 VAQQKSLAQAE-AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL
1620 1630 1640 1650 1660 1670
1230 1240 1250 1260 1270 1280
pF1KE2 EVTKEVIKYKTDPE--------MEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKD
. .:.:. ... : .:.:: ::..: . :. .. . :. ... :...:
NP_958 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA
1680 1690 1700 1710 1720 1730
1290 1300 1310 1320
pF1KE2 TKPQVQ-----TKEVVQEILQFQEDP--QTKEEVASLRAKLSEEQKKQV-----DLERER
.: ... :.: .. :. . . ::.: ::: :.:: :.: : :.:
NP_958 SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQR
1740 1750 1760 1770 1780 1790
1330 1340 1350 1360 1370 1380
pF1KE2 ASQEEQIARKEEELSRVKERVVQQEVVRYEEEPG---LR--AEASAFAESIDVELRQIDK
: :. .:.: .... . .. :.. :.: :: :: :: . : :
NP_958 AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK
1800 1810 1820 1830 1840 1850
1390 1400 1410 1420 1430
pF1KE2 LRAELRRLQRRR---TELERQLEELERERQARREAEREVQRLQQRL-------AALEQEE
: : : :. .::::: .: . ::..:.:. :. . : :: :
NP_958 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL
1860 1870 1880 1890 1900 1910
1440 1450 1460 1470 1480 1490
pF1KE2 AEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAE
.. : .. : . : . . ::.. .: :::..:: :.: : ....::: :.:
NP_958 GRIRSNAEDTLRSKEQAELEAARQR---QLAAEEERRRR---EAE-ERVQKSLAAEEEAA
1920 1930 1940 1950 1960
1500 1510 1520 1530 1540 1550
pF1KE2 VKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVS--RLEARLSELEFHNS
..:..: : :. :. .: : .::. :.:: . .: :.. ::.:. . : .
NP_958 RQRKAAL-EEVERLKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ
1970 1980 1990 2000 2010 2020
1560 1570 1580 1590 1600 1610
pF1KE2 KSSKELDFLREENHKLQLERENLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRL
.. .::. . :: :. :. .:..: . : ... .. : .::
NP_958 QKEQELQ------QTLQQEQSVLD----QLRGEAEAARRAAEEAEEARVQAEREAAQSR-
2030 2040 2050 2060 2070
1620 1630 1640 1650 1660 1670
pF1KE2 WSLERELDDLKRLSKDKDLEID-ELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSP
:.... .::... . . . . : . .. ...: ... ::.
NP_958 ----RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD
2080 2090 2100 2110 2120 2130
1680 1690 1700 1710 1720 1730
pF1KE2 EEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQSGRLT
NP_958 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS
2140 2150 2160 2170 2180 2190
1756 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 19:36:05 2016 done: Sun Nov 6 19:36:08 2016
Total Scan time: 22.500 Total Display time: 1.140
Function used was FASTA [36.3.4 Apr, 2011]